GO:0048154

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Name S100 beta binding
Categary Function
Go Slim No
Go Link GO:0048154
Unique Molecular Interactions 96
Total Molecular Interactions 146
Total Single Events 1331
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for S100 beta binding. They are ordered first by their pain relevance and then by number of times they were reported for S100 beta binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT266391 Binding of Ager and S100a1 1 0.01 5.63 1.69
2 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
3 INT130839 Gfap Positive_regulation of S100B 1 0.51 1.9 1.56
4 INT274785 S100B Positive_regulation of Ngf 1 0.05 0.61 0.8
5 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76
6 INT152867 HTR1A Negative_regulation of Localization of S100b 1 0.46 0 0.75
7 INT274786 Ngf Positive_regulation of Gene_expression of S100B 1 0.05 0.63 0.71
8 INT2685 S100A6 Positive_regulation of Regulation of Thra 1 0.47 0.09 0.58
9 INT2684 S100A6 Regulation of Regulation of Thra 1 0.45 0.09 0.58
10 INT290594 BDNF Positive_regulation of Localization of S100B 1 0.08 0.6 0.57
11 INT266381 Positive_regulation of Ager Positive_regulation of Nfkb1 1 0.00 0.77 0.55
12 INT266376 Binding of Ager and Itgam 1 0.00 2.31 0.54
13 INT266393 Binding of Ager and Fn1 1 0.00 0.82 0.39
14 INT266397 Binding of Ager and Col4a1 1 0.00 0.81 0.38
15 INT175016 Binding of REN and S100A6 2 0.11 1.13 0.37
16 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37
17 INT129769 Binding of LYZ and S100B 1 0.33 0.86 0.37
18 INT266402 Binding of S100P and Ager 1 0.00 2.25 0.35
19 INT266383 Binding of Ager and S100b 1 0.01 3.48 0.33
20 INT266375 S100b Positive_regulation of Ager 1 0.02 1.8 0.31
21 INT175017 Negative_regulation of Binding of REN and S100A6 1 0.13 0.45 0.29
22 INT175018 Positive_regulation of Binding of REN and S100A6 1 0.15 0.45 0.29
23 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22
24 INT344833 Binding of Ager and Hmgb1 1 0.08 0.72 0.22
25 INT266405 S100b Positive_regulation of Gene_expression of TFAM 1 0.00 1.02 0.21
26 INT266417 Binding of TGM2 and S100a11 1 0.01 0.86 0.16
27 INT266422 HMGB1 Positive_regulation of Binding of Ager 1 0.01 0.92 0.16
28 INT122529 Apoe Regulation of S100B 1 0.18 0.29 0.16
29 INT266412 Binding of S100A12 and Ager 1 0.01 1.03 0.15
30 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
31 INT96590 Mog Regulation of S100B 1 0.32 0.97 0.13
32 INT261381 Nsdhl Regulation of Gene_expression of S100b 1 0.06 0.82 0.13
33 INT237442 Ass1 Positive_regulation of S100b 1 0.00 0.18 0.13
34 INT330800 Binding of S100A1 and S100B 1 0.32 0.5 0.13
35 INT266403 Negative_regulation of Binding of S100P and Ager 1 0.00 0.74 0.13
36 INT96589 Mbp Regulation of S100B 1 0.34 0.97 0.13
37 INT308659 Binding of Ager and ecs 1 0.01 1.14 0.12
38 INT308647 Ager Positive_regulation of Gene_expression of Bace1 1 0.09 1.01 0.12
39 INT308660 Binding of Ager and App 1 0.08 1.22 0.12
40 INT266384 Binding of Ager and S100a6 1 0.01 1.32 0.11
41 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
42 INT266385 S100a6 Positive_regulation of Ager 1 0.01 0.84 0.1
43 INT266373 Itgam Positive_regulation of Ager 1 0.01 0.84 0.1
44 INT266396 Binding of Ager and S100a4 1 0.01 0.59 0.1
45 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
46 INT137395 Binding of CD99 and S100B 1 0.17 1.04 0.09
47 INT316112 Binding of S100B and SAE1 1 0.05 1.5 0.08
48 INT266389 Binding of C2 and S100a6 1 0.04 0.5 0.07
49 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
50 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
51 INT266388 S100a6 Negative_regulation of Mapk8 1 0.03 0.49 0.06
52 INT197617 Binding of S100a6 and Rb1 1 0.03 0 0.06
53 INT266374 Binding of S100a1 and S100a9 1 0.09 0.17 0.05
54 INT266387 Binding of S100a1 and S100a8 1 0.09 0.17 0.05
55 INT316109 TEAD1 Regulation of S100B 1 0.00 1.16 0.04
56 INT238803 Ager Positive_regulation of Cbl 1 0.01 1.57 0.04
57 INT266379 S100a8 Positive_regulation of Ager 1 0.01 0.3 0.04
58 INT266372 Binding of S100a1 and S100a4 1 0.11 0.15 0.04
59 INT266392 S100a9 Positive_regulation of Ager 1 0.01 0.3 0.04
60 INT204247 S100B Regulation of CD68 1 0.03 1.05 0.04
61 INT244656 Binding of S100B and SLC4A1 1 0.14 1.72 0.03
62 INT266415 Binding of ROS1 and S100a6 1 0.02 0.82 0.03
63 INT262617 Ager Positive_regulation of Rpe 1 0.00 0.81 0
64 INT180294 Positive_regulation of Binding of CPB1 and S100B 1 0.09 0 0
65 INT249185 Binding of S100B and Positive_regulation of CYBB 1 0.11 0 0
66 INT249195 Binding of CA2 and S100B 1 0.07 0 0
67 INT197907 Dlst Regulation of S100a6 1 0.10 0 0
68 INT266407 Binding of ALB and Ager 1 0.00 1.42 0
69 INT197902 Regulation of Oxt Regulation of S100a6 1 0.08 0 0
70 INT180295 Binding of CPB1 and S100B 1 0.08 0 0
71 INT180302 Positive_regulation of Binding of S100B and Tg(EGFR)0Jlj 1 0.05 0 0
72 INT249180 Binding of NCF2 and S100B 1 0.05 0 0
73 INT180303 Binding of S100B and Tg(EGFR)0Jlj 1 0.03 0 0
74 INT266395 Renbp Positive_regulation of Ager 1 0.00 0.31 0
75 INT197913 Oxt Regulation of Gene_expression of S100a6 1 0.08 0 0
76 INT235486 S100B Positive_regulation of Binding of CA2 1 0.13 0.08 0
77 INT197904 Dlst Positive_regulation of Positive_regulation of S100a6 1 0.09 0 0
78 INT197898 Dlst Regulation of Gene_expression of S100a6 1 0.14 0 0
79 INT249155 Binding of CYBA and S100B 1 0.06 0 0
80 INT249174 Binding of AKT1 and S100B 1 0.02 0 0
81 INT197905 Oxt Regulation of S100a6 1 0.08 0 0
82 INT249194 S100B Positive_regulation of CYBA 1 0.06 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for S100 beta binding. They are ordered first by their pain relevance and then by number of times they were reported in S100 beta binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4
2 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17
3 INT224366 Gene_expression of Ager 111 0.77 125.37 8.49
4 INT112986 Positive_regulation of S100b 19 0.70 17.61 6.86
5 INT117299 Localization of S100b 19 0.78 1.58 6.8
6 INT23465 Gene_expression of S100b 31 0.76 15.09 6.2
7 INT17742 Localization of S100B 44 0.80 17.14 4.65
8 INT26368 Positive_regulation of S100A6 30 0.45 9.72 3.89
9 INT224369 Binding of Ager 43 0.42 40.57 3.86
10 INT73602 Positive_regulation of Ager 35 0.69 30.66 3.74
11 INT82168 Positive_regulation of S100b 20 0.68 9.72 3.08
12 INT131929 Positive_regulation of Gene_expression of S100B 25 0.67 12.61 2.83
13 INT23775 Regulation of S100B 24 0.62 16.75 2.57
14 INT152865 Positive_regulation of Localization of S100b 3 0.68 0 2.53
15 INT195085 Gene_expression of S100b 12 0.56 12.26 2.33
16 INT26369 Gene_expression of S100A6 19 0.65 5.39 1.81
17 INT58563 Negative_regulation of S100B 13 0.51 11.75 1.77
18 INT152864 Regulation of Localization of S100b 2 0.52 0 1.66
19 INT155153 Binding of S100a1 15 0.35 6.42 1.63
20 INT143850 Gene_expression of S100a1 19 0.73 9.52 1.54
21 INT125767 Positive_regulation of Gene_expression of S100b 6 0.49 4.08 1.52
22 INT112988 Positive_regulation of Transcription of S100b 2 0.47 1.62 1.36
23 INT112987 Transcription of S100b 2 0.53 1.61 1.35
24 INT51064 Regulation of Gene_expression of S100B 13 0.60 5.02 1.34
25 INT125766 Regulation of S100b 7 0.38 4.31 1.33
26 INT161706 Negative_regulation of Gene_expression of S100B 8 0.43 2.69 1.06
27 INT293678 Positive_regulation of Gene_expression of S100A6 1 0.34 2.42 1.04
28 INT224368 Negative_regulation of Gene_expression of Ager 8 0.39 13.94 1.03
29 INT51066 Binding of S100B 24 0.48 13.5 0.97
30 INT43919 Negative_regulation of S100A6 19 0.16 4.45 0.96
31 INT169759 Localization of S100a1 5 0.43 0.78 0.9
32 INT224365 Positive_regulation of Gene_expression of Ager 13 0.69 11.6 0.88
33 INT180300 Positive_regulation of Positive_regulation of S100B 3 0.50 2.07 0.79
34 INT128447 Positive_regulation of Localization of S100B 2 0.67 0.9 0.79
35 INT224367 Negative_regulation of Ager 15 0.46 25.57 0.78
36 INT169766 Negative_regulation of S100a1 1 0.15 0 0.77
37 INT73433 Gene_expression of S100a6 10 0.71 2.74 0.76
38 INT36200 Gene_expression of S100A1 9 0.77 9.56 0.75
39 INT152863 Negative_regulation of Localization of S100b 1 0.42 0 0.75
40 INT147008 Negative_regulation of Gene_expression of S100b 2 0.27 0.55 0.74
41 INT195107 Localization of S100b 3 0.51 2.63 0.73
42 INT195095 Positive_regulation of Gene_expression of S100b 4 0.36 5.37 0.61
43 INT195094 Binding of S100b 2 0.35 3.49 0.51
44 INT143162 Gene_expression of S100a6 7 0.78 5.86 0.49
45 INT110498 Localization of S100a6 1 0.31 1.57 0.44
46 INT224372 Regulation of Gene_expression of Ager 6 0.39 4.98 0.43
47 INT125765 Negative_regulation of Positive_regulation of S100b 2 0.42 0.06 0.4
48 INT43387 Regulation of S100A6 2 0.15 0.4 0.4
49 INT266330 Positive_regulation of S100a1 4 0.44 2.98 0.39
50 INT213648 Phosphorylation of S100A6 2 0.30 1.43 0.36
51 INT143165 Positive_regulation of S100a6 8 0.69 3.5 0.34
52 INT156723 Regulation of Localization of S100B 2 0.44 2.61 0.34
53 INT266343 Positive_regulation of Positive_regulation of Ager 1 0.02 0.7 0.33
54 INT266327 Negative_regulation of Binding of S100a1 1 0.16 1.23 0.33
55 INT224370 Localization of Ager 7 0.65 11.64 0.3
56 INT197585 Positive_regulation of S100a6 3 0.43 1.67 0.29
57 INT266318 Negative_regulation of Negative_regulation of Ager 1 0.02 0.66 0.29
58 INT161705 Positive_regulation of Negative_regulation of S100B 1 0.50 0.56 0.28
59 INT224363 Regulation of Ager 3 0.36 4.62 0.26
60 INT143164 Positive_regulation of Gene_expression of S100a6 3 0.69 2.33 0.25
61 INT165392 Positive_regulation of Regulation of S100B 2 0.50 0.56 0.23
62 INT93077 Negative_regulation of Localization of S100B 3 0.57 0.58 0.2
63 INT73435 Negative_regulation of S100a6 1 0.21 0.26 0.2
64 INT143163 Regulation of S100a6 2 0.45 1.47 0.18
65 INT195111 Negative_regulation of Positive_regulation of S100b 1 0.06 1.06 0.18
66 INT51065 Transcription of S100B 3 0.60 0.83 0.17
67 INT293679 Positive_regulation of Positive_regulation of S100A6 2 0.24 1.19 0.14
68 INT347326 Regulation of S100a1 1 0.26 0.79 0.14
69 INT237441 Positive_regulation of Positive_regulation of S100b 2 0.36 3 0.12
70 INT266345 Binding of S100a11 1 0.13 0.76 0.12
71 INT266329 Localization of S100a11 1 0.26 0.82 0.11
72 INT266317 Phosphorylation of S100a11 1 0.24 0.81 0.11
73 INT147009 Regulation of Gene_expression of S100b 2 0.07 0.34 0.1
74 INT237438 Regulation of Gene_expression of S100b 2 0.31 2.45 0.1
75 INT266337 Protein_catabolism of Ager 1 0.02 0.26 0.1
76 INT197584 Binding of S100a6 2 0.14 0.81 0.09
77 INT152469 Binding of S100A1 2 0.36 1.55 0.08
78 INT82169 Negative_regulation of S100b 2 0.31 0.69 0.08
79 INT311813 Binding of S100A6 1 0.14 0.13 0.07
80 INT266338 Negative_regulation of Binding of Ager 1 0.02 1.37 0.05
81 INT266346 Gene_expression of S100a11 1 0.23 0.74 0.05
82 INT266336 Positive_regulation of Gene_expression of S100a11 1 0.18 0.74 0.05
83 INT180298 Regulation of Positive_regulation of S100B 3 0.39 1.09 0.04
84 INT238794 Positive_regulation of Localization of Ager 1 0.40 1.2 0.03
85 INT293673 Transcription of S100A6 1 0.38 0.15 0.03
86 INT222338 Positive_regulation of Gene_expression of S100a1 2 0.44 0.09 0
87 INT197866 Binding of S100a6 2 0.41 0 0
88 INT200568 Negative_regulation of Regulation of S100b 1 0.01 1.03 0
89 INT197879 Positive_regulation of Binding of S100a6 1 0.42 0 0
90 INT235488 Negative_regulation of Transcription of S100B 1 0.37 0.09 0
91 INT235487 Regulation of Transcription of S100B 1 0.39 0.09 0
92 INT77428 Negative_regulation of Positive_regulation of S100A6 1 0.15 0 0
93 INT266331 Transcription of S100a1 1 0.30 0.76 0
94 INT327450 Negative_regulation of Gene_expression of S100A6 1 0.12 0.19 0
95 INT163587 Positive_regulation of Positive_regulation of S100b 1 0.40 0 0
96 INT347327 Regulation of Gene_expression of S100a1 1 0.43 0.09 0
97 INT82588 Regulation of Gene_expression of S100A6 1 0.44 0.05 0
98 INT224371 Phosphorylation of Ager 1 0.70 0 0
99 INT238789 Regulation of Regulation of Ager 1 0.36 1.1 0
100 INT224364 Negative_regulation of Phosphorylation of Ager 1 0.37 0 0
101 INT315909 Positive_regulation of S100A1 1 0.49 0.71 0
102 INT197884 Transcription of S100a6 1 0.45 0 0
103 INT266323 Negative_regulation of S100a11 1 0.16 0.2 0
104 INT238786 Positive_regulation of Binding of Ager 1 0.40 6.84 0
105 INT293674 Positive_regulation of Transcription of S100A6 1 0.28 0.15 0
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