GO:0048403

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Name brain-derived neurotrophic factor binding
Categary Function
Go Slim No
Go Link GO:0048403
Unique Molecular Interactions 183
Total Molecular Interactions 337
Total Single Events 1928
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for brain-derived neurotrophic factor binding. They are ordered first by their pain relevance and then by number of times they were reported for brain-derived neurotrophic factor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
2 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25
3 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
4 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
5 INT284088 Binding of BDNF and NTRK2 5 0.41 3.4 2.37
6 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
7 INT161190 CRX Regulation of Gene_expression of Ntrk2 1 0.04 3.05 2.06
8 INT161187 NMS Regulation of Gene_expression of Ntrk2 1 0.43 3.05 2.06
9 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
10 INT107104 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.42 1.86 1.34
11 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
12 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11
13 INT132610 Bdnf Positive_regulation of Ntrk2 4 0.46 1.09 0.93
14 INT298289 Runx1 Negative_regulation of Ntrk2 1 0.60 1.09 0.87
15 INT245564 Runx3 Negative_regulation of Ntrk2 3 0.61 1.61 0.79
16 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78
17 INT351375 Mir470 Negative_regulation of Ntrk2 1 0.01 1.54 0.7
18 INT161186 Bdnf Regulation of Gene_expression of Ntrk2 1 0.44 1.05 0.68
19 INT142244 Positive_regulation of Ntrk2 Positive_regulation of Tcrg-C1 1 0.77 0 0.67
20 INT142243 Ntrk2 Positive_regulation of Tcrg-C1 1 0.77 0 0.67
21 INT161184 NMS Positive_regulation of Gene_expression of Ntrk2 1 0.55 1.3 0.67
22 INT284089 Binding of NTRK2 and SERPINE1 1 0.27 0.73 0.61
23 INT90119 Ntrk2 Regulation of Gene_expression of Nfkb1 1 0.01 0.27 0.6
24 INT79740 Ntf3 Regulation of Positive_regulation of Ntrk2 1 0.28 0 0.6
25 INT90115 Ntrk2 Regulation of Jun 1 0.01 0.27 0.57
26 INT298271 Proc Negative_regulation of Gene_expression of Ntrk2 1 0.01 0.79 0.56
27 INT298278 Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.8 0.56
28 INT261481 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.02 0.21 0.56
29 INT193554 Ntrk2 Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.73 0.52
30 INT134533 Binding of Ntrk2 and Psds1 1 0.01 0 0.5
31 INT128043 Positive_regulation of Ntrk2 Positive_regulation of Phosphorylation of Trib3 1 0.07 0.34 0.45
32 INT154592 Binding of Ntrk2 and Positive_regulation of Gene_expression of Kcna3 1 0.11 0.16 0.44
33 INT298296 Gene_expression of Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.33 0.39
34 INT201485 Ntrk2 Positive_regulation of Prkcg 1 0.01 0.73 0.38
35 INT53127 Binding of Ntrk2 and Ntf4 1 0.12 0 0.33
36 INT298297 Pou4f1 Positive_regulation of Gene_expression of Ntrk2 1 0.50 0.36 0.24
37 INT287103 Binding of FL and Ntrk2 1 0.28 0.67 0.24
38 INT298290 Pou4f1 Regulation of Gene_expression of Ntrk2 1 0.29 0.48 0.23
39 INT154591 Binding of Ntrk2 and Positive_regulation of Kcna3 1 0.11 0.08 0.22
40 INT308650 Binding of nt and Ntrk2 1 0.01 0.41 0.21
41 INT298275 Binding of Runx3 and Ntrk2 1 0.37 0.16 0.21
42 INT47694 sps Regulation of Ntrk2 1 0.00 0.98 0.2
43 INT287100 FL Positive_regulation of Ntrk2 1 0.30 0.61 0.2
44 INT298294 Gene_expression of Runx3 Negative_regulation of Ntrk2 1 0.39 0.16 0.19
45 INT154593 Ntrk2 Regulation of Kcna3 1 0.06 0.06 0.19
46 INT287097 T Positive_regulation of Ntrk2 1 0.21 0.6 0.19
47 INT280485 Ntrk2 Positive_regulation of Localization of Bdnf 1 0.55 0.45 0.19
48 INT280486 Binding of Ngfr and Ntrk2 2 0.18 1.21 0.17
49 INT320259 Binding of Ntrk2 and Atf3 1 0.01 0.38 0.17
50 INT320263 Binding of Ntrk2 and Atf4 1 0.01 0.38 0.17
51 INT298265 Runx3 Negative_regulation of Gene_expression of Ntrk2 1 0.61 0.25 0.17
52 INT298293 Runx1 Positive_regulation of Negative_regulation of Ntrk2 1 0.52 0.54 0.16
53 INT300876 Bdnf Positive_regulation of NTRK2 1 0.01 0.27 0.15
54 INT300875 Ngf Positive_regulation of NTRK2 1 0.01 0.27 0.15
55 INT300861 Ngf Positive_regulation of Ntrk2 1 0.29 0.27 0.15
56 INT223475 Binding of Ntrk1 and Ntrk2 2 0.22 0.25 0.14
57 INT321181 Binding of Ntrk2 and Ntf5 1 0.09 0.08 0.14
58 INT320261 Binding of Myc and Ntrk2 1 0.01 0.36 0.13
59 INT349858 Binding of Ngfr and Ntrk2 1 0.09 0.32 0.11
60 INT340318 Gopc Regulation of Ntrk2 1 0.24 0.1 0.08
61 INT300869 Ntrk2 Positive_regulation of Gene_expression of Ngf 1 0.21 0.16 0.08
62 INT215188 Binding of Ntrk2 and Nnat 1 0.00 0.15 0.07
63 INT270705 Negative_regulation of Bdnf Positive_regulation of Ntrk2 1 0.22 0 0.05
64 INT257878 Ins1 Positive_regulation of Gene_expression of Ntrk2 1 0.00 0.65 0.04
65 INT307462 Gsk3a Regulation of Ntrk2 1 0.04 0.09 0.04
66 INT257877 Ins1 Positive_regulation of Phosphorylation of Ntrk2 1 0.00 0.66 0.04
67 INT307456 Bdnf Positive_regulation of Transcription of Ntrk2 1 0.14 0.25 0.04
68 INT307461 Bdnf Positive_regulation of Ntrk2 1 0.19 0.25 0.04
69 INT321178 Binding of Ntrk2 and Mgst1 1 0.07 0 0.03
70 INT85473 Ntrk2 Regulation of Gene_expression of Pdyn 1 0.01 0.38 0.03
71 INT307458 Ntrk2 Positive_regulation of Phosphorylation of Gsk3a 1 0.05 0 0
72 INT321180 Ntrk2 Regulation of Ntrk1 1 0.16 0 0
73 INT321179 Negative_regulation of Binding of Bdnf and Ntrk2 1 0.38 0 0
74 INT223479 Binding of Ntrk2 and Dok5 1 0.26 0.17 0
75 INT210873 Binding of Ntrk2 and Adarb1 1 0.00 0 0
76 INT65173 Negative_regulation of Ntrk2 Negative_regulation of Bdnf 1 0.37 0 0
77 INT340319 Ntrk2 Regulation of Gopc 1 0.24 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for brain-derived neurotrophic factor binding. They are ordered first by their pain relevance and then by number of times they were reported in brain-derived neurotrophic factor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68
2 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
3 INT47689 Positive_regulation of Ntrk2 44 0.68 16.84 19.59
4 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23
5 INT65172 Negative_regulation of Ntrk2 35 0.59 9.89 13.08
6 INT6499 Localization of Ntrk2 44 0.79 11.78 8.75
7 INT47682 Transcription of Ntrk2 19 0.69 6.32 8.6
8 INT48314 Gene_expression of NTRK2 17 0.75 7.84 7.83
9 INT47691 Positive_regulation of Gene_expression of Ntrk2 17 0.62 13.64 6.96
10 INT47681 Regulation of Ntrk2 17 0.62 3.61 6.31
11 INT106552 Positive_regulation of Gene_expression of Ntrk2 19 0.68 9.72 5.51
12 INT107103 Negative_regulation of Ntrk2 21 0.59 10.38 5.28
13 INT106555 Binding of Ntrk2 15 0.48 6.31 5.05
14 INT65056 Binding of Ntrk2 20 0.36 3.72 4.42
15 INT122882 Regulation of Ntrk2 13 0.62 9.7 4.3
16 INT47686 Regulation of Gene_expression of Ntrk2 5 0.44 5.24 4.14
17 INT200047 Negative_regulation of Gene_expression of Ntrk2 8 0.56 10.78 3.95
18 INT134527 Phosphorylation of Ntrk2 7 0.69 3.72 3.65
19 INT142237 Phosphorylation of Ntrk2 8 0.82 2.24 2.82
20 INT280459 Regulation of Gene_expression of Ntrk2 13 0.62 8.48 2.71
21 INT132685 Negative_regulation of NTRK2 4 0.42 2.89 2.58
22 INT67621 Negative_regulation of Gene_expression of Ntrk2 7 0.41 2.71 2.52
23 INT95799 Binding of NTRK2 8 0.35 2.95 2.47
24 INT47687 Positive_regulation of Transcription of Ntrk2 5 0.45 2.42 2.24
25 INT107102 Negative_regulation of Positive_regulation of Ntrk2 6 0.54 1.61 2.21
26 INT326192 Negative_regulation of Binding of Ntrk2 1 0.10 1 1.47
27 INT142241 Positive_regulation of Positive_regulation of Ntrk2 3 0.66 0.87 1.43
28 INT108603 Positive_regulation of NTRK2 3 0.49 1.3 1.38
29 INT245544 Localization of Ntrk2 7 0.77 4.52 1.32
30 INT284108 Positive_regulation of Gene_expression of NTRK2 1 0.43 1.48 1.15
31 INT132686 Positive_regulation of Phosphorylation of NTRK2 1 0.13 0.98 1.06
32 INT132684 Phosphorylation of NTRK2 1 0.21 0.97 1.04
33 INT214113 Transcription of Ntrk2 2 0.72 1.84 0.96
34 INT138941 Regulation of Transcription of Ntrk2 2 0.47 0.76 0.95
35 INT228443 Regulation of Positive_regulation of Ntrk2 3 0.22 0.81 0.84
36 INT107101 Positive_regulation of Negative_regulation of Ntrk2 1 0.46 0.56 0.77
37 INT228439 Positive_regulation of Regulation of Ntrk2 1 0.01 0.28 0.76
38 INT142239 Regulation of Phosphorylation of Ntrk2 1 0.45 0 0.74
39 INT108602 Positive_regulation of Positive_regulation of NTRK2 1 0.22 0.56 0.6
40 INT150459 Positive_regulation of Phosphorylation of Ntrk2 2 0.42 0.24 0.52
41 INT69892 Regulation of Regulation of Ntrk2 1 0.62 0.14 0.49
42 INT47688 Negative_regulation of Positive_regulation of Ntrk2 2 0.41 1.79 0.47
43 INT320453 Positive_regulation of Transcription of NTRK2 1 0.21 1.18 0.46
44 INT169092 Transcription of NTRK2 2 0.69 1.26 0.45
45 INT228438 Negative_regulation of Regulation of Ntrk2 1 0.00 0.05 0.42
46 INT128040 Positive_regulation of Binding of Ntrk2 1 0.49 0.32 0.37
47 INT52344 Localization of NTRK2 2 0.81 0.56 0.3
48 INT69891 Positive_regulation of Negative_regulation of Ntrk2 1 0.50 0.08 0.26
49 INT206803 Positive_regulation of Positive_regulation of Ntrk2 4 0.15 1.78 0.24
50 INT235325 Positive_regulation of Localization of Ntrk2 2 0.23 0.2 0.19
51 INT280469 Regulation of Localization of Ntrk2 1 0.43 1.74 0.14
52 INT167518 Regulation of Localization of Ntrk2 1 0.01 0.1 0.08
53 INT307478 Negative_regulation of Transcription of Ntrk2 1 0.18 0.13 0.07
54 INT321173 Positive_regulation of Phosphorylation of Ntrk2 1 0.50 0.19 0.06
55 INT250943 Regulation of NTRK2 1 0.17 0.22 0.04
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