GO:0048019

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Name receptor antagonist activity
Categary Function
Go Slim No
Go Link GO:0048019
Unique Molecular Interactions 37
Total Molecular Interactions 47
Total Single Events 380
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for receptor antagonist activity. They are ordered first by their pain relevance and then by number of times they were reported for receptor antagonist activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
2 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
3 INT50883 Binding of AGTR2 and ALB 1 0.37 0.19 0.56
4 INT176370 IL18BP Negative_regulation of IL18 1 0.15 0.76 0.56
5 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4
6 INT176362 Binding of IL18 and IL18BP 1 0.12 0.49 0.32
7 INT146893 TNF Negative_regulation of Dkk1 1 0.01 1.27 0.3
8 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28
9 INT108663 Lrpap1 Negative_regulation of Positive_regulation of Ephb1 1 0.11 0.28 0.17
10 INT108664 Lrpap1 Negative_regulation of Positive_regulation of Trpv1 1 0.26 0.28 0.17
11 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
12 INT281912 Binding of AGTR2 and ANG 1 0.13 0.37 0.1
13 INT352555 DKK1 Positive_regulation of Wnt2 1 0.01 0.25 0.1
14 INT233907 Positive_regulation of Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08
15 INT233906 Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08
16 INT335890 Binding of Dkk1 and Lrp4 1 0.37 0.64 0.07
17 INT351001 Binding of Adh7 and Ins1 1 0.00 1.62 0.05
18 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05
19 INT242167 Binding of Dkk1 and Kremen2 1 0.01 0.06 0.04
20 INT198919 Binding of Lrp1 and Lrpap1 1 0.07 0 0.04
21 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04
22 INT198920 Binding of Ldlr and Lrpap1 1 0.05 0.06 0
23 INT145336 Binding of PYGO1 and Positive_regulation of Transcription of DKK1 1 0.07 0 0
24 INT145333 Binding of BCL9 and Positive_regulation of Transcription of DKK1 1 0.41 0 0
25 INT279282 Binding of EGFR and ESR2 1 0.45 1.39 0
26 INT335891 Binding of Dkk1 and Lrp5 1 0.39 0.57 0
27 INT293981 MYC Negative_regulation of DKK1 1 0.07 0.62 0
28 INT223318 Binding of ESR1 and ESR2 1 0.40 1.22 0
29 INT335882 Dkk1 Negative_regulation of Wnt2 1 0.02 0.15 0
30 INT191258 Binding of LRPAP1 and GOPC 1 0.01 0 0
31 INT223319 Binding of ESR2 and SNRNP70 1 0.40 0 0
32 INT351002 Binding of Adh7 and Mrgpre 1 0.00 3.65 0
33 INT213584 Binding of AGTR2 and ACE 1 0.17 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for receptor antagonist activity. They are ordered first by their pain relevance and then by number of times they were reported in receptor antagonist activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52
2 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69
3 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27
4 INT32517 Positive_regulation of LRPAP1 13 0.49 7.4 3.44
5 INT111153 Positive_regulation of Dkk1 13 0.68 10.56 2.58
6 INT159604 Gene_expression of IL18BP 3 0.49 4.56 2.42
7 INT188255 Gene_expression of DKK1 19 0.60 12.69 2.39
8 INT108796 Binding of ESR2 5 0.46 6.84 2.36
9 INT102234 Gene_expression of ESR2 17 0.65 9.29 2.3
10 INT139475 Negative_regulation of DKK1 14 0.52 9.2 1.76
11 INT150215 Localization of LRPAP1 1 0.73 1.52 1.62
12 INT344978 Negative_regulation of Gene_expression of Dkk1 1 0.58 4.38 1.59
13 INT176382 Negative_regulation of IL18BP 1 0.19 3.16 1.56
14 INT159605 Binding of IL18BP 2 0.24 2.56 1.5
15 INT321889 Negative_regulation of Dkk1 2 0.38 5.7 1.42
16 INT176387 Negative_regulation of Binding of IL18BP 1 0.14 2.37 1.16
17 INT165338 Binding of Dkk1 4 0.37 3.64 1.04
18 INT182513 Regulation of AGTR2 4 0.14 4.31 0.91
19 INT165337 Regulation of Dkk1 3 0.44 2.16 0.83
20 INT70818 Negative_regulation of Adh7 2 0.16 1.04 0.79
21 INT176388 Localization of IL18BP 2 0.68 1.42 0.78
22 INT188251 Localization of DKK1 6 0.50 3.26 0.77
23 INT242131 Localization of Dkk1 5 0.79 6 0.76
24 INT344975 Regulation of Gene_expression of Dkk1 1 0.44 3.44 0.73
25 INT129882 Positive_regulation of Gene_expression of Dkk1 4 0.69 4.62 0.72
26 INT77914 Binding of LRPAP1 5 0.47 1.1 0.64
27 INT56481 Regulation of Lrpap1 2 0.05 1.25 0.58
28 INT176377 Regulation of IL18BP 1 0.15 1.17 0.58
29 INT176378 Regulation of Binding of IL18BP 1 0.15 1.18 0.58
30 INT28931 Negative_regulation of LRPAP1 6 0.57 1.42 0.57
31 INT233916 Positive_regulation of AGTR2 5 0.37 3.67 0.51
32 INT176376 Negative_regulation of Gene_expression of IL18BP 1 0.16 1.03 0.51
33 INT182508 Positive_regulation of Gene_expression of AGTR2 1 0.26 3.13 0.46
34 INT182510 Negative_regulation of Gene_expression of AGTR2 1 0.23 0.78 0.37
35 INT159607 Transcription of IL18BP 1 0.44 0.41 0.35
36 INT194086 Negative_regulation of Gene_expression of ESR2 1 0.03 1.22 0.35
37 INT198871 Gene_expression of Lrpap1 1 0.18 0.14 0.34
38 INT198897 Positive_regulation of Gene_expression of Lrpap1 1 0.13 0.15 0.34
39 INT242130 Positive_regulation of Positive_regulation of Dkk1 2 0.49 1.71 0.33
40 INT344976 Positive_regulation of Negative_regulation of Dkk1 1 0.49 1.13 0.33
41 INT344977 Negative_regulation of Localization of Dkk1 2 0.42 2.57 0.3
42 INT182515 Binding of AGTR2 3 0.32 2.4 0.29
43 INT182509 Regulation of Gene_expression of AGTR2 1 0.24 1.72 0.29
44 INT19917 Regulation of DKK1 3 0.24 1.61 0.28
45 INT159601 Positive_regulation of Gene_expression of IL18BP 2 0.32 0.6 0.27
46 INT102801 Regulation of ESR2 1 0.51 0 0.27
47 INT102800 Regulation of Gene_expression of ESR2 1 0.22 0 0.27
48 INT138751 Localization of ESR2 2 0.72 1.51 0.24
49 INT209345 Negative_regulation of AGTR2 5 0.17 4.83 0.2
50 INT344979 Negative_regulation of Gene_expression of DKK1 1 0.17 0.98 0.17
51 INT159603 Positive_regulation of Transcription of IL18BP 1 0.32 0.24 0.17
52 INT242127 Positive_regulation of Localization of Dkk1 1 0.05 0.35 0.17
53 INT344980 Negative_regulation of Localization of DKK1 1 0.17 0.97 0.16
54 INT326469 Positive_regulation of Negative_regulation of AGTR2 1 0.09 2.96 0.16
55 INT49618 Regulation of LRPAP1 2 0.15 1.1 0.09
56 INT188252 Positive_regulation of DKK1 4 0.41 2.94 0.08
57 INT118020 Gene_expression of LRPAP1 9 0.65 0.18 0.07
58 INT288913 Regulation of Positive_regulation of AGTR2 1 0.28 0.43 0.06
59 INT198883 Binding of Lrpap1 3 0.32 0.82 0.05
60 INT145370 Transcription of DKK1 3 0.53 1.07 0.05
61 INT350999 Gene_expression of Adh7 1 0.02 1.64 0.05
62 INT321885 Localization of Dkk1 1 0.56 0.87 0.04
63 INT351000 Binding of Adh7 1 0.01 3.4 0.03
64 INT191267 Negative_regulation of Positive_regulation of LRPAP1 1 0.07 0 0.03
65 INT191264 Positive_regulation of Gene_expression of LRPAP1 1 0.10 0 0.03
66 INT307589 Positive_regulation of Gene_expression of ESR2 1 0.42 0.5 0
67 INT138752 Transcription of ESR2 1 0.60 0 0
68 INT165336 Negative_regulation of Negative_regulation of Dkk1 1 0.33 0 0
69 INT198910 Negative_regulation of Lrpap1 1 0.12 0.54 0
70 INT350998 Positive_regulation of Adh7 1 0.01 1.25 0
71 INT102799 Negative_regulation of ESR2 1 0.35 0 0
72 INT211940 Regulation of Negative_regulation of Dkk1 1 0.36 0.21 0
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