GO:0048408

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Name epidermal growth factor binding
Categary Function
Go Slim No
Go Link GO:0048408
Unique Molecular Interactions 61
Total Molecular Interactions 81
Total Single Events 803
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for epidermal growth factor binding. They are ordered first by their pain relevance and then by number of times they were reported for epidermal growth factor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
2 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
3 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
4 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
5 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
6 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
7 INT324525 PGE Positive_regulation of Positive_regulation of Egfr 1 0.41 1.05 0.33
8 INT324522 PGE Positive_regulation of Phosphorylation of Egfr 1 0.56 1.04 0.33
9 INT324524 PGE Positive_regulation of Egfr 1 0.38 1.05 0.33
10 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26
11 INT112132 Gast Positive_regulation of Positive_regulation of Egfr 1 0.33 0.13 0.16
12 INT178446 Binding of Egfr and ras 1 0.04 0.13 0.13
13 INT178431 Positive_regulation of Binding of Egfr and ras 1 0.05 0.13 0.13
14 INT171390 Src Positive_regulation of Phosphorylation of Egfr 1 0.13 0 0.11
15 INT171385 Ppp1cc Positive_regulation of Phosphorylation of Egfr 1 0.15 0 0.11
16 INT356272 Egf Negative_regulation of Gene_expression of Egfr 1 0.15 0.2 0.1
17 INT231273 Binding of Egfr and Nrg1 1 0.12 0 0.09
18 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
19 INT120569 Binding of Egfr and Pik3r1 1 0.40 1.22 0.06
20 INT120570 Positive_regulation of Binding of Egfr and Pik3r1 1 0.55 1.22 0.06
21 INT120573 Positive_regulation of Binding of Egfr and Gab1 1 0.63 1.22 0.05
22 INT120572 Positive_regulation of Binding of Egfr and Cltc 1 0.38 1.21 0.05
23 INT120571 Binding of Egfr and Gab1 1 0.44 1.21 0.05
24 INT120568 Binding of Egfr and Cltc 1 0.28 1.21 0.05
25 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
26 INT188737 Egfr Positive_regulation of EGFR 1 0.21 0.6 0.04
27 INT225259 Egfr Regulation of Gene_expression of S100a7a 1 0.04 0.98 0.04
28 INT188735 EGFR Positive_regulation of Egfr 1 0.21 0.6 0.04
29 INT188732 EGFR Positive_regulation of Gene_expression of Egfr 1 0.21 0.6 0.04
30 INT205480 Egfr Positive_regulation of Stat3 5 0.58 4.11 0.03
31 INT45690 PRSS1 Positive_regulation of NRD1 1 0.00 0 0.03
32 INT45687 PRSS1 Negative_regulation of NRD1 1 0.00 0 0.03
33 INT188736 Egfr Regulation of IGLV3-1 1 0.46 0.59 0.03
34 INT188731 Egfr Regulation of EGFR 1 0.46 0.59 0.03
35 INT45689 Negative_regulation of PRSS1 Positive_regulation of NRD1 1 0.00 0 0.03
36 INT205481 Regulation of Egfr Positive_regulation of Stat3 1 0.38 3.37 0
37 INT315161 Egfr Negative_regulation of Erbb2 1 0.36 0.83 0
38 INT226732 Egf Negative_regulation of Egfr 1 0.01 0.15 0
39 INT315167 Egfr Negative_regulation of Mapk3 1 0.04 0.83 0
40 INT188733 Egfr Positive_regulation of Gene_expression of IGLV3-1 1 0.52 0.61 0
41 INT121314 Tgfb1 Positive_regulation of Egfr 1 0.08 0.16 0
42 INT205479 Egfr Positive_regulation of Transcription of Stat3 1 0.42 1.66 0
43 INT276907 Negative_regulation of Egfr Negative_regulation of Gene_expression of VEGFA 1 0.14 1.05 0
44 INT226726 Egf Positive_regulation of Egfr 1 0.01 0.49 0
45 INT276904 Regulation of Binding of Egfr and Prkdc 1 0.03 0.42 0
46 INT315166 Erbb2 Negative_regulation of Egfr 1 0.36 0.83 0
47 INT121315 Negative_regulation of Egfr Negative_regulation of Ercc1 1 0.42 0.08 0
48 INT185353 Eri1 Negative_regulation of Transcription of Egfr 1 0.01 0.5 0
49 INT161454 Mmp8 Positive_regulation of Egfr 1 0.36 0 0
50 INT225260 S100a7a Positive_regulation of Phosphorylation of Egfr 1 0.07 0.18 0
51 INT315169 Egfr Negative_regulation of PCNA 1 0.03 0.84 0
52 INT276905 Binding of Egfr and Prkdc 1 0.04 0.41 0
53 INT188734 Egfr Positive_regulation of Gene_expression of EGFR 1 0.52 0.61 0
54 INT311659 Egfr Positive_regulation of Mapk1 1 0.08 0.18 0
55 INT315160 Egfr Negative_regulation of Myc 1 0.45 0.84 0
56 INT226757 Egfr Positive_regulation of Protein_catabolism of Sdf2l1 1 0.01 0.3 0
57 INT315162 Egfr Negative_regulation of Akt1 1 0.17 0.83 0
58 INT226719 Negative_regulation of Tsg101 Negative_regulation of Negative_regulation of Egfr 1 0.05 0.41 0
59 INT226735 Egf Positive_regulation of Negative_regulation of Egfr 1 0.01 0.49 0
60 INT185357 Eri1 Negative_regulation of Gene_expression of Egfr 1 0.01 0.57 0
61 INT185354 Binding of Egfr and H2-Ab1 1 0.42 0.69 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for epidermal growth factor binding. They are ordered first by their pain relevance and then by number of times they were reported in epidermal growth factor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
2 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
3 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
4 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
5 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
6 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12
7 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11
8 INT103917 Positive_regulation of Phosphorylation of Egfr 12 0.68 7.23 2.18
9 INT112131 Positive_regulation of Positive_regulation of Egfr 10 0.49 9.95 1.85
10 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82
11 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75
12 INT144415 Regulation of Positive_regulation of Egfr 2 0.27 0.42 0.86
13 INT144416 Regulation of Egfr 5 0.57 4.97 0.83
14 INT171361 Regulation of Egfr 16 0.62 8.36 0.81
15 INT144414 Positive_regulation of Positive_regulation of Egfr 1 0.49 0.65 0.8
16 INT131286 Binding of Egfr 26 0.44 13.58 0.78
17 INT45696 Negative_regulation of NRD1 3 0.19 0 0.62
18 INT320644 Binding of Egfr 7 0.34 5.9 0.56
19 INT103916 Negative_regulation of Phosphorylation of Egfr 12 0.59 7.03 0.47
20 INT142943 Phosphorylation of Egfr 5 0.81 1.56 0.45
21 INT142942 Positive_regulation of Phosphorylation of Egfr 4 0.68 1.52 0.45
22 INT169355 Localization of Egfr 6 0.75 3.24 0.43
23 INT185350 Negative_regulation of Gene_expression of Egfr 24 0.59 13.21 0.35
24 INT341548 Regulation of Gene_expression of NRD1 1 0.01 0.18 0.2
25 INT341579 Gene_expression of NRD1 1 0.01 0.18 0.19
26 INT185352 Regulation of Gene_expression of Egfr 5 0.62 2.33 0.16
27 INT171378 Negative_regulation of Binding of Egfr 3 0.43 1.48 0.16
28 INT171365 Negative_regulation of Regulation of Egfr 1 0.33 0.06 0.16
29 INT144682 Negative_regulation of Regulation of Egfr 1 0.43 0.41 0.15
30 INT299514 Localization of Egfr 2 0.37 0.38 0.14
31 INT233419 Negative_regulation of Positive_regulation of Egfr 2 0.40 0.97 0.12
32 INT219647 Negative_regulation of Negative_regulation of Egfr 1 0.19 0.13 0.1
33 INT226648 Negative_regulation of Positive_regulation of Egfr 1 0.10 0 0.08
34 INT211211 Positive_regulation of Negative_regulation of Egfr 1 0.50 1.36 0.08
35 INT299512 Regulation of Localization of Egfr 1 0.13 0.11 0.06
36 INT205021 Positive_regulation of Gene_expression of Egfr 3 0.64 4.15 0.05
37 INT279191 Regulation of Negative_regulation of Egfr 2 0.45 1.44 0.05
38 INT185349 Transcription of Egfr 8 0.72 4.01 0.04
39 INT185347 Negative_regulation of Transcription of Egfr 1 0.59 1.1 0.04
40 INT226657 Negative_regulation of Negative_regulation of Egfr 2 0.43 1.39 0
41 INT231270 Positive_regulation of Localization of Egfr 1 0.15 0 0
42 INT226635 Negative_regulation of Protein_catabolism of Egfr 1 0.10 0.48 0
43 INT226703 Protein_catabolism of Egfr 1 0.22 0.61 0
44 INT226650 Positive_regulation of Protein_catabolism of Egfr 1 0.16 0.47 0
45 INT279188 Regulation of Localization of Egfr 1 0.45 0.76 0
46 INT279189 Regulation of Positive_regulation of Egfr 1 0.45 0.96 0
47 INT301988 Positive_regulation of Binding of Egfr 1 0.18 0.42 0
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