GO:0048365

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Name Rac GTPase binding
Categary Function
Go Slim No
Go Link GO:0048365
Unique Molecular Interactions 78
Total Molecular Interactions 129
Total Single Events 655
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Rac GTPase binding. They are ordered first by their pain relevance and then by number of times they were reported for Rac GTPase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT259209 Binding of Glul and Flna 1 0.03 0 4.2
4 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
5 INT221181 Binding of GOPC and Flna 1 0.03 0.06 2.08
6 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
7 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
8 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33
9 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
10 INT113946 Binding of FLNA and OPRM1 1 0.10 0.37 0.9
11 INT337157 Iqgap1 Regulation of Gene_expression of Ros1 1 0.07 1.91 0.72
12 INT154766 Nox1 Positive_regulation of Localization of Prkce 1 0.47 0.45 0.66
13 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
14 INT333991 Binding of FLNA and SELL 1 0.00 1.69 0.55
15 INT222691 Negative_regulation of Binding of FLNA and TNF 1 0.14 1.92 0.54
16 INT222692 Binding of FLNA and TNF 1 0.12 1.92 0.53
17 INT113950 FLNA Regulation of Oprd1 1 0.00 0.16 0.32
18 INT330100 Binding of Sh3rf1 and Map3k11 1 0.08 1.21 0.31
19 INT337162 Binding of Kdr and Iqgap1 1 0.32 0.98 0.28
20 INT337161 Binding of Diap1 and Iqgap1 1 0.29 0.78 0.28
21 INT215273 Siglec1 Regulation of Ncf2 1 0.01 0.73 0.26
22 INT191619 Binding of App and Flna 1 0.04 0.18 0.24
23 INT337158 Binding of Iqgap1 and Wasl 1 0.09 0.55 0.22
24 INT45934 PKN1 Regulation of NOTCH2NL 1 0.01 0 0.2
25 INT45933 PKN1 Regulation of PKN3 1 0.05 0 0.2
26 INT337154 Binding of Iqgap1 and Braf 1 0.13 0.64 0.18
27 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
28 INT191609 Binding of Drd3 and Flna 1 0.06 0.42 0.17
29 INT190637 Negative_regulation of Binding of Rab7 and Rnf115 1 0.25 0.68 0.17
30 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17
31 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
32 INT190630 Binding of Rab7 and Rnf115 1 0.22 0.68 0.17
33 INT215269 Binding of Ncf2 and Ncf4 1 0.02 0.38 0.17
34 INT337164 Binding of DIAPH1 and Iqgap1 1 0.53 0.37 0.14
35 INT47351 Binding of Ralbp1 and Ccl4 1 0.11 0.17 0.14
36 INT47352 Positive_regulation of Binding of Ralbp1 and Ccl4 1 0.14 0.17 0.14
37 INT345290 AGT Positive_regulation of NOX1 1 0.00 1.11 0.12
38 INT337165 Iqgap1 Positive_regulation of Gene_expression of VEGFA 1 0.03 0.27 0.09
39 INT55502 NDUFC1 Regulation of Nox1 1 0.00 0 0.08
40 INT297964 Binding of CDK8 and MAP3K11 1 0.26 0.29 0.07
41 INT297969 Positive_regulation of Binding of CDK8 and MAP3K11 1 0.35 0.29 0.07
42 INT236531 Binding of Cacna1f and Flna 1 0.08 0 0.07
43 INT250015 Binding of FLNA and Nos3 1 0.05 1.09 0.06
44 INT199107 Binding of Akt1 and Ncf2 1 0.04 0.09 0.05
45 INT325261 Ralbp1 Positive_regulation of Gene_expression of Il33 1 0.01 0 0.05
46 INT354715 Binding of PKN1 and Pick1 1 0.01 0.19 0.04
47 INT204172 Regulation of Binding of Cs and Nox1 1 0.08 1.01 0.04
48 INT354682 Binding of ASIC1 and PKN1 1 0.01 0.19 0.04
49 INT199103 Akt1 Positive_regulation of Ncf2 1 0.05 0.09 0.04
50 INT252808 TNF Positive_regulation of NOX1 1 0.06 1.03 0.04
51 INT305383 Binding of NKX2-5 and FLNA 1 0.10 0.7 0.04
52 INT204173 Binding of Cs and Nox1 1 0.07 1 0.04
53 INT213585 Binding of CFTR and FLNA 1 0.14 0.11 0.03
54 INT316500 INO80B Positive_regulation of RALBP1 1 0.00 0.31 0
55 INT222868 Binding of Chuk and Pkn1 1 0.00 0 0
56 INT338018 Binding of AR and Flna 1 0.11 0.33 0
57 INT255164 Regulation of PM20D2 Regulation of FLNA 1 0.00 0.82 0
58 INT257344 Gene_expression of Cyba Positive_regulation of Nox1 1 0.23 1.15 0
59 INT225908 Binding of RAC1 and IQGAP1 1 0.00 0.09 0
60 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
61 INT236528 Binding of Cav1 and Flna 1 0.06 0.09 0
62 INT249180 Binding of NCF2 and S100B 1 0.05 0 0
63 INT255165 PM20D2 Regulation of FLNA 1 0.00 0.76 0
64 INT286422 Binding of Cdc42ep5 and Dock4 1 0.01 0.84 0
65 INT325999 Binding of Cybb and Ncf2 1 0.18 0.77 0
66 INT276589 Binding of Iqgap1 and Plce1 1 0.19 0.34 0
67 INT277864 Binding of ERBB2 and Ralbp1 1 0.28 0.57 0
68 INT327872 Binding of Postn and Pkn1 1 0.03 0.21 0
69 INT338021 Binding of Flna and Regulation of Transcription of AR 1 0.14 0.33 0
70 INT249173 Binding of NCF2 and S100A8 1 0.10 0 0
71 INT276587 Binding of Iqgap1 and Nphs1 1 0.08 0.33 0
72 INT255163 Binding of FLNA and PM20D2 1 0.00 0 0
73 INT257346 Gene_expression of Lox Positive_regulation of Nox1 1 0.02 0.57 0
74 INT254510 Binding of CYBB and NCF2 1 0.06 0 0
75 INT236529 Binding of Om and Flna 1 0.00 0.09 0
76 INT249181 Binding of NCF2 and S100A9 1 0.09 0 0
77 INT326000 Binding of Cyba and Ncf2 1 0.10 0.77 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Rac GTPase binding. They are ordered first by their pain relevance and then by number of times they were reported in Rac GTPase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT221172 Binding of Flna 32 0.42 1.37 51.59
2 INT221167 Gene_expression of Flna 11 0.60 0.69 11.81
3 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55
4 INT221173 Negative_regulation of Binding of Flna 4 0.33 0.13 8.25
5 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81
6 INT39948 Binding of FLNA 45 0.42 58.05 4.27
7 INT221168 Localization of Flna 1 0.58 0.05 4.05
8 INT63880 Positive_regulation of FLNA 29 0.59 13.88 3.97
9 INT4545 Negative_regulation of Nox1 15 0.53 10.08 3.4
10 INT276520 Gene_expression of Iqgap1 2 0.76 8.67 3.1
11 INT221171 Positive_regulation of Localization of Flna 1 0.39 0.05 2.9
12 INT99550 Regulation of FLNA 51 0.54 27.88 2.58
13 INT46646 Localization of FLNA 19 0.73 18.83 2.53
14 INT259224 Negative_regulation of Flna 1 0.23 0.15 2.51
15 INT221177 Negative_regulation of Gene_expression of Flna 2 0.33 0 2.22
16 INT221179 Regulation of Flna 1 0.24 0.13 2.04
17 INT48850 Gene_expression of PKN1 16 0.52 1.93 1.92
18 INT221166 Positive_regulation of Flna 2 0.39 0.09 1.7
19 INT152569 Positive_regulation of Gene_expression of NOX1 1 0.31 0.67 1.51
20 INT152560 Gene_expression of NOX1 3 0.49 0.73 1.49
21 INT154763 Gene_expression of Nox1 3 0.67 1.83 1.48
22 INT259219 Negative_regulation of Negative_regulation of Flna 1 0.23 0 1.47
23 INT154764 Localization of Nox1 1 0.65 1.07 1.47
24 INT337151 Positive_regulation of Gene_expression of Iqgap1 1 0.68 3.69 1.16
25 INT337150 Negative_regulation of Iqgap1 1 0.42 2.47 0.92
26 INT42504 Negative_regulation of Nox1 5 0.43 0.55 0.91
27 INT142423 Negative_regulation of Positive_regulation of FLNA 2 0.05 0.99 0.89
28 INT287954 Gene_expression of DVL1 8 0.24 2.48 0.83
29 INT48851 Positive_regulation of Gene_expression of PKN1 2 0.27 0.67 0.78
30 INT66783 Positive_regulation of Negative_regulation of Nox1 1 0.63 0.81 0.66
31 INT66903 Positive_regulation of Nox1 3 0.25 1.1 0.62
32 INT114405 Regulation of Pkn1 1 0.44 1.58 0.61
33 INT147440 Gene_expression of Nox1 3 0.57 1.61 0.6
34 INT276535 Binding of Iqgap1 2 0.47 2.16 0.59
35 INT172310 Positive_regulation of PKN1 6 0.12 2 0.51
36 INT92328 Gene_expression of Map3k11 1 0.06 0.46 0.49
37 INT199064 Phosphorylation of Ncf2 6 0.48 0.27 0.39
38 INT113949 Positive_regulation of Gene_expression of FLNA 2 0.44 0.34 0.39
39 INT65962 Negative_regulation of NOX1 1 0.07 0.89 0.39
40 INT221178 Positive_regulation of Gene_expression of Flna 1 0.39 0 0.38
41 INT214618 Transcription of FLNA 4 0.51 8.06 0.37
42 INT337149 Positive_regulation of Iqgap1 1 0.46 0.84 0.34
43 INT330099 Binding of Map3k11 1 0.24 1.21 0.31
44 INT66060 Regulation of Gene_expression of PKN1 1 0.23 0 0.3
45 INT287931 Positive_regulation of Gene_expression of DVL1 2 0.09 0.08 0.29
46 INT105135 Positive_regulation of Ralbp1 1 0.60 1.49 0.26
47 INT105134 Regulation of Ralbp1 1 0.23 1.5 0.26
48 INT287251 Negative_regulation of PKN1 6 0.01 1.86 0.25
49 INT199079 Localization of Ncf2 3 0.21 1.17 0.25
50 INT199085 Binding of Ncf2 3 0.16 0.43 0.24
51 INT234591 Gene_expression of Ncf2 3 0.52 0.17 0.18
52 INT233130 Regulation of PKN1 2 0.02 0.69 0.18
53 INT134059 Negative_regulation of Negative_regulation of FLNA 1 0.02 0.38 0.18
54 INT289128 Negative_regulation of Gene_expression of DVL1 1 0.07 0.31 0.17
55 INT289117 Negative_regulation of DVL1 1 0.07 0.31 0.17
56 INT257557 Negative_regulation of MAP3K11 3 0.30 2.38 0.16
57 INT223459 Gene_expression of Dock4 2 0.71 1.5 0.16
58 INT223465 Regulation of Dock4 1 0.08 0.13 0.16
59 INT223463 Regulation of Gene_expression of Dock4 1 0.31 0.13 0.16
60 INT316515 Positive_regulation of RALBP1 28 0.25 10.37 0.14
61 INT287249 Localization of PKN1 3 0.03 0.78 0.14
62 INT188260 Gene_expression of Ralbp1 1 0.02 0.53 0.14
63 INT234586 Transcription of Ncf2 1 0.41 0.23 0.14
64 INT47350 Binding of Ralbp1 1 0.10 0.17 0.14
65 INT287922 Phosphorylation of DVL1 4 0.20 1.21 0.12
66 INT337147 Localization of Iqgap1 1 0.74 0.45 0.12
67 INT304610 Positive_regulation of Localization of FLNA 1 0.09 0.98 0.12
68 INT316511 Gene_expression of RALBP1 5 0.28 5.24 0.1
69 INT234589 Positive_regulation of Ncf2 2 0.36 0.66 0.1
70 INT234592 Positive_regulation of Gene_expression of Ncf2 1 0.36 0.11 0.1
71 INT234584 Positive_regulation of Transcription of Ncf2 1 0.36 0.14 0.1
72 INT105132 Localization of Ralbp1 2 0.60 0.52 0.09
73 INT105133 Positive_regulation of Localization of Ralbp1 1 0.40 0.47 0.09
74 INT94000 Positive_regulation of NOX1 1 0.20 0.2 0.09
75 INT121918 Binding of Rab7 1 0.34 0.64 0.09
76 INT276543 Regulation of Iqgap1 2 0.27 0.49 0.08
77 INT199075 Positive_regulation of Phosphorylation of Ncf2 1 0.14 0.17 0.08
78 INT305385 Negative_regulation of Localization of FLNA 1 0.16 0.79 0.08
79 INT71291 Binding of Nox1 1 0.11 0.25 0.08
80 INT71290 Regulation of Nox1 1 0.08 0.25 0.08
81 INT234593 Positive_regulation of Positive_regulation of Ncf2 1 0.36 0.14 0.07
82 INT287947 Binding of DVL1 3 0.10 0.95 0.06
83 INT178278 Regulation of Positive_regulation of FLNA 1 0.04 0.4 0.05
84 INT336595 Negative_regulation of Localization of Ncf2 1 0.08 0.7 0.04
85 INT204169 Regulation of Nox1 1 0.16 1 0.04
86 INT336603 Regulation of Ncf2 1 0.12 0.52 0.04
87 INT287920 Positive_regulation of DVL1 3 0.49 1.29 0.03
88 INT236523 Binding of Flna 3 0.30 0.45 0.03
89 INT326159 Positive_regulation of Gene_expression of RALBP1 1 0.25 1.58 0.03
90 INT249247 Binding of NCF2 1 0.10 0.34 0.03
91 INT254554 Positive_regulation of Localization of NCF2 1 0.09 0.45 0.03
92 INT204164 Negative_regulation of Positive_regulation of Nox1 1 0.17 1.02 0.03
93 INT222851 Binding of Pkn1 4 0.03 0.1 0
94 INT233129 Binding of PKN1 3 0.03 0 0
95 INT276544 Gene_expression of Flna 3 0.63 1.97 0
96 INT249237 Localization of NCF2 2 0.21 0.35 0
97 INT287937 Positive_regulation of Positive_regulation of DVL1 2 0.12 0.52 0
98 INT276523 Negative_regulation of Gene_expression of Flna 2 0.48 0.8 0
99 INT327869 Positive_regulation of Pkn1 1 0.04 0.32 0
100 INT249233 Phosphorylation of NCF2 1 0.24 0 0
101 INT300638 Transcription of DVL1 1 0.33 1.11 0
102 INT204167 Positive_regulation of Nox1 1 0.19 1 0
103 INT316514 Regulation of Positive_regulation of RALBP1 1 0.07 0.38 0
104 INT249290 Positive_regulation of Phosphorylation of NCF2 1 0.15 0 0
105 INT286398 Positive_regulation of Transcription of Dock4 1 0.46 0 0
106 INT269598 Regulation of Positive_regulation of PKN1 1 0.07 0 0
107 INT204162 Negative_regulation of Binding of Nox1 1 0.17 0.06 0
108 INT204166 Regulation of Negative_regulation of Nox1 1 0.11 0.96 0
109 INT257320 Negative_regulation of Gene_expression of Nox1 1 0.22 0.58 0
110 INT298775 Regulation of NOX1 1 0.00 0.67 0
111 INT287594 Negative_regulation of Pkn1 1 0.01 0.12 0
112 INT327859 Gene_expression of Pkn1 1 0.07 0 0
113 INT255171 Negative_regulation of Binding of FLNA 1 0.14 0.39 0
114 INT204163 Binding of Nox1 1 0.15 0.06 0
115 INT165482 Gene_expression of Rab7 1 0.09 0.06 0
116 INT214620 Regulation of Localization of FLNA 1 0.02 0.46 0
117 INT316512 Negative_regulation of Gene_expression of RALBP1 1 0.07 0.23 0
118 INT286408 Transcription of Dock4 1 0.66 0 0
119 INT214621 Regulation of Gene_expression of FLNA 1 0.02 1.09 0
120 INT316509 Positive_regulation of Positive_regulation of RALBP1 1 0.08 0.65 0
121 INT287254 Positive_regulation of Negative_regulation of PKN1 1 0.01 0.41 0
122 INT337958 Localization of Flna 1 0.61 0.43 0
123 INT225855 Binding of IQGAP1 1 0.02 0.09 0
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