GO:0048568

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Name embryonic organ development
Categary Process
Go Slim No
Go Link GO:0048568
Unique Molecular Interactions 118
Total Molecular Interactions 179
Total Single Events 937
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for embryonic organ development. They are ordered first by their pain relevance and then by number of times they were reported for embryonic organ development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
2 INT237896 Epn1 Regulation of Nps 1 0.06 0.19 0.41
3 INT318678 Atf4 Positive_regulation of Gene_expression of Ddit3 1 0.53 0.77 0.23
4 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
5 INT318682 Atf4 Positive_regulation of Ddit3 1 0.73 1.71 0.18
6 INT318677 Xbp1 Positive_regulation of Ddit3 1 0.73 1.72 0.18
7 INT318680 Binding of Cebpg and Ddit3 1 0.39 1.73 0.18
8 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
9 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
10 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
11 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
12 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
13 INT261379 Nsdhl Positive_regulation of Thra 1 0.07 1.12 0.11
14 INT84867 Ptger1 Negative_regulation of SETD2 1 0.00 1.09 0.11
15 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
16 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
17 INT201173 Sox2 Positive_regulation of Localization of Ryr2 1 0.40 0.9 0.07
18 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
19 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
20 INT201172 Sox2 Positive_regulation of Localization of Ca2 1 0.47 0.9 0.07
21 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07
22 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
23 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
24 INT355432 Gene_expression of Pdia3 Negative_regulation of Ddit3 1 0.04 1.29 0.06
25 INT355431 Binding of Pdia3 and Positive_regulation of Gene_expression of Ddit3 1 0.04 1.14 0.06
26 INT355433 Gene_expression of Pdia3 Negative_regulation of Transcription of Ddit3 1 0.03 1.79 0.06
27 INT355434 Binding of Pdia3 and Positive_regulation of Transcription of Ddit3 1 0.04 1.14 0.06
28 INT355438 Gene_expression of Pdia3 Negative_regulation of Gene_expression of Ddit3 1 0.05 4.79 0.06
29 INT213562 Ctnnd2 Regulation of Gene_expression of Sox2 1 0.35 0.07 0.05
30 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
31 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
32 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
33 INT355430 Pdia3 Regulation of Gene_expression of Ddit3 1 0.04 1 0.03
34 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
35 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03
36 INT355441 VEGFA Positive_regulation of Gene_expression of Ddit3 1 0.05 0.43 0.03
37 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
38 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
39 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
40 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
41 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
42 INT274435 Binding of Zfpm2 and Mir130a 1 0.30 0.26 0
43 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
44 INT352148 Ift88 Negative_regulation of Bcl2l2 1 0.00 0.19 0
45 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
46 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
47 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
48 INT355437 Negative_regulation of Pdia3 Positive_regulation of Gene_expression of Ddit3 1 0.04 0.47 0
49 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
50 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
51 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
52 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
53 INT269948 Sox17 Positive_regulation of Gene_expression of Ccnd1 1 0.61 0.19 0
54 INT252842 ENOPH1 Positive_regulation of Gene_expression of Ddit3 1 0.06 2.42 0
55 INT183091 Binding of FGF2 and FGFR2 1 0.03 0.79 0
56 INT269940 Binding of Sox17 and Scn4a 1 0.17 0.15 0
57 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
58 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
59 INT274432 Mir130a Regulation of Zfpm2 1 0.22 0.08 0
60 INT285772 ERCC1 Positive_regulation of Binding of RAD51 1 0.05 0 0
61 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
62 INT269928 Binding of Sox17 and Mgst1 1 0.12 0 0
63 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
64 INT274431 Mir130a Regulation of Gene_expression of Zfpm2 1 0.50 0.79 0
65 INT269949 Sox17 Positive_regulation of Ccnd1 1 0.61 0.96 0
66 INT269954 Sox17 Regulation of Gene_expression of Foxa2 1 0.43 0 0
67 INT355436 Pdia3 Regulation of Transcription of Ddit3 1 0.04 0.59 0
68 INT269950 Sox17 Negative_regulation of Gene_expression of Cdkn2b 1 0.27 0.24 0
69 INT274434 Binding of Gata4 and Zfpm2 1 0.12 0.56 0
70 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
71 INT269947 Sox17 Positive_regulation of Gene_expression of Atxn1 1 0.08 0 0
72 INT285771 ERCC1 Regulation of Binding of RAD51 1 0.05 0 0
73 INT269957 Sox17 Negative_regulation of Gene_expression of TGFB1 1 0.04 0 0
74 INT269941 Sox17 Regulation of Gene_expression of Foxa1 1 0.56 0 0
75 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
76 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
77 INT335022 Fgf15 Regulation of Pbx1 1 0.15 0.17 0
78 INT269934 Sox17 Regulation of Gopc 1 0.12 0 0
79 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
80 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
81 INT269951 Binding of Sox17 and Gopc 1 0.11 0 0
82 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
83 INT269945 Sox17 Positive_regulation of Localization of Ccnd1 1 0.39 0 0
84 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
85 INT274433 Binding of Zfpm2 and Uts2r 1 0.08 0.17 0
86 INT352150 Ift88 Negative_regulation of Bcl2 1 0.00 0.19 0
87 INT274436 Mir130a Regulation of Transcription of Zfpm2 1 0.22 0 0
88 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
89 INT269922 Sox17 Regulation of Ccnd1 1 0.47 0 0
90 INT269931 Binding of Ccnd1 and Sox17 1 0.33 0.19 0
91 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
92 INT269918 Binding of Scn5a and Sox17 1 0.18 0.15 0
93 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
94 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
95 INT269916 Sox17 Positive_regulation of Pcna 1 0.16 0 0
96 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
97 INT174720 Ddit3 Regulation of Gtf3a 1 0.01 0.35 0
98 INT352149 Ift88 Negative_regulation of Bcl2l1 1 0.00 0.19 0
99 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
100 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
101 INT183089 Positive_regulation of Binding of FGF2 and FGFR2 1 0.04 0.4 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for embryonic organ development. They are ordered first by their pain relevance and then by number of times they were reported in embryonic organ development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
2 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
3 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
4 INT237875 Gene_expression of Epn1 1 0.10 1.26 2.4
5 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
6 INT237873 Regulation of Epn1 1 0.07 2.12 1.91
7 INT173419 Gene_expression of Ddit3 16 0.75 23.31 1.87
8 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
9 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
10 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
11 INT116008 Binding of Gata3 2 0.34 1.37 1.41
12 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
13 INT165800 Positive_regulation of Ddit3 17 0.67 11.69 1.21
14 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
15 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
16 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
17 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
18 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
19 INT318666 Negative_regulation of Ddit3 1 0.56 6.86 0.7
20 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
21 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
22 INT318667 Negative_regulation of Gene_expression of Ddit3 6 0.56 3.16 0.65
23 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
24 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
25 INT237871 Positive_regulation of Epn1 1 0.07 0.84 0.62
26 INT185244 Gene_expression of Sox2 27 0.65 4.71 0.61
27 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
28 INT237867 Binding of Epn1 1 0.07 0.09 0.52
29 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
30 INT206484 Localization of Shh 2 0.75 1.14 0.46
31 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
32 INT237864 Negative_regulation of Gene_expression of Epn1 1 0.06 0 0.43
33 INT185255 Positive_regulation of Sox2 3 0.26 1.22 0.42
34 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
35 INT173418 Transcription of Ddit3 6 0.65 7.91 0.41
36 INT219001 Gene_expression of ERCC1 12 0.54 3.77 0.38
37 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
38 INT201143 Regulation of Sox2 6 0.44 2.71 0.26
39 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
40 INT252833 Positive_regulation of Gene_expression of Ddit3 4 0.67 7.58 0.25
41 INT237861 Negative_regulation of Positive_regulation of Epn1 1 0.06 0.7 0.25
42 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24
43 INT223739 Binding of Fgfr2 3 0.30 0.94 0.22
44 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
45 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
46 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
47 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
48 INT253190 Localization of Shh 2 0.77 1.06 0.13
49 INT192056 Binding of Pbx1 2 0.31 0.46 0.13
50 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12
51 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
52 INT194746 Phosphorylation of Gata3 1 0.10 0.08 0.12
53 INT143825 Regulation of Ddit3 3 0.58 2.03 0.11
54 INT201144 Regulation of Gene_expression of Sox2 3 0.44 0.82 0.11
55 INT201140 Transcription of Sox2 4 0.67 1.31 0.1
56 INT270442 Transcription of Shh 1 0.53 0.25 0.09
57 INT285813 Negative_regulation of ERCC1 13 0.30 2.03 0.08
58 INT213515 Binding of Shh 8 0.37 1.92 0.08
59 INT173416 Localization of Ddit3 2 0.71 0.98 0.08
60 INT173421 Positive_regulation of Transcription of Ddit3 2 0.47 0.7 0.08
61 INT174717 Negative_regulation of Transcription of Ddit3 1 0.32 0.5 0.08
62 INT270453 Regulation of Shh 1 0.27 0.83 0.08
63 INT174709 Positive_regulation of Positive_regulation of Ddit3 1 0.38 0.85 0.08
64 INT205973 Binding of SHH 3 0.35 1.03 0.07
65 INT173420 Regulation of Gene_expression of Ddit3 2 0.37 0.84 0.07
66 INT256862 Regulation of Shh 1 0.25 0 0.07
67 INT303546 Binding of Fgfr2 1 0.46 0.74 0.06
68 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
69 INT352129 Negative_regulation of Ift88 1 0.00 0.72 0.05
70 INT185260 Positive_regulation of Positive_regulation of Sox2 1 0.15 0 0.05
71 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
72 INT213537 Positive_regulation of Gene_expression of Sox2 3 0.48 1.34 0.04
73 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
74 INT213528 Negative_regulation of Gene_expression of Sox2 1 0.30 0.07 0.04
75 INT303525 Localization of Fgfr2 1 0.72 0.28 0.03
76 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
77 INT303547 Positive_regulation of Negative_regulation of Fgfr2 1 0.48 1.07 0.03
78 INT253181 Transcription of Shh 1 0.68 0.54 0.03
79 INT201142 Negative_regulation of Sox2 4 0.57 0.59 0
80 INT207729 Regulation of FGFR2 4 0.22 2.35 0
81 INT238985 Positive_regulation of FGFR2 3 0.49 1.19 0
82 INT201141 Binding of Sox2 3 0.36 0.53 0
83 INT192055 Gene_expression of Pbx1 3 0.65 0.57 0
84 INT99716 Transcription of FGFR2 2 0.34 0.22 0
85 INT305351 Positive_regulation of Regulation of FGFR2 2 0.37 0.97 0
86 INT99715 Regulation of Gene_expression of FGFR2 2 0.22 0.19 0
87 INT303555 Negative_regulation of Gene_expression of FGFR2 2 0.41 0.31 0
88 INT200864 Positive_regulation of Sox17 2 0.50 0.07 0
89 INT274420 Positive_regulation of Gene_expression of Zfpm2 1 0.49 0.51 0
90 INT210870 Gene_expression of Thra 1 0.35 0.23 0
91 INT269903 Localization of Sox17 1 0.75 0.07 0
92 INT202623 Negative_regulation of Gene_expression of Fgfr2 1 0.32 0 0
93 INT319036 Gene_expression of Fgfr2 1 0.48 0.08 0
94 INT269907 Positive_regulation of Localization of Sox17 1 0.50 0.2 0
95 INT285815 Binding of ERCC1 1 0.26 0 0
96 INT274412 Transcription of Zfpm2 1 0.53 0 0
97 INT233212 Positive_regulation of Gene_expression of Pbx1 1 0.26 0.48 0
98 INT286555 Binding of Ift88 1 0.30 0.08 0
99 INT274418 Regulation of Gene_expression of Zfpm2 1 0.45 1.42 0
100 INT269904 Regulation of Sox17 1 0.45 0 0
101 INT274417 Negative_regulation of Zfpm2 1 0.43 6.99 0
102 INT274428 Regulation of Binding of Zfpm2 1 0.45 0.15 0
103 INT269876 Binding of Sox17 1 0.48 0.72 0
104 INT285814 Positive_regulation of ERCC1 1 0.35 0.14 0
105 INT274405 Gene_expression of Zfpm2 1 0.77 6.51 0
106 INT274425 Negative_regulation of Gene_expression of Zfpm2 1 0.42 0.06 0
107 INT274411 Positive_regulation of Zfpm2 1 0.46 0.53 0
108 INT201146 Negative_regulation of Binding of Sox2 1 0.41 0.28 0
109 INT269885 Negative_regulation of Sox17 1 0.42 0.32 0
110 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
111 INT269891 Positive_regulation of Gene_expression of Sox17 1 0.69 0.4 0
112 INT286544 Localization of Ift88 1 0.52 1.26 0
113 INT269878 Negative_regulation of Gene_expression of Sox17 1 0.42 0 0
114 INT269892 Transcription of Sox17 1 0.71 0 0
115 INT285819 Negative_regulation of Negative_regulation of ERCC1 1 0.30 0.18 0
116 INT99717 Positive_regulation of Transcription of FGFR2 1 0.10 0.08 0
117 INT183117 Positive_regulation of Binding of FGFR2 1 0.09 0.81 0
118 INT201139 Localization of Sox2 1 0.73 0.15 0
119 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
120 INT274414 Regulation of Zfpm2 1 0.61 0.59 0
121 INT290929 Binding of Shh 1 0.31 0.1 0
122 INT269898 Positive_regulation of Binding of Sox17 1 0.44 0 0
123 INT274408 Binding of Zfpm2 1 0.37 0.77 0
124 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
125 INT269869 Gene_expression of Sox17 1 0.77 2.48 0
126 INT303524 Positive_regulation of Fgfr2 1 0.66 0.22 0
127 INT269882 Regulation of Gene_expression of Sox17 1 0.61 0.14 0
128 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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