GO:0048185

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Name activin binding
Categary Function
Go Slim No
Go Link GO:0048185
Unique Molecular Interactions 149
Total Molecular Interactions 181
Total Single Events 1301
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activin binding. They are ordered first by their pain relevance and then by number of times they were reported for activin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
2 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
3 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
4 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
5 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
6 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
7 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
8 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
9 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
10 INT280949 Binding of Fst and Inhbe 3 0.01 2.51 1.15
11 INT31444 ENG Positive_regulation of Prl 1 0.01 0 1.14
12 INT167819 IFNA1 Positive_regulation of Fst 1 0.39 0 1.07
13 INT146897 Binding of Fst and OR13H1 1 0.01 0 1.05
14 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
15 INT32187 Binding of ENG and Negative_regulation of Localization of LH 1 0.01 0 0.91
16 INT291011 Pomc Regulation of Gene_expression of ENG 1 0.08 0.86 0.91
17 INT148452 Inhbe Regulation of Acvrl1 1 0.01 0.69 0.69
18 INT137102 Fst Regulation of Sec22b 1 0.07 0 0.67
19 INT137101 Fst Regulation of Htr1a 1 0.24 0 0.67
20 INT32719 ENG Regulation of LH 2 0.00 0 0.64
21 INT31443 ENG Positive_regulation of Localization of Pomc 1 0.00 0 0.63
22 INT144320 Binding of Fst and Rbm39 1 0.04 0 0.59
23 INT305744 Fst Positive_regulation of Creb1 1 0.12 0.33 0.57
24 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
25 INT32151 ENG Positive_regulation of Gene_expression of IFNA1 1 0.37 0 0.53
26 INT32291 ENG Negative_regulation of LH 2 0.00 0 0.52
27 INT30618 Slc3a1 Regulation of ENG 1 0.00 0 0.5
28 INT30619 Pomc Regulation of ENG 1 0.00 0 0.5
29 INT102214 ENG Negative_regulation of HP 1 0.01 0 0.49
30 INT60872 Binding of ENG and Abat 1 0.00 0 0.49
31 INT60871 ENG Regulation of Localization of LH 1 0.00 0 0.49
32 INT43695 ENG Regulation of Regulation of Prl 1 0.00 0 0.47
33 INT60870 ENG Negative_regulation of Localization of LH 1 0.00 0 0.47
34 INT102213 Binding of ENG and HP 1 0.01 0 0.47
35 INT202516 Positive_regulation of Binding of ENG and Penk 1 0.03 0.58 0.42
36 INT202515 Binding of ENG and Penk 1 0.02 0.57 0.41
37 INT32720 Negative_regulation of ENG Regulation of LH 1 0.00 0 0.41
38 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38
39 INT55404 Binding of ENG and Th 1 0.02 0 0.3
40 INT29137 ENG Regulation of POMC 1 0.00 0 0.28
41 INT29139 ENG Regulation of Oprl1 1 0.00 0 0.28
42 INT32156 Binding of ENG and Oprd1 1 0.00 0 0.26
43 INT32149 Binding of ENG and LLGL1 1 0.11 0 0.26
44 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
45 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25
46 INT212568 Fst Regulation of Gene_expression of Il2 1 0.30 0.07 0.24
47 INT43713 ENG Regulation of Prl 1 0.00 0 0.23
48 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
49 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
50 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
51 INT32294 ENG Positive_regulation of Trh 1 0.01 0 0.13
52 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
53 INT60399 ENG Regulation of Localization of Prl 1 0.04 0.57 0.1
54 INT158011 KLRF1 Positive_regulation of ENG 1 0.03 0.39 0.09
55 INT228808 Smad7 Regulation of Rgs1 1 0.19 0.24 0.09
56 INT158012 Binding of ENG and FLT1 1 0.21 0.39 0.09
57 INT228812 Smad7 Regulation of Stap1 1 0.00 0.24 0.09
58 INT32290 ENG Regulation of Positive_regulation of Trh 1 0.01 0 0.09
59 INT222511 Il1a Positive_regulation of Gene_expression of Fst 1 0.01 0.32 0.08
60 INT134837 TGFB1 Regulation of SMAD7 1 0.34 0.68 0.08
61 INT134833 TGFB1 Regulation of Gene_expression of SMAD7 1 0.34 0.69 0.08
62 INT134838 TGFB1 Positive_regulation of SMAD7 1 0.52 0.79 0.08
63 INT311903 Acvrl1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
64 INT25491 TFPI Regulation of Localization of ENG 1 0.27 0.31 0.06
65 INT222431 Tlr4 Positive_regulation of Gene_expression of Fst 1 0.01 0.29 0.06
66 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06
67 INT25490 Binding of ENG and TFPI 1 0.27 0.4 0.06
68 INT222463 Inhba Positive_regulation of Gene_expression of Fst 1 0.01 0 0.05
69 INT222520 Mzb1 Positive_regulation of Gene_expression of Fst 1 0.04 0 0.05
70 INT222476 Gnrh1 Negative_regulation of Gene_expression of Fst 1 0.04 0 0.05
71 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05
72 INT207760 Fkbp1a Regulation of MSMB 1 0.12 0.69 0.04
73 INT32293 ENG Regulation of Positive_regulation of Gnrh1 1 0.00 0 0.04
74 INT32297 ENG Regulation of Positive_regulation of LH 1 0.00 0 0.04
75 INT353287 Prdx2 Positive_regulation of Phosphorylation of Smad7 1 0.22 0.06 0.03
76 INT340558 Gene_expression of Fst Positive_regulation of Akt1 1 0.09 0.41 0.03
77 INT353291 Prdx2 Positive_regulation of Smad7 1 0.31 0.06 0.03
78 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03
79 INT353288 Smad7 Negative_regulation of Phosphorylation of Tgif1 1 0.08 0.06 0.03
80 INT340614 Binding of ENG and MMP9 1 0.16 0.14 0
81 INT120077 Gene_expression of Smad7 Negative_regulation of Positive_regulation of Itk 1 0.02 0.27 0
82 INT314869 Binding of Gdf11 and Tgfbr3 1 0.29 0.14 0
83 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0
84 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
85 INT293355 Binding of Fkbp1a and CABIN1 1 0.00 0.12 0
86 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0
87 INT273116 Binding of Fkbp1a and Mtor 1 0.37 0 0
88 INT32148 POMC Regulation of ENG 1 0.24 0 0
89 INT314871 Binding of Tgfbr3 and Atoh7 1 0.33 0.09 0
90 INT218663 Olr811 Positive_regulation of Gene_expression of Smad7 1 0.01 0.45 0
91 INT306626 Gprasp1 Negative_regulation of Fstl3 1 0.08 0 0
92 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
93 INT134836 Binding of SMAD7 and YAP1 1 0.53 0.89 0
94 INT313842 Mstn Regulation of Gene_expression of Fstl3 1 0.32 0.08 0
95 INT15847 Avp Positive_regulation of Localization of ENG 1 0.07 0 0
96 INT222539 Negative_regulation of Binding of Inhba and Acvr2a 1 0.01 0 0
97 INT340613 Binding of COL4A4 and ENG 1 0.07 0.14 0
98 INT329746 ENG Positive_regulation of SMAD1 1 0.15 0.44 0
99 INT310188 Binding of Adcyap1r1 and Smad7 1 0.00 0 0
100 INT293354 Binding of CSH1 and Fkbp1a 1 0.00 0.12 0
101 INT347155 Mirlet7a-1 Negative_regulation of Smad7 1 0.10 0 0
102 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
103 INT222504 Binding of Inhba and Acvr2a 1 0.01 0 0
104 INT228288 Binding of ENG and Ptprc 1 0.06 0.25 0
105 INT265234 Binding of FKBP1A and SGCG 1 0.03 0.35 0
106 INT293366 Binding of CABIN1 and Fkbp1a 1 0.00 0.05 0
107 INT310187 Acvrl1 Regulation of Gene_expression of Bmpr2 1 0.04 0 0
108 INT295571 Binding of Acvr2b and Mstn 1 0.08 0 0
109 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
110 INT228287 Binding of ENG and Cd14 1 0.20 0.25 0
111 INT313840 Binding of Acvr2b and Mstn 1 0.02 0.07 0
112 INT160761 Cma1 Regulation of Positive_regulation of ENG 1 0.01 0.07 0
113 INT271999 Binding of Fkbp1a and Positive_regulation of Negative_regulation of Mtor 1 0.00 0.18 0
114 INT310189 Binding of Acvrl1 and Gdf2 1 0.01 0 0
115 INT295572 Binding of Fst and Mstn 1 0.13 0.38 0
116 INT190681 Binding of Bcl2 and Fkbp1a 1 0.01 0.46 0
117 INT271994 Binding of Fkbp1a and Mtor 1 0.00 0.22 0
118 INT310192 Tgfbr1 Positive_regulation of Regulation of Acvrl1 1 0.01 0 0
119 INT351095 Binding of FKBP1A and RPS6KB1 1 0.24 0.36 0
120 INT351101 Negative_regulation of Binding of FKBP1A and RPS6KB1 1 0.27 0.36 0
121 INT314853 Binding of Cdc7 and Tgfbr3 1 0.24 0.09 0
122 INT351096 Binding of FKBP1A and MTOR 1 0.28 1.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activin binding. They are ordered first by their pain relevance and then by number of times they were reported in activin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
2 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
3 INT10799 Localization of ENG 63 0.78 18.67 27.28
4 INT7674 Regulation of ENG 42 0.30 11.41 14.44
5 INT65277 Negative_regulation of Fst 20 0.43 4.61 11.83
6 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61
7 INT70572 Gene_expression of Fst 33 0.78 5.22 8.24
8 INT60931 Negative_regulation of Fst 15 0.57 5.44 7.21
9 INT23375 Binding of ENG 17 0.47 6.02 6.46
10 INT86060 Positive_regulation of Fst 13 0.64 3.04 6.33
11 INT65276 Gene_expression of Fst 12 0.65 4.99 5.05
12 INT60575 Binding of Fkbp1a 9 0.26 2.09 4.46
13 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69
14 INT15844 Positive_regulation of Localization of ENG 7 0.67 4.2 3.47
15 INT33237 Regulation of Fst 10 0.39 1.3 3
16 INT32222 Negative_regulation of Gene_expression of ENG 9 0.37 2.23 2.89
17 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
18 INT22071 Positive_regulation of Gene_expression of ENG 13 0.50 5.44 2.62
19 INT13997 Regulation of Gene_expression of ENG 11 0.36 3.31 2.31
20 INT12133 Regulation of Localization of ENG 3 0.03 0.57 2.24
21 INT163580 Positive_regulation of Fst 4 0.19 2.85 2.17
22 INT138316 Regulation of Fst 5 0.44 1.15 1.99
23 INT32135 Positive_regulation of Positive_regulation of ENG 2 0.02 0.98 1.99
24 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81
25 INT174924 Gene_expression of Smad7 6 0.41 3.59 1.76
26 INT174923 Positive_regulation of Gene_expression of Smad7 3 0.37 2.3 1.73
27 INT15845 Negative_regulation of Localization of ENG 3 0.05 0.76 1.71
28 INT280933 Binding of Fst 4 0.12 3.53 1.63
29 INT310167 Gene_expression of Acvrl1 2 0.40 5.47 1.4
30 INT120076 Positive_regulation of Gene_expression of Smad7 16 0.65 11.33 1.25
31 INT32717 Negative_regulation of Regulation of ENG 3 0.00 0.43 1.25
32 INT51863 Negative_regulation of Negative_regulation of ENG 2 0.04 0.51 1.13
33 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03
34 INT230251 Binding of FKBP1A 6 0.28 2.24 0.94
35 INT280942 Localization of Fst 2 0.22 2.13 0.91
36 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87
37 INT311884 Negative_regulation of Acvrl1 1 0.30 2.16 0.81
38 INT265328 Positive_regulation of Acvrl1 5 0.40 3.18 0.78
39 INT114604 Positive_regulation of Acvr2a 2 0.41 0 0.73
40 INT272878 Negative_regulation of Smad7 4 0.41 3.86 0.72
41 INT156967 Localization of Fst 2 0.66 0.1 0.66
42 INT11763 Positive_regulation of Regulation of ENG 1 0.01 0.97 0.64
43 INT156968 Negative_regulation of Localization of Fst 1 0.37 0.1 0.64
44 INT349703 Positive_regulation of Transcription of Fst 1 0.46 0.14 0.53
45 INT349725 Transcription of Fst 1 0.63 0.13 0.53
46 INT120074 Regulation of Gene_expression of Smad7 1 0.58 2.05 0.5
47 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
48 INT224538 Negative_regulation of Gene_expression of Smad7 1 0.09 0.25 0.43
49 INT311889 Negative_regulation of Gene_expression of Acvrl1 1 0.22 1.27 0.37
50 INT317694 Negative_regulation of Localization of Fst 1 0.12 0.79 0.36
51 INT207064 Gene_expression of Fkbp1a 2 0.32 1.52 0.34
52 INT288541 Negative_regulation of Gene_expression of Fst 2 0.23 1.18 0.34
53 INT207065 Localization of Fkbp1a 1 0.36 0.82 0.33
54 INT349714 Binding of Fst 1 0.34 0.19 0.32
55 INT134840 Gene_expression of SMAD7 1 0.74 2.74 0.31
56 INT184716 Binding of Smad7 2 0.34 0.91 0.29
57 INT311895 Regulation of Positive_regulation of Acvrl1 1 0.23 0.97 0.29
58 INT272890 Regulation of Negative_regulation of Smad7 1 0.19 1.33 0.29
59 INT190676 Binding of Fkbp1a 15 0.36 3.11 0.28
60 INT202802 Regulation of Fkbp1a 4 0.26 0.96 0.28
61 INT139741 Positive_regulation of Gene_expression of ACVRL1 2 0.38 1.33 0.28
62 INT228793 Negative_regulation of Gene_expression of Smad7 5 0.25 2.33 0.23
63 INT164519 Gene_expression of FKBP1A 2 0.39 0.22 0.19
64 INT131558 Protein_catabolism of ENG 1 0.01 0 0.18
65 INT189590 Positive_regulation of ACVRL1 3 0.08 1.3 0.16
66 INT228790 Positive_regulation of Smad7 4 0.41 0.58 0.15
67 INT222654 Regulation of Gene_expression of Fst 1 0.09 0 0.15
68 INT293345 Negative_regulation of Binding of FKBP1A 1 0.02 0.19 0.13
69 INT222585 Transcription of Acvr2a 1 0.16 0 0.13
70 INT210224 Localization of Acvrl1 1 0.03 0.33 0.12
71 INT26064 Regulation of Positive_regulation of ENG 1 0.01 0.1 0.09
72 INT299319 Localization of FKBP1A 1 0.44 0 0.09
73 INT353267 Negative_regulation of Positive_regulation of Smad7 1 0.25 0.32 0.08
74 INT313838 Gene_expression of Fstl3 1 0.61 1.21 0.06
75 INT222593 Negative_regulation of Gene_expression of Fst 1 0.07 0 0.05
76 INT347149 Localization of Smad7 1 0.67 0 0.05
77 INT299313 Positive_regulation of Gene_expression of FKBP1A 1 0.29 0 0.05
78 INT222608 Negative_regulation of Gene_expression of Acvr2a 3 0.10 0.29 0.03
79 INT340535 Positive_regulation of Gene_expression of Fst 1 0.26 0.4 0.03
80 INT340540 Regulation of Gene_expression of Fst 1 0.17 0.42 0.03
81 INT350515 Transcription of SMAD7 1 0.07 0.38 0.03
82 INT353280 Phosphorylation of Smad7 1 0.48 0.06 0.03
83 INT222613 Positive_regulation of Gene_expression of Fst 4 0.42 0.25 0
84 INT190471 Transcription of ENG 3 0.21 1.76 0
85 INT265340 Binding of Acvrl1 3 0.30 0.46 0
86 INT222633 Negative_regulation of Acvr2a 1 0.10 0 0
87 INT310166 Regulation of Acvrl1 1 0.07 0 0
88 INT286084 Regulation of Acvr2a 1 0.02 0.32 0
89 INT313833 Negative_regulation of Gene_expression of Fstl3 1 0.33 0 0
90 INT347148 Regulation of Smad7 1 0.26 0 0
91 INT310163 Positive_regulation of Positive_regulation of Acvrl1 1 0.08 0 0
92 INT189611 Negative_regulation of Gene_expression of ACVRL1 1 0.06 0.29 0
93 INT286081 Regulation of Gene_expression of Acvr2a 1 0.05 0.32 0
94 INT218291 Positive_regulation of Gene_expression of Acvr2b 1 0.49 0.55 0
95 INT313834 Negative_regulation of Fstl3 1 0.33 0.64 0
96 INT218701 Negative_regulation of Binding of Smad7 1 0.14 0.15 0
97 INT166121 Binding of SMAD7 1 0.30 0.39 0
98 INT353273 Negative_regulation of Phosphorylation of Smad7 1 0.25 0 0
99 INT297259 Regulation of ACVRL1 1 0.18 0.55 0
100 INT347145 Transcription of Smad7 1 0.68 0 0
101 INT314839 Binding of Tgfbr3 1 0.42 0.09 0
102 INT218282 Regulation of Acvr2a 1 0.23 0.33 0
103 INT218296 Regulation of Acvr2b 1 0.12 0.33 0
104 INT218286 Regulation of Gene_expression of Acvr2b 1 0.60 0.5 0
105 INT313837 Regulation of Gene_expression of Fstl3 1 0.21 0 0
106 INT218289 Gene_expression of Acvr2a 1 0.65 1.44 0
107 INT314836 Gene_expression of Tgfbr3 1 0.59 0.09 0
108 INT222620 Binding of Acvr2a 1 0.08 0 0
109 INT218685 Binding of Smad7 1 0.13 0.15 0
110 INT286082 Positive_regulation of Gene_expression of Acvr2a 1 0.06 1.25 0
111 INT218281 Binding of Acvr2b 1 0.36 0.07 0
112 INT313835 Regulation of Fstl3 1 0.21 0.36 0
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