GO:0048014

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Name Tie receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0048014
Unique Molecular Interactions 69
Total Molecular Interactions 81
Total Single Events 516
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Tie receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for Tie receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT21607 ACE Positive_regulation of ANGPT2 1 0.03 0.13 0.61
2 INT254348 Binding of ANGPT1 and TEK 1 0.04 1.72 0.48
3 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
4 INT224700 TNF Positive_regulation of Angpt1 1 0.00 0.63 0.34
5 INT181896 TNF Regulation of TEK 1 0.03 1.21 0.33
6 INT181899 TNF Regulation of ANGPT1 1 0.03 1.22 0.33
7 INT181893 TNF Regulation of ANGPT2 1 0.04 1.22 0.33
8 INT298348 ANGPT2 Positive_regulation of Phosphorylation of Stat3 1 0.18 0.14 0.28
9 INT254351 Binding of ANGPT2 and TEK 1 0.04 0.87 0.22
10 INT303029 Binding of TEK and Angpt1 1 0.26 1.82 0.22
11 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19
12 INT355504 ANGPT2 Positive_regulation of CYBB 1 0.01 0.81 0.18
13 INT265827 ACE Negative_regulation of ANGPT2 1 0.09 0.59 0.17
14 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1
15 INT192249 Angpt1 Positive_regulation of Localization of NOS3 1 0.01 0.46 0.09
16 INT192248 Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
17 INT192250 Positive_regulation of Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
18 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
19 INT298699 Kdr Regulation of Tek 1 0.11 0.28 0.06
20 INT298701 Manea Regulation of Tek 1 0.03 0.28 0.06
21 INT355577 ANGPT2 Positive_regulation of MMP1 1 0.04 0.79 0.05
22 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05
23 INT355605 ANGPT2 Positive_regulation of Mmp9 1 0.10 0.79 0.05
24 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04
25 INT178501 Angpt1 Positive_regulation of Tek 1 0.06 0.78 0.04
26 INT298703 Angpt1 Regulation of Tek 1 0.12 0.27 0.03
27 INT291199 Binding of VEGFA and Angpt1 1 0.08 0.69 0
28 INT294065 ANGPT2 Positive_regulation of VEGFA 1 0.02 0.1 0
29 INT292088 Binding of AMELX and ANGPT1 1 0.00 0.9 0
30 INT294066 ANGPT1 Positive_regulation of VEGFA 1 0.01 0.1 0
31 INT109817 Ace2 Positive_regulation of Angpt1 1 0.05 0.31 0
32 INT298702 Tek Regulation of Kdr 1 0.03 0.33 0
33 INT268887 Binding of ANGPT1 and Tek 1 0.10 0 0
34 INT176096 Regulation of Binding of Angpt1 and Tek 1 0.07 0.54 0
35 INT176097 Binding of Angpt1 and Tek 1 0.06 0.48 0
36 INT172839 Binding of ANGPT2 and T2dm2 1 0.00 1.72 0
37 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
38 INT298704 Tek Regulation of Manea 1 0.02 0.33 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Tie receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in Tie receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82
2 INT54886 Negative_regulation of ANGPT2 25 0.42 9.33 3.79
3 INT21610 Positive_regulation of ANGPT2 23 0.41 13.28 3.03
4 INT176088 Gene_expression of Tek 39 0.65 14.25 2.19
5 INT153718 Gene_expression of ANGPT1 15 0.45 10.82 2.13
6 INT153719 Gene_expression of TEK 10 0.49 9.82 1.88
7 INT123926 Gene_expression of Angpt1 28 0.54 21.74 1.47
8 INT178494 Gene_expression of Angpt1 10 0.37 9.77 1.28
9 INT109078 Positive_regulation of ANGPT1 7 0.22 3.08 1.21
10 INT94393 Localization of ANGPT2 8 0.17 5.02 0.96
11 INT56972 Regulation of ANGPT2 6 0.44 3.48 0.86
12 INT109080 Negative_regulation of ANGPT1 8 0.14 3.17 0.82
13 INT58765 Positive_regulation of Gene_expression of ANGPT2 11 0.38 8.2 0.81
14 INT123927 Positive_regulation of Gene_expression of Angpt1 12 0.48 10.18 0.71
15 INT37544 Binding of ANGPT2 9 0.19 6.51 0.69
16 INT58764 Negative_regulation of Gene_expression of ANGPT2 7 0.34 2.64 0.69
17 INT96909 Regulation of Angpt1 2 0.17 0.37 0.43
18 INT176085 Regulation of Tek 6 0.37 3.36 0.4
19 INT178497 Positive_regulation of Gene_expression of Angpt1 4 0.19 3.65 0.39
20 INT176079 Positive_regulation of Tek 6 0.41 3.15 0.36
21 INT254367 Transcription of TEK 1 0.14 1.08 0.36
22 INT181921 Binding of TEK 2 0.09 1.88 0.32
23 INT254372 Negative_regulation of TEK 1 0.12 1.05 0.31
24 INT56971 Negative_regulation of Negative_regulation of ANGPT2 1 0.31 0 0.26
25 INT265833 Negative_regulation of Binding of ANGPT2 1 0.08 0.82 0.24
26 INT96908 Protein_catabolism of Angpt1 1 0.41 0.26 0.24
27 INT220396 Negative_regulation of Angpt1 4 0.26 1.64 0.23
28 INT146397 Regulation of Gene_expression of ANGPT2 2 0.28 0.49 0.22
29 INT181791 Positive_regulation of Gene_expression of ANGPT1 1 0.29 1.27 0.2
30 INT181788 Positive_regulation of Gene_expression of TEK 1 0.27 1.26 0.2
31 INT178481 Binding of Tek 2 0.28 1.55 0.19
32 INT176091 Regulation of Positive_regulation of Tek 1 0.37 0.22 0.18
33 INT156590 Negative_regulation of Negative_regulation of ANGPT1 1 0.10 0.33 0.16
34 INT265834 Negative_regulation of Localization of ANGPT2 1 0.08 0.96 0.15
35 INT290923 Positive_regulation of Angpt1 3 0.48 3.62 0.14
36 INT298697 Negative_regulation of Tek 2 0.35 0.85 0.14
37 INT146398 Transcription of ANGPT2 1 0.32 0.15 0.14
38 INT265832 Regulation of Localization of ANGPT2 1 0.08 0.39 0.12
39 INT226281 Regulation of TEK 1 0.60 1.33 0.11
40 INT354414 Localization of ANGPT1 1 0.10 0 0.1
41 INT291188 Regulation of Gene_expression of Angpt1 1 0.31 1.78 0.08
42 INT291183 Negative_regulation of Angpt1 1 0.30 0.89 0.08
43 INT291195 Negative_regulation of Gene_expression of Angpt1 1 0.41 2.29 0.07
44 INT178495 Negative_regulation of Positive_regulation of Tek 1 0.14 1.05 0.06
45 INT200861 Negative_regulation of Binding of Tek 1 0.32 0.3 0.06
46 INT97920 Negative_regulation of Angpt2 1 0.26 0 0.06
47 INT97918 Localization of Angpt2 1 0.31 0 0.06
48 INT97921 Negative_regulation of Localization of Angpt2 1 0.19 0 0.06
49 INT290930 Localization of Angpt1 1 0.21 0 0.06
50 INT290916 Regulation of Angpt1 2 0.31 1.01 0.04
51 INT258065 Protein_catabolism of ANGPT1 1 0.01 0.47 0.04
52 INT178484 Positive_regulation of Phosphorylation of Tek 1 0.23 0.79 0.04
53 INT291193 Binding of Angpt1 1 0.26 1.87 0.04
54 INT178486 Phosphorylation of Tek 1 0.27 0.73 0.04
55 INT312928 Localization of Tek 1 0.31 0.66 0.03
56 INT294078 Regulation of ANGPT1 3 0.04 1.25 0
57 INT268882 Binding of ANGPT1 3 0.07 0.89 0
58 INT294081 Negative_regulation of Gene_expression of ANGPT1 2 0.04 0.19 0
59 INT116543 Regulation of Negative_regulation of ANGPT2 1 0.09 0 0
60 INT312931 Negative_regulation of Regulation of Tek 1 0.19 0.23 0
61 INT294077 Negative_regulation of Positive_regulation of ANGPT2 1 0.06 0.06 0
62 INT218765 Regulation of Localization of TEK 1 0.02 0.87 0
63 INT200860 Transcription of Tek 1 0.39 0.26 0
64 INT218764 Localization of TEK 1 0.04 0.87 0
65 INT243005 Positive_regulation of Positive_regulation of Tek 1 0.10 0.98 0
66 INT97922 Regulation of Angpt2 1 0.12 0 0
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