GO:0048669

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Name collateral sprouting in absence of injury
Categary Process
Go Slim No
Go Link GO:0048669
Unique Molecular Interactions 159
Total Molecular Interactions 237
Total Single Events 2668
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for collateral sprouting in absence of injury. They are ordered first by their pain relevance and then by number of times they were reported for collateral sprouting in absence of injury. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
2 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
3 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
4 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
5 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
6 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
7 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
8 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
9 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
10 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
11 INT2700 Binding of App and Cpe 1 0.00 0 0.63
12 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
13 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
14 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
15 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
16 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
17 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
18 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
19 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
20 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
21 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
22 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
23 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
24 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
25 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
26 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
27 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
28 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
29 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
30 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
31 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
32 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4
33 INT78122 Binding of App and 20S 1 0.16 0.61 0.4
34 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
35 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37
36 INT124376 Prodh2 Positive_regulation of App 1 0.00 0.66 0.33
37 INT124379 Prodh2 Positive_regulation of Localization of App 1 0.00 0.66 0.33
38 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32
39 INT147434 Psenen Positive_regulation of APP 1 0.01 0.58 0.32
40 INT68977 App Positive_regulation of Localization of Mmp9 1 0.05 0.38 0.3
41 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
42 INT319220 FSIP1 Regulation of APP 1 0.29 1.46 0.29
43 INT79592 Binding of APP and Reg1 1 0.01 0.16 0.27
44 INT25946 Regulation of Binding of Penk and App 1 0.18 0.19 0.27
45 INT25944 Binding of Penk and App 1 0.15 0.19 0.27
46 INT356094 Binding of App and Tg 1 0.08 0.12 0.26
47 INT139980 Negative_regulation of CTSB Negative_regulation of Gene_expression of APP 1 0.15 0.7 0.26
48 INT139981 CTSB Negative_regulation of Gene_expression of APP 1 0.11 0.7 0.26
49 INT39010 App Negative_regulation of Gene_expression of Gnrh1 1 0.05 0.07 0.26
50 INT114244 Cpox Negative_regulation of Gene_expression of APP 1 0.00 0.7 0.25
51 INT191619 Binding of App and Flna 1 0.04 0.18 0.24
52 INT70082 Binding of APP and TGM1 1 0.00 1.22 0.22
53 INT319971 App Regulation of Enpp1 1 0.02 0.72 0.21
54 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19
55 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19
56 INT25945 Plat Regulation of App 1 0.15 0.25 0.17
57 INT25947 Plat Regulation of Transcription of App 1 0.15 0.25 0.17
58 INT319974 App Negative_regulation of Enpp1 1 0.02 0.58 0.16
59 INT204478 Fmr1 Regulation of Gene_expression of App 1 0.50 1.44 0.16
60 INT201744 Ngf Regulation of Transcription of App 1 0.06 0.39 0.15
61 INT201728 Ntrk1 Regulation of Transcription of App 1 0.03 0.39 0.15
62 INT319972 App Negative_regulation of Gene_expression of Enpp1 1 0.02 1.87 0.15
63 INT286476 Binding of App and Itm2b 1 0.47 5.24 0.14
64 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
65 INT139849 Binding of App and Bace1 7 0.41 0.85 0.13
66 INT204489 Fmr1 Regulation of App 1 0.50 1.71 0.13
67 INT220622 App Positive_regulation of Rip 2 0.14 0.24 0.12
68 INT308660 Binding of Ager and App 1 0.08 1.22 0.12
69 INT70084 Negative_regulation of Binding of APP and TGM1 1 0.00 0.61 0.11
70 INT70083 TGM1 Positive_regulation of Binding of APP 1 0.00 0.61 0.11
71 INT123101 Binding of APP and Ache 1 0.07 0.32 0.11
72 INT204477 Binding of App and Scn10a 1 0.17 0.36 0.1
73 INT139847 Binding of App and Bace2 1 0.03 0.16 0.1
74 INT139850 Binding of MBTPS1 and App 1 0.00 0.16 0.1
75 INT193963 App Regulation of Gene_expression of Ps 1 0.06 0.93 0.09
76 INT356112 Binding of App and Apba1 1 0.24 0.29 0.09
77 INT262701 App Positive_regulation of Aplp2 1 0.12 0.25 0.09
78 INT262705 App Positive_regulation of Aplp1 1 0.13 0.25 0.09
79 INT124036 Binding of App and Dnahc8 1 0.03 0.14 0.09
80 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
81 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
82 INT204487 Positive_regulation of Fmr1 Regulation of Gene_expression of App 1 0.30 0.8 0.08
83 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
84 INT198934 Binding of App and Lrp1b 2 0.27 1.62 0.05
85 INT288099 Binding of APP and App 1 0.01 1.04 0.05
86 INT356086 Negative_regulation of Binding of App and Lrp1b 1 0.30 1.42 0.05
87 INT356110 Binding of App and Slc5a7 1 0.02 0.25 0.05
88 INT236009 HIST2H2AA3 Positive_regulation of Protein_catabolism of APP 1 0.02 0.19 0.04
89 INT236015 HIST2H2AA3 Positive_regulation of Gene_expression of APP 1 0.02 0.95 0.04
90 INT162753 Binding of APP and Slc30a2 1 0.00 1.25 0.04
91 INT319973 App Regulation of Gene_expression of Mapk12 1 0.02 0.98 0.04
92 INT162754 Negative_regulation of Binding of APP and Slc30a2 1 0.00 1.26 0.04
93 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
94 INT198921 Binding of App and Lrp1 3 0.32 2.7 0.03
95 INT356102 Negative_regulation of Binding of App and Lrp1 1 0.32 0.71 0.03
96 INT237090 Binding of App and Bnip3l 1 0.18 1.66 0.03
97 INT230137 OSBP Regulation of APP 1 0.59 0.15 0.03
98 INT356097 Binding of App and Apba3 1 0.12 0.12 0.03
99 INT270432 Lhb Positive_regulation of APP 1 0.03 0.51 0.03
100 INT356090 Binding of Apba2 and App 1 0.00 0.12 0.03
101 INT270431 Gnrh1 Positive_regulation of APP 1 0.06 0.51 0.03
102 INT220628 Gene_expression of Gga1 Positive_regulation of App 2 0.22 0 0
103 INT220625 Negative_regulation of Binding of App and Bace1 1 0.44 0.09 0
104 INT356108 App Positive_regulation of Positive_regulation of Lrp1 1 0.43 0.52 0
105 INT333770 Bace1 Regulation of Gene_expression of App 1 0.57 0 0
106 INT204493 App Negative_regulation of Scn10a 1 0.20 0.74 0
107 INT236013 HIST2H2AA3 Regulation of Gene_expression of APP 1 0.01 0 0
108 INT204499 App Regulation of Fmr1 1 0.50 0.59 0
109 INT204492 Negative_regulation of Binding of App and Fmr1 1 0.42 0.28 0
110 INT356083 Binding of App and Notch1 1 0.02 0.2 0
111 INT356095 Lrp1 Positive_regulation of App 1 0.37 0.53 0
112 INT204502 Binding of App and RNPC3 1 0.01 0.09 0
113 INT356091 Lrp1 Positive_regulation of Positive_regulation of App 1 0.43 0.52 0
114 INT204481 App Negative_regulation of Positive_regulation of Scn10a 1 0.20 0.74 0
115 INT356100 Binding of Apbb1 and App 1 0.14 0.43 0
116 INT356087 Binding of App and Ncstn 1 0.17 0.07 0
117 INT230140 Gene_expression of OSBP Regulation of Localization of APP 1 0.30 0.06 0
118 INT198933 Binding of Apoe and App 1 0.33 0.19 0
119 INT198927 Lrp1 Regulation of App 1 0.14 0.42 0
120 INT204482 Fmr1 Negative_regulation of App 1 0.42 0.74 0
121 INT334643 Binding of APP and HM13 1 0.02 0 0
122 INT356118 Binding of SORL1 and App 1 0.41 0.43 0
123 INT230146 Binding of APP and SORL1 1 0.20 0.17 0
124 INT356109 Rab6a Regulation of App 1 0.14 0.05 0
125 INT180123 Egfl7 Positive_regulation of App 1 0.02 0.07 0
126 INT356106 Gene_expression of Pld1 Positive_regulation of App 1 0.29 0.21 0
127 INT225629 APP Positive_regulation of Positive_regulation of nr 1 0.01 0.08 0
128 INT217396 Binding of Abca1 and App 1 0.26 0.83 0
129 INT262708 Bace1 Positive_regulation of Gene_expression of App 1 0.44 2.82 0
130 INT198915 Binding of App and Lrp8 1 0.24 0.17 0
131 INT230139 OSBP Regulation of Phosphorylation of APP 1 0.50 0 0
132 INT142955 Positive_regulation of Binding of APP and BACE1 1 0.48 0.5 0
133 INT262713 App Regulation of Transcription of Bace1 1 0.45 0.31 0
134 INT198925 Binding of App and Ldlr 1 0.14 0.15 0
135 INT333773 Bace1 Regulation of App 1 0.25 0 0
136 INT230143 OSBP Regulation of Gene_expression of APP 1 0.50 0.1 0
137 INT142954 Binding of APP and BACE1 1 0.37 0.5 0
138 INT204491 Ass1 Positive_regulation of App 1 0.01 0.43 0
139 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
140 INT50104 Bche Regulation of Localization of App 1 0.43 0.2 0
141 INT356104 Positive_regulation of Binding of App and Lrp1 1 0.40 0.52 0
142 INT230151 OSBP Regulation of Localization of APP 1 0.50 0 0
143 INT220624 Eif1 Regulation of App 1 0.00 0.1 0
144 INT204496 App Positive_regulation of Scn10a 1 0.20 0.48 0
145 INT225627 APP Positive_regulation of nr 1 0.02 0.08 0
146 INT230149 Binding of APP and NOTCH2 1 0.32 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for collateral sprouting in absence of injury. They are ordered first by their pain relevance and then by number of times they were reported in collateral sprouting in absence of injury. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31
2 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
3 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
4 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
5 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
6 INT11625 Localization of App 98 0.78 55.46 20.86
7 INT16794 Binding of App 103 0.48 64.87 19.79
8 INT65502 Regulation of App 77 0.62 52.05 19.44
9 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
10 INT54052 Gene_expression of App 33 0.78 25.08 14.7
11 INT29745 Binding of APP 47 0.48 26.49 12.4
12 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
13 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
14 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
15 INT41569 Regulation of APP 32 0.62 17.15 9.4
16 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
17 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
18 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
19 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
20 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
21 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
22 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
23 INT58003 Localization of APP 32 0.80 13.75 4.2
24 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
25 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
26 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
27 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
28 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96
29 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93
30 INT178772 Transcription of App 17 0.70 10.79 2.79
31 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78
32 INT54054 Binding of App 4 0.48 10.89 2.78
33 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36
34 INT11626 Regulation of Localization of App 4 0.45 1.51 2.34
35 INT56030 Regulation of App 8 0.62 4.06 2.32
36 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09
37 INT39008 Localization of App 13 0.77 9.07 2.05
38 INT142774 Regulation of Phosphorylation of App 1 0.59 2.27 1.93
39 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78
40 INT107915 Regulation of Negative_regulation of App 6 0.45 4.47 1.76
41 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52
42 INT58004 Positive_regulation of Localization of APP 5 0.46 2.1 1.5
43 INT25943 Transcription of App 5 0.53 1.79 1.44
44 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41
45 INT129700 Regulation of Positive_regulation of App 3 0.43 1.86 1.41
46 INT141529 Regulation of Positive_regulation of APP 3 0.44 0.31 1.34
47 INT103488 Positive_regulation of Localization of App 5 0.50 3.05 1.28
48 INT100137 Positive_regulation of Negative_regulation of App 2 0.41 1.26 1.16
49 INT135899 Regulation of Binding of APP 3 0.45 1.22 1.14
50 INT39009 Negative_regulation of App 6 0.38 3.37 1.07
51 INT167607 Positive_regulation of Binding of App 8 0.50 2.97 0.86
52 INT162514 Positive_regulation of Regulation of APP 1 0.41 0.37 0.86
53 INT99375 Positive_regulation of Binding of APP 3 0.61 1.63 0.83
54 INT118078 Phosphorylation of APP 10 0.79 2.5 0.76
55 INT99820 Negative_regulation of Localization of APP 2 0.37 0.75 0.76
56 INT112208 Negative_regulation of Gene_expression of App 4 0.59 1.88 0.68
57 INT25942 Regulation of Transcription of App 3 0.27 0.95 0.68
58 INT141528 Regulation of Localization of APP 2 0.52 0.4 0.67
59 INT61147 Protein_catabolism of App 3 0.60 3.76 0.63
60 INT118077 Negative_regulation of Phosphorylation of APP 1 0.07 0.74 0.61
61 INT142112 Regulation of Regulation of App 3 0.39 2.46 0.59
62 INT225462 Positive_regulation of Positive_regulation of APP 3 0.44 1.41 0.55
63 INT78117 Positive_regulation of Positive_regulation of App 4 0.48 2.6 0.51
64 INT167614 Positive_regulation of Protein_catabolism of App 1 0.30 0.88 0.44
65 INT54056 Negative_regulation of Binding of App 2 0.37 0.99 0.32
66 INT178773 Positive_regulation of Regulation of App 2 0.49 1.01 0.32
67 INT178774 Positive_regulation of Transcription of App 2 0.49 1.17 0.31
68 INT180104 Positive_regulation of Phosphorylation of App 2 0.54 0.87 0.16
69 INT286326 Regulation of Transcription of App 3 0.45 0.26 0.15
70 INT69045 Negative_regulation of Positive_regulation of App 1 0.05 0.28 0.13
71 INT142958 Positive_regulation of Protein_catabolism of APP 3 0.55 2.04 0.1
72 INT39007 Negative_regulation of Localization of App 3 0.10 0.94 0.08
73 INT180116 Negative_regulation of Transcription of App 1 0.38 0 0.04
74 INT182830 Negative_regulation of Protein_catabolism of APP 2 0.35 2.09 0.03
75 INT255657 Negative_regulation of Protein_catabolism of App 1 0.20 1.07 0.03
76 INT351386 Negative_regulation of Phosphorylation of App 1 0.42 0.82 0.03
77 INT50103 Regulation of Localization of App 2 0.26 0.2 0
78 INT234255 Transcription of APP 2 0.49 0.98 0
79 INT286323 Negative_regulation of Protein_catabolism of App 1 0.11 0.54 0
80 INT236037 Positive_regulation of Phosphorylation of APP 1 0.48 0.14 0
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