GO:0048011

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Name nerve growth factor receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0048011
Unique Molecular Interactions 1972
Total Molecular Interactions 2583
Total Single Events 14908
Pain Genes Associated 130

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nerve growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for nerve growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
2 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
3 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
4 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92
5 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
6 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41
7 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
8 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
9 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
10 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
11 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
12 INT284088 Binding of BDNF and NTRK2 5 0.41 3.4 2.37
13 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
14 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
15 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
16 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
17 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
18 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
19 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
20 INT185097 NGF Regulation of Gene_expression of NAV1 1 0.61 0.81 1.85
21 INT305741 Binding of Kcnk2 and Sort1 1 0.54 1.01 1.8
22 INT150456 Binding of Sort1 and Nts 3 0.45 0.64 1.79
23 INT136273 NGF Regulation of Gene_expression of BDNF 2 0.41 1.14 1.78
24 INT116092 TFF2 Positive_regulation of NFKB1 1 0.17 0.06 1.77
25 INT86997 Binding of HIVEP1 and NGF 2 0.03 1.75 1.73
26 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
27 INT145098 NGF Positive_regulation of BDNF 1 0.66 1.33 1.67
28 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67
29 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
30 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
31 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
32 INT266768 NGF Positive_regulation of Localization of SFTPA1 1 0.01 1.65 1.6
33 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
34 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
35 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
36 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
37 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
38 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48
39 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48
40 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48
41 INT83416 Binding of OPRK1 and Ntrk1 1 0.02 0 1.45
42 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43
43 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4
44 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
45 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39
46 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39
47 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
48 INT82025 Negative_regulation of Binding of Ntrk1 and Ngf 1 0.47 0.64 1.37
49 INT83197 Binding of Ntrk1 and Gdnf 1 0.01 1.05 1.36
50 INT250934 Binding of BDNF and NGF 3 0.39 0.62 1.34
51 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
52 INT181492 NGF Regulation of TRPV1 1 0.21 0.93 1.31
53 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3
54 INT112961 NGF Positive_regulation of ICAM1 1 0.40 0.96 1.28
55 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
56 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
57 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24
58 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
59 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23
60 INT59707 PSENEN Regulation of Negative_regulation of YY1 1 0.12 0.07 1.21
61 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
62 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2
63 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
64 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
65 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
66 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
67 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
68 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
69 INT351373 Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
70 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
71 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
72 INT351378 Gene_expression of Ngf Positive_regulation of Ntrk1 1 0.35 0.41 1.18
73 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
74 INT351377 Gene_expression of Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
75 INT62382 Binding of IGHG3 and SMPD2 1 0.02 0.37 1.17
76 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
77 INT62379 Negative_regulation of Binding of IGHG3 and SMPD2 1 0.03 0.37 1.17
78 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
79 INT147446 ADCYAP1 Regulation of Localization of CP 1 0.02 1.12 1.16
80 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
81 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
82 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
83 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
84 INT160540 Binding of NGF and PSIP1 2 0.29 1.43 1.12
85 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
86 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12
87 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
88 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
89 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
90 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
91 INT305734 Binding of Sort1 and Trpv1 1 0.01 0.5 1.08
92 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
93 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
94 INT181494 TRPV3 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
95 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
96 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
97 INT93614 Ngf Positive_regulation of Ntrk1 2 0.52 0.85 1.05
98 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
99 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
100 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
101 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
102 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
103 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
104 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
105 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 0.01 0.66 0.99
106 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
107 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
108 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
109 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
110 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
111 INT83415 Binding of Oprm1 and Ntrk1 1 0.01 0 0.96
112 INT166790 HRAS Negative_regulation of Gene_expression of PTGER1 1 0.01 1.46 0.95
113 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
114 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
115 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
116 INT271409 NGF Positive_regulation of TRPV1 1 0.08 2.45 0.94
117 INT271410 NGF Positive_regulation of Gene_expression of TRPV1 1 0.07 2.45 0.94
118 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94
119 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
120 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
121 INT72213 Positive_regulation of PRKCA Regulation of Gene_expression of METTL3 1 0.05 0.17 0.93
122 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
123 INT127673 NGF Regulation of Gene_expression of NTRK1 1 0.48 2.12 0.92
124 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
125 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
126 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9
127 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9
128 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89
129 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
130 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88
131 INT165540 NGF Positive_regulation of GRIN1 1 0.07 0.17 0.88
132 INT305742 Binding of Sort1 and Gtf3a 1 0.01 0.64 0.88
133 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
134 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
135 INT297463 Binding of Ntrk1 and Ngf 1 0.10 0.78 0.87
136 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
137 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
138 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
139 INT298295 Runx1 Negative_regulation of Gene_expression of Ntrk1 2 0.38 0.45 0.86
140 INT52390 OPRD1 Regulation of ADCY1 1 0.09 0.13 0.86
141 INT104126 STAT3 Regulation of Phospho1 1 0.00 0.06 0.86
142 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
143 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
144 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
145 INT80877 Negative_regulation of PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
146 INT80878 PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
147 INT256045 Binding of BDNF and Ntrk1 3 0.34 0.65 0.83
148 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
149 INT106312 NFKB1 Regulation of S100A4 1 0.14 1.1 0.83
150 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
151 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
152 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
153 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
154 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
155 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
156 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
157 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
158 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8
159 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
160 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
161 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
162 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
163 INT78714 Ntrk1 Positive_regulation of Ngf 2 0.50 0.63 0.78
164 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
165 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78
166 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
167 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78
168 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
169 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
170 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
171 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
172 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
173 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
174 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76
175 INT65593 CALCA Negative_regulation of Positive_regulation of ADCY1 1 0.23 0.07 0.76
176 INT166674 YY1 Regulation of Binding of PRKCA 1 0.38 0 0.75
177 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
178 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
179 INT213726 Binding of Ngfr and Ntrk1 1 0.14 0.96 0.72
180 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
181 INT148453 Gene_expression of Inhbe Positive_regulation of Src 1 0.06 0.68 0.72
182 INT146463 TNFSF10 Positive_regulation of NFKB1 2 0.08 2.45 0.71
183 INT146461 IFNG Positive_regulation of NFKB1 1 0.01 1.44 0.71
184 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
185 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71
186 INT103134 DCSTAMP Positive_regulation of NFKB1 2 0.07 1.43 0.7
187 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
188 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
189 INT351376 Mir470 Negative_regulation of Ntrk1 1 0.01 1.54 0.7
190 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
191 INT197115 Binding of MCF2 and RETNLB 1 0.00 1.06 0.7
192 INT166673 PRKCA Negative_regulation of UGT1A6 1 0.36 0 0.69
193 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
194 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
195 INT74599 YY1 Negative_regulation of ADCY1 2 0.36 0.31 0.67
196 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
197 INT118979 NGF Positive_regulation of Phosphorylation of NTRK1 1 0.56 0.67 0.67
198 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67
199 INT189704 PRKCA Regulation of CHKB 1 0.13 0.18 0.66
200 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66

Single Events

The table below shows the top 100 pain related interactions that have been reported for nerve growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in nerve growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
2 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32
3 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45
4 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
5 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
6 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
7 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
8 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
9 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
10 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
11 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11
12 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
13 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19
14 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
15 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
16 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
17 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
18 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
19 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04
20 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83
21 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
22 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62
23 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38
24 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
25 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
26 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
27 INT56769 Gene_expression of Ntrk1 36 0.77 15.79 20.75
28 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
29 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
30 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
31 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
32 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
33 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
34 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29
35 INT20216 Localization of NGF 40 0.80 18.16 16.61
36 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
37 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46
38 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
39 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09
40 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95
41 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
42 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
43 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47
44 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
45 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
46 INT71150 Binding of NGF 22 0.46 13.67 14.81
47 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
48 INT39733 Localization of NFKB1 59 0.79 22.76 13.99
49 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
50 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
51 INT55168 Binding of NFKB1 55 0.48 22.94 13.15
52 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
53 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
54 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
55 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
56 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
57 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
58 INT85048 Regulation of NGF 19 0.62 11.61 10.5
59 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
60 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
61 INT147452 Gene_expression of ADCYAP1 14 0.77 12.54 9.28
62 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
63 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
64 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09
65 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
66 INT66213 Localization of RELA 63 0.78 14.71 8.77
67 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
68 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
69 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42
70 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42
71 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37
72 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
73 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14
74 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
75 INT81345 Gene_expression of ADRBK1 21 0.70 2.89 7.9
76 INT48314 Gene_expression of NTRK2 17 0.75 7.84 7.83
77 INT11568 Gene_expression of ADORA2A 14 0.73 1.51 7.79
78 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
79 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
80 INT75526 Positive_regulation of Positive_regulation of PRKCA 16 0.50 4.34 7.46
81 INT50973 Negative_regulation of Gene_expression of Ntrk1 22 0.56 11.12 7.38
82 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
83 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
84 INT63373 Negative_regulation of Gene_expression of NGF 14 0.57 8.9 7.1
85 INT66210 Regulation of Positive_regulation of NFKB1 16 0.60 9.46 7.08
86 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
87 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
88 INT72222 Positive_regulation of Localization of PRKCA 8 0.70 0.55 6.56
89 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
90 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
91 INT63374 Regulation of Gene_expression of NGF 12 0.45 5.6 6.4
92 INT129020 Phosphorylation of Ntrk1 17 0.80 5.97 6.37
93 INT38595 Localization of BCAR1 8 0.73 2.9 6.25
94 INT79737 Positive_regulation of Ntrk1 12 0.49 3.98 6.24
95 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21
96 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
97 INT48313 Binding of NTRK1 19 0.47 14.44 6.12
98 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
99 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94
100 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
101 INT333909 Positive_regulation of Gene_expression of HDAC1 1 0.44 14.15 5.9
102 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84
103 INT97018 Binding of CALM3 7 0.43 0.13 5.82
104 INT26919 Gene_expression of ITPR3 47 0.42 5.86 5.79
105 INT47976 Protein_catabolism of NFKBIA 17 0.88 7.57 5.79
106 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54
107 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5
108 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
109 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
110 INT78728 Negative_regulation of Binding of NFKB1 18 0.58 6.89 5.39
111 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
112 INT100222 Binding of Src 9 0.26 5.41 5.37
113 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33
114 INT66209 Negative_regulation of Localization of NFKB1 23 0.58 8.2 5.31
115 INT80881 Phosphorylation of ADCY1 7 0.69 1.22 5.29
116 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
117 INT70800 Negative_regulation of Positive_regulation of PRKCA 9 0.34 2.18 5.17
118 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
119 INT26334 Localization of ITPR3 39 0.49 2.53 5.07
120 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02
121 INT66211 Positive_regulation of Localization of NFKB1 20 0.68 8.18 5.01
122 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
123 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
124 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
125 INT201653 Gene_expression of Sort1 6 0.75 6.29 4.89
126 INT128178 Positive_regulation of RHOA 59 0.68 9.3 4.7
127 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
128 INT96492 Gene_expression of NGFR 24 0.00 12.3 4.59
129 INT166678 Negative_regulation of Phosphorylation of PRKCA 12 0.38 5.77 4.59
130 INT1807 Negative_regulation of Bcar1 9 0.38 4.04 4.59
131 INT78981 Regulation of Ntrk1 6 0.44 3.89 4.52
132 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47
133 INT14574 Positive_regulation of Negative_regulation of ADCY1 9 0.66 2.45 4.39
134 INT81750 Regulation of Ntrk1 13 0.52 6.03 4.37
135 INT148901 Binding of Sort1 2 0.39 3.65 4.32
136 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
137 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28
138 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
139 INT20981 Binding of HRAS 42 0.48 24.49 4.23
140 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
141 INT34184 Localization of FGD1 7 0.65 2.68 4.21
142 INT58875 Positive_regulation of FGD1 20 0.60 3.88 4.19
143 INT105171 Phosphorylation of RAF1 11 0.74 2.33 4.19
144 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
145 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
146 INT79736 Negative_regulation of Ntrk1 11 0.57 2.31 4.14
147 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08
148 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
149 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02
150 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
151 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97
152 INT100741 Positive_regulation of ADRBK1 10 0.64 1.01 3.95
153 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
154 INT56077 Protein_catabolism of NFKB1 16 0.98 8.03 3.94
155 INT169475 Localization of HRAS 14 0.73 9.02 3.9
156 INT56075 Transcription of NFKB1 13 0.71 9.03 3.83
157 INT56768 Positive_regulation of Gene_expression of Ntrk1 5 0.67 3.91 3.83
158 INT151684 Gene_expression of MCF2L 7 0.54 6.25 3.76
159 INT78619 Positive_regulation of RAC1 27 0.65 10.43 3.75
160 INT26191 Positive_regulation of ITPR3 24 0.44 1.9 3.74
161 INT83411 Binding of Ntrk1 6 0.19 3.7 3.74
162 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
163 INT87408 Negative_regulation of ADCY2 3 0.01 0.1 3.68
164 INT121818 Binding of STAT3 25 0.47 11.16 3.67
165 INT79231 Positive_regulation of Gene_expression of NFKB1 18 0.67 9.16 3.66
166 INT84925 Transcription of NGF 11 0.65 4.13 3.65
167 INT134149 Negative_regulation of Gene_expression of NFKB1 7 0.55 4.25 3.63
168 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
169 INT122327 Regulation of Src 6 0.59 0.59 3.6
170 INT12385 Localization of NGFR 6 0.81 3.05 3.47
171 INT148899 Regulation of Sort1 2 0.50 2.72 3.46
172 INT73557 Positive_regulation of RELA 57 0.46 8.7 3.43
173 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
174 INT87281 Localization of ADCY1 7 0.64 1.84 3.42
175 INT121967 Regulation of RAC1 9 0.45 6.14 3.41
176 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32
177 INT119421 Negative_regulation of RAF1 10 0.41 6.94 3.31
178 INT192450 Gene_expression of CLTC 26 0.55 18.82 3.26
179 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
180 INT72216 Regulation of Positive_regulation of PRKCA 9 0.37 1.36 3.26
181 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23
182 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
183 INT53495 Negative_regulation of Negative_regulation of PRKCA 4 0.42 2.37 3.18
184 INT11015 Regulation of Phosphorylation of CREB1 4 0.46 1.45 3.17
185 INT139801 Phosphorylation of NFKB1 9 0.66 5.2 3.13
186 INT66212 Negative_regulation of Localization of RELA 13 0.57 2.48 3.09
187 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
188 INT13179 Regulation of Positive_regulation of ADCY1 5 0.34 0.89 3.08
189 INT38594 Positive_regulation of Localization of BCAR1 3 0.63 0.44 3.07
190 INT192676 Binding of PTEN 14 0.46 10.58 3.06
191 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
192 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
193 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
194 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
195 INT128179 Gene_expression of RHOA 7 0.64 2.48 3.01
196 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99
197 INT59309 Negative_regulation of Gene_expression of ADCY1 3 0.42 1.04 2.98
198 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
199 INT173179 Binding of MAPK14 13 0.29 4.51 2.92
200 INT61714 Binding of FGD1 12 0.35 7.72 2.91
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