GO:0048387

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Name negative regulation of retinoic acid receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0048387
Unique Molecular Interactions 39
Total Molecular Interactions 47
Total Single Events 378
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of retinoic acid receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of retinoic acid receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT129881 Binding of Calr and Cbll1 1 0.00 0.58 0.84
2 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
3 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64
4 INT316675 Binding of CALR and SFTPD 1 0.35 0.96 0.37
5 INT39594 TPO Positive_regulation of CALR 1 0.30 0.91 0.32
6 INT318980 Binding of CALR and Positive_regulation of Localization of GOPC 1 0.04 0.32 0.24
7 INT354114 Binding of CALR and SST 1 0.01 0.1 0.16
8 INT256320 Binding of CYP26A1 and Hapln1 1 0.01 1.27 0.14
9 INT192860 Binding of Calr and Esr1 1 0.06 0.67 0.08
10 INT233278 Binding of LBX1 and Tgif1 1 0.00 0.25 0.06
11 INT335702 Esr1 Regulation of Calr 1 0.03 0 0.04
12 INT335703 Esr1 Regulation of Localization of Calr 1 0.03 0 0.04
13 INT353288 Smad7 Negative_regulation of Phosphorylation of Tgif1 1 0.08 0.06 0.03
14 INT353283 Prdx2 Positive_regulation of Phosphorylation of Tgif1 1 0.10 0.06 0.03
15 INT353292 Prdx2 Positive_regulation of Tgif1 1 0.10 0.06 0.03
16 INT348584 EZH2 Regulation of Gene_expression of PPARG 1 0.30 0.43 0
17 INT336994 CALR Negative_regulation of ESR1 1 0.04 0 0
18 INT339096 Ezh2 Regulation of Rcc1 1 0.02 1.1 0
19 INT335705 Binding of ITGA4 and Calr 1 0.01 0.43 0
20 INT351732 SSD Regulation of CALR 1 0.01 2.95 0
21 INT20322 Binding of CYP1A2 and CYP26A1 1 0.00 0 0
22 INT348588 MECP2 Positive_regulation of Gene_expression of EZH2 1 0.28 0.42 0
23 INT307306 Gene_expression of COMP Positive_regulation of CALR 1 0.27 0.99 0
24 INT307305 Gene_expression of COMP Positive_regulation of Positive_regulation of CALR 1 0.27 0.41 0
25 INT348596 EZH2 Positive_regulation of Gene_expression of MECP2 1 0.28 0.42 0
26 INT233279 Binding of TLX1 and Tgif1 1 0.00 0.05 0
27 INT333928 Binding of CALR and ESR1 1 0.09 0.09 0
28 INT351733 CALR Positive_regulation of ROS1 1 0.03 0.3 0
29 INT351730 CALR Positive_regulation of Positive_regulation of ROS1 1 0.02 0.72 0
30 INT348591 EZH2 Regulation of Negative_regulation of MECP2 1 0.15 0.73 0
31 INT316772 Calr Positive_regulation of Ddit3 1 0.10 0.12 0
32 INT20324 Binding of CYP2D6 and CYP26A1 1 0.00 0 0
33 INT333931 Binding of CALR and PDIA3 1 0.18 0.18 0
34 INT307309 Binding of CALR and EREG 1 0.00 0.83 0
35 INT316771 Calr Positive_regulation of Localization of Ddit3 1 0.10 0.12 0
36 INT348585 EZH2 Regulation of PPARG 1 0.41 0.73 0
37 INT279131 LTF Positive_regulation of CALR 1 0.03 2.39 0
38 INT307310 Binding of CALR and COMP 1 0.28 0.82 0
39 INT20323 Binding of CYP2E1 and CYP26A1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of retinoic acid receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of retinoic acid receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT54555 Negative_regulation of CALR 10 0.41 4.41 2.4
2 INT70526 Binding of CALR 11 0.35 7.09 1.97
3 INT21941 Regulation of CALR 7 0.53 3.88 1.96
4 INT98687 Gene_expression of Calr 38 0.61 7.03 1.59
5 INT66118 Binding of Calr 4 0.46 1.46 1.26
6 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25
7 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95
8 INT177557 Positive_regulation of Calr 12 0.48 5.47 0.61
9 INT162801 Localization of CALR 7 0.73 8.69 0.6
10 INT60540 Positive_regulation of CYP26A1 1 0.35 2.94 0.46
11 INT195871 Positive_regulation of Gene_expression of CALR 9 0.29 3 0.27
12 INT318982 Positive_regulation of Binding of CALR 1 0.09 0.32 0.24
13 INT222087 Regulation of Calr 3 0.42 0.56 0.22
14 INT335675 Localization of Calr 1 0.63 1.23 0.2
15 INT177555 Regulation of Gene_expression of Calr 3 0.28 0.82 0.16
16 INT177554 Positive_regulation of Gene_expression of Calr 3 0.37 1.08 0.14
17 INT353269 Negative_regulation of Positive_regulation of Tgif1 1 0.11 0.5 0.13
18 INT353275 Positive_regulation of Tgif1 1 0.13 0.5 0.13
19 INT335686 Regulation of Localization of Calr 1 0.48 0.12 0.12
20 INT192855 Transcription of Calr 1 0.11 0.99 0.08
21 INT354146 Regulation of Gene_expression of CALR 1 0.04 0.73 0.07
22 INT339094 Gene_expression of Ezh2 1 0.78 67.79 0.05
23 INT316766 Negative_regulation of Calr 2 0.40 0.71 0.03
24 INT242969 Protein_catabolism of Calr 2 0.68 0.94 0.03
25 INT353260 Gene_expression of Tgif1 1 0.21 0 0.03
26 INT348609 Negative_regulation of EZH2 1 0.29 1.33 0.03
27 INT348611 Localization of EZH2 1 0.50 0.35 0.03
28 INT353277 Positive_regulation of Gene_expression of Tgif1 1 0.18 0 0.03
29 INT353546 Positive_regulation of Localization of CALR 1 0.05 0.49 0.03
30 INT353279 Phosphorylation of Tgif1 1 0.22 0.06 0.03
31 INT257291 Gene_expression of CYP26A1 5 0.75 4.04 0
32 INT307326 Negative_regulation of Gene_expression of CALR 3 0.25 1.78 0
33 INT273277 Phosphorylation of Calr 2 0.56 0.82 0
34 INT339087 Binding of Ezh2 1 0.37 1.14 0
35 INT257293 Regulation of Gene_expression of CYP26A1 1 0.34 1.2 0
36 INT348622 Binding of EZH2 1 0.21 0.39 0
37 INT233252 Binding of Tgif1 1 0.01 0.74 0
38 INT335676 Positive_regulation of Localization of Calr 1 0.48 0 0
39 INT348618 Gene_expression of EZH2 1 0.51 2.32 0
40 INT233211 Regulation of Binding of Tgif1 1 0.00 0.36 0
41 INT335682 Negative_regulation of Positive_regulation of Calr 1 0.29 0 0
42 INT307324 Positive_regulation of Positive_regulation of CALR 1 0.25 0.36 0
43 INT257287 Regulation of CYP26A1 1 0.34 0.82 0
44 INT348612 Regulation of Gene_expression of EZH2 1 0.30 0.65 0
45 INT335679 Negative_regulation of Gene_expression of Calr 1 0.29 0 0
46 INT335685 Negative_regulation of Localization of Calr 1 0.29 0 0
47 INT257277 Negative_regulation of CYP26A1 1 0.33 0.82 0
48 INT353276 Negative_regulation of Tgif1 1 0.11 0 0
49 INT257273 Positive_regulation of Gene_expression of CYP26A1 1 0.35 1.2 0
50 INT339090 Positive_regulation of Ezh2 1 0.47 0.82 0
51 INT348624 Positive_regulation of EZH2 1 0.31 0.42 0
52 INT307331 Negative_regulation of Positive_regulation of CALR 1 0.29 0.36 0
53 INT339091 Positive_regulation of Gene_expression of Ezh2 1 0.70 11.65 0
54 INT339095 Negative_regulation of Gene_expression of Ezh2 1 0.59 4.48 0
55 INT335678 Regulation of Binding of Calr 1 0.35 0 0
56 INT339089 Regulation of Gene_expression of Ezh2 1 0.45 3.76 0
57 INT307332 Negative_regulation of Localization of CALR 1 0.29 0.72 0
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