GO:0048660

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Name regulation of smooth muscle cell proliferation
Categary Process
Go Slim No
Go Link GO:0048660
Unique Molecular Interactions 107
Total Molecular Interactions 133
Total Single Events 1806
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of smooth muscle cell proliferation. They are ordered first by their pain relevance and then by number of times they were reported for regulation of smooth muscle cell proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106338 Positive_regulation of Tacr1 Positive_regulation of Localization of Abat 5 0.34 0 3.01
2 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
3 INT117821 Binding of Tacr1 and Cd4 1 0.34 0.86 2.02
4 INT23889 Calca Positive_regulation of Localization of Tacr1 1 0.11 0.45 1.65
5 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 0.05 1.65 1.42
6 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41
7 INT51160 Binding of TAC1 and Tacr1 2 0.28 0.55 1.38
8 INT95457 Nka1 Positive_regulation of Tacr1 1 0.63 0.29 1.3
9 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
10 INT122370 Positive_regulation of Tacr1 Positive_regulation of Ngf 1 0.30 0.17 1.18
11 INT122369 Tacr1 Positive_regulation of Ngf 1 0.30 0.16 1.14
12 INT296950 Tacr1 Negative_regulation of Gene_expression of Cck 1 0.30 0.94 1.11
13 INT63181 Oprl1 Regulation of Localization of Tacr1 1 0.06 0.09 1.04
14 INT113235 Tacr1 Regulation of Gene_expression of Ifng 1 0.26 1 1.04
15 INT75247 Abat Regulation of Gene_expression of Tacr1 1 0.23 0.41 1.03
16 INT84959 Negative_regulation of Tacr1 Negative_regulation of Positive_regulation of Tac1 1 0.48 0.59 1.02
17 INT252880 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Tacr1 1 0.02 0.29 0.92
18 INT86349 Negative_regulation of Tacr1 Negative_regulation of Positive_regulation of Fos 1 0.42 0.8 0.92
19 INT252879 Creb1 Positive_regulation of Gene_expression of Tacr1 1 0.03 0.24 0.91
20 INT252876 Positive_regulation of Prkaca Regulation of Gene_expression of Tacr1 1 0.01 0.28 0.89
21 INT252881 Crcp Positive_regulation of Gene_expression of Tacr1 1 0.00 0.28 0.88
22 INT121745 Tacr1 Negative_regulation of Positive_regulation of Ephb1 1 0.04 0 0.87
23 INT113237 Il10 Negative_regulation of Gene_expression of Tacr1 1 0.35 0.81 0.84
24 INT113240 Il12a Regulation of Transcription of Tacr1 1 0.21 0.79 0.82
25 INT113239 Il10 Regulation of Transcription of Tacr1 1 0.45 0.79 0.81
26 INT208946 Positive_regulation of Tacr1 Positive_regulation of Gene_expression of S100a8 1 0.02 1.11 0.8
27 INT113238 Il12a Positive_regulation of Transcription of Tacr1 1 0.38 0.78 0.79
28 INT92293 Tacr1 Regulation of Tac2 1 0.17 0.07 0.79
29 INT79339 Phax Regulation of Gene_expression of Tacr1 1 0.07 0 0.78
30 INT148061 Binding of Tacr1 and B4galt4 1 0.01 0.06 0.77
31 INT76498 Binding of Tacr1 and Adora2a 1 0.09 0 0.77
32 INT95458 Nka1 Positive_regulation of Positive_regulation of Tacr1 1 0.52 0.16 0.77
33 INT148062 Binding of Tacr1 and St3gal3 1 0.01 0.06 0.77
34 INT202909 Binding of Tacr1 and Fig4 1 0.03 0.33 0.74
35 INT41919 Binding of Tacr1 and Trh 1 0.06 0 0.74
36 INT8367 Tacr1 Positive_regulation of Localization of Prss12 1 0.05 0 0.72
37 INT207411 Sst Negative_regulation of Gene_expression of Tacr1 1 0.05 0.76 0.69
38 INT207410 Ptger2 Regulation of Gene_expression of Tacr1 1 0.02 0.69 0.65
39 INT189020 Tacr1 Positive_regulation of Pla2g1b 1 0.14 0.13 0.65
40 INT124904 Binding of Tacr1 and Adarb1 2 0.01 0.5 0.63
41 INT93690 Bdnf Regulation of Localization of Tacr1 1 0.10 0.28 0.61
42 INT167859 Tac1 Regulation of Gene_expression of Tacr1 1 0.09 0 0.6
43 INT69898 Binding of Olfr19 and Tacr1 1 0.00 0.1 0.55
44 INT48646 Sst Regulation of Tacr1 1 0.03 0.09 0.52
45 INT15273 Calca Regulation of Tacr1 1 0.22 0 0.5
46 INT157003 Gal Regulation of Localization of Tacr1 1 0.01 0.1 0.49
47 INT127398 Negative_regulation of Mdk Negative_regulation of Gene_expression of Tacr1 1 0.01 0.71 0.45
48 INT127395 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Tacr1 1 0.07 0.71 0.45
49 INT170157 NPPC Regulation of CSF2 1 0.12 1.36 0.42
50 INT15356 Abat Regulation of Tacr1 1 0.02 0 0.42
51 INT151633 Binding of Npy and Tacr1 1 0.16 0.39 0.4
52 INT163918 Ntp Negative_regulation of Gene_expression of Tacr1 1 0.04 0.74 0.38
53 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
54 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
55 INT207408 Il6 Positive_regulation of Gene_expression of Tacr1 1 0.08 0.56 0.33
56 INT207409 Ptger2 Positive_regulation of Gene_expression of Tacr1 1 0.04 0.56 0.32
57 INT208940 Pax3 Positive_regulation of Tacr1 1 0.07 0.55 0.29
58 INT75108 Binding of Tac2 and Tacr1 1 0.18 0.1 0.29
59 INT208941 Positive_regulation of Pax3 Positive_regulation of Tacr1 1 0.05 0.55 0.29
60 INT124340 Tacr1 Positive_regulation of Tac2 1 0.48 0 0.27
61 INT208936 Tac1 Positive_regulation of Tacr1 1 0.13 0.39 0.25
62 INT278581 Tacr2 Positive_regulation of Tacr1 1 0.55 0 0.24
63 INT278578 Tacr3 Positive_regulation of Tacr1 1 0.55 0 0.24
64 INT278570 Nka1 Positive_regulation of Tacr1 1 0.06 0 0.24
65 INT65525 Tacr1 Regulation of Regulation of Spn 1 0.15 0.36 0.22
66 INT146993 Binding of NPPA and NPPC 1 0.27 0.82 0.22
67 INT107031 Regulation of Binding of Tacr1 and Oprm1 1 0.29 0.5 0.21
68 INT107032 Binding of Tacr1 and Oprm1 1 0.31 0.5 0.21
69 INT196822 Negative_regulation of Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
70 INT196815 Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
71 INT245183 Binding of CTSB and TCF7L2 1 0.39 6.39 0.18
72 INT87110 Apom Negative_regulation of Pde1a 1 0.00 0 0.15
73 INT196811 Binding of Pde1a and Adcy5 1 0.01 0 0.14
74 INT196837 Binding of CALM1 and Pde1a 1 0.00 0 0.14
75 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
76 INT271478 Tacr1 Regulation of Binding of Mthfd1 1 0.09 0.48 0.13
77 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
78 INT170159 Negative_regulation of NPPC Regulation of CSF2 1 0.20 0.33 0.11
79 INT245185 Binding of RRAD and TCF7L2 1 0.00 6.88 0.1
80 INT208938 Positive_regulation of Tacr1 Positive_regulation of Nkx2-5 1 0.17 0 0.1
81 INT208939 Positive_regulation of Tacr1 Positive_regulation of Nfkb1 1 0.19 0 0.1
82 INT245182 Binding of SPINK1 and TCF7L2 1 0.39 2.05 0.1
83 INT146721 Nppc Positive_regulation of Positive_regulation of Oprl1 1 0.16 0.34 0.07
84 INT275800 Binding of Sh2d1a and Tacr1 1 0.01 0.29 0.07
85 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
86 INT276038 Camk2a Negative_regulation of Pde1a 1 0.14 0 0.03
87 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
88 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
89 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
90 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
91 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
92 INT308352 Binding of Ctnnd2 and Tcf7l2 1 0.15 0.74 0
93 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
94 INT263181 Binding of Pde1a and Pde5a 1 0.03 0 0
95 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
96 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
97 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
98 INT245193 Binding of TCF7L2 and Abpa 1 0.02 10.66 0
99 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
100 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
101 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0
102 INT277368 Regulation of TFAM Positive_regulation of Gene_expression of TCF7L2 1 0.01 0.9 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of smooth muscle cell proliferation. They are ordered first by their pain relevance and then by number of times they were reported in regulation of smooth muscle cell proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92
2 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46
3 INT4936 Localization of Tacr1 125 0.80 35.7 107.7
4 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52
5 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07
6 INT4925 Binding of Tacr1 57 0.48 17.39 38.38
7 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35
8 INT4892 Positive_regulation of Gene_expression of Tacr1 56 0.69 25.64 34.69
9 INT8881 Regulation of Gene_expression of Tacr1 38 0.61 17.49 27.19
10 INT41494 Negative_regulation of Gene_expression of Tacr1 25 0.58 11.73 19.91
11 INT15202 Regulation of Tacr1 26 0.60 9.65 16.48
12 INT51158 Positive_regulation of Tacr1 33 0.70 15.22 13.91
13 INT49041 Transcription of Tacr1 25 0.72 12.52 12.8
14 INT48691 Negative_regulation of Tacr1 20 0.59 4.96 11.25
15 INT8589 Positive_regulation of Positive_regulation of Tacr1 14 0.69 7.85 10.86
16 INT23519 Positive_regulation of Localization of Tacr1 12 0.41 3.84 10.82
17 INT76814 Positive_regulation of Gene_expression of Tacr1 13 0.69 6.11 8.42
18 INT4940 Negative_regulation of Localization of Tacr1 8 0.37 4.29 8.25
19 INT48877 Binding of Tacr1 16 0.43 5.26 8.04
20 INT24884 Negative_regulation of Positive_regulation of Tacr1 8 0.43 2.35 6.66
21 INT24536 Regulation of Localization of Tacr1 5 0.30 3.39 6.44
22 INT63395 Regulation of Regulation of Tacr1 6 0.45 2.26 5.39
23 INT66288 Positive_regulation of Transcription of Tacr1 10 0.70 5.06 5.37
24 INT14936 Negative_regulation of Binding of Tacr1 4 0.58 0.75 3.67
25 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
26 INT107950 Regulation of Gene_expression of Tacr1 6 0.61 1.13 2.84
27 INT65126 Transcription of Tacr1 5 0.63 3.44 2.77
28 INT8590 Regulation of Positive_regulation of Tacr1 4 0.62 1.43 2.73
29 INT122367 Positive_regulation of Positive_regulation of Tacr1 5 0.46 1.47 2.4
30 INT91046 Negative_regulation of Regulation of Tacr1 3 0.40 1.33 2.31
31 INT98898 Localization of Tacr1 6 0.72 2.47 2.25
32 INT36642 Negative_regulation of Pde1a 4 0.43 0.89 2.15
33 INT136471 Phosphorylation of Tacr1 4 0.46 1.03 1.99
34 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
35 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
36 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
37 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
38 INT14856 Regulation of Negative_regulation of Tacr1 1 0.20 0.21 1.46
39 INT100569 Positive_regulation of Binding of Tacr1 1 0.50 0.66 1.37
40 INT64562 Positive_regulation of Pde1a 2 0.06 0.28 1.28
41 INT49204 Protein_catabolism of Tacr1 3 0.50 0.84 1.24
42 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
43 INT67852 Negative_regulation of Pde1a 1 0.25 0.18 1.2
44 INT65124 Negative_regulation of Positive_regulation of Tacr1 3 0.53 0.9 1.18
45 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
46 INT219031 Positive_regulation of Regulation of Tacr1 1 0.26 0.65 0.95
47 INT14935 Regulation of Binding of Tacr1 1 0.24 0 0.88
48 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
49 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
50 INT132587 Negative_regulation of Gene_expression of Tacr1 3 0.57 1.22 0.85
51 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
52 INT80118 Gene_expression of NPPC 2 0.68 4.14 0.77
53 INT165240 Negative_regulation of Transcription of Tacr1 3 0.42 0.81 0.74
54 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
55 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
56 INT167854 Positive_regulation of Regulation of Tacr1 1 0.41 0 0.59
57 INT51159 Positive_regulation of Binding of Tacr1 1 0.34 0.17 0.59
58 INT167857 Positive_regulation of Localization of Tacr1 1 0.44 0 0.59
59 INT99832 Regulation of Negative_regulation of Tacr1 2 0.27 1.28 0.56
60 INT51157 Regulation of Binding of Tacr1 1 0.31 0.2 0.56
61 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
62 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
63 INT219033 Regulation of Transcription of Tacr1 1 0.15 0.62 0.46
64 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
65 INT65558 Regulation of Nppc 1 0.21 0.79 0.44
66 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
67 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
68 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
69 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
70 INT116066 Positive_regulation of Nppc 1 0.02 0.44 0.39
71 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
72 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
73 INT146994 Regulation of NPPC 2 0.22 1.46 0.37
74 INT170161 Localization of NPPC 2 0.62 2.06 0.32
75 INT84195 Negative_regulation of Binding of Tacr1 1 0.02 0 0.32
76 INT80117 Positive_regulation of NPPC 3 0.61 0.6 0.31
77 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
78 INT113391 Regulation of Positive_regulation of Tacr1 2 0.35 0.5 0.27
79 INT76401 Localization of Nppc 2 0.54 1.09 0.24
80 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
81 INT170164 Regulation of Gene_expression of NPPC 1 0.37 0.94 0.23
82 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
83 INT170162 Negative_regulation of Localization of NPPC 1 0.35 0.64 0.2
84 INT114371 Negative_regulation of Tcf7l2 1 0.05 0.7 0.2
85 INT166869 Positive_regulation of Pde1a 2 0.59 0.74 0.18
86 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
87 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
88 INT76402 Gene_expression of Nppc 2 0.30 1.8 0.17
89 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
90 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
91 INT245190 Binding of TCF7L2 6 0.48 12.29 0.13
92 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
93 INT196773 Negative_regulation of Positive_regulation of Pde1a 1 0.01 0 0.11
94 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
95 INT245191 Positive_regulation of TCF7L2 2 0.46 1.54 0.07
96 INT175695 Positive_regulation of Gene_expression of Nppc 1 0.06 1.06 0.07
97 INT210243 Negative_regulation of Bmp4 1 0.55 0.55 0.07
98 INT196030 Positive_regulation of Bmp4 6 0.62 2.55 0.04
99 INT210238 Positive_regulation of Negative_regulation of Bmp4 1 0.47 0 0.04
100 INT253182 Positive_regulation of Positive_regulation of Bmp4 1 0.45 0.58 0.04
101 INT276013 Phosphorylation of Pde1a 1 0.18 0 0.03
102 INT263191 Gene_expression of Pde1a 7 0.21 0.33 0
103 INT196034 Positive_regulation of Gene_expression of Bmp4 4 0.45 0.63 0
104 INT260779 Negative_regulation of Bmp4 4 0.23 0.94 0
105 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
106 INT196027 Binding of Bmp4 2 0.13 0.97 0
107 INT142119 Regulation of Bmp4 2 0.58 0.29 0
108 INT210256 Positive_regulation of Tcf7l2 2 0.28 1.25 0
109 INT277402 Gene_expression of TCF7L2 1 0.48 1.67 0
110 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
111 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
112 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
113 INT300368 Regulation of TCF7L2 1 0.15 2.43 0
114 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
115 INT339667 Localization of Bmp4 1 0.38 0.27 0
116 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
117 INT277384 Transcription of TCF7L2 1 0.55 0.82 0
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