GO:0048468

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Name cell development
Categary Process
Go Slim No
Go Link GO:0048468
Unique Molecular Interactions 459
Total Molecular Interactions 668
Total Single Events 2943
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cell development. They are ordered first by their pain relevance and then by number of times they were reported for cell development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
3 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47
4 INT88883 IRF6 Positive_regulation of Nfkb1 1 0.11 0.53 2.01
5 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
6 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
7 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 0.04 0.66 1.49
8 INT318491 IRF6 Positive_regulation of FPR2 1 0.10 6.14 1.44
9 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
10 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
11 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
12 INT318490 IRF6 Positive_regulation of LTB4R 1 0.01 4.39 1.03
13 INT88881 Negative_regulation of IRF6 Positive_regulation of Nfkb1 1 0.09 0.27 1.03
14 INT293014 IRF6 Positive_regulation of Localization of CA2 1 0.04 0.71 1.02
15 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
16 INT74934 Regulation of IRF6 Positive_regulation of Nfkb1 1 0.01 0.52 1.02
17 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
18 INT74933 IRF6 Positive_regulation of Nfkb1 1 0.02 0.52 1.01
19 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
20 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
21 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
22 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
23 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
24 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
25 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
26 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
27 INT227325 Binding of IRF6 and Cd14 1 0.01 2.51 0.93
28 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91
29 INT343834 Binding of CD14 and IRF6 1 0.02 2.08 0.9
30 INT343847 IRF6 Positive_regulation of TBCE 1 0.01 1.11 0.87
31 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
32 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
33 INT188567 IRF6 Positive_regulation of Gene_expression of CD28 1 0.05 1.28 0.82
34 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
35 INT286346 IRF6 Positive_regulation of IL8 3 0.03 0.88 0.8
36 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
37 INT221415 IRF6 Positive_regulation of Gene_expression of IL10 2 0.05 1.73 0.75
38 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73
39 INT104835 IRF6 Positive_regulation of IL10 4 0.32 0.91 0.69
40 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
41 INT318476 IRF6 Positive_regulation of Localization of RETNLB 1 0.00 1.42 0.65
42 INT103870 IRF6 Positive_regulation of Hmox1 1 0.14 0.83 0.64
43 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63
44 INT115592 IRF6 Positive_regulation of Gene_expression of FAS 1 0.34 0.34 0.62
45 INT85489 IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
46 INT85488 Negative_regulation of IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
47 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
48 INT318481 IRF6 Positive_regulation of Gene_expression of FPR2 1 0.14 5.09 0.59
49 INT318487 Negative_regulation of IRF6 Positive_regulation of FPR2 1 0.09 1.39 0.59
50 INT263454 Negative_regulation of IRF6 Positive_regulation of TNF 1 0.12 0.49 0.59
51 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
52 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
53 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
54 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
55 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
56 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
57 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
58 INT286349 IRF6 Positive_regulation of Localization of IL10 1 0.03 1.22 0.55
59 INT318478 Negative_regulation of IRF6 Positive_regulation of LTB4R 1 0.01 2.38 0.53
60 INT343859 Binding of IRF6 and TBCE 1 0.01 1.1 0.51
61 INT97800 Gm5564 Regulation of IRF6 1 0.00 0.07 0.5
62 INT343825 IRF6 Regulation of Gene_expression of FUT1 1 0.00 1.74 0.5
63 INT217037 Binding of IRF6 and Il12a 1 0.01 0.08 0.5
64 INT169400 Negative_regulation of IRF6 Positive_regulation of Gene_expression of Il1b 1 0.50 0.62 0.5
65 INT289464 Negative_regulation of IRF6 Positive_regulation of ICAM1 1 0.07 0.31 0.5
66 INT84515 IRF6 Positive_regulation of Gene_expression of F2 1 0.02 0.15 0.49
67 INT289462 Negative_regulation of IRF6 Positive_regulation of IL1B 2 0.04 0.31 0.48
68 INT127663 IRF6 Positive_regulation of PDE4A 1 0.14 0.76 0.48
69 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
70 INT289463 IRF6 Positive_regulation of Localization of IL1B 1 0.05 0.52 0.48
71 INT217040 Negative_regulation of IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
72 INT217039 IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
73 INT193480 Binding of ABCA1 and IRF6 1 0.00 1.08 0.46
74 INT103871 Negative_regulation of IRF6 Positive_regulation of Hmox1 1 0.12 0.61 0.45
75 INT84517 IRF6 Positive_regulation of TF 1 0.14 0.19 0.44
76 INT188564 IRF6 Positive_regulation of Gene_expression of PRF1 1 0.01 0.44 0.44
77 INT188565 IRF6 Regulation of Gene_expression of CD28 1 0.03 0.7 0.43
78 INT243682 IRF6 Positive_regulation of NEU2 1 0.01 0.18 0.43
79 INT343853 IRF6 Positive_regulation of PECAM1 1 0.00 0.53 0.43
80 INT188562 IRF6 Regulation of Gene_expression of PRF1 1 0.01 0.7 0.43
81 INT283714 Positive_regulation of Binding of Id2 and Homer1 1 0.08 1.34 0.42
82 INT283713 Binding of Id2 and Homer1 1 0.06 1.34 0.42
83 INT293007 IRF6 Positive_regulation of ELANE 1 0.00 0 0.42
84 INT84518 IRF6 Positive_regulation of Gene_expression of TF 1 0.14 0.09 0.41
85 INT343844 Binding of IRF6 and LY96 1 0.01 1.03 0.4
86 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39
87 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
88 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
89 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
90 INT188560 Negative_regulation of Binding of IRF6 and TLR4 1 0.04 0.58 0.38
91 INT318489 Positive_regulation of IRF6 Negative_regulation of Gene_expression of FPR2 1 0.09 1.18 0.38
92 INT318482 IRF6 Negative_regulation of Gene_expression of FPR2 1 0.09 1.18 0.38
93 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
94 INT144044 IRF6 Positive_regulation of PTGES 1 0.10 0.43 0.37
95 INT286351 IL8 Positive_regulation of Gene_expression of IRF6 1 0.03 0.71 0.36
96 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
97 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
98 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
99 INT286350 IL6 Positive_regulation of Gene_expression of IRF6 1 0.04 0.71 0.36
100 INT185379 Binding of IRF6 and TLR2 4 0.08 2.88 0.35
101 INT250781 IRF6 Positive_regulation of AMIGO2 1 0.02 1.25 0.35
102 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
103 INT318484 IRF6 Positive_regulation of Positive_regulation of LTB4R 1 0.01 1.38 0.35
104 INT144048 IRF6 Positive_regulation of Gene_expression of PTGES 1 0.12 0.46 0.35
105 INT318486 IRF6 Positive_regulation of Negative_regulation of FPR2 1 0.10 1.39 0.35
106 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
107 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
108 INT182126 IRF6 Positive_regulation of Gene_expression of SELE 1 0.03 0.86 0.34
109 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
110 INT133021 IRF6 Positive_regulation of Gene_expression of IL8 1 0.11 0.51 0.32
111 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
112 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
113 INT76088 IFNA1 Positive_regulation of IRF6 1 0.19 0.18 0.31
114 INT76086 IRF6 Positive_regulation of ISYNA1 1 0.07 0.18 0.31
115 INT105437 IRF6 Positive_regulation of Localization of PTGER1 1 0.01 0.61 0.31
116 INT187523 IRF6 Positive_regulation of Gene_expression of Cpox 1 0.00 1.38 0.31
117 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
118 INT105438 IRF6 Positive_regulation of PTGER1 1 0.01 0.61 0.3
119 INT318480 IRF6 Positive_regulation of Gene_expression of LTB4R 1 0.01 1.63 0.29
120 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
121 INT237679 IRF6 Positive_regulation of MAPK8 1 0.00 0.56 0.28
122 INT294709 IRF6 Positive_regulation of Gene_expression of CCL2 1 0.08 0.14 0.28
123 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
124 INT193479 TLR2 Regulation of Binding of IRF6 1 0.04 0.75 0.28
125 INT295472 IRF6 Positive_regulation of Gene_expression of TNF 2 0.16 0.95 0.27
126 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
127 INT318477 Regulation of IRF6 Positive_regulation of LTB4R 1 0.00 1 0.27
128 INT155530 IRF6 Regulation of Gene_expression of IL8 1 0.06 0.79 0.26
129 INT155529 IRF6 Regulation of Transcription of IL6 1 0.08 0.79 0.26
130 INT267631 IRF6 Positive_regulation of Gene_expression of Il1 1 0.00 0.96 0.25
131 INT179233 IRF6 Negative_regulation of Binding of GSR 1 0.03 0.83 0.25
132 INT355567 IRF6 Positive_regulation of MIF 1 0.01 0.29 0.25
133 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
134 INT188561 IRF6 Positive_regulation of Transcription of CD14 1 0.03 0.25 0.25
135 INT118418 Gata1 Positive_regulation of Transcription of Tac2 1 0.61 0.77 0.25
136 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
137 INT118419 Binding of Gata1 and Tac2 1 0.31 0.7 0.24
138 INT14065 IRF6 Positive_regulation of PCA 1 0.24 0.51 0.24
139 INT70661 Binding of Hrasls and Nkx2-2 1 0.02 0 0.24
140 INT14064 Negative_regulation of IRF6 Positive_regulation of PCA 1 0.22 0.52 0.24
141 INT318485 Positive_regulation of IRF6 Positive_regulation of LTB4R 1 0.00 1.03 0.23
142 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
143 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
144 INT84522 IRF6 Positive_regulation of Gene_expression of F3 1 0.08 0.1 0.21
145 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
146 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
147 INT103869 Binding of IRF6 and Positive_regulation of Hmox1 1 0.10 0.27 0.21
148 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
149 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
150 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
151 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
152 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
153 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
154 INT188568 Negative_regulation of IRF6 Positive_regulation of CD28 1 0.05 0.19 0.19
155 INT335299 IRF6 Positive_regulation of TIMP1 1 0.03 0.21 0.19
156 INT188570 Negative_regulation of IRF6 Positive_regulation of CD4 1 0.04 0.19 0.19
157 INT335298 IRF6 Positive_regulation of MMP9 1 0.01 0.21 0.19
158 INT335311 Binding of IRF6 and SLC15A4 1 0.00 0.23 0.19
159 INT323593 IRF6 Positive_regulation of PROCR 1 0.00 0.46 0.19
160 INT188573 IRF6 Positive_regulation of CD4 1 0.05 0.19 0.19
161 INT323592 IRF6 Positive_regulation of Positive_regulation of PROCR 1 0.00 0.46 0.19
162 INT188571 IRF6 Positive_regulation of CD28 1 0.06 0.19 0.19
163 INT335306 IRF6 Positive_regulation of MMP3 1 0.03 0.21 0.18
164 INT340447 Negative_regulation of IRF6 Positive_regulation of RELA 1 0.00 0.87 0.18
165 INT335304 IRF6 Positive_regulation of Gene_expression of MMP1 1 0.01 0.21 0.18
166 INT335302 IRF6 Positive_regulation of MMP1 1 0.01 0.21 0.18
167 INT355569 IRF6 Positive_regulation of Gene_expression of NOS2 1 0.00 0.27 0.17
168 INT231033 Igf1 Positive_regulation of Sec22b 1 0.06 0 0.17
169 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17
170 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17
171 INT73506 Binding of IFNG and IRF6 1 0.02 0.42 0.17
172 INT220387 Gh1 Regulation of Localization of Igf1 1 0.05 0.3 0.17
173 INT340448 IRF6 Positive_regulation of RELA 1 0.00 0.86 0.17
174 INT104827 IRF6 Positive_regulation of IL12A 2 0.07 0.13 0.16
175 INT208217 IRF6 Positive_regulation of Gene_expression of ISYNA1 1 0.00 0.54 0.16
176 INT104829 Negative_regulation of IRF6 Positive_regulation of IL10 1 0.30 0 0.16
177 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
178 INT185515 Binding of Igf1 and Csf2 1 0.29 0.4 0.15
179 INT334590 IRF6 Positive_regulation of Localization of Ptger2 1 0.00 0 0.15
180 INT188694 Traf6 Positive_regulation of Positive_regulation of Irf3 1 0.08 0.2 0.15
181 INT50302 Igf1 Regulation of Gh1 1 0.22 0 0.14
182 INT223538 Binding of HAND1 and Tcf3 1 0.39 1.13 0.14
183 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14
184 INT213551 Proc Regulation of Bmp7 1 0.00 0.15 0.14
185 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14
186 INT220386 Binding of Gh1 and Igf1 1 0.07 0.99 0.14
187 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
188 INT65272 Igf1 Positive_regulation of Binding of Col7a1 1 0.42 0 0.14
189 INT343836 Binding of IRF6 and LBP 1 0.02 0.8 0.14
190 INT65269 Igf1 Positive_regulation of Gene_expression of Lox 1 0.15 0 0.14
191 INT298715 Igf1 Positive_regulation of Gene_expression of PDGFA 1 0.00 0.22 0.14
192 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13
193 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13
194 INT316130 IRF6 Positive_regulation of Gene_expression of HLA-DRA 1 0.02 0.27 0.13
195 INT343917 Binding of IRF6 and Hmgb1 1 0.05 0.98 0.13
196 INT65267 Igf1 Regulation of Gene_expression of Plod3 1 0.07 0 0.13
197 INT322014 Binding of IRF6 and Positive_regulation of Localization of IL1B 1 0.01 0 0.13
198 INT65271 Igf1 Positive_regulation of Gene_expression of Plod3 1 0.12 0 0.13
199 INT223530 Binding of Tcf3 and Szf1 1 0.33 0.92 0.13
200 INT223526 Binding of Pax6 and Tcf3 1 0.33 0.92 0.13

Single Events

The table below shows the top 100 pain related interactions that have been reported for cell development. They are ordered first by their pain relevance and then by number of times they were reported in cell development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
2 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
3 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81
4 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51
5 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
6 INT97798 Localization of IRF6 86 0.73 33.27 20.94
7 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
8 INT22046 Negative_regulation of IRF6 52 0.43 25.69 14.13
9 INT99586 Binding of IRF6 60 0.36 27.87 13.2
10 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
11 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
12 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
13 INT76096 Positive_regulation of Gene_expression of IRF6 37 0.49 14.24 6.39
14 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
15 INT150417 Negative_regulation of Gene_expression of IRF6 20 0.41 11.48 6.28
16 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
17 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
18 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
19 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
20 INT151032 Localization of Igf1 49 0.76 26.32 5.71
21 INT48840 Gene_expression of Nkx2-2 8 0.23 1.55 5.44
22 INT138779 Positive_regulation of Localization of IRF6 25 0.45 11.51 4.51
23 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
24 INT49360 Localization of Igf1 22 0.76 6.96 4.26
25 INT15257 Positive_regulation of Nkx2-2 10 0.21 1.75 4.2
26 INT51180 Regulation of Nkx2-2 5 0.26 2.16 4.14
27 INT8600 Binding of Nkx2-2 6 0.10 0.87 3.82
28 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
29 INT97799 Regulation of IRF6 23 0.26 6.54 3.75
30 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
31 INT76098 Positive_regulation of Positive_regulation of IRF6 16 0.27 6.05 3.35
32 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
33 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
34 INT72618 Regulation of Tcf3 5 0.44 1.48 3.16
35 INT181008 Negative_regulation of Localization of IRF6 13 0.14 2.32 2.96
36 INT237700 Regulation of Negative_regulation of IRF6 2 0.11 1.08 2.58
37 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
38 INT66544 Binding of Igf1 23 0.46 8.33 2.44
39 INT72616 Negative_regulation of Tcf3 2 0.41 0.97 2.04
40 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
41 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
42 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
43 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
44 INT129610 Gene_expression of Id2 7 0.74 17.07 1.69
45 INT118412 Gene_expression of Gata1 5 0.62 0.83 1.6
46 INT118413 Positive_regulation of Gene_expression of Gata1 3 0.40 0.68 1.56
47 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
48 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
49 INT188397 Regulation of Positive_regulation of IRF6 4 0.12 1.34 1.47
50 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
51 INT112845 Negative_regulation of Binding of Nkx2-2 2 0.12 0.14 1.47
52 INT132081 Regulation of Gene_expression of Nkx2-2 2 0.10 0.24 1.43
53 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
54 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
55 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
56 INT121307 Gene_expression of Ercc1 4 0.73 12.69 1.37
57 INT90491 Binding of Igf1 25 0.44 9.75 1.36
58 INT95367 Negative_regulation of Positive_regulation of IRF6 7 0.21 3.5 1.34
59 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
60 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
61 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
62 INT72614 Negative_regulation of Regulation of Tcf3 1 0.41 0.17 1.2
63 INT169251 Gene_expression of Phox2b 9 0.70 3.88 1.17
64 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
65 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
66 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
67 INT185929 Regulation of Gene_expression of IRF6 9 0.20 1.66 0.99
68 INT351296 Regulation of Maf 1 0.01 0.9 0.88
69 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
70 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
71 INT270447 Binding of Smo 2 0.07 2.61 0.78
72 INT30050 Gene_expression of Tcf3 13 0.48 2.57 0.77
73 INT141150 Localization of BMP7 4 0.56 2.84 0.76
74 INT138396 Transcription of Nkx2-2 1 0.26 0.05 0.75
75 INT138395 Positive_regulation of Transcription of Nkx2-2 1 0.19 0.05 0.75
76 INT144995 Positive_regulation of Gata1 1 0.37 0.14 0.71
77 INT173794 Gene_expression of Maf 3 0.12 1.39 0.68
78 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
79 INT100294 Positive_regulation of Gene_expression of Bmp7 8 0.46 5.41 0.61
80 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
81 INT105266 Localization of Tcf3 3 0.32 1.08 0.59
82 INT106343 Positive_regulation of Positive_regulation of Igf1 2 0.69 1.45 0.59
83 INT89126 Regulation of BMP7 7 0.45 2.5 0.58
84 INT185397 Positive_regulation of Binding of IRF6 3 0.12 0.56 0.57
85 INT129615 Positive_regulation of Id2 2 0.66 2.22 0.57
86 INT220365 Negative_regulation of Transcription of Igf1 3 0.45 1.28 0.56
87 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53
88 INT165537 Negative_regulation of Bmp7 2 0.43 0.55 0.52
89 INT159214 Positive_regulation of Gene_expression of BMP7 6 0.46 2.16 0.51
90 INT185513 Phosphorylation of Igf1 3 0.67 0.46 0.5
91 INT97796 Regulation of Localization of IRF6 2 0.20 0.32 0.5
92 INT213535 Transcription of Phox2b 3 0.62 2.69 0.49
93 INT216998 Regulation of Binding of IRF6 2 0.05 0.06 0.48
94 INT129620 Regulation of Gene_expression of Bmp7 3 0.42 3.2 0.47
95 INT237703 Phosphorylation of IRF6 2 0.05 0.91 0.47
96 INT206484 Localization of Shh 2 0.75 1.14 0.46
97 INT188395 Regulation of Regulation of IRF6 1 0.06 0.89 0.46
98 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
99 INT289471 Negative_regulation of Negative_regulation of IRF6 1 0.10 0.31 0.45
100 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
101 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43
102 INT121310 Positive_regulation of Ercc1 2 0.45 1.78 0.42
103 INT48503 Positive_regulation of Positive_regulation of Nkx2-2 1 0.15 0 0.42
104 INT118460 Binding of Bmp7 3 0.46 1.3 0.4
105 INT181007 Protein_catabolism of IRF6 3 0.61 1.17 0.39
106 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
107 INT30052 Positive_regulation of Tcf3 3 0.41 0.27 0.37
108 INT261774 Positive_regulation of Phosphorylation of Igf1 1 0.08 0.09 0.36
109 INT217464 Binding of Traf6 5 0.29 1.28 0.35
110 INT283683 Binding of Id2 5 0.35 0.8 0.35
111 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34
112 INT111230 Transcription of LEF1 3 0.30 1.72 0.33
113 INT105968 Positive_regulation of Binding of Igf1 2 0.20 0.56 0.32
114 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
115 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
116 INT196032 Positive_regulation of Gene_expression of Bmp7 10 0.17 1.31 0.31
117 INT122619 Gene_expression of Nkx2-2 6 0.36 0.15 0.31
118 INT196024 Gene_expression of Bmp7 20 0.26 1.88 0.3
119 INT356400 Transcription of Smo 1 0.02 0.05 0.3
120 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
121 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
122 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
123 INT208497 Localization of Nkx2-2 1 0.01 0 0.26
124 INT173787 Positive_regulation of Maf 1 0.10 0.06 0.26
125 INT185399 Negative_regulation of Binding of IRF6 1 0.07 1.12 0.25
126 INT210927 Positive_regulation of Traf6 4 0.32 0.99 0.22
127 INT129612 Positive_regulation of Gene_expression of Id2 4 0.67 3.61 0.22
128 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22
129 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
130 INT121311 Positive_regulation of Gene_expression of Ercc1 3 0.62 1.23 0.21
131 INT263475 Negative_regulation of Protein_catabolism of IRF6 1 0.36 0.48 0.21
132 INT254173 Transcription of Traf6 1 0.25 0.26 0.21
133 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
134 INT173753 Positive_regulation of Negative_regulation of Igf1 1 0.34 0.47 0.19
135 INT318506 Positive_regulation of Negative_regulation of IRF6 1 0.11 0.75 0.19
136 INT169875 Negative_regulation of Ercc1 3 0.43 3.07 0.17
137 INT339267 Negative_regulation of BMP7 1 0.43 0.55 0.17
138 INT231055 Regulation of Localization of Igf1 1 0.15 0 0.17
139 INT198357 Negative_regulation of Localization of Igf1 1 0.03 0.51 0.17
140 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
141 INT286068 Positive_regulation of Positive_regulation of Igf1 2 0.40 1.03 0.16
142 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
143 INT118459 Regulation of Bmp7 3 0.43 0.25 0.15
144 INT188688 Regulation of Traf6 1 0.24 0.15 0.15
145 INT201968 Positive_regulation of Bmp7 2 0.43 1.11 0.14
146 INT220570 Transcription of Gata1 2 0.05 0.91 0.14
147 INT185511 Regulation of Phosphorylation of Igf1 1 0.37 0 0.14
148 INT90229 Transcription of Tcf3 2 0.12 0.39 0.13
149 INT253190 Localization of Shh 2 0.77 1.06 0.13
150 INT175970 Negative_regulation of Phosphorylation of Igf1 2 0.39 2.1 0.13
151 INT342320 Positive_regulation of Irf6 1 0.44 1.08 0.13
152 INT285632 Regulation of Binding of Igf1 1 0.37 0.55 0.13
153 INT283702 Transcription of Id2 1 0.66 0.64 0.13
154 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
155 INT283708 Localization of Id2 2 0.71 0.72 0.11
156 INT175968 Phosphorylation of Igf1 6 0.74 2.54 0.1
157 INT270442 Transcription of Shh 1 0.53 0.25 0.09
158 INT213515 Binding of Shh 8 0.37 1.92 0.08
159 INT129614 Positive_regulation of Positive_regulation of Id2 1 0.48 0.31 0.08
160 INT270453 Regulation of Shh 1 0.27 0.83 0.08
161 INT355332 Localization of Bmp7 1 0.09 1.92 0.08
162 INT316570 Binding of BMP7 3 0.37 0.95 0.07
163 INT205973 Binding of SHH 3 0.35 1.03 0.07
164 INT287244 Transcription of BMP7 1 0.66 0.15 0.07
165 INT175972 Regulation of Phosphorylation of Igf1 1 0.41 0.95 0.07
166 INT256862 Regulation of Shh 1 0.25 0 0.07
167 INT287242 Positive_regulation of Transcription of BMP7 1 0.64 0.15 0.07
168 INT129613 Regulation of Gene_expression of Id2 1 0.43 0.24 0.06
169 INT345344 Regulation of SMO 1 0.23 1.07 0.06
170 INT153022 Negative_regulation of Bmp7 1 0.01 0.27 0.06
171 INT286067 Regulation of Regulation of Igf1 2 0.37 0.21 0.05
172 INT213532 Negative_regulation of Gene_expression of Phox2b 1 0.39 0.1 0.05
173 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
174 INT262772 Binding of SMO 1 0.27 0.59 0.05
175 INT220802 Binding of LEF1 7 0.36 3.86 0.04
176 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
177 INT289116 Positive_regulation of Localization of LEF1 2 0.22 1.19 0.04
178 INT289110 Localization of LEF1 2 0.32 1.19 0.04
179 INT295091 Positive_regulation of Gene_expression of Tcf3 2 0.19 0.4 0.04
180 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
181 INT262777 Localization of SMO 1 0.59 0.6 0.04
182 INT122620 Negative_regulation of Gene_expression of Nkx2-2 1 0.20 0 0.04
183 INT201965 Transcription of Bmp7 2 0.49 0.93 0.03
184 INT213514 Regulation of Gene_expression of Phox2b 1 0.56 0.23 0.03
185 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
186 INT213539 Regulation of Phox2b 1 0.11 0.23 0.03
187 INT253181 Transcription of Shh 1 0.68 0.54 0.03
188 INT176243 Positive_regulation of Binding of Igf1 3 0.07 1.36 0
189 INT185508 Protein_catabolism of Igf1 2 0.84 0 0
190 INT289127 Positive_regulation of LEF1 2 0.22 0.76 0
191 INT142343 Negative_regulation of Regulation of Igf1 2 0.41 0.35 0
192 INT200834 Positive_regulation of Foxa2 2 0.32 0.08 0
193 INT151839 Positive_regulation of Bmp7 2 0.27 0.24 0
194 INT295084 Regulation of Gene_expression of Tcf3 1 0.20 0.36 0
195 INT260766 Negative_regulation of Gene_expression of Bmp7 1 0.35 0 0
196 INT342249 Binding of Ercc1 1 0.33 2.69 0
197 INT252242 Gene_expression of Smo 1 0.01 0.23 0
198 INT213508 Positive_regulation of Gene_expression of Phox2b 1 0.45 0.17 0
199 INT216450 Regulation of Transcription of Igf1 1 0.26 0 0
200 INT112084 Negative_regulation of Positive_regulation of Igf1 1 0.31 0.11 0
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