GO:0048015

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Name phosphatidylinositol-mediated signaling
Categary Process
Go Slim No
Go Link GO:0048015
Unique Molecular Interactions 1153
Total Molecular Interactions 1551
Total Single Events 10951
Pain Genes Associated 69

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported for phosphatidylinositol-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
2 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
3 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
4 INT132228 Negative_regulation of Binding of Pik3cg and Sh2d6 1 0.07 1.96 3.6
5 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
6 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
7 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
8 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
9 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
10 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
11 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
12 INT185097 NGF Regulation of Gene_expression of NAV1 1 0.61 0.81 1.85
13 INT136273 NGF Regulation of Gene_expression of BDNF 2 0.41 1.14 1.78
14 INT86997 Binding of HIVEP1 and NGF 2 0.03 1.75 1.73
15 INT145098 NGF Positive_regulation of BDNF 1 0.66 1.33 1.67
16 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
17 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
18 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
19 INT266768 NGF Positive_regulation of Localization of SFTPA1 1 0.01 1.65 1.6
20 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
21 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48
22 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48
23 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48
24 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43
25 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
26 INT148451 Gene_expression of Inhbe Positive_regulation of Pik3cd 1 0.04 1.35 1.4
27 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4
28 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39
29 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39
30 INT96262 Positive_regulation of Pik3cd Positive_regulation of Plcg1 1 0.03 0 1.39
31 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
32 INT250934 Binding of BDNF and NGF 3 0.39 0.62 1.34
33 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
34 INT181492 NGF Regulation of TRPV1 1 0.21 0.93 1.31
35 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3
36 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
37 INT112961 NGF Positive_regulation of ICAM1 1 0.40 0.96 1.28
38 INT96261 Positive_regulation of Pik3cd Positive_regulation of Plcg2 1 0.02 0 1.21
39 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
40 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2
41 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
42 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
43 INT121725 Binding of Trpv1 and Pik3cb 1 0.35 0.62 1.15
44 INT348398 LPA Positive_regulation of Pik3cb 1 0.04 0.88 1.14
45 INT160540 Binding of NGF and PSIP1 2 0.29 1.43 1.12
46 INT121728 Ngf Positive_regulation of Phosphorylation of Pik3cb 1 0.45 0.69 1.11
47 INT122268 Binding of Grin2b and Grm5 1 0.40 0.52 1.1
48 INT121730 Pik3cb Regulation of Trpv1 1 0.58 0.54 1.09
49 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
50 INT181494 TRPV3 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
51 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
52 INT121727 Pik3cb Positive_regulation of Ephb1 1 0.49 0.6 1.06
53 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
54 INT116751 Positive_regulation of Oprm1 Positive_regulation of Pik3cd 1 0.28 0.38 1.01
55 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
56 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
57 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
58 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
59 INT271409 NGF Positive_regulation of TRPV1 1 0.08 2.45 0.94
60 INT271410 NGF Positive_regulation of Gene_expression of TRPV1 1 0.07 2.45 0.94
61 INT127673 NGF Regulation of Gene_expression of NTRK1 1 0.48 2.12 0.92
62 INT96260 Pik3cd Regulation of Plcg2 1 0.02 0 0.92
63 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
64 INT132227 Binding of Pik3cg and Sh2d6 1 0.06 0.49 0.9
65 INT272144 PTAFR Positive_regulation of HRASLS 1 0.08 1.08 0.89
66 INT165540 NGF Positive_regulation of GRIN1 1 0.07 0.17 0.88
67 INT121467 Binding of Avp and Ptafr 1 0.11 0.98 0.88
68 INT339318 Ngf Positive_regulation of Pik3cg 1 0.02 0.69 0.87
69 INT342986 PTAFR Positive_regulation of Gene_expression of IL6 1 0.14 0.39 0.84
70 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
71 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
72 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
73 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
74 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
75 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
76 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78
77 INT16014 Ptafr Regulation of Ns5atp9 1 0.32 1.17 0.78
78 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
79 INT342992 Negative_regulation of PTAFR Negative_regulation of Gene_expression of HIST2H2AA3 1 0.01 0.4 0.78
80 INT308483 Paf Positive_regulation of Gene_expression of Ptafr 1 0.12 1.14 0.78
81 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
82 INT308485 Paf Positive_regulation of Ptafr 1 0.12 1.13 0.77
83 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
84 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
85 INT251729 Binding of FEN1 and EXOSC1 1 0.19 1.13 0.74
86 INT272147 PTAFR Positive_regulation of CA2 1 0.13 0 0.71
87 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71
88 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
89 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
90 INT282141 Grm5 Regulation of Grip2 1 0.00 0.61 0.69
91 INT214368 Pik3cb Regulation of Ubqln1 1 0.01 0.36 0.68
92 INT118979 NGF Positive_regulation of Phosphorylation of NTRK1 1 0.56 0.67 0.67
93 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
94 INT171825 Binding of Prkcg and Ncs1 1 0.00 0.07 0.66
95 INT114843 NTRK1 Regulation of Gene_expression of Lgals1 1 0.06 0.84 0.66
96 INT171824 Binding of Ncs1 and Aspm 1 0.00 0.07 0.65
97 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 0.44 0.06 0.65
98 INT168206 Binding of Pik3cd and Sh3 1 0.14 0.37 0.65
99 INT168205 Binding of Dlg4 and Pik3cd 1 0.11 0.37 0.65
100 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
101 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
102 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
103 INT116753 Ngf Regulation of Pik3cd 1 0.40 0.29 0.63
104 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
105 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
106 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
107 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6
108 INT342981 PTAFR Regulation of SFTPA1 1 0.03 0.38 0.6
109 INT272146 PTAFR Positive_regulation of Localization of IL8 3 0.38 0.28 0.59
110 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59
111 INT202160 Binding of ARSD and CSF1R 1 0.16 1.69 0.59
112 INT250054 Positive_regulation of Binding of Gpr143 and Spdya 1 0.04 0.52 0.59
113 INT250053 Binding of Gpr143 and Spdya 1 0.03 0.51 0.59
114 INT107523 Negative_regulation of Grm5 Negative_regulation of Gene_expression of Fos 1 0.37 0.09 0.58
115 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
116 INT261482 Pik3cb Positive_regulation of Phosphorylation of Ephb1 1 0.23 0.67 0.58
117 INT164457 Ngf Positive_regulation of NTRK1 1 0.15 0.57 0.58
118 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
119 INT164458 Negative_regulation of Ngf Positive_regulation of NTRK1 1 0.14 0.57 0.58
120 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
121 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
122 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
123 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
124 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
125 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
126 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
127 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
128 INT202157 Binding of CSF1R and SLC6A4 1 0.08 0.9 0.54
129 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53
130 INT69343 Binding of NTRK1 and Igh-6 1 0.02 0.69 0.53
131 INT177504 Gabrg1 Positive_regulation of PCNA 1 0.07 0.22 0.52
132 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
133 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
134 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
135 INT127677 NGF Regulation of Gene_expression of NGFR 1 0.20 1.11 0.5
136 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
137 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
138 INT341428 EPO Positive_regulation of NGF 1 0.52 0.37 0.48
139 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
140 INT341426 EPO Regulation of NGF 1 0.51 0.5 0.47
141 INT342983 HCL1 Positive_regulation of PTAFR 1 0.03 0.07 0.47
142 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
143 INT142826 UPF1 Positive_regulation of CREB1 1 0.11 0 0.46
144 INT177794 BUB1B Positive_regulation of Gene_expression of ASNS 1 0.11 0.77 0.46
145 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
146 INT177781 BUB1B Positive_regulation of ATF4 1 0.07 0.76 0.46
147 INT177780 BUB1B Positive_regulation of ASNS 1 0.05 0.76 0.46
148 INT177787 BUB1B Positive_regulation of MTHFD2 1 0.15 0.76 0.46
149 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
150 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
151 INT337325 PIK3CD Positive_regulation of Phosphorylation of IL2RG 1 0.00 0 0.43
152 INT342987 TRPV1 Positive_regulation of Localization of PTAFR 1 0.33 0.84 0.43
153 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
154 INT201092 Binding of KNG1 and NGF 1 0.00 0.31 0.43
155 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
156 INT127676 NGF Regulation of TNFRSF1B 1 0.21 1.02 0.42
157 INT80824 NGF Positive_regulation of NTF3 1 0.47 0.26 0.42
158 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
159 INT127675 NGF Regulation of NTRK1 1 0.48 1.01 0.42
160 INT127674 NGF Regulation of Gene_expression of TNFRSF1B 1 0.48 1.02 0.42
161 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
162 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
163 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
164 INT322394 Hist1h1t Positive_regulation of Pik3cb 1 0.01 0 0.42
165 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
166 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
167 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
168 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
169 INT157650 Phosphorylation of Prkcc Positive_regulation of Pik3c3 1 0.51 0 0.41
170 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
171 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
172 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
173 INT157647 Positive_regulation of Oprd1 Positive_regulation of Pik3c3 1 0.01 0 0.4
174 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
175 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
176 INT157649 Prkcc Regulation of Pik3c3 1 0.30 0 0.39
177 INT345006 CSF2 Regulation of GSN 1 0.16 0.82 0.39
178 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
179 INT13715 PDYN Positive_regulation of TYMS 1 0.27 0 0.39
180 INT257738 PIK3CA Regulation of Localization of ACTN4 1 0.16 1.03 0.39
181 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
182 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
183 INT272148 PTAFR Regulation of Localization of CA2 1 0.14 0 0.38
184 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38
185 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37
186 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37
187 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
188 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
189 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
190 INT345012 GSN Regulation of CCBE1 1 0.00 0.82 0.36
191 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
192 INT345010 GSN Regulation of DBP 1 0.26 0.81 0.36
193 INT157648 Binding of Prkcc and Pik3c3 1 0.39 0 0.36
194 INT337304 PTAFR Positive_regulation of Gene_expression of TLR4 1 0.62 1.99 0.36
195 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
196 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
197 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
198 INT214374 Pik3cb Regulation of Gene_expression of Slc6a3 1 0.37 0.3 0.35
199 INT182559 Binding of Pi4kb and Trpv1 1 0.02 0.2 0.35
200 INT213484 Binding of Lep and Pik3c3 1 0.01 0 0.35

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported in phosphatidylinositol-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45
2 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
3 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
4 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
5 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11
6 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58
7 INT51602 Gene_expression of Grm5 59 0.75 17.29 26.99
8 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
9 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
10 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
11 INT78571 Positive_regulation of Grm5 35 0.69 11.81 22.45
12 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38
13 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
14 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
15 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
16 INT5160 Localization of PTAFR 61 0.80 42.6 19.16
17 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
18 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42
19 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
20 INT20216 Localization of NGF 40 0.80 18.16 16.61
21 INT120966 Positive_regulation of Pik3cb 34 0.68 15.15 16.59
22 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
23 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46
24 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
25 INT94573 Negative_regulation of Pik3cb 42 0.50 15.83 15.4
26 INT71150 Binding of NGF 22 0.46 13.67 14.81
27 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
28 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18
29 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
30 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
31 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
32 INT13303 Positive_regulation of PTAFR 40 0.69 16.27 11.56
33 INT107522 Regulation of Grm5 9 0.44 6.42 11.46
34 INT85048 Regulation of NGF 19 0.62 11.61 10.5
35 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
36 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
37 INT78570 Negative_regulation of Grm5 15 0.57 5.45 9.17
38 INT107657 Positive_regulation of Positive_regulation of Grm5 6 0.69 1.83 8.92
39 INT34777 Localization of IGF1 82 0.80 42.68 8.62
40 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
41 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42
42 INT30526 Negative_regulation of PTAFR 15 0.58 8.15 8.19
43 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
44 INT308473 Positive_regulation of Ptafr 1 0.58 13.26 7.92
45 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
46 INT32454 Gene_expression of Ptafr 3 0.65 15.19 7.87
47 INT189230 Gene_expression of GSN 12 0.75 25.04 7.6
48 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56
49 INT120401 Positive_regulation of PIK3CD 33 0.45 14.89 7.37
50 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
51 INT63373 Negative_regulation of Gene_expression of NGF 14 0.57 8.9 7.1
52 INT10505 Gene_expression of Ptafr 18 0.62 10.7 6.83
53 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
54 INT10507 Positive_regulation of Gene_expression of PTAFR 15 0.61 10.24 6.61
55 INT250050 Gene_expression of Gpr143 1 0.48 5.76 6.53
56 INT63374 Regulation of Gene_expression of NGF 12 0.45 5.6 6.4
57 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36
58 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
59 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
60 INT48234 Negative_regulation of Gene_expression of PTAFR 11 0.57 3.97 6.25
61 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21
62 INT48313 Binding of NTRK1 19 0.47 14.44 6.12
63 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
64 INT250048 Positive_regulation of Gpr143 12 0.43 5.85 6.1
65 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
66 INT254400 Negative_regulation of GSN 22 0.57 18.15 5.89
67 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84
68 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
69 INT151032 Localization of Igf1 49 0.76 26.32 5.71
70 INT152433 Binding of CSF1R 6 0.33 10.97 5.54
71 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5
72 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
73 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33
74 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
75 INT96258 Positive_regulation of Pik3cd 14 0.43 8.74 5.16
76 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
77 INT107655 Positive_regulation of Gene_expression of Grm5 6 0.67 5.09 5.06
78 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02
79 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
80 INT308479 Transcription of Ptafr 1 0.60 10.05 4.76
81 INT128178 Positive_regulation of RHOA 59 0.68 9.3 4.7
82 INT97847 Regulation of Ptafr 3 0.43 5.41 4.64
83 INT97903 Negative_regulation of FGFR1 16 0.17 5.6 4.57
84 INT10896 Regulation of PTAFR 16 0.61 4.22 4.5
85 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
86 INT9334 Positive_regulation of Igfbp1 22 0.54 9.3 4.31
87 INT49360 Localization of Igf1 22 0.76 6.96 4.26
88 INT74815 Binding of Grm5 11 0.36 3.62 4.25
89 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
90 INT110343 Negative_regulation of PIK3CD 22 0.40 5.84 4.2
91 INT116643 Phosphorylation of Pik3cb 12 0.80 4.73 3.87
92 INT54701 Localization of Ptafr 19 0.49 18.68 3.82
93 INT152254 Gene_expression of CSF1R 16 0.75 12.93 3.81
94 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
95 INT13302 Binding of PTAFR 20 0.48 7.03 3.7
96 INT91887 Negative_regulation of Pik3cg 12 0.41 5.01 3.67
97 INT308474 Positive_regulation of Transcription of Ptafr 1 0.58 7.33 3.66
98 INT84925 Transcription of NGF 11 0.65 4.13 3.65
99 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57
100 INT32453 Positive_regulation of Gene_expression of Ptafr 2 0.58 7.01 3.47
101 INT116645 Regulation of Pik3cb 11 0.41 3.78 3.43
102 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
103 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
104 INT60174 Positive_regulation of Pik3c3 12 0.67 1.05 3.23
105 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
106 INT11015 Regulation of Phosphorylation of CREB1 4 0.46 1.45 3.17
107 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09
108 INT192676 Binding of PTEN 14 0.46 10.58 3.06
109 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
110 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
111 INT128179 Gene_expression of RHOA 7 0.64 2.48 3.01
112 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99
113 INT16130 Binding of IGF1 67 0.48 27.43 2.95
114 INT177993 Localization of CSF1R 4 0.73 7.49 2.94
115 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83
116 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81
117 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
118 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78
119 INT79360 Negative_regulation of Ptafr 6 0.36 4.15 2.77
120 INT178002 Positive_regulation of CSF1R 2 0.37 6.52 2.74
121 INT234111 Gene_expression of NCS1 3 0.74 15.23 2.68
122 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66
123 INT317124 Positive_regulation of Gene_expression of Ncs1 1 0.69 10.64 2.66
124 INT98919 Negative_regulation of Phosphorylation of CREB1 8 0.58 2.4 2.63
125 INT51683 Regulation of Gene_expression of PTAFR 11 0.60 5.06 2.59
126 INT51680 Protein_catabolism of PTAFR 7 0.64 3.69 2.59
127 INT317117 Gene_expression of Ncs1 1 0.77 13.85 2.58
128 INT142908 Localization of FGFR1 18 0.38 11.46 2.57
129 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
130 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5
131 INT9330 Binding of Igfbp1 8 0.31 2.99 2.5
132 INT337317 Positive_regulation of Localization of PTAFR 2 0.51 3.88 2.5
133 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
134 INT4435 Gene_expression of PIK3C2A 20 0.77 14.43 2.48
135 INT14561 Gene_expression of Igfbp1 12 0.35 6.27 2.46
136 INT108333 Phosphorylation of BAD 43 0.68 33.77 2.45
137 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45
138 INT213681 Gene_expression of TYMS 9 0.33 8.96 2.45
139 INT66544 Binding of Igf1 23 0.46 8.33 2.44
140 INT107656 Regulation of Gene_expression of Grm5 4 0.26 0.84 2.38
141 INT128174 Positive_regulation of Gene_expression of RHOA 7 0.36 1.5 2.36
142 INT112026 Gene_expression of Pik3cd 6 0.72 4.89 2.34
143 INT148025 Localization of Pik3cg 1 0.58 0.69 2.34
144 INT205683 Localization of Ptafr 4 0.12 4.63 2.31
145 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3
146 INT308477 Positive_regulation of Positive_regulation of Ptafr 1 0.51 4.3 2.29
147 INT74306 Negative_regulation of Pik3cd 7 0.24 1.93 2.27
148 INT118791 Binding of AKT1 32 0.48 15.51 2.25
149 INT132893 Binding of CHUK 1 0.00 0.63 2.25
150 INT128745 Positive_regulation of Positive_regulation of Pik3cb 4 0.56 0.95 2.24
151 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22
152 INT101572 Negative_regulation of Gene_expression of PCNA 24 0.53 13.87 2.21
153 INT163545 Gene_expression of PDGFRB 39 0.78 25.5 2.2
154 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
155 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
156 INT55469 Positive_regulation of Positive_regulation of PTAFR 9 0.47 3 2.17
157 INT91519 Negative_regulation of Positive_regulation of PTAFR 4 0.41 1.52 2.15
158 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
159 INT264967 Positive_regulation of Positive_regulation of PIK3CD 4 0.18 1.97 2.13
160 INT7745 Regulation of Ptafr 7 0.40 1.99 2.12
161 INT63375 Positive_regulation of Positive_regulation of NGF 2 0.48 1.17 2.08
162 INT55070 Binding of Ptafr 5 0.41 3.5 2.07
163 INT151467 Localization of CASP9 9 0.73 7.62 2.04
164 INT118701 Positive_regulation of Ncs1 2 0.69 4.13 2.03
165 INT132892 Positive_regulation of CHUK 3 0.08 1.62 2.01
166 INT12965 Negative_regulation of RICTOR 3 0.37 0.32 2
167 INT99547 Positive_regulation of CDKN1B 18 0.67 8.42 1.96
168 INT66941 Localization of NTRK1 8 0.78 5.89 1.96
169 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
170 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
171 INT137906 Positive_regulation of Phosphorylation of Pdgfrb 6 0.50 2.55 1.94
172 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
173 INT189239 Binding of GSN 11 0.36 9.34 1.93
174 INT99970 Regulation of Binding of NGF 2 0.27 2.35 1.93
175 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92
176 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
177 INT51603 Localization of Grm5 5 0.73 0.33 1.87
178 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
179 INT85348 Localization of RHOA 12 0.59 4.81 1.83
180 INT213676 Negative_regulation of Gene_expression of TYMS 2 0.08 1.95 1.83
181 INT174240 Negative_regulation of TYMS 12 0.57 6.35 1.82
182 INT149335 Gene_expression of Pik3cb 10 0.57 2.93 1.82
183 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8
184 INT122488 Protein_catabolism of CASP9 8 0.46 8.64 1.8
185 INT122487 Positive_regulation of Positive_regulation of CASP9 16 0.67 17.88 1.79
186 INT68952 Localization of PCNA 17 0.62 5.64 1.78
187 INT63272 Positive_regulation of Binding of Igfbp1 1 0.42 0 1.72
188 INT70322 Gene_expression of MAPKAP1 10 0.65 6.06 1.7
189 INT189226 Protein_catabolism of GSN 3 0.54 7.1 1.7
190 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68
191 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
192 INT132890 Positive_regulation of Binding of CHUK 1 0.00 0.44 1.6
193 INT69917 Negative_regulation of CREB1 8 0.58 2.28 1.59
194 INT132891 Gene_expression of CHUK 1 0.01 0.47 1.58
195 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
196 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
197 INT119835 Positive_regulation of Gene_expression of BAD 6 0.44 7.66 1.51
198 INT26579 Regulation of RICTOR 2 0.23 0.09 1.51
199 INT85046 Positive_regulation of Positive_regulation of NTRK1 2 0.50 0.63 1.51
200 INT243799 Gene_expression of PIK3CD 15 0.45 6.63 1.5
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