GO:0048609

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Name multicellular organismal reproductive process
Categary Process
Go Slim No
Go Link GO:0048609
Unique Molecular Interactions 51
Total Molecular Interactions 67
Total Single Events 643
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for multicellular organismal reproductive process. They are ordered first by their pain relevance and then by number of times they were reported for multicellular organismal reproductive process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT172203 Binding of Comt and Maoa 1 0.31 0.98 1.43
2 INT128913 Binding of COMT and PENK 1 0.30 0.07 1.41
3 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
4 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29
5 INT261617 SNRNP70 Regulation of Comt 1 0.01 0.4 1.18
6 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
7 INT165627 Binding of COMT and SLTM 1 0.09 0.86 0.88
8 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
9 INT167944 Binding of Oprm1 and Stat5a 1 0.00 0 0.85
10 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84
11 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83
12 INT340114 Comt Regulation of Localization of Pain1 1 0.02 0.83 0.83
13 INT340113 Comt Regulation of Bdnf 1 0.21 0.74 0.82
14 INT266100 Binding of COMT and SH2B2 1 0.25 1.22 0.74
15 INT327707 Binding of Comt and Drd1a 1 0.18 0.27 0.74
16 INT266108 Binding of COMT and HPS1 1 0.23 1.21 0.74
17 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
18 INT327712 Binding of Comt and Rbm39 1 0.00 0.27 0.74
19 INT287132 Binding of NT5E and Comt 1 0.03 0.11 0.73
20 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64
21 INT126615 Binding of Oprd1 and Stat5a 1 0.28 0.07 0.61
22 INT167455 Binding of MSD and Comt 1 0.15 0.28 0.5
23 INT311616 Binding of MET and Comt 1 0.01 0.2 0.37
24 INT327701 Comt Regulation of Npcd 1 0.01 0 0.29
25 INT327706 Comt Regulation of Gopc 1 0.10 0 0.29
26 INT216040 Binding of Comt and Prodh 1 0.30 1.71 0.26
27 INT287131 Negative_regulation of Binding of NT5E and Comt 1 0.03 0.06 0.23
28 INT266103 Binding of COMT and SNRNP70 1 0.04 0.78 0.21
29 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
30 INT195423 COMT Negative_regulation of GBE1 1 0.00 0.22 0.19
31 INT289251 Ptpn11 Regulation of Il6 1 0.09 0.86 0.18
32 INT327700 Binding of Comt and 4930579C15Rik 1 0.08 0 0.15
33 INT202253 Binding of COMT and TCN1 1 0.16 0 0.12
34 INT327703 Cish Regulation of Transcription of Comt 1 0.13 0.77 0.12
35 INT287130 Positive_regulation of Binding of NT5E and Comt 1 0.04 0 0.12
36 INT327709 Uts2r Positive_regulation of Comt 1 0.14 0.47 0.1
37 INT295337 Egf Positive_regulation of Ptpn11 1 0.15 0.08 0.05
38 INT295349 Binding of Ptpn11 and Grb7 1 0.13 0.11 0.03
39 INT295338 Ptpn11 Regulation of Binding of Xpo1 1 0.02 0 0
40 INT353192 Stat5a Positive_regulation of Plxna3 1 0.01 0 0
41 INT295340 Binding of Ptpn11 and Fig4 1 0.04 0 0
42 INT154023 Binding of NOVA2 and Comt 1 0.03 0.08 0
43 INT295359 Ptpn11 Regulation of Phosphorylation of Grb7 1 0.10 0 0
44 INT353190 Stat5a Positive_regulation of Cyp2c11 1 0.31 0 0
45 INT295345 Egf Regulation of Ptpn11 1 0.08 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for multicellular organismal reproductive process. They are ordered first by their pain relevance and then by number of times they were reported in multicellular organismal reproductive process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49
2 INT101120 Gene_expression of Comt 63 0.77 34.75 26.13
3 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05
4 INT519 Negative_regulation of Comt 52 0.59 17.65 20.39
5 INT135629 Binding of COMT 33 0.48 16.68 19.37
6 INT101119 Negative_regulation of Comt 19 0.58 8.77 13.09
7 INT17619 Regulation of COMT 12 0.45 8.46 12.22
8 INT520 Binding of Comt 24 0.48 8.98 12.21
9 INT144736 Negative_regulation of Gene_expression of COMT 13 0.58 6.47 9.28
10 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89
11 INT44537 Positive_regulation of Comt 7 0.69 2.62 7.78
12 INT101121 Regulation of Comt 19 0.53 10.66 7.22
13 INT144739 Regulation of Gene_expression of COMT 11 0.61 3.07 7.08
14 INT150825 Binding of Comt 13 0.42 6.65 6.42
15 INT50712 Gene_expression of Comt 13 0.68 6.33 6.23
16 INT2162 Regulation of Comt 13 0.60 2.9 5.18
17 INT2871 Positive_regulation of Comt 9 0.50 2.8 4.78
18 INT126608 Binding of Stat5a 7 0.48 0.46 4.38
19 INT172197 Positive_regulation of Gene_expression of Comt 12 0.69 7.61 4.06
20 INT172198 Protein_catabolism of Comt 7 0.88 2.78 3.6
21 INT206598 Regulation of Gene_expression of Comt 9 0.60 6 3.56
22 INT195964 Transcription of Comt 8 0.71 4.72 3.4
23 INT194289 Transcription of COMT 3 0.72 3.56 2.72
24 INT202257 Localization of COMT 7 0.75 2.13 2.65
25 INT128983 Protein_catabolism of Comt 5 0.87 0.22 2.6
26 INT126610 Phosphorylation of Stat5a 5 0.82 0.8 2.52
27 INT206593 Negative_regulation of Gene_expression of Comt 3 0.56 1.68 2.52
28 INT265662 Negative_regulation of Binding of COMT 4 0.37 1.29 2.42
29 INT136962 Protein_catabolism of COMT 4 0.89 1.12 2.14
30 INT447 Localization of Comt 4 0.75 0.76 1.8
31 INT126609 Positive_regulation of Phosphorylation of Stat5a 1 0.69 0.26 1.79
32 INT265659 Positive_regulation of Negative_regulation of COMT 1 0.43 0.78 1.57
33 INT126605 Negative_regulation of Binding of Stat5a 1 0.58 0.15 1.27
34 INT65165 Positive_regulation of Negative_regulation of Comt 1 0.03 0 1.15
35 INT246088 Negative_regulation of Negative_regulation of COMT 2 0.37 2.01 1
36 INT282479 Regulation of Protein_catabolism of Comt 2 0.45 1.17 0.85
37 INT265663 Positive_regulation of Gene_expression of COMT 2 0.50 0.26 0.79
38 INT195983 Localization of Comt 2 0.74 0.93 0.76
39 INT344931 Positive_regulation of Protein_catabolism of Comt 1 0.49 0 0.76
40 INT136963 Regulation of Protein_catabolism of COMT 1 0.24 0.49 0.72
41 INT42722 Negative_regulation of Ptpn11 1 0.21 0 0.71
42 INT126606 Negative_regulation of Stat5a 1 0.43 0.08 0.64
43 INT159942 Positive_regulation of Stat5a 3 0.41 0.95 0.61
44 INT126612 Negative_regulation of Phosphorylation of Stat5a 1 0.42 0.1 0.61
45 INT265655 Regulation of Positive_regulation of COMT 1 0.39 0.38 0.49
46 INT327677 Regulation of Transcription of Comt 2 0.60 1.49 0.48
47 INT266128 Positive_regulation of Transcription of COMT 1 0.44 0.35 0.41
48 INT50711 Regulation of Gene_expression of Comt 2 0.01 0 0.39
49 INT266123 Negative_regulation of Transcription of COMT 1 0.59 0.65 0.3
50 INT287124 Negative_regulation of Protein_catabolism of Comt 1 0.38 0.22 0.29
51 INT266127 Regulation of Binding of COMT 1 0.39 0.54 0.27
52 INT287126 Negative_regulation of Negative_regulation of Comt 1 0.37 0.78 0.25
53 INT266124 Positive_regulation of Binding of COMT 1 0.44 0 0.23
54 INT266122 Regulation of Localization of COMT 1 0.39 0 0.21
55 INT327698 Regulation of Binding of Comt 1 0.39 0 0.2
56 INT327691 Negative_regulation of Transcription of Comt 1 0.37 0.33 0.18
57 INT289228 Localization of Ptpn11 1 0.15 0.87 0.18
58 INT327679 Regulation of Positive_regulation of Comt 1 0.39 0.39 0.17
59 INT184029 Binding of Ptpn11 2 0.19 0.18 0.12
60 INT220368 Negative_regulation of Positive_regulation of Stat5a 1 0.34 0.46 0.11
61 INT209806 Transcription of Comt 1 0.69 2.12 0.11
62 INT295368 Localization of Ptpn11 1 0.25 0 0.11
63 INT213470 Positive_regulation of Ptpn11 1 0.05 0.07 0.1
64 INT213468 Regulation of Ptpn11 1 0.05 0.08 0.09
65 INT266125 Regulation of Transcription of COMT 1 0.24 0.88 0.08
66 INT225246 Phosphorylation of Ptpn11 1 0.28 0.9 0
67 INT295391 Positive_regulation of Ptpn11 1 0.23 0 0
68 INT295371 Positive_regulation of Positive_regulation of Ptpn11 1 0.15 0 0
69 INT295379 Gene_expression of Ptpn11 1 0.20 0 0
70 INT295369 Regulation of Binding of Ptpn11 1 0.15 0 0
71 INT290423 Gene_expression of Ptpn11 1 0.39 0.15 0
72 INT290402 Regulation of Gene_expression of Ptpn11 1 0.26 0.15 0
73 INT225245 Negative_regulation of Phosphorylation of Ptpn11 1 0.19 0.26 0
74 INT295393 Binding of Ptpn11 1 0.12 0 0
75 INT292012 Positive_regulation of Localization of COMT 1 0.44 0.13 0
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