GO:0048155

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Name S100 alpha binding
Categary Function
Go Slim No
Go Link GO:0048155
Unique Molecular Interactions 80
Total Molecular Interactions 139
Total Single Events 1041
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for S100 alpha binding. They are ordered first by their pain relevance and then by number of times they were reported for S100 alpha binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
2 INT266391 Binding of Ager and S100a1 1 0.01 5.63 1.69
3 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
4 INT66334 Fgf2 Regulation of Fgf1 1 0.37 0.17 0.9
5 INT21233 Ngf Regulation of Fgf1 1 0.46 0.09 0.79
6 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76
7 INT266381 Positive_regulation of Ager Positive_regulation of Nfkb1 1 0.00 0.77 0.55
8 INT266376 Binding of Ager and Itgam 1 0.00 2.31 0.54
9 INT184291 Binding of AGER and Crp 1 0.01 1.23 0.46
10 INT66335 Fgf1 Regulation of Fgf2 1 0.10 0.08 0.45
11 INT205567 Regulation of Binding of Fgf1 and Chat 1 0.29 0.28 0.41
12 INT184292 Binding of AGER and chromosomal protein 1 1 0.01 0.87 0.41
13 INT205566 Binding of Fgf1 and Chat 1 0.24 0.28 0.41
14 INT266393 Binding of Ager and Fn1 1 0.00 0.82 0.39
15 INT266397 Binding of Ager and Col4a1 1 0.00 0.81 0.38
16 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37
17 INT266402 Binding of S100P and Ager 1 0.00 2.25 0.35
18 INT266383 Binding of Ager and S100b 1 0.01 3.48 0.33
19 INT266375 S100b Positive_regulation of Ager 1 0.02 1.8 0.31
20 INT107189 Atp2a2 Negative_regulation of Atp2a1 1 0.27 0 0.26
21 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22
22 INT344833 Binding of Ager and Hmgb1 1 0.08 0.72 0.22
23 INT245866 Binding of VEGFA and Fgf1 1 0.07 0.52 0.22
24 INT250853 Binding of Fgf1 and Mtpn 1 0.00 0.28 0.21
25 INT266422 HMGB1 Positive_regulation of Binding of Ager 1 0.01 0.92 0.16
26 INT266412 Binding of S100A12 and Ager 1 0.01 1.03 0.15
27 INT347338 Binding of Fgf1 and S100a9 1 0.26 0.46 0.15
28 INT347331 Binding of Fgf1 and S100a8 1 0.26 0.46 0.15
29 INT330800 Binding of S100A1 and S100B 1 0.32 0.5 0.13
30 INT266403 Negative_regulation of Binding of S100P and Ager 1 0.00 0.74 0.13
31 INT308659 Binding of Ager and ecs 1 0.01 1.14 0.12
32 INT308647 Ager Positive_regulation of Gene_expression of Bace1 1 0.09 1.01 0.12
33 INT308660 Binding of Ager and App 1 0.08 1.22 0.12
34 INT266384 Binding of Ager and S100a6 1 0.01 1.32 0.11
35 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
36 INT266385 S100a6 Positive_regulation of Ager 1 0.01 0.84 0.1
37 INT266373 Itgam Positive_regulation of Ager 1 0.01 0.84 0.1
38 INT266396 Binding of Ager and S100a4 1 0.01 0.59 0.1
39 INT237813 Binding of Atp2a2 and soc 1 0.02 0 0.09
40 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
41 INT199604 Binding of FGF7 and Fgf1 1 0.03 0.21 0.08
42 INT199603 Positive_regulation of Binding of FGF7 and Fgf1 1 0.04 0.21 0.08
43 INT237823 Binding of Atp2a2 and Stim1 1 0.06 0 0.07
44 INT266374 Binding of S100a1 and S100a9 1 0.09 0.17 0.05
45 INT285184 Negative_regulation of Atp2a2 Negative_regulation of Localization of Ca2 1 0.04 0.66 0.05
46 INT266387 Binding of S100a1 and S100a8 1 0.09 0.17 0.05
47 INT238803 Ager Positive_regulation of Cbl 1 0.01 1.57 0.04
48 INT266379 S100a8 Positive_regulation of Ager 1 0.01 0.3 0.04
49 INT340568 Fgf1 Positive_regulation of Mapk1 1 0.06 1.02 0.04
50 INT266372 Binding of S100a1 and S100a4 1 0.11 0.15 0.04
51 INT266392 S100a9 Positive_regulation of Ager 1 0.01 0.3 0.04
52 INT236078 Binding of AGER and HLA-DMA 1 0.08 0.81 0
53 INT262617 Ager Positive_regulation of Rpe 1 0.00 0.81 0
54 INT249200 ATP2A2 Negative_regulation of CA2 1 0.01 0 0
55 INT260269 Binding of FGF1 and FGFBP1 1 0.47 0.94 0
56 INT65036 Fgf1 Regulation of Anxa5 1 0.01 0.35 0
57 INT266407 Binding of ALB and Ager 1 0.00 1.42 0
58 INT222474 Binding of Fgf1 and Ecm1 1 0.00 0.62 0
59 INT178433 Fgf1 Positive_regulation of Mapk14 1 0.02 0.65 0
60 INT314683 NUDT6 Positive_regulation of FGF1 1 0.02 1.17 0
61 INT65035 Fgf1 Regulation of F2 1 0.07 0.34 0
62 INT266395 Renbp Positive_regulation of Ager 1 0.00 0.31 0
63 INT324660 Vash1 Regulation of Gene_expression of Fgf1 1 0.14 0.44 0
64 INT273287 Binding of Atp2a2 and Pln 1 0.08 0.26 0
65 INT273290 Binding of Atp2a2 and Tlx2 1 0.05 0.26 0
66 INT236079 Binding of AGER and HLA-DQB1 1 0.25 1.06 0
67 INT273291 Atp2a2 Regulation of Car2 1 0.10 0.31 0
68 INT260265 Binding of FGF1 and FGFR1 1 0.45 0.93 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for S100 alpha binding. They are ordered first by their pain relevance and then by number of times they were reported in S100 alpha binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139830 Gene_expression of AGER 47 0.75 41.71 16.53
2 INT224366 Gene_expression of Ager 111 0.77 125.37 8.49
3 INT184281 Binding of AGER 25 0.37 23.06 7.32
4 INT88182 Gene_expression of Atp2a2 40 0.78 22.91 4.26
5 INT224369 Binding of Ager 43 0.42 40.57 3.86
6 INT73602 Positive_regulation of Ager 35 0.69 30.66 3.74
7 INT48143 Gene_expression of Fgf1 32 0.78 8.2 3.72
8 INT184270 Negative_regulation of AGER 8 0.32 10.48 3.45
9 INT184286 Regulation of AGER 1 0.46 6.7 3
10 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96
11 INT184280 Positive_regulation of AGER 8 0.52 9.05 2.43
12 INT65034 Regulation of Fgf1 7 0.61 2.42 2.34
13 INT88183 Localization of Atp2a2 6 0.63 2.1 2.22
14 INT184284 Regulation of Gene_expression of AGER 1 0.34 4.95 2.11
15 INT99426 Negative_regulation of Gene_expression of Atp2a2 19 0.59 13.7 1.96
16 INT184273 Localization of AGER 1 0.60 3.59 1.67
17 INT155153 Binding of S100a1 15 0.35 6.42 1.63
18 INT143850 Gene_expression of S100a1 19 0.73 9.52 1.54
19 INT73816 Positive_regulation of Fgf1 5 0.70 2.31 1.49
20 INT63328 Binding of Fgf1 10 0.37 1.5 1.4
21 INT92966 Positive_regulation of FGF1 4 0.38 2.25 1.33
22 INT139829 Negative_regulation of Gene_expression of AGER 2 0.57 3.76 1.3
23 INT184276 Positive_regulation of Negative_regulation of AGER 1 0.35 2.87 1.2
24 INT99427 Positive_regulation of Gene_expression of Atp2a2 5 0.64 4.13 1.14
25 INT224368 Negative_regulation of Gene_expression of Ager 8 0.39 13.94 1.03
26 INT106495 Positive_regulation of Localization of Atp2a2 1 0.37 0.19 0.91
27 INT169759 Localization of S100a1 5 0.43 0.78 0.9
28 INT184279 Regulation of Regulation of AGER 1 0.20 1.99 0.9
29 INT114704 Positive_regulation of Fgf1 13 0.50 8.89 0.89
30 INT224365 Positive_regulation of Gene_expression of Ager 13 0.69 11.6 0.88
31 INT86474 Negative_regulation of Fgf1 6 0.58 0.64 0.88
32 INT94833 Gene_expression of FGF1 4 0.53 2.01 0.81
33 INT224367 Negative_regulation of Ager 15 0.46 25.57 0.78
34 INT169766 Negative_regulation of S100a1 1 0.15 0 0.77
35 INT36200 Gene_expression of S100A1 9 0.77 9.56 0.75
36 INT139828 Positive_regulation of Gene_expression of AGER 2 0.67 3 0.75
37 INT73429 Negative_regulation of Atp2a2 20 0.20 9.05 0.74
38 INT73815 Localization of Fgf1 10 0.80 1.73 0.69
39 INT104233 Positive_regulation of Gene_expression of Fgf1 2 0.63 1.79 0.62
40 INT184290 Regulation of Localization of AGER 1 0.34 1.17 0.59
41 INT94834 Positive_regulation of Gene_expression of FGF1 2 0.48 1.82 0.56
42 INT184690 Transcription of Fgf1 6 0.51 1.97 0.55
43 INT184274 Negative_regulation of Binding of AGER 1 0.37 2.02 0.55
44 INT184285 Positive_regulation of Binding of AGER 1 0.38 1.04 0.49
45 INT166435 Negative_regulation of Atp2a2 8 0.43 0.4 0.44
46 INT224372 Regulation of Gene_expression of Ager 6 0.39 4.98 0.43
47 INT159051 Positive_regulation of Transcription of Fgf1 1 0.45 0.71 0.41
48 INT159052 Transcription of Fgf1 1 0.62 0.71 0.41
49 INT266330 Positive_regulation of S100a1 4 0.44 2.98 0.39
50 INT107188 Regulation of Gene_expression of Atp2a2 1 0.54 0 0.39
51 INT133874 Negative_regulation of Gene_expression of Fgf1 2 0.24 2.82 0.36
52 INT82817 Localization of FGF1 2 0.60 2.12 0.36
53 INT252961 Localization of Fgf1 3 0.27 5.91 0.35
54 INT266343 Positive_regulation of Positive_regulation of Ager 1 0.02 0.7 0.33
55 INT266327 Negative_regulation of Binding of S100a1 1 0.16 1.23 0.33
56 INT224370 Localization of Ager 7 0.65 11.64 0.3
57 INT114699 Positive_regulation of Gene_expression of Fgf1 4 0.32 2.21 0.29
58 INT266318 Negative_regulation of Negative_regulation of Ager 1 0.02 0.66 0.29
59 INT224363 Regulation of Ager 3 0.36 4.62 0.26
60 INT166432 Positive_regulation of Atp2a2 5 0.44 0.45 0.24
61 INT183120 Regulation of FGF1 3 0.10 2.53 0.23
62 INT332259 Positive_regulation of Positive_regulation of Fgf1 1 0.18 2.33 0.23
63 INT332258 Positive_regulation of Localization of Fgf1 1 0.18 2.32 0.23
64 INT65834 Negative_regulation of ATP2A2 4 0.07 2.39 0.21
65 INT245856 Regulation of Transcription of Fgf1 1 0.21 0.51 0.21
66 INT245863 Positive_regulation of Transcription of Fgf1 1 0.22 0.51 0.21
67 INT184278 Regulation of Binding of AGER 1 0.34 0.52 0.2
68 INT166433 Gene_expression of Atp2a2 7 0.68 2.82 0.15
69 INT297202 Regulation of Atp2a2 2 0.16 1.71 0.14
70 INT347326 Regulation of S100a1 1 0.26 0.79 0.14
71 INT205562 Positive_regulation of Localization of Fgf1 1 0.50 0.25 0.13
72 INT193777 Negative_regulation of Fgf1 6 0.13 4.26 0.12
73 INT106015 Negative_regulation of Regulation of Fgf1 1 0.41 0.15 0.12
74 INT266337 Protein_catabolism of Ager 1 0.02 0.26 0.1
75 INT205563 Regulation of Gene_expression of Fgf1 1 0.27 0.06 0.09
76 INT65031 Negative_regulation of Gene_expression of Fgf1 3 0.43 0.25 0.08
77 INT152469 Binding of S100A1 2 0.36 1.55 0.08
78 INT270684 Positive_regulation of Positive_regulation of AGER 1 0.05 0.87 0.08
79 INT240717 Negative_regulation of Localization of Atp2a2 1 0.13 1.3 0.08
80 INT266341 Regulation of Localization of Fgf1 1 0.03 0.92 0.08
81 INT237804 Binding of Atp2a2 1 0.06 0 0.07
82 INT266338 Negative_regulation of Binding of Ager 1 0.02 1.37 0.05
83 INT336604 Regulation of Gene_expression of Atp2a2 1 0.05 0.81 0.05
84 INT205607 Regulation of Fgf1 4 0.24 3.34 0.04
85 INT201163 Regulation of Atp2a2 4 0.08 2.97 0.03
86 INT201169 Negative_regulation of Regulation of Atp2a2 1 0.08 0.61 0.03
87 INT238794 Positive_regulation of Localization of Ager 1 0.40 1.2 0.03
88 INT201161 Positive_regulation of Regulation of Atp2a2 1 0.06 0.56 0.03
89 INT260288 Binding of FGF1 3 0.32 2.46 0
90 INT222338 Positive_regulation of Gene_expression of S100a1 2 0.44 0.09 0
91 INT240720 Transcription of Atp2a2 2 0.20 1.26 0
92 INT265570 Binding of Fgf1 2 0.10 0.91 0
93 INT266331 Transcription of S100a1 1 0.30 0.76 0
94 INT296913 Positive_regulation of Transcription of Atp2a2 1 0.02 1.33 0
95 INT255202 Gene_expression of ATP2A2 1 0.65 0.41 0
96 INT166436 Negative_regulation of Localization of Atp2a2 1 0.37 0 0
97 INT347327 Regulation of Gene_expression of S100a1 1 0.43 0.09 0
98 INT224371 Phosphorylation of Ager 1 0.70 0 0
99 INT311652 Negative_regulation of Regulation of Fgf1 1 0.13 0.32 0
100 INT238789 Regulation of Regulation of Ager 1 0.36 1.1 0
101 INT224364 Negative_regulation of Phosphorylation of Ager 1 0.37 0 0
102 INT315909 Positive_regulation of S100A1 1 0.49 0.71 0
103 INT166434 Localization of Atp2a2 1 0.66 0 0
104 INT273281 Regulation of Negative_regulation of Atp2a2 1 0.11 0.23 0
105 INT296912 Positive_regulation of Atp2a2 1 0.02 0.66 0
106 INT196110 Negative_regulation of Gene_expression of Atp2a2 1 0.09 0.05 0
107 INT238786 Positive_regulation of Binding of Ager 1 0.40 6.84 0
108 INT240721 Negative_regulation of Negative_regulation of Atp2a2 1 0.13 1.07 0
109 INT296924 Positive_regulation of Positive_regulation of Atp2a2 1 0.02 0.67 0
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