GO:0048665

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Name neuron fate specification
Categary Process
Go Slim No
Go Link GO:0048665
Unique Molecular Interactions 79
Total Molecular Interactions 110
Total Single Events 553
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neuron fate specification. They are ordered first by their pain relevance and then by number of times they were reported for neuron fate specification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
2 INT298283 Pou4f1 Positive_regulation of Gene_expression of Runx1 1 0.50 1.4 1.48
3 INT242623 Binding of Ntf3 and Ntrk3 5 0.22 1.31 1.29
4 INT298260 Binding of Runx3 and Pou4f1 1 0.52 2.08 1.22
5 INT298272 Runx1 Positive_regulation of Gene_expression of Ntrk3 1 0.52 0.88 1.09
6 INT298292 Runx3 Positive_regulation of Gene_expression of Ntrk3 1 0.35 1.36 1.09
7 INT298279 Pou4f1 Positive_regulation of Gene_expression of Runx3 1 0.50 1.31 0.81
8 INT242626 Binding of Ngf and Ntrk3 3 0.15 0.27 0.77
9 INT351374 Mir470 Negative_regulation of Ntrk3 1 0.00 1.55 0.7
10 INT242635 Binding of Bdnf and Ntrk3 3 0.25 0.98 0.64
11 INT298262 Pou4f1 Positive_regulation of Positive_regulation of Ntrk3 1 0.36 0.79 0.63
12 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
13 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
14 INT298263 Pou4f1 Regulation of Gene_expression of Ntrk1 1 0.34 0.61 0.43
15 INT298287 Runx1 Negative_regulation of Gene_expression of Ntrk3 1 0.32 0.4 0.43
16 INT298291 Runx3 Negative_regulation of Gene_expression of Ntrk3 1 0.32 0.4 0.43
17 INT298270 Gene_expression of Runx1 Positive_regulation of Ntrk3 1 0.35 0.34 0.4
18 INT298259 Pou4f1 Negative_regulation of Gene_expression of Runx3 1 0.46 0.58 0.4
19 INT298261 Pou4f1 Negative_regulation of Gene_expression of Runx1 1 0.45 0.58 0.4
20 INT298281 Pou4f1 Regulation of Gene_expression of Runx3 1 0.66 0.61 0.37
21 INT298285 Pou4f1 Positive_regulation of Runx3 1 0.50 0.56 0.32
22 INT298269 Positive_regulation of Pou4f1 Positive_regulation of Runx3 1 0.50 0.56 0.32
23 INT156151 POU4F1 Positive_regulation of Gene_expression of NTRK1 1 0.46 0.37 0.31
24 INT156163 POU4F1 Positive_regulation of NTRK1 1 0.46 0.37 0.31
25 INT203529 Pou4f1 Regulation of target gene 1 0.01 0.53 0.3
26 INT298264 Binding of Pou4f1 and Hist1h3f 1 0.12 0.49 0.3
27 INT203526 Regulation of Pou4f1 Regulation of target gene 1 0.01 0.54 0.3
28 INT298282 Pou4f1 Regulation of Gene_expression of Runx1 1 0.48 0.36 0.29
29 INT156152 POU4F1 Positive_regulation of Positive_regulation of NTRK1 1 0.31 0.38 0.29
30 INT245562 Ntrk3 Regulation of Runx3 1 0.40 0.77 0.29
31 INT156149 Binding of HCFC1 and POU4F1 1 0.27 0.39 0.28
32 INT156154 POU4F1 Positive_regulation of HCFC1 1 0.36 0.38 0.28
33 INT298277 Pou4f1 Negative_regulation of Gene_expression of Neurod1 1 0.58 0.48 0.27
34 INT298280 Pou4f1 Negative_regulation of Gene_expression of Neurod4 1 0.38 0.48 0.27
35 INT156150 POU4F1 Regulation of Gene_expression of NTRK1 1 0.18 0.39 0.27
36 INT298297 Pou4f1 Positive_regulation of Gene_expression of Ntrk2 1 0.50 0.36 0.24
37 INT70661 Binding of Hrasls and Nkx2-2 1 0.02 0 0.24
38 INT298290 Pou4f1 Regulation of Gene_expression of Ntrk2 1 0.29 0.48 0.23
39 INT203527 Pou4f1 Negative_regulation of Neurod1 1 0.32 0.54 0.2
40 INT203531 Pou4f1 Negative_regulation of Neurod4 1 0.46 0.54 0.2
41 INT223477 Binding of Ntrk1 and Ntrk3 2 0.16 0.3 0.19
42 INT203532 Negative_regulation of Pou4f1 Negative_regulation of Gene_expression of Pou4f2 1 0.34 0.44 0.19
43 INT298273 Binding of Pou4f1 and target gene site 1 0.01 0.53 0.18
44 INT203528 Binding of Pou4f1 and H3 1 0.17 0.42 0.18
45 INT298288 Negative_regulation of Runx3 Positive_regulation of Negative_regulation of Ntrk3 1 0.35 0.27 0.17
46 INT23780 Ntrk3 Positive_regulation of Localization of Prl 1 0.11 0 0.08
47 INT243255 Binding of Cfp and Pou4f1 1 0.23 0.6 0.07
48 INT125208 Pou4f1 Negative_regulation of Gene_expression of Th 1 0.28 0.67 0.07
49 INT125209 Pou4f1 Positive_regulation of Gene_expression of Th 1 0.33 0.67 0.07
50 INT298257 Pou4f1 Negative_regulation of Proc 1 0.01 0.54 0.03
51 INT244856 Lbx1 Regulation of Isl1 1 0.60 0 0
52 INT262169 Binding of Foxa2 and Nr1i2 1 0.17 0.33 0
53 INT262183 Foxa2 Positive_regulation of Gene_expression of Hmgcs2 1 0.10 0.22 0
54 INT197309 Ascl1 Regulation of Neurod1 1 0.01 0.13 0
55 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0
56 INT298268 Regulation of Pou4f1 Regulation of Gene_expression of Avp 1 0.00 0.09 0
57 INT269954 Sox17 Regulation of Gene_expression of Foxa2 1 0.43 0 0
58 INT323254 Binding of Ptprv and Isl1 1 0.00 0.6 0
59 INT244860 Lbx1 Negative_regulation of Isl1 1 0.16 0 0
60 INT269933 Foxa2 Regulation of Gene_expression of Foxj1 1 0.27 0 0
61 INT244851 Lbx1 Negative_regulation of Pou4f1 1 0.38 0 0
62 INT323253 Binding of Ins1 and Isl1 1 0.00 0.59 0
63 INT269941 Sox17 Regulation of Gene_expression of Foxa1 1 0.56 0 0
64 INT269917 Foxa1 Regulation of Gene_expression of Scgb1a1 1 0.24 0 0
65 INT240011 Ass1 Positive_regulation of Gene_expression of Nkx2-2 1 0.00 0 0
66 INT323251 Binding of Isl1 and Uchl1 1 0.00 0.6 0
67 INT197314 Hes5 Regulation of Ascl1 1 0.00 0.14 0
68 INT197310 Hes1 Regulation of Ascl1 1 0.01 0.14 0
69 INT197307 Ascl1 Regulation of Neurod6 1 0.00 0.13 0
70 INT269939 Foxa1 Regulation of Gene_expression of Foxj1 1 0.26 0 0
71 INT223476 Binding of Ntrk3 and Dok5 1 0.20 0.17 0
72 INT269927 Foxa2 Regulation of Gene_expression of Scgb1a1 1 0.26 0 0
73 INT323252 Binding of H2-Ab1 and Isl1 1 0.00 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for neuron fate specification. They are ordered first by their pain relevance and then by number of times they were reported in neuron fate specification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77
2 INT203473 Gene_expression of Pou4f1 69 0.76 25.94 11.36
3 INT67116 Gene_expression of Ntrk3 20 0.59 7.64 8.94
4 INT105215 Negative_regulation of Pou4f1 16 0.53 9.42 5.97
5 INT48840 Gene_expression of Nkx2-2 8 0.23 1.55 5.44
6 INT203506 Positive_regulation of Pou4f1 3 0.49 6.17 4.85
7 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
8 INT15257 Positive_regulation of Nkx2-2 10 0.21 1.75 4.2
9 INT51180 Regulation of Nkx2-2 5 0.26 2.16 4.14
10 INT105217 Regulation of Pou4f1 8 0.60 6.15 3.88
11 INT8600 Binding of Nkx2-2 6 0.10 0.87 3.82
12 INT298246 Positive_regulation of Ntrk3 7 0.48 3.81 3.01
13 INT122881 Negative_regulation of Ntrk3 10 0.51 5.52 2.04
14 INT162454 Positive_regulation of Gene_expression of Ntrk3 3 0.69 4.28 1.74
15 INT200051 Negative_regulation of Gene_expression of Ntrk3 4 0.40 3.55 1.6
16 INT244735 Gene_expression of Ascl1 12 0.58 2.48 1.54
17 INT112845 Negative_regulation of Binding of Nkx2-2 2 0.12 0.14 1.47
18 INT132081 Regulation of Gene_expression of Nkx2-2 2 0.10 0.24 1.43
19 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
20 INT203436 Negative_regulation of Gene_expression of Pou4f1 4 0.57 2.88 1.14
21 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
22 INT298235 Binding of Pou4f1 1 0.47 2.95 1.11
23 INT242519 Localization of Ntrk3 3 0.52 3.32 1.08
24 INT203498 Localization of Pou4f1 5 0.73 3.29 1.07
25 INT242562 Binding of Ntrk3 4 0.26 1.34 0.99
26 INT67117 Negative_regulation of Gene_expression of Ntrk3 1 0.30 0.24 0.96
27 INT243240 Transcription of Pou4f1 2 0.68 1.91 0.94
28 INT203489 Positive_regulation of Gene_expression of Pou4f1 3 0.49 2.33 0.84
29 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
30 INT67115 Transcription of Ntrk3 1 0.37 0.19 0.81
31 INT67118 Regulation of Gene_expression of Ntrk3 1 0.31 0.17 0.79
32 INT82071 Regulation of Ntrk3 1 0.14 0.25 0.76
33 INT138396 Transcription of Nkx2-2 1 0.26 0.05 0.75
34 INT138395 Positive_regulation of Transcription of Nkx2-2 1 0.19 0.05 0.75
35 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
36 INT122880 Regulation of Ntrk3 4 0.43 1.89 0.66
37 INT298240 Regulation of Positive_regulation of Ntrk3 1 0.31 0.78 0.62
38 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
39 INT125207 Positive_regulation of Negative_regulation of Pou4f1 1 0.21 0.69 0.5
40 INT48503 Positive_regulation of Positive_regulation of Nkx2-2 1 0.15 0 0.42
41 INT203518 Regulation of Localization of Pou4f1 1 0.44 1.15 0.42
42 INT17937 Gene_expression of Isl1 4 0.27 0.48 0.36
43 INT131415 Gene_expression of POU4F1 1 0.60 1.87 0.36
44 INT237469 Positive_regulation of Ntrk3 1 0.46 0.05 0.34
45 INT122619 Gene_expression of Nkx2-2 6 0.36 0.15 0.31
46 INT172806 Localization of ISL1 4 0.26 2.64 0.29
47 INT242533 Positive_regulation of Binding of Ntrk3 1 0.24 0 0.29
48 INT78132 Binding of Isl1 1 0.16 0 0.27
49 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26
50 INT173797 Negative_regulation of Isl1 3 0.37 0.15 0.26
51 INT208497 Localization of Nkx2-2 1 0.01 0 0.26
52 INT173792 Negative_regulation of Negative_regulation of Isl1 1 0.08 0.15 0.26
53 INT310471 Regulation of Ascl1 1 0.34 0.19 0.22
54 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19
55 INT243778 Binding of Isl1 1 0.26 0 0.19
56 INT310462 Positive_regulation of Gene_expression of Ascl1 1 0.37 0.52 0.17
57 INT98772 Localization of Isl1 2 0.65 0 0.16
58 INT201210 Negative_regulation of ISL1 2 0.02 0.4 0.16
59 INT310488 Binding of Ascl1 1 0.28 0.25 0.16
60 INT203450 Negative_regulation of Localization of Pou4f1 1 0.42 0.4 0.14
61 INT131412 Regulation of POU4F1 1 0.21 0.69 0.14
62 INT131409 Positive_regulation of Gene_expression of POU4F1 1 0.54 0.63 0.13
63 INT98774 Regulation of Localization of Isl1 1 0.08 0 0.13
64 INT256032 Phosphorylation of Ntrk3 2 0.39 0.61 0.12
65 INT203492 Negative_regulation of Positive_regulation of Pou4f1 1 0.36 0.68 0.11
66 INT207829 Positive_regulation of Localization of ISL1 1 0.02 0.1 0.1
67 INT173473 Positive_regulation of Positive_regulation of Isl1 1 0.02 0.06 0.09
68 INT310484 Positive_regulation of Ascl1 1 0.37 0.47 0.09
69 INT173470 Positive_regulation of Phosphorylation of Isl1 1 0.02 0 0.09
70 INT173471 Phosphorylation of Isl1 1 0.04 0 0.09
71 INT298237 Regulation of Isl1 1 0.03 0.24 0.06
72 INT289490 Negative_regulation of Negative_regulation of Pou4f1 1 0.32 0.09 0.06
73 INT122620 Negative_regulation of Gene_expression of Nkx2-2 1 0.20 0 0.04
74 INT352541 Transcription of ISL1 1 0.36 0.2 0.03
75 INT200834 Positive_regulation of Foxa2 2 0.32 0.08 0
76 INT180121 Phosphorylation of Isl1 1 0.27 0 0
77 INT180097 Positive_regulation of Phosphorylation of Isl1 1 0.17 0 0
78 INT227625 Regulation of ISL1 1 0.05 0.35 0
79 INT269871 Gene_expression of Foxa1 1 0.61 0 0
80 INT243237 Regulation of Gene_expression of Pou4f1 1 0.25 0.27 0
81 INT143655 Transcription of Nkx2-2 1 0.58 0 0
82 INT262045 Phosphorylation of Foxa2 1 0.34 0.08 0
83 INT243780 Positive_regulation of Gene_expression of Isl1 1 0.35 0 0
84 INT183071 Negative_regulation of Gene_expression of ISL1 1 0.20 0.34 0
85 INT262071 Binding of Foxa2 1 0.15 0.68 0
86 INT143654 Positive_regulation of Transcription of Nkx2-2 1 0.56 0 0
87 INT262084 Negative_regulation of Binding of Foxa2 1 0.18 0.23 0
88 INT262125 Negative_regulation of Foxa2 1 0.18 0.08 0
89 INT298239 Positive_regulation of Binding of Pou4f1 1 0.46 0.09 0
90 INT269888 Gene_expression of Foxa2 1 0.65 0 0
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