GO:0048016

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Name inositol phosphate-mediated signaling
Categary Process
Go Slim No
Go Link GO:0048016
Unique Molecular Interactions 420
Total Molecular Interactions 618
Total Single Events 4003
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for inositol phosphate-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported for inositol phosphate-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
2 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
3 INT297488 Itpr3 Regulation of Positive_regulation of Ltp 1 0.02 0.47 1.87
4 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
5 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
6 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
7 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
8 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
9 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
10 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
11 INT60208 Binding of Htr1a and Htr2c 2 0.52 0.25 1
12 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
13 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
14 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
15 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
16 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
17 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
18 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
19 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
20 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
21 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
22 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
23 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78
24 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
25 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
26 INT297490 Itpr3 Regulation of Ltp 1 0.02 0 0.7
27 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
28 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
29 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
30 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
31 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
32 INT94020 Binding of EDN2 and INSRR 1 0.03 0 0.65
33 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
34 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
35 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
36 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
37 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
38 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
39 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
40 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
41 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
42 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
43 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
44 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
45 INT94018 Binding of EDN2 and EDN3 1 0.19 0 0.48
46 INT34006 Binding of ITPR3 and YY1 1 0.22 0.33 0.48
47 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
48 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
49 INT237810 Itpr3 Positive_regulation of Localization of Car2 2 0.08 0.68 0.45
50 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
51 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
52 INT349686 Nmu Positive_regulation of Nmur1 1 0.36 0.2 0.45
53 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
54 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
55 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
56 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
57 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
58 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
59 INT33713 Binding of ITPR3 and Trh 1 0.00 0.86 0.39
60 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
61 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
62 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
63 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
64 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
65 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
66 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
67 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
68 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
69 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
70 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
71 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
72 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
73 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
74 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
75 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
76 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
77 INT54639 Edn3 Negative_regulation of Edn2 1 0.00 0 0.28
78 INT189200 Binding of CA2 and ITPR3 3 0.03 1.9 0.27
79 INT72820 EDN3 Positive_regulation of Avp 1 0.31 0.64 0.27
80 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
81 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
82 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
83 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
84 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
85 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
86 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
87 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
88 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
89 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
90 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
91 INT247475 P2RY6 Positive_regulation of ITPR3 1 0.01 0.45 0.23
92 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
93 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
94 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
95 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
96 INT33714 Positive_regulation of Binding of ITPR3 and Trh 1 0.00 0.46 0.21
97 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
98 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2
99 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
100 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
101 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
102 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
103 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
104 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
105 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
106 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
107 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
108 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17
109 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
110 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
111 INT94017 Binding of EDN3 and INSRR 1 0.03 0 0.16
112 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
113 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
114 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
115 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
116 INT94013 Positive_regulation of Binding of EDN2 and INSRR 1 0.04 0 0.16
117 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
118 INT94023 Positive_regulation of Binding of EDN2 and EDN3 1 0.25 0 0.16
119 INT94019 Positive_regulation of Binding of EDN3 and INSRR 1 0.04 0 0.16
120 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
121 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
122 INT216601 Itpr3 Positive_regulation of Localization of Ca2 1 0.00 0.05 0.15
123 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
124 INT34451 Binding of Itpr3 and Ptprg 1 0.03 0 0.15
125 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
126 INT335459 ABCA1 Positive_regulation of ITPR3 1 0.00 0 0.15
127 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
128 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
129 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
130 INT172241 Binding of NMUR1 and NMU 1 0.40 0 0.14
131 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14
132 INT72818 Edn3 Negative_regulation of Avp 1 0.08 0.34 0.14
133 INT72819 Regulation of EDN3 Positive_regulation of Avp 1 0.28 0.32 0.13
134 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
135 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
136 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
137 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12
138 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
139 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12
140 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
141 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
142 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11
143 INT350735 PRKDC Negative_regulation of ITPR3 1 0.01 0.16 0.11
144 INT292383 Binding of Itpr3 and Mrvi1 1 0.18 0 0.11
145 INT182270 EDN1 Positive_regulation of Gene_expression of MMP1 1 0.18 0.55 0.1
146 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
147 INT181570 Binding of Edn1 and Mapk1 1 0.13 2.72 0.1
148 INT6674 Edn1 Positive_regulation of Gene_expression of FOS 1 0.08 0.19 0.1
149 INT139476 Edn1 Positive_regulation of Ednra 1 0.00 1.07 0.1
150 INT10904 Edn1 Regulation of Localization of Nppb 1 0.22 0.54 0.1
151 INT33712 Trh Positive_regulation of Localization of ITPR3 1 0.00 0.8 0.1
152 INT201747 Itpr3 Positive_regulation of Localization of Esr1 2 0.03 1.19 0.09
153 INT249183 Binding of ITPR3 and GOPC 2 0.01 0.26 0.09
154 INT92956 Edn1 Regulation of Positive_regulation of Nos2 1 0.18 0.17 0.09
155 INT332688 Ros1 Positive_regulation of Binding of Edn1 1 0.10 0.57 0.09
156 INT230750 Crp Positive_regulation of Edn1 1 0.10 0.27 0.09
157 INT350220 Positive_regulation of HSPG2 Positive_regulation of Localization of ITPR3 1 0.05 0.09 0.09
158 INT174093 Htr2c Regulation of Gene_expression of Csf2 1 0.00 0 0.09
159 INT350216 ITPR3 Regulation of Localization of TNIP3 1 0.01 0.08 0.09
160 INT350217 Positive_regulation of HSPG2 Positive_regulation of ITPR3 1 0.05 0.09 0.09
161 INT174070 Htr2c Positive_regulation of Itpr3 1 0.00 0 0.09
162 INT237820 Binding of Itpr3 and soc 1 0.02 0 0.09
163 INT92957 Edn1 Regulation of Gene_expression of Nos2 1 0.18 0.17 0.09
164 INT208979 Binding of Itpr3 and Trpc3 1 0.00 0.33 0.09
165 INT178072 Gene_expression of EDNRB Positive_regulation of EDN3 1 0.05 1.11 0.08
166 INT242257 Binding of EDN1 and ELF3 1 0.17 0.21 0.08
167 INT181584 Binding of EDNRB and Edn1 1 0.46 0.85 0.08
168 INT181583 Binding of Edn1 and Positive_regulation of NOS1 1 0.02 0.86 0.08
169 INT178100 Gene_expression of EDNRB Positive_regulation of EDN1 1 0.17 1.11 0.08
170 INT113369 Edn1 Regulation of Adarb1 1 0.02 0.14 0.08
171 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
172 INT237814 Itpr3 Positive_regulation of Localization of Tmie 1 0.01 0.68 0.08
173 INT350218 Positive_regulation of HSPG2 Positive_regulation of Gene_expression of ITPR3 1 0.04 0.09 0.08
174 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
175 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07
176 INT182269 EDN1 Positive_regulation of Localization of MMP1 1 0.17 0.31 0.07
177 INT192908 Edn1 Positive_regulation of Ednra 1 0.21 0.35 0.07
178 INT242258 ELF3 Negative_regulation of EDN1 1 0.15 0.09 0.07
179 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
180 INT178093 EDN3 Positive_regulation of Gene_expression of EDNRB 1 0.05 1.01 0.07
181 INT172382 AGT Positive_regulation of Localization of EDN1 1 0.03 0.34 0.07
182 INT182268 Negative_regulation of MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
183 INT192907 Edn1 Positive_regulation of Ednrb 1 0.10 0.35 0.07
184 INT182274 MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
185 INT191219 Edn1 Positive_regulation of Amigo2 1 0.06 1.26 0.07
186 INT324896 Ece1 Positive_regulation of Negative_regulation of Edn1 1 0.19 0.42 0.07
187 INT237815 Binding of Itpr3 and Stim1 1 0.04 0 0.07
188 INT172381 AVP Positive_regulation of Localization of EDN1 1 0.01 0.34 0.07
189 INT178096 EDN1 Positive_regulation of Gene_expression of EDNRB 1 0.17 1.01 0.07
190 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07
191 INT178090 EDN1 Positive_regulation of Phosphorylation of GJA1 1 0.09 0.88 0.06
192 INT350219 ITPR3 Positive_regulation of CA2 1 0.22 0 0.05
193 INT191216 Binding of Edn1 and Cotl1 1 0.14 0.63 0.05
194 INT182259 EDN1 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.27 0.05
195 INT34447 Ptprg Positive_regulation of Itpr3 1 0.04 0 0.05
196 INT208988 Binding of CALM1 and Itpr3 1 0.01 0.15 0.05
197 INT180668 Edn1 Positive_regulation of Gene_expression of Col1a1 1 0.02 0 0.05
198 INT182264 EDN1 Positive_regulation of Positive_regulation of MAPK14 1 0.26 0.1 0.05
199 INT180667 Edn1 Regulation of Ecm1 1 0.04 0 0.05
200 INT213263 INS Positive_regulation of EDN1 1 0.12 0.54 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for inositol phosphate-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported in inositol phosphate-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
2 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
3 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
4 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
5 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
6 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
7 INT5048 Binding of Edn1 55 0.47 18.86 19.16
8 INT9191 Localization of EDN1 94 0.81 57.01 14.78
9 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
10 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
11 INT6365 Localization of Edn1 56 0.81 18.84 13.83
12 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
13 INT18001 Positive_regulation of Htr2c 21 0.67 7.63 11.39
14 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
15 INT6361 Localization of Edn1 30 0.81 19.09 9.7
16 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
17 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
18 INT56775 Binding of Htr2c 16 0.47 3.77 8.74
19 INT10237 Binding of EDN1 40 0.48 16 8.48
20 INT31761 Positive_regulation of Itpr3 32 0.58 5.95 8.22
21 INT9032 Regulation of Htr2c 11 0.60 2.77 7.81
22 INT36040 Localization of Itpr3 21 0.70 4.87 7.77
23 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
24 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
25 INT26919 Gene_expression of ITPR3 47 0.42 5.86 5.79
26 INT49477 Gene_expression of Htr2c 12 0.75 3.26 5.73
27 INT26334 Localization of ITPR3 39 0.49 2.53 5.07
28 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
29 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
30 INT52402 Negative_regulation of Htr2c 7 0.42 1.46 4.21
31 INT31762 Gene_expression of Itpr3 22 0.74 1.6 4.15
32 INT26191 Positive_regulation of ITPR3 24 0.44 1.9 3.74
33 INT5782 Gene_expression of Edn3 17 0.67 3.38 3.65
34 INT63621 Transcription of Htr2c 6 0.52 0.62 3.49
35 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
36 INT55236 Regulation of Htr2c 6 0.44 3.31 3.36
37 INT37180 Negative_regulation of Itpr3 6 0.51 1.43 3.27
38 INT54999 Regulation of Itpr3 6 0.24 0.18 3.11
39 INT55033 Localization of Edn3 7 0.80 1.4 3.05
40 INT53374 Binding of Edn1 17 0.43 11.66 2.98
41 INT36039 Gene_expression of Itpr3 19 0.72 3.75 2.93
42 INT65000 Positive_regulation of Positive_regulation of Htr2c 4 0.67 0.69 2.8
43 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
44 INT26918 Positive_regulation of Gene_expression of ITPR3 14 0.27 2.31 2.41
45 INT37347 Positive_regulation of Itpr3 6 0.34 1.3 2.31
46 INT31763 Positive_regulation of Gene_expression of Itpr3 10 0.30 0.83 2.28
47 INT26335 Binding of ITPR3 22 0.18 3.3 2.27
48 INT77309 Positive_regulation of Htr2c 3 0.49 2.72 2.25
49 INT64505 Localization of Htr2c 3 0.78 0.87 2.24
50 INT69020 Gene_expression of Htr2c 9 0.74 6.09 2.22
51 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
52 INT63081 Localization of Itpr3 13 0.67 1.08 2.12
53 INT55000 Positive_regulation of Regulation of Itpr3 1 0.41 0 2.08
54 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
55 INT37181 Negative_regulation of Localization of Itpr3 3 0.37 0.83 1.97
56 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
57 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
58 INT95544 Negative_regulation of Itpr1 4 0.59 1.6 1.85
59 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
60 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
61 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
62 INT74088 Negative_regulation of Positive_regulation of Htr2c 1 0.41 0 1.75
63 INT120505 Negative_regulation of ITPR3 6 0.27 1.46 1.68
64 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
65 INT31760 Negative_regulation of Itpr3 5 0.23 0.84 1.61
66 INT37346 Positive_regulation of Localization of Itpr3 3 0.47 0.45 1.59
67 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
68 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
69 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
70 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
71 INT272340 Transcription of Htr2c 1 0.52 2.77 1.28
72 INT235401 Negative_regulation of Gene_expression of ITPR3 4 0.20 1.69 1.24
73 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
74 INT243729 Localization of Itpr1 2 0.05 0.37 1.16
75 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
76 INT262550 Negative_regulation of Localization of Itpr1 1 0.03 0.37 1.09
77 INT37241 Negative_regulation of Localization of ITPR3 7 0.13 1.22 1.05
78 INT61123 Localization of Edn2 1 0.55 0.27 1.05
79 INT116829 Regulation of Itpr3 2 0.39 0 1.02
80 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
81 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
82 INT55243 Positive_regulation of Positive_regulation of Itpr3 4 0.58 0.89 0.95
83 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
84 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
85 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
86 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
87 INT6243 Regulation of Edn3 2 0.35 0.2 0.83
88 INT151532 Regulation of Itpr1 2 0.01 0.63 0.83
89 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
90 INT116830 Binding of Itpr3 10 0.45 0.29 0.78
91 INT31764 Negative_regulation of Positive_regulation of Itpr3 4 0.25 0 0.77
92 INT75712 Gene_expression of Itpr1 3 0.59 1.89 0.77
93 INT62887 Regulation of Gene_expression of ITPR3 3 0.14 0.95 0.76
94 INT186681 Gene_expression of Edn2 2 0.09 1.01 0.76
95 INT129797 Negative_regulation of Binding of ITPR3 3 0.14 0.58 0.75
96 INT61122 Regulation of Regulation of Edn3 1 0.35 0.2 0.75
97 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
98 INT8614 Negative_regulation of Edn2 3 0.06 0.07 0.73
99 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
100 INT125261 Positive_regulation of Gene_expression of Htr2c 2 0.67 2.22 0.7
101 INT63556 Binding of Edn3 1 0.24 0.63 0.7
102 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
103 INT26333 Positive_regulation of Localization of ITPR3 6 0.43 0.17 0.68
104 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
105 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
106 INT50061 Negative_regulation of Edn3 4 0.58 0.77 0.65
107 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
108 INT272356 Positive_regulation of Transcription of Htr2c 1 0.45 1.66 0.63
109 INT26336 Regulation of Localization of ITPR3 2 0.13 0.37 0.61
110 INT101274 Gene_expression of ITPR1 1 0.52 0.79 0.59
111 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
112 INT100754 Negative_regulation of Binding of Htr2c 1 0.41 0.49 0.57
113 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
114 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
115 INT59819 Phosphorylation of ITPR3 2 0.06 0 0.54
116 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
117 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
118 INT8663 Positive_regulation of EDN2 3 0.38 0.65 0.5
119 INT159387 Binding of Nmur1 1 0.29 0.43 0.5
120 INT230986 Positive_regulation of Transcription of Htr2c 1 0.45 0.25 0.49
121 INT64935 Negative_regulation of Regulation of Itpr3 1 0.26 0 0.49
122 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
123 INT174055 Negative_regulation of Htr2c 5 0.41 2.63 0.45
124 INT55370 Positive_regulation of Localization of Edn3 2 0.47 1.13 0.44
125 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
126 INT92195 Negative_regulation of Edn3 3 0.43 1.92 0.43
127 INT63082 Binding of Itpr3 12 0.12 0.54 0.39
128 INT55577 Negative_regulation of Gene_expression of Itpr3 1 0.06 0 0.39
129 INT81433 Negative_regulation of Positive_regulation of Edn1 4 0.39 0.81 0.38
130 INT168066 Transcription of Edn3 1 0.38 0.87 0.38
131 INT8664 Positive_regulation of EDN3 2 0.38 0 0.37
132 INT121073 Gene_expression of NMUR1 2 0.15 0.85 0.35
133 INT129487 Negative_regulation of EDN3 1 0.38 0.35 0.35
134 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35
135 INT141013 Regulation of Gene_expression of Edn1 2 0.24 0.55 0.34
136 INT211023 Positive_regulation of Gene_expression of Htr2c 2 0.45 2.03 0.33
137 INT240951 Positive_regulation of Positive_regulation of Itpr3 1 0.03 0.06 0.33
138 INT53375 Binding of Edn3 1 0.36 0 0.32
139 INT16368 Protein_catabolism of Edn1 2 0.72 0.18 0.31
140 INT131110 Localization of EDN3 1 0.03 0.74 0.31
141 INT131109 Positive_regulation of Localization of EDN3 1 0.02 0.76 0.31
142 INT33706 Regulation of ITPR3 6 0.28 0.46 0.3
143 INT16366 Gene_expression of Edn3 4 0.49 1.35 0.29
144 INT55240 Regulation of Positive_regulation of Itpr3 1 0.52 0.48 0.28
145 INT149738 Regulation of Gene_expression of Itpr3 1 0.22 0.09 0.27
146 INT84038 Protein_catabolism of Edn1 2 0.86 0.69 0.26
147 INT211029 Negative_regulation of Gene_expression of Htr2c 1 0.56 2.54 0.25
148 INT8660 Positive_regulation of Positive_regulation of EDN2 2 0.38 0.23 0.22
149 INT8665 Positive_regulation of Positive_regulation of EDN3 1 0.38 0 0.22
150 INT67265 Positive_regulation of Negative_regulation of Edn1 1 0.61 0.05 0.21
151 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
152 INT53376 Positive_regulation of Regulation of Edn3 1 0.48 0 0.19
153 INT53372 Positive_regulation of Regulation of Edn1 1 0.50 0 0.19
154 INT100397 Regulation of Transcription of Edn1 1 0.00 0.1 0.19
155 INT174049 Positive_regulation of Negative_regulation of Htr2c 1 0.01 0 0.19
156 INT53373 Regulation of Edn3 2 0.45 1.38 0.18
157 INT174053 Phosphorylation of Htr2c 1 0.01 0.06 0.18
158 INT26353 Binding of Edn2 1 0.01 0 0.17
159 INT216609 Protein_catabolism of Itpr3 2 0.24 0.42 0.14
160 INT55371 Positive_regulation of Edn3 1 0.69 0.38 0.14
161 INT172309 Binding of NMUR1 1 0.35 0 0.14
162 INT272355 Regulation of Regulation of Htr2c 1 0.44 1.1 0.14
163 INT323040 Gene_expression of EDN2 1 0.32 0.13 0.13
164 INT284152 Regulation of Transcription of EDN1 1 0.32 0.44 0.13
165 INT6362 Negative_regulation of Localization of Edn1 3 0.16 1.92 0.12
166 INT237797 Positive_regulation of Gene_expression of Itpr3 3 0.05 1.08 0.11
167 INT124453 Binding of Itpr1 1 0.33 0 0.11
168 INT15391 Negative_regulation of Positive_regulation of Edn1 2 0.07 0.1 0.1
169 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1
170 INT323038 Regulation of Positive_regulation of EDN2 1 0.21 0 0.1
171 INT49257 Positive_regulation of Transcription of EDN1 2 0.46 1.1 0.08
172 INT126441 Negative_regulation of Transcription of Edn1 1 0.40 0.17 0.08
173 INT281233 Positive_regulation of Protein_catabolism of Itpr3 1 0.11 0.16 0.08
174 INT272152 Positive_regulation of Positive_regulation of ITPR3 1 0.06 0 0.08
175 INT120506 Negative_regulation of Negative_regulation of ITPR3 1 0.01 0.08 0.08
176 INT281239 Negative_regulation of Protein_catabolism of Itpr3 1 0.10 0.16 0.07
177 INT178109 Binding of EDN3 1 0.06 1.65 0.07
178 INT216802 Positive_regulation of Localization of Itpr3 1 0.07 0 0.06
179 INT174050 Binding of Htr2c 1 0.01 0 0.06
180 INT211025 Regulation of Gene_expression of Htr2c 1 0.43 1.01 0.06
181 INT63083 Positive_regulation of Binding of Itpr3 2 0.11 0.16 0.04
182 INT33707 Positive_regulation of Transcription of ITPR3 1 0.01 0.27 0.04
183 INT33705 Transcription of ITPR3 1 0.02 0.27 0.04
184 INT249279 Regulation of Binding of ITPR3 1 0.03 0.44 0.04
185 INT249235 Positive_regulation of Binding of ITPR3 3 0.17 0.2 0.03
186 INT270323 Gene_expression of EDN3 1 0.01 0.76 0.03
187 INT292373 Regulation of Gene_expression of Itpr3 1 0.57 0.14 0
188 INT323037 Negative_regulation of EDN2 1 0.20 0.23 0
189 INT222587 Gene_expression of Nmur1 1 0.31 0.68 0
190 INT226251 Protein_catabolism of EDN3 1 0.02 0 0
191 INT22196 Positive_regulation of Gene_expression of Edn3 1 0.17 0.15 0
192 INT280682 Positive_regulation of Transcription of Edn1 1 0.34 0 0
193 INT49261 Negative_regulation of Protein_catabolism of EDN1 1 0.58 0 0
194 INT323036 Regulation of EDN2 1 0.13 0 0
195 INT292378 Regulation of Binding of Itpr3 1 0.25 0 0
196 INT323041 Binding of EDN2 1 0.18 0.12 0
197 INT292377 Regulation of Localization of Itpr3 1 0.37 0 0
198 INT323039 Regulation of Binding of EDN2 1 0.21 0.12 0
199 INT281234 Negative_regulation of Binding of Itpr3 1 0.14 0 0
200 INT181578 Negative_regulation of Phosphorylation of Edn1 1 0.37 0.1 0
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