GO:0048485

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Name sympathetic nervous system development
Categary Process
Go Slim No
Go Link GO:0048485
Unique Molecular Interactions 446
Total Molecular Interactions 680
Total Single Events 4272
Pain Genes Associated 25

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for sympathetic nervous system development. They are ordered first by their pain relevance and then by number of times they were reported for sympathetic nervous system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
2 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
3 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
4 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
5 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
6 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92
7 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
8 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
9 INT103330 Ngf Positive_regulation of Gdnf 2 0.28 1.27 2.45
10 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
11 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
12 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2
13 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
14 INT108129 GDNF Regulation of Gene_expression of GRHL3 1 0.21 0.39 1.71
15 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67
16 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
17 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
18 INT180812 Gdnf Positive_regulation of Gene_expression of Sorbs1 1 0.02 0.83 1.61
19 INT180811 Gdnf Positive_regulation of Regulation of Sorbs1 1 0.01 0.83 1.61
20 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
21 INT83416 Binding of OPRK1 and Ntrk1 1 0.02 0 1.45
22 INT180790 Gdnf Regulation of Localization of Trpv1 1 0.15 1.21 1.43
23 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39
24 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39
25 INT82025 Negative_regulation of Binding of Ntrk1 and Ngf 1 0.47 0.64 1.37
26 INT83197 Binding of Ntrk1 and Gdnf 1 0.01 1.05 1.36
27 INT180802 Gdnf Positive_regulation of Sorbs1 1 0.02 0.98 1.34
28 INT180764 Calca Regulation of Positive_regulation of Gdnf 1 0.21 0 1.32
29 INT242605 Gdnf Positive_regulation of Trpv1 1 0.26 0.17 1.3
30 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2
31 INT351373 Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
32 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
33 INT351378 Gene_expression of Ngf Positive_regulation of Ntrk1 1 0.35 0.41 1.18
34 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
35 INT351377 Gene_expression of Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
36 INT148435 Binding of Bdnf and Gdnf 2 0.35 1.9 1.17
37 INT180814 Binding of Ret and Gdnf 1 0.01 1.31 1.17
38 INT242625 Gdnf Positive_regulation of Pax3 1 0.01 0.34 1.15
39 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
40 INT142413 Oprm1 Positive_regulation of Gdnf 1 0.19 0.29 1.09
41 INT93614 Ngf Positive_regulation of Ntrk1 2 0.52 0.85 1.05
42 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
43 INT180770 Gdnf Positive_regulation of Zbtb38 1 0.00 0.27 0.99
44 INT147504 Binding of Ncam1 and Gdnf 1 0.31 0.87 0.98
45 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
46 INT180780 Ngf Regulation of Gdnf 1 0.22 0.28 0.96
47 INT83415 Binding of Oprm1 and Ntrk1 1 0.01 0 0.96
48 INT180803 Sorbs1 Regulation of Gdnf 1 0.01 0.28 0.95
49 INT133071 STAT6 Positive_regulation of Gene_expression of GATA3 1 0.55 0 0.95
50 INT180787 Calca Regulation of Gdnf 1 0.18 0.28 0.95
51 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
52 INT127673 NGF Regulation of Gene_expression of NTRK1 1 0.48 2.12 0.92
53 INT147505 Binding of Ret and Gdnf 1 0.27 0.81 0.92
54 INT242621 Gdnf Positive_regulation of Gene_expression of Scn11a 1 0.05 0.12 0.88
55 INT297463 Binding of Ntrk1 and Ngf 1 0.10 0.78 0.87
56 INT298295 Runx1 Negative_regulation of Gene_expression of Ntrk1 2 0.38 0.45 0.86
57 INT256045 Binding of BDNF and Ntrk1 3 0.34 0.65 0.83
58 INT108128 GDNF Regulation of Localization of GRHL3 1 0.24 0.18 0.83
59 INT103331 Ngf Positive_regulation of Gdnf 1 0.01 0.57 0.8
60 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
61 INT78714 Ntrk1 Positive_regulation of Ngf 2 0.50 0.63 0.78
62 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78
63 INT103334 Gdnf Regulation of Gene_expression of TRPV1 1 0.02 0.53 0.77
64 INT103333 Gdnf Regulation of TRPV1 1 0.02 0.53 0.77
65 INT64067 Tp63 Negative_regulation of Localization of Gh1 1 0.08 0.07 0.76
66 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
67 INT180773 Calca Regulation of Binding of Gdnf 1 0.18 0.15 0.72
68 INT213726 Binding of Ngfr and Ntrk1 1 0.14 0.96 0.72
69 INT180783 Binding of Gdnf and Man2a2 1 0.00 0.52 0.71
70 INT180775 Binding of Gdnf and Gfra1 1 0.06 0.52 0.71
71 INT102121 Gdnf Regulation of Gene_expression of Cnr1 1 0.45 0.42 0.71
72 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7
73 INT260832 Binding of NRP2 and Nrp1 1 0.00 2.32 0.7
74 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
75 INT351376 Mir470 Negative_regulation of Ntrk1 1 0.01 1.54 0.7
76 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
77 INT64070 Tp63 Regulation of Ghrh 1 0.04 0.06 0.69
78 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
79 INT64068 Tp63 Regulation of Fdft1 1 0.00 0.06 0.69
80 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
81 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
82 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
83 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
84 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
85 INT118979 NGF Positive_regulation of Phosphorylation of NTRK1 1 0.56 0.67 0.67
86 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
87 INT114843 NTRK1 Regulation of Gene_expression of Lgals1 1 0.06 0.84 0.66
88 INT221847 Binding of Calca and Ntrk1 1 0.03 0.9 0.65
89 INT122777 Gdnf Negative_regulation of Gene_expression of Trpv1 1 0.36 0.8 0.62
90 INT122774 Gdnf Negative_regulation of Positive_regulation of Trpv1 1 0.32 0.78 0.61
91 INT79747 Ntf3 Regulation of Positive_regulation of Ntrk1 1 0.35 0 0.6
92 INT242584 Gdnf Regulation of Gene_expression of Qrfp 1 0.00 0.09 0.58
93 INT91267 Gdnf Negative_regulation of Gdnf 1 0.05 0.81 0.58
94 INT164457 Ngf Positive_regulation of NTRK1 1 0.15 0.57 0.58
95 INT164458 Negative_regulation of Ngf Positive_regulation of NTRK1 1 0.14 0.57 0.58
96 INT98035 Binding of Ntrk1 and Trpv1 1 0.54 0.41 0.57
97 INT242602 Binding of Ntf3 and Ntrk1 1 0.10 0.14 0.57
98 INT69343 Binding of NTRK1 and Igh-6 1 0.02 0.69 0.53
99 INT245553 Runx1 Positive_regulation of Gene_expression of Ntrk1 2 0.45 1.41 0.52
100 INT242631 Binding of Gfra2 and Ntrk1 1 0.01 0 0.52
101 INT242598 Binding of Gdnf and Gfra2 4 0.16 0.38 0.51
102 INT242614 Binding of Gdnf and Gfra1 1 0.03 0 0.51
103 INT278105 Negative_regulation of TP63 Negative_regulation of Binding of P2RX7 1 0.00 0 0.51
104 INT356279 Gdnf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
105 INT98117 Gdnf Regulation of SCN11A 1 0.05 0.39 0.5
106 INT242597 Gene_expression of Gdnf Negative_regulation of Trpv1 1 0.27 0.08 0.5
107 INT98116 Gdnf Regulation of SCN10A 1 0.03 0.39 0.5
108 INT256040 Ngf Regulation of Gene_expression of Ntrk1 1 0.36 0.73 0.5
109 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
110 INT242638 Binding of BDNF and Gdnf 1 0.29 0 0.49
111 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
112 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
113 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
114 INT242600 Binding of Gdnf and Gopc 1 0.06 0 0.49
115 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
116 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
117 INT165582 Binding of Bdnf and Gdnf 1 0.36 0.47 0.49
118 INT242604 Gdnf Regulation of Gene_expression of Trpv1 1 0.17 0.36 0.48
119 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
120 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
121 INT242634 Binding of Gfra1 and Ntrk1 1 0.02 0 0.46
122 INT242596 Binding of Ntrk1 and Ret 1 0.12 0 0.46
123 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
124 INT98119 Gdnf Regulation of SCN10A 1 0.01 0.34 0.45
125 INT98118 Gdnf Regulation of SCN11A 1 0.01 0.34 0.45
126 INT104459 Gdnf Regulation of Ngf 1 0.26 0.56 0.45
127 INT256042 Negative_regulation of Musk Negative_regulation of Ntrk1 1 0.08 0.48 0.44
128 INT127074 Gdnf Regulation of Gene_expression of Jun 1 0.10 0.28 0.43
129 INT298284 Runx3 Negative_regulation of Gene_expression of Ntrk1 1 0.26 0.39 0.43
130 INT298263 Pou4f1 Regulation of Gene_expression of Ntrk1 1 0.34 0.61 0.43
131 INT127072 Gdnf Regulation of Gene_expression of Fos 1 0.38 0.28 0.43
132 INT127077 Gdnf Positive_regulation of Gene_expression of IER3 1 0.02 0.26 0.42
133 INT127079 Gene_expression of Gdnf Positive_regulation of Gene_expression of IER3 1 0.02 0.26 0.42
134 INT127675 NGF Regulation of NTRK1 1 0.48 1.01 0.42
135 INT148436 Binding of Gdnf and Ngf 1 0.35 1.14 0.4
136 INT242607 Negative_regulation of Ntrk1 Positive_regulation of Ret 1 0.16 0 0.39
137 INT298266 Gene_expression of Runx1 Positive_regulation of Ntrk1 1 0.28 0.34 0.39
138 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
139 INT166247 Ngf Regulation of Ntrk1 1 0.05 0.09 0.38
140 INT78627 Gdnf Negative_regulation of Negative_regulation of P2rx3 1 0.00 0.42 0.38
141 INT140869 Binding of Gdnf and Trib3 1 0.04 0.15 0.37
142 INT223470 Ret Regulation of Ntrk1 1 0.21 0 0.36
143 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
144 INT148241 Binding of Kit and Ntrk1 1 0.25 0.44 0.35
145 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
146 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
147 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
148 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
149 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
150 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
151 INT191616 Binding of Cbln1 and Nf1 1 0.01 0.2 0.32
152 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
153 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
154 INT191620 Binding of Nf1 and Gopc 1 0.08 0.2 0.32
155 INT129022 Ngf Positive_regulation of Phosphorylation of Ntrk1 1 0.39 0.37 0.31
156 INT156151 POU4F1 Positive_regulation of Gene_expression of NTRK1 1 0.46 0.37 0.31
157 INT156163 POU4F1 Positive_regulation of NTRK1 1 0.46 0.37 0.31
158 INT326090 Binding of Erbb2 and Mmp2 1 0.09 1.39 0.31
159 INT156158 CREBZF Positive_regulation of Gene_expression of NTRK1 1 0.42 0.37 0.31
160 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
161 INT191611 Nf1 Regulation of ras 1 0.26 0.18 0.3
162 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
163 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
164 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3
165 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
166 INT356278 Gdnf Positive_regulation of Mapk1 1 0.05 0.17 0.3
167 INT156159 CREBZF Positive_regulation of NTRK1 1 0.63 0.36 0.3
168 INT356282 Gdnf Positive_regulation of Trib3 1 0.00 0.17 0.3
169 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
170 INT242622 Binding of Bdnf and Ntrk1 1 0.05 0.07 0.29
171 INT245554 Tbx15 Positive_regulation of Gene_expression of Ntrk1 1 0.02 0.65 0.29
172 INT156152 POU4F1 Positive_regulation of Positive_regulation of NTRK1 1 0.31 0.38 0.29
173 INT118652 Positive_regulation of Bdnf Positive_regulation of Ntrk1 1 0.31 0.24 0.29
174 INT355038 NRP1 Negative_regulation of CKAP4 1 0.02 1.23 0.29
175 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
176 INT144434 Gene_expression of Erbb2 Positive_regulation of ras 1 0.16 0.6 0.28
177 INT118654 Bdnf Positive_regulation of Ntrk1 1 0.43 0.24 0.28
178 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
179 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
180 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
181 INT180788 Gdnf Regulation of Trpv1 1 0.13 0.2 0.28
182 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
183 INT156160 TFAM Regulation of Gene_expression of NTRK1 1 0.03 0.39 0.27
184 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
185 INT156150 POU4F1 Regulation of Gene_expression of NTRK1 1 0.18 0.39 0.27
186 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
187 INT159656 Binding of BDNF and NTRK1 1 0.26 0.34 0.26
188 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
189 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
190 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
191 INT245567 Tbx15 Positive_regulation of Ntrk1 1 0.02 0.9 0.24
192 INT334522 Ngf Positive_regulation of Nrp1 1 0.19 0.93 0.22
193 INT298876 RAB7A Positive_regulation of Protein_catabolism of NTRK1 1 0.14 0.44 0.22
194 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22
195 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 0.19 0.93 0.22
196 INT144433 Gene_expression of Erbb2 Positive_regulation of Positive_regulation of Mapk3 1 0.41 0.56 0.21
197 INT277434 Cd5 Regulation of Gdnf 1 0.01 0 0.21
198 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
199 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
200 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2

Single Events

The table below shows the top 100 pain related interactions that have been reported for sympathetic nervous system development. They are ordered first by their pain relevance and then by number of times they were reported in sympathetic nervous system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
2 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06
3 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
4 INT48890 Gene_expression of Gdnf 91 0.77 28.62 31.49
5 INT77793 Positive_regulation of Gdnf 54 0.70 23.76 25.08
6 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83
7 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
8 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
9 INT56769 Gene_expression of Ntrk1 36 0.77 15.79 20.75
10 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
11 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29
12 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
13 INT173505 Localization of Hand2 63 0.57 45.32 13.66
14 INT102897 Positive_regulation of Gene_expression of Gdnf 34 0.69 11.13 13.28
15 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64
16 INT79981 Positive_regulation of Gene_expression of Gdnf 27 0.70 12.49 10.77
17 INT82950 Positive_regulation of Gdnf 36 0.51 11.72 10.5
18 INT85844 Regulation of Gdnf 18 0.50 11.08 10.43
19 INT21952 Gene_expression of GDNF 42 0.78 20.32 9.62
20 INT98111 Negative_regulation of Gdnf 12 0.59 10.85 9.29
21 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
22 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
23 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09
24 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
25 INT77795 Localization of Gdnf 26 0.81 6.29 8.55
26 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42
27 INT77794 Binding of Gdnf 15 0.48 8.38 8.22
28 INT92003 Positive_regulation of Transcription of Gdnf 10 0.66 5.54 7.84
29 INT87546 Transcription of Gdnf 15 0.71 7.49 7.76
30 INT50973 Negative_regulation of Gene_expression of Ntrk1 22 0.56 11.12 7.38
31 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
32 INT92001 Regulation of Gene_expression of Gdnf 12 0.62 6.62 6.65
33 INT129020 Phosphorylation of Ntrk1 17 0.80 5.97 6.37
34 INT79737 Positive_regulation of Ntrk1 12 0.49 3.98 6.24
35 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21
36 INT48313 Binding of NTRK1 19 0.47 14.44 6.12
37 INT87548 Negative_regulation of Gene_expression of Gdnf 9 0.54 5.67 5.94
38 INT115087 Negative_regulation of Gdnf 10 0.51 5.78 5.73
39 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5
40 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
41 INT78626 Regulation of Gdnf 7 0.45 3.3 4.64
42 INT68216 Binding of NF1 40 0.48 51.24 4.59
43 INT78981 Regulation of Ntrk1 6 0.44 3.89 4.52
44 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
45 INT81750 Regulation of Ntrk1 13 0.52 6.03 4.37
46 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
47 INT79736 Negative_regulation of Ntrk1 11 0.57 2.31 4.14
48 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13
49 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
50 INT156131 Binding of Hand2 14 0.25 10.35 3.99
51 INT56768 Positive_regulation of Gene_expression of Ntrk1 5 0.67 3.91 3.83
52 INT83411 Binding of Ntrk1 6 0.19 3.7 3.74
53 INT88008 Positive_regulation of Gene_expression of GDNF 14 0.70 8.9 3.61
54 INT78625 Regulation of Gene_expression of Gdnf 7 0.37 2.5 3.47
55 INT12844 Binding of TP63 15 0.47 10.57 3.38
56 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99
57 INT133080 Gene_expression of GATA3 15 0.61 5.64 2.89
58 INT156189 Positive_regulation of Gene_expression of Ntrk1 11 0.49 2.81 2.89
59 INT209744 Transcription of Gdnf 5 0.67 1.36 2.84
60 INT62610 Phosphorylation of Ntrk1 5 0.56 1.64 2.68
61 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66
62 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
63 INT144366 Negative_regulation of Positive_regulation of Gdnf 4 0.41 1.43 2.41
64 INT61434 Regulation of Nf1 3 0.26 1.39 2.4
65 INT64700 Binding of Nf1 14 0.45 15.24 2.29
66 INT98650 Positive_regulation of Localization of Gdnf 4 0.68 0.94 2.27
67 INT240113 Gene_expression of Nrp1 11 0.30 10.88 2.24
68 INT196176 Gene_expression of SEMA3A 3 0.75 4.75 2.17
69 INT88006 Positive_regulation of GDNF 5 0.45 2.55 2.14
70 INT180801 Regulation of Binding of Gdnf 1 0.20 1.31 2.03
71 INT66941 Localization of NTRK1 8 0.78 5.89 1.96
72 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93
73 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
74 INT209745 Positive_regulation of Transcription of Gdnf 4 0.58 0.97 1.91
75 INT68181 Binding of Nf1 6 0.48 8.14 1.88
76 INT107477 Positive_regulation of Phosphorylation of Ntrk1 3 0.30 0.88 1.86
77 INT223447 Regulation of Gene_expression of Ntrk1 7 0.34 1.29 1.82
78 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8
79 INT113676 Gene_expression of NRP1 22 0.72 10.81 1.71
80 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68
81 INT93182 Binding of Gdnf 7 0.35 1.96 1.64
82 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62
83 INT98651 Regulation of Positive_regulation of Gdnf 3 0.44 0.97 1.58
84 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57
85 INT21951 Negative_regulation of Gene_expression of GDNF 5 0.43 2.82 1.57
86 INT85046 Positive_regulation of Positive_regulation of NTRK1 2 0.50 0.63 1.51
87 INT52962 Binding of ERBB2 77 0.47 50.03 1.49
88 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48
89 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
90 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
91 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
92 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
93 INT129017 Negative_regulation of Phosphorylation of Ntrk1 3 0.41 1.5 1.42
94 INT116008 Binding of Gata3 2 0.34 1.37 1.41
95 INT87547 Negative_regulation of Transcription of Gdnf 1 0.58 1.24 1.4
96 INT108130 Localization of GDNF 3 0.74 1.36 1.38
97 INT98653 Negative_regulation of Localization of Gdnf 1 0.57 0.31 1.35
98 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34
99 INT245532 Negative_regulation of Positive_regulation of Ntrk1 2 0.34 1.56 1.34
100 INT108601 Negative_regulation of Gene_expression of NTRK1 2 0.41 0.28 1.31
101 INT85047 Positive_regulation of Negative_regulation of NTRK1 3 0.47 2.13 1.3
102 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
103 INT93612 Transcription of Ntrk1 2 0.52 1.31 1.26
104 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24
105 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23
106 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
107 INT93610 Negative_regulation of Gene_expression of Ntrk1 2 0.41 0.84 1.15
108 INT124069 Localization of Ntrk1 9 0.59 3.32 1.13
109 INT278117 Negative_regulation of TP63 5 0.32 3.38 1.13
110 INT133079 Positive_regulation of Gene_expression of GATA3 3 0.50 1.03 1.11
111 INT180795 Positive_regulation of Positive_regulation of Gdnf 2 0.29 0.1 1.07
112 INT293487 Regulation of Gene_expression of Erbb2 4 0.61 3.4 1.06
113 INT84511 Positive_regulation of Tfap2a 3 0.27 0.72 1.04
114 INT108985 Negative_regulation of Regulation of Gdnf 1 0.43 1.11 1.04
115 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
116 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
117 INT243974 Binding of Tfap2a 7 0.18 1.36 0.93
118 INT213917 Negative_regulation of Phosphorylation of ERBB2 9 0.54 8.68 0.91
119 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
120 INT201635 Positive_regulation of Positive_regulation of Ntrk1 3 0.40 1.15 0.85
121 INT88718 Negative_regulation of Erbb2 11 0.58 12.98 0.84
122 INT149291 Negative_regulation of NRP1 5 0.40 2.64 0.84
123 INT71649 Localization of ERBB2 23 0.78 13.63 0.83
124 INT221796 Positive_regulation of Gene_expression of Tfap2a 2 0.10 1.19 0.83
125 INT176588 Phosphorylation of ERBB2 27 0.78 16.37 0.81
126 INT149298 Protein_catabolism of NRP1 2 0.82 1.52 0.77
127 INT44293 Regulation of TP63 6 0.24 2.88 0.76
128 INT121947 Negative_regulation of Positive_regulation of Gdnf 1 0.20 0.07 0.76
129 INT81396 Regulation of Gene_expression of ERBB2 14 0.43 10.73 0.74
130 INT207535 Transcription of Tfap2a 3 0.31 0.98 0.74
131 INT139205 Binding of NRP1 27 0.45 4.34 0.71
132 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
133 INT3536 Positive_regulation of Nrp1 2 0.19 0.93 0.7
134 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
135 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
136 INT265800 Localization of NRP1 14 0.75 3.66 0.69
137 INT196155 Binding of Nrp1 5 0.16 2.38 0.69
138 INT135197 Gene_expression of Tfap2a 1 0.45 0.48 0.69
139 INT93609 Positive_regulation of Transcription of Ntrk1 1 0.45 0.86 0.69
140 INT62608 Negative_regulation of Phosphorylation of Ntrk1 1 0.40 0.24 0.69
141 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68
142 INT236094 Localization of Gdnf 4 0.70 2.51 0.68
143 INT209746 Regulation of Positive_regulation of Gdnf 2 0.37 0.11 0.68
144 INT179133 Localization of Nf1 2 0.80 2.18 0.68
145 INT49650 Gene_expression of Nf1 4 0.76 3.38 0.67
146 INT271488 Negative_regulation of Negative_regulation of Hand2 3 0.18 2.36 0.67
147 INT118981 Positive_regulation of Phosphorylation of NTRK1 1 0.49 0.66 0.66
148 INT260823 Positive_regulation of Gene_expression of Nrp1 3 0.19 2.14 0.65
149 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
150 INT85049 Negative_regulation of Positive_regulation of NTRK1 1 0.59 0.56 0.64
151 INT17840 Negative_regulation of GATA3 3 0.41 1.96 0.63
152 INT205470 Positive_regulation of GATA3 4 0.33 2.53 0.61
153 INT241673 Phosphorylation of GDNF 2 0.79 1.06 0.61
154 INT207529 Localization of Tfap2a 2 0.34 0.13 0.6
155 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
156 INT93613 Regulation of Gene_expression of Ntrk1 1 0.60 0.8 0.59
157 INT85138 Binding of GDNF 6 0.37 2.01 0.58
158 INT132588 Positive_regulation of Negative_regulation of Hand2 1 0.03 0.47 0.58
159 INT226481 Negative_regulation of Gene_expression of GATA3 1 0.06 1.41 0.57
160 INT118730 Regulation of Transcription of Ntrk1 1 0.43 0.45 0.57
161 INT98112 Positive_regulation of Negative_regulation of Gdnf 1 0.05 0.44 0.57
162 INT243970 Phosphorylation of Tfap2a 2 0.25 0.56 0.56
163 INT298887 Protein_catabolism of NTRK1 1 0.25 1.1 0.56
164 INT311943 Negative_regulation of Gene_expression of SEMA3A 1 0.56 0.66 0.55
165 INT144053 Transcription of GATA3 1 0.67 0.89 0.54
166 INT202196 Transcription of Erbb2 3 0.69 3.87 0.51
167 INT61992 Positive_regulation of Gene_expression of NF1 3 0.50 4.47 0.51
168 INT306741 Positive_regulation of Positive_regulation of TP63 2 0.05 1.16 0.49
169 INT278121 Negative_regulation of Negative_regulation of TP63 1 0.03 0 0.48
170 INT299799 Negative_regulation of Negative_regulation of GATA3 1 0.09 1.32 0.47
171 INT316933 Transcription of Nf1 1 0.18 0.49 0.47
172 INT316939 Positive_regulation of Transcription of Nf1 1 0.16 0.49 0.47
173 INT79935 Negative_regulation of Nrp1 3 0.17 1.36 0.46
174 INT127069 Regulation of Localization of Gdnf 1 0.34 0.46 0.46
175 INT97723 Negative_regulation of Regulation of Ntrk1 1 0.37 0.52 0.45
176 INT149293 Negative_regulation of Protein_catabolism of NRP1 1 0.05 0.93 0.44
177 INT297454 Negative_regulation of Negative_regulation of Ntrk1 1 0.09 0.23 0.41
178 INT325217 Regulation of Positive_regulation of Hand2 1 0.21 0.32 0.41
179 INT148433 Negative_regulation of Binding of Gdnf 1 0.41 1.14 0.4
180 INT194745 Regulation of Regulation of Hand2 1 0.03 0.95 0.39
181 INT242553 Positive_regulation of Negative_regulation of Ntrk1 1 0.21 0 0.39
182 INT71153 Regulation of Negative_regulation of NTRK1 1 0.27 0.29 0.37
183 INT226424 Negative_regulation of Transcription of Hand2 1 0.08 0.66 0.37
184 INT199559 Binding of Erbb2 5 0.36 4.23 0.36
185 INT112334 Regulation of NF1 18 0.52 15.85 0.34
186 INT148814 Localization of Ntrk1 1 0.78 0.16 0.34
187 INT84923 Transcription of NTRK1 2 0.67 1.65 0.33
188 INT283698 Gene_expression of Sox11 1 0.68 4.6 0.33
189 INT88012 Regulation of Gene_expression of GDNF 2 0.43 0.48 0.31
190 INT143442 Positive_regulation of NRP1 11 0.57 2.62 0.3
191 INT181756 Positive_regulation of Erbb2 6 0.46 4.12 0.28
192 INT226394 Regulation of Phosphorylation of Hand2 1 0.05 0.97 0.28
193 INT244625 Negative_regulation of Localization of Ntrk1 1 0.04 0.56 0.28
194 INT242536 Negative_regulation of Gene_expression of Gdnf 1 0.30 0.06 0.28
195 INT156165 Regulation of Gene_expression of NTRK1 2 0.37 1.91 0.27
196 INT264305 Negative_regulation of Gene_expression of NRP1 3 0.40 1.4 0.25
197 INT178191 Regulation of Erbb2 7 0.36 4.11 0.24
198 INT100671 Positive_regulation of Transcription of Hand2 2 0.36 0.81 0.23
199 INT129342 Positive_regulation of Positive_regulation of Nf1 1 0.50 0.79 0.23
200 INT68180 Regulation of Nf1 2 0.27 2.02 0.22
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