GO:0048404

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Name neurotrophin-3 binding
Categary Function
Go Slim No
Go Link GO:0048404
Unique Molecular Interactions 196
Total Molecular Interactions 366
Total Single Events 1913
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neurotrophin-3 binding. They are ordered first by their pain relevance and then by number of times they were reported for neurotrophin-3 binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
2 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25
3 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4
4 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
5 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
6 INT284088 Binding of BDNF and NTRK2 5 0.41 3.4 2.37
7 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
8 INT161190 CRX Regulation of Gene_expression of Ntrk2 1 0.04 3.05 2.06
9 INT161187 NMS Regulation of Gene_expression of Ntrk2 1 0.43 3.05 2.06
10 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48
11 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
12 INT107104 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.42 1.86 1.34
13 INT280480 Binding of Bdnf and Ngfr 5 0.25 3.14 1.27
14 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
15 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
16 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11
17 INT82024 Binding of Ngfr and Ngf 2 0.33 1.48 1.05
18 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05
19 INT242642 Binding of BDNF and Ngfr 2 0.21 1.38 1.01
20 INT132610 Bdnf Positive_regulation of Ntrk2 4 0.46 1.09 0.93
21 INT298289 Runx1 Negative_regulation of Ntrk2 1 0.60 1.09 0.87
22 INT73538 Ngf Positive_regulation of Ngfr 2 0.41 1.05 0.85
23 INT245564 Runx3 Negative_regulation of Ntrk2 3 0.61 1.61 0.79
24 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78
25 INT213726 Binding of Ngfr and Ntrk1 1 0.14 0.96 0.72
26 INT289333 Binding of Ngfr and Rtn4r 1 0.03 2.35 0.72
27 INT289332 Binding of Ngfr and Lingo1 1 0.04 2.36 0.72
28 INT351375 Mir470 Negative_regulation of Ntrk2 1 0.01 1.54 0.7
29 INT82021 Negative_regulation of Binding of Ngfr and Ngf 1 0.29 0.32 0.69
30 INT161186 Bdnf Regulation of Gene_expression of Ntrk2 1 0.44 1.05 0.68
31 INT142244 Positive_regulation of Ntrk2 Positive_regulation of Tcrg-C1 1 0.77 0 0.67
32 INT142243 Ntrk2 Positive_regulation of Tcrg-C1 1 0.77 0 0.67
33 INT161184 NMS Positive_regulation of Gene_expression of Ntrk2 1 0.55 1.3 0.67
34 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
35 INT284089 Binding of NTRK2 and SERPINE1 1 0.27 0.73 0.61
36 INT90119 Ntrk2 Regulation of Gene_expression of Nfkb1 1 0.01 0.27 0.6
37 INT79740 Ntf3 Regulation of Positive_regulation of Ntrk2 1 0.28 0 0.6
38 INT90115 Ntrk2 Regulation of Jun 1 0.01 0.27 0.57
39 INT134532 Grin2a Regulation of Ngfr 1 0.02 0 0.57
40 INT134528 Grin1 Regulation of Ngfr 1 0.03 0 0.57
41 INT134531 Gria1 Regulation of Ngfr 1 0.01 0 0.57
42 INT298271 Proc Negative_regulation of Gene_expression of Ntrk2 1 0.01 0.79 0.56
43 INT298278 Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.8 0.56
44 INT261481 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.02 0.21 0.56
45 INT76002 Ngf Positive_regulation of Ngfr 1 0.05 0.48 0.53
46 INT245558 Runx3 Regulation of Ngfr 1 0.06 1 0.53
47 INT193554 Ntrk2 Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.73 0.52
48 INT134533 Binding of Ntrk2 and Psds1 1 0.01 0 0.5
49 INT161227 Binding of Ngfr and Tnf 1 0.06 0.41 0.49
50 INT128043 Positive_regulation of Ntrk2 Positive_regulation of Phosphorylation of Trib3 1 0.07 0.34 0.45
51 INT154592 Binding of Ntrk2 and Positive_regulation of Gene_expression of Kcna3 1 0.11 0.16 0.44
52 INT120295 Ngf Positive_regulation of Positive_regulation of Ngfr 1 0.47 0.22 0.43
53 INT298296 Gene_expression of Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.33 0.39
54 INT201485 Ntrk2 Positive_regulation of Prkcg 1 0.01 0.73 0.38
55 INT73537 Ntf3 Positive_regulation of Ngfr 1 0.21 0.1 0.38
56 INT73536 Ngf Regulation of Ngfr 1 0.22 0.08 0.37
57 INT112283 Bdnf Regulation of Gene_expression of Ngfr 1 0.14 0.28 0.34
58 INT53127 Binding of Ntrk2 and Ntf4 1 0.12 0 0.33
59 INT298297 Pou4f1 Positive_regulation of Gene_expression of Ntrk2 1 0.50 0.36 0.24
60 INT287103 Binding of FL and Ntrk2 1 0.28 0.67 0.24
61 INT298290 Pou4f1 Regulation of Gene_expression of Ntrk2 1 0.29 0.48 0.23
62 INT154591 Binding of Ntrk2 and Positive_regulation of Kcna3 1 0.11 0.08 0.22
63 INT308650 Binding of nt and Ntrk2 1 0.01 0.41 0.21
64 INT241451 Mag Positive_regulation of Ngfr 1 0.09 0.1 0.21
65 INT298275 Binding of Runx3 and Ntrk2 1 0.37 0.16 0.21
66 INT308654 Binding of Ngfr and Nts 1 0.06 0.39 0.21
67 INT47694 sps Regulation of Ntrk2 1 0.00 0.98 0.2
68 INT287100 FL Positive_regulation of Ntrk2 1 0.30 0.61 0.2
69 INT298294 Gene_expression of Runx3 Negative_regulation of Ntrk2 1 0.39 0.16 0.19
70 INT154593 Ntrk2 Regulation of Kcna3 1 0.06 0.06 0.19
71 INT287097 T Positive_regulation of Ntrk2 1 0.21 0.6 0.19
72 INT280485 Ntrk2 Positive_regulation of Localization of Bdnf 1 0.55 0.45 0.19
73 INT280486 Binding of Ngfr and Ntrk2 2 0.18 1.21 0.17
74 INT320259 Binding of Ntrk2 and Atf3 1 0.01 0.38 0.17
75 INT320263 Binding of Ntrk2 and Atf4 1 0.01 0.38 0.17
76 INT298265 Runx3 Negative_regulation of Gene_expression of Ntrk2 1 0.61 0.25 0.17
77 INT298293 Runx1 Positive_regulation of Negative_regulation of Ntrk2 1 0.52 0.54 0.16
78 INT241462 Binding of OMG and Ngfr 1 0.11 0.15 0.15
79 INT300876 Bdnf Positive_regulation of NTRK2 1 0.01 0.27 0.15
80 INT241457 Binding of Mag and Ngfr 1 0.09 0.15 0.15
81 INT241453 Binding of Ngfr and Rtn4r 1 0.03 0.15 0.15
82 INT300875 Ngf Positive_regulation of NTRK2 1 0.01 0.27 0.15
83 INT300861 Ngf Positive_regulation of Ntrk2 1 0.29 0.27 0.15
84 INT223475 Binding of Ntrk1 and Ntrk2 2 0.22 0.25 0.14
85 INT321181 Binding of Ntrk2 and Ntf5 1 0.09 0.08 0.14
86 INT320261 Binding of Myc and Ntrk2 1 0.01 0.36 0.13
87 INT349858 Binding of Ngfr and Ntrk2 1 0.09 0.32 0.11
88 INT280493 Ngfr Regulation of Protein_catabolism of BDNF 1 0.09 0.14 0.1
89 INT164675 Binding of NGF and Ngfr 1 0.00 0.5 0.08
90 INT340318 Gopc Regulation of Ntrk2 1 0.24 0.1 0.08
91 INT164676 Negative_regulation of Binding of NGF and Ngfr 1 0.00 0.5 0.08
92 INT300869 Ntrk2 Positive_regulation of Gene_expression of Ngf 1 0.21 0.16 0.08
93 INT215188 Binding of Ntrk2 and Nnat 1 0.00 0.15 0.07
94 INT270705 Negative_regulation of Bdnf Positive_regulation of Ntrk2 1 0.22 0 0.05
95 INT257878 Ins1 Positive_regulation of Gene_expression of Ntrk2 1 0.00 0.65 0.04
96 INT201766 Binding of RIPK2 and Ngfr 1 0.02 0.41 0.04
97 INT307462 Gsk3a Regulation of Ntrk2 1 0.04 0.09 0.04
98 INT257877 Ins1 Positive_regulation of Phosphorylation of Ntrk2 1 0.00 0.66 0.04
99 INT307456 Bdnf Positive_regulation of Transcription of Ntrk2 1 0.14 0.25 0.04
100 INT307461 Bdnf Positive_regulation of Ntrk2 1 0.19 0.25 0.04
101 INT241449 Mag Positive_regulation of Protein_catabolism of Ngfr 1 0.09 0 0.03
102 INT321178 Binding of Ntrk2 and Mgst1 1 0.07 0 0.03
103 INT85473 Ntrk2 Regulation of Gene_expression of Pdyn 1 0.01 0.38 0.03
104 INT201732 Ngfr Positive_regulation of Nfkb1 1 0.01 0.43 0.03
105 INT200063 Binding of MAGED1 and Ngfr 1 0.44 0.45 0
106 INT307458 Ntrk2 Positive_regulation of Phosphorylation of Gsk3a 1 0.05 0 0
107 INT321180 Ntrk2 Regulation of Ntrk1 1 0.16 0 0
108 INT338013 Binding of Ngfrap1 and Ngfr 1 0.06 1.3 0
109 INT200062 Binding of Ngfr and Bbs4 1 0.30 0.3 0
110 INT321179 Negative_regulation of Binding of Bdnf and Ntrk2 1 0.38 0 0
111 INT200053 Binding of Nuc and Ngfr 1 0.10 0.3 0
112 INT200057 Binding of Ndn and Ngfr 1 0.43 1.96 0
113 INT320346 Binding of Ngfr and Np4 1 0.01 0 0
114 INT201742 Binding of Ngfr and Gtf3a 1 0.00 0.77 0
115 INT200061 Binding of Ngfr and Fez1 1 0.31 0.3 0
116 INT223479 Binding of Ntrk2 and Dok5 1 0.26 0.17 0
117 INT210873 Binding of Ntrk2 and Adarb1 1 0.00 0 0
118 INT65173 Negative_regulation of Ntrk2 Negative_regulation of Bdnf 1 0.37 0 0
119 INT290372 Binding of Ngfr and Scarb1 1 0.01 0.48 0
120 INT201741 Binding of Rhoa and Ngfr 1 0.01 1 0
121 INT200055 Binding of Ngfr and Mageh1 1 0.33 0.45 0
122 INT340319 Ntrk2 Regulation of Gopc 1 0.24 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for neurotrophin-3 binding. They are ordered first by their pain relevance and then by number of times they were reported in neurotrophin-3 binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68
2 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
3 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8
4 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8
5 INT47689 Positive_regulation of Ntrk2 44 0.68 16.84 19.59
6 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23
7 INT65172 Negative_regulation of Ntrk2 35 0.59 9.89 13.08
8 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75
9 INT6499 Localization of Ntrk2 44 0.79 11.78 8.75
10 INT47682 Transcription of Ntrk2 19 0.69 6.32 8.6
11 INT75921 Negative_regulation of Ngfr 13 0.59 8.58 8.35
12 INT48310 Binding of Ngfr 25 0.48 9.72 8.16
13 INT48314 Gene_expression of NTRK2 17 0.75 7.84 7.83
14 INT61542 Positive_regulation of Ngfr 15 0.70 6.35 7.34
15 INT47691 Positive_regulation of Gene_expression of Ntrk2 17 0.62 13.64 6.96
16 INT78713 Negative_regulation of Ngfr 9 0.54 7.07 6.73
17 INT47681 Regulation of Ntrk2 17 0.62 3.61 6.31
18 INT106552 Positive_regulation of Gene_expression of Ntrk2 19 0.68 9.72 5.51
19 INT107103 Negative_regulation of Ntrk2 21 0.59 10.38 5.28
20 INT106555 Binding of Ntrk2 15 0.48 6.31 5.05
21 INT65056 Binding of Ntrk2 20 0.36 3.72 4.42
22 INT64711 Regulation of Ngfr 10 0.45 3.12 4.33
23 INT122882 Regulation of Ntrk2 13 0.62 9.7 4.3
24 INT47686 Regulation of Gene_expression of Ntrk2 5 0.44 5.24 4.14
25 INT200047 Negative_regulation of Gene_expression of Ntrk2 8 0.56 10.78 3.95
26 INT121170 Positive_regulation of Gene_expression of Ngfr 10 0.64 9.32 3.94
27 INT121171 Negative_regulation of Gene_expression of Ngfr 6 0.58 3.46 3.89
28 INT55907 Binding of Ngfr 13 0.47 5.79 3.75
29 INT134527 Phosphorylation of Ntrk2 7 0.69 3.72 3.65
30 INT61540 Negative_regulation of Gene_expression of Ngfr 11 0.59 6.36 3.43
31 INT142237 Phosphorylation of Ntrk2 8 0.82 2.24 2.82
32 INT61541 Positive_regulation of Gene_expression of Ngfr 7 0.53 2.87 2.75
33 INT280459 Regulation of Gene_expression of Ntrk2 13 0.62 8.48 2.71
34 INT132685 Negative_regulation of NTRK2 4 0.42 2.89 2.58
35 INT67621 Negative_regulation of Gene_expression of Ntrk2 7 0.41 2.71 2.52
36 INT95799 Binding of NTRK2 8 0.35 2.95 2.47
37 INT75225 Transcription of Ngfr 4 0.60 1.95 2.44
38 INT47687 Positive_regulation of Transcription of Ntrk2 5 0.45 2.42 2.24
39 INT107102 Negative_regulation of Positive_regulation of Ntrk2 6 0.54 1.61 2.21
40 INT64712 Localization of Ngfr 4 0.78 1.19 1.91
41 INT140247 Negative_regulation of Negative_regulation of Ngfr 3 0.33 3.15 1.59
42 INT163594 Regulation of Ngfr 5 0.43 2.55 1.53
43 INT326192 Negative_regulation of Binding of Ntrk2 1 0.10 1 1.47
44 INT142241 Positive_regulation of Positive_regulation of Ntrk2 3 0.66 0.87 1.43
45 INT108603 Positive_regulation of NTRK2 3 0.49 1.3 1.38
46 INT64713 Regulation of Gene_expression of Ngfr 4 0.50 2.04 1.36
47 INT245544 Localization of Ntrk2 7 0.77 4.52 1.32
48 INT138939 Positive_regulation of Transcription of Ngfr 3 0.43 0.89 1.31
49 INT164372 Positive_regulation of Positive_regulation of Ngfr 6 0.62 4.1 1.22
50 INT110392 Transcription of Ngfr 3 0.52 2.48 1.19
51 INT284108 Positive_regulation of Gene_expression of NTRK2 1 0.43 1.48 1.15
52 INT132686 Positive_regulation of Phosphorylation of NTRK2 1 0.13 0.98 1.06
53 INT132684 Phosphorylation of NTRK2 1 0.21 0.97 1.04
54 INT163595 Positive_regulation of Regulation of Ngfr 1 0.46 0.57 1.04
55 INT214113 Transcription of Ntrk2 2 0.72 1.84 0.96
56 INT138941 Regulation of Transcription of Ntrk2 2 0.47 0.76 0.95
57 INT228443 Regulation of Positive_regulation of Ntrk2 3 0.22 0.81 0.84
58 INT107101 Positive_regulation of Negative_regulation of Ntrk2 1 0.46 0.56 0.77
59 INT228439 Positive_regulation of Regulation of Ntrk2 1 0.01 0.28 0.76
60 INT142239 Regulation of Phosphorylation of Ntrk2 1 0.45 0 0.74
61 INT317733 Positive_regulation of Binding of Ngfr 1 0.18 0.51 0.71
62 INT133018 Regulation of Gene_expression of Ngfr 2 0.43 1.47 0.7
63 INT108602 Positive_regulation of Positive_regulation of NTRK2 1 0.22 0.56 0.6
64 INT139929 Phosphorylation of Ngfr 3 0.58 1.67 0.57
65 INT118729 Regulation of Transcription of Ngfr 1 0.36 0.45 0.57
66 INT110393 Positive_regulation of Transcription of Ngfr 1 0.46 1 0.54
67 INT150459 Positive_regulation of Phosphorylation of Ntrk2 2 0.42 0.24 0.52
68 INT69892 Regulation of Regulation of Ntrk2 1 0.62 0.14 0.49
69 INT47688 Negative_regulation of Positive_regulation of Ntrk2 2 0.41 1.79 0.47
70 INT320453 Positive_regulation of Transcription of NTRK2 1 0.21 1.18 0.46
71 INT169092 Transcription of NTRK2 2 0.69 1.26 0.45
72 INT228438 Negative_regulation of Regulation of Ntrk2 1 0.00 0.05 0.42
73 INT165518 Positive_regulation of Regulation of Ngfr 2 0.47 0.47 0.37
74 INT128040 Positive_regulation of Binding of Ntrk2 1 0.49 0.32 0.37
75 INT52344 Localization of NTRK2 2 0.81 0.56 0.3
76 INT69891 Positive_regulation of Negative_regulation of Ntrk2 1 0.50 0.08 0.26
77 INT206803 Positive_regulation of Positive_regulation of Ntrk2 4 0.15 1.78 0.24
78 INT297460 Regulation of Regulation of Ngfr 1 0.33 0.32 0.21
79 INT235325 Positive_regulation of Localization of Ntrk2 2 0.23 0.2 0.19
80 INT280469 Regulation of Localization of Ntrk2 1 0.43 1.74 0.14
81 INT297459 Protein_catabolism of Ngfr 1 0.21 0.5 0.1
82 INT167518 Regulation of Localization of Ntrk2 1 0.01 0.1 0.08
83 INT307478 Negative_regulation of Transcription of Ntrk2 1 0.18 0.13 0.07
84 INT321173 Positive_regulation of Phosphorylation of Ntrk2 1 0.50 0.19 0.06
85 INT250943 Regulation of NTRK2 1 0.17 0.22 0.04
86 INT241405 Localization of Ngfr 2 0.56 0.4 0.03
87 INT241402 Protein_catabolism of Ngfr 1 0.39 0 0.03
88 INT193880 Regulation of Phosphorylation of Ngfr 1 0.02 0.25 0
89 INT201629 Negative_regulation of Positive_regulation of Ngfr 1 0.07 0.37 0
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