GO:0048701

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Name embryonic cranial skeleton morphogenesis
Categary Process
Go Slim No
Go Link GO:0048701
Unique Molecular Interactions 341
Total Molecular Interactions 428
Total Single Events 3392
Pain Genes Associated 30

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for embryonic cranial skeleton morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for embryonic cranial skeleton morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
2 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
3 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
4 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
5 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
6 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
7 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95
8 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
9 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
10 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
11 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
12 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
13 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
14 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
15 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
16 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
17 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
18 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
19 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
20 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
21 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
22 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
23 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
24 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
25 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
26 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
27 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
28 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
29 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
30 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
31 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
32 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
33 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
34 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
35 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
36 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
37 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
38 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
39 INT152158 NENF Regulation of TWIST1 1 0.01 0.33 0.4
40 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
41 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
42 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
43 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
44 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
45 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
46 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
47 INT245554 Tbx15 Positive_regulation of Gene_expression of Ntrk1 1 0.02 0.65 0.29
48 INT137023 Gene_expression of SMAD2 Negative_regulation of Gene_expression of Acta2 1 0.00 0.43 0.29
49 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26
50 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
51 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26
52 INT245557 Runx1 Positive_regulation of Gene_expression of Tbx15 1 0.02 0.75 0.25
53 INT245561 Gene_expression of Runx1 Positive_regulation of Gene_expression of Tbx15 1 0.02 0.8 0.25
54 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
55 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
56 INT245567 Tbx15 Positive_regulation of Ntrk1 1 0.02 0.9 0.24
57 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
58 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
59 INT302367 Dlx2 Regulation of Gene_expression of Arx 1 0.59 0.23 0.22
60 INT310494 Gene_expression of Dlx2 Positive_regulation of Fate1 1 0.04 0.1 0.18
61 INT306425 Positive_regulation of Binding of TBX1 and VCF 1 0.02 1.15 0.18
62 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
63 INT306426 Binding of TBX1 and VCF 1 0.01 1.09 0.17
64 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
65 INT148563 Ngf Positive_regulation of GNAS 1 0.06 0.07 0.16
66 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
67 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
68 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
69 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15
70 INT350713 MIR219-1 Negative_regulation of Pdgfra 1 0.00 0.4 0.15
71 INT95103 TGFBR2 Positive_regulation of CD34 1 0.11 0.61 0.14
72 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
73 INT223963 Binding of Bglap and Runx2 1 0.14 1.74 0.13
74 INT184704 Binding of Prrx2 and Sr1 1 0.21 1.65 0.13
75 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
76 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
77 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
78 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11
79 INT84867 Ptger1 Negative_regulation of SETD2 1 0.00 1.09 0.11
80 INT316823 Sparc Positive_regulation of Phosphorylation of Smad2 1 0.44 0.49 0.1
81 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
82 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
83 INT255289 Snap25 Regulation of Gene_expression of Gnas 1 0.00 0 0.09
84 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
85 INT284303 Mir155 Negative_regulation of Gnas 1 0.00 0.49 0.08
86 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
87 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08
88 INT191758 ROS1 Positive_regulation of TFAP2A 1 0.01 0.54 0.08
89 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
90 INT273372 IL6 Regulation of Regulation of TWIST1 1 0.10 0.1 0.07
91 INT273366 IL6 Regulation of TWIST1 1 0.06 0.1 0.07
92 INT84751 Binding of HRAS and TWIST1 1 0.29 2.6 0.07
93 INT349886 Negative_regulation of Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
94 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
95 INT243637 Il12a Positive_regulation of Transcription of Twist1 1 0.18 0.12 0.06
96 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
97 INT349887 Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
98 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
99 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
100 INT243633 Il23a Positive_regulation of Gene_expression of Twist1 1 0.14 0.11 0.05
101 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
102 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
103 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
104 INT233852 Twist1 Positive_regulation of Snai1 1 0.02 0.58 0.04
105 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
106 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
107 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
108 INT263431 Trib3 Regulation of Pdgfra 1 0.00 0 0.04
109 INT233851 Twist1 Positive_regulation of Zeb1 1 0.06 0.58 0.04
110 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
111 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
112 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04
113 INT263428 Abl1 Regulation of Pdgfra 1 0.00 0 0.04
114 INT233854 Twist1 Positive_regulation of Itk 1 0.03 0.58 0.04
115 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03
116 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03
117 INT265347 Binding of Ocln and Tgfbr1 1 0.18 0.06 0.03
118 INT265345 Binding of Tgfbr1 and Tjp1 1 0.09 0.06 0.03
119 INT243636 Stat1 Positive_regulation of Gene_expression of Twist1 1 0.46 0.05 0.03
120 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03
121 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03
122 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
123 INT301415 Positive_regulation of Binding of Twist1 and IL19 1 0.11 0.18 0.03
124 INT301416 Binding of Twist1 and IL19 1 0.08 0.18 0.03
125 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03
126 INT265343 Positive_regulation of Binding of Tgfbr1 and Tjp1 1 0.12 0.06 0.03
127 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03
128 INT265348 Positive_regulation of Binding of Ocln and Tgfbr1 1 0.25 0.06 0.03
129 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03
130 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
131 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
132 INT183412 Dnmt3a Positive_regulation of Tbx15 1 0.05 0.27 0
133 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
134 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
135 INT209580 Twist1 Positive_regulation of Localization of VEGFA 1 0.05 0.53 0
136 INT280164 Twist1 Negative_regulation of Mod2 1 0.06 1.76 0
137 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
138 INT249538 Binding of BDNF and GNAS 1 0.08 0 0
139 INT218669 Olr811 Negative_regulation of Phosphorylation of Smad2 1 0.01 0.18 0
140 INT284304 Binding of Adrb3 and Gnas 1 0.00 0.23 0
141 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
142 INT179302 Gene_expression of GNAS Negative_regulation of CA2 1 0.01 0 0
143 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
144 INT265344 sb Negative_regulation of Tgfbr1 1 0.00 0.06 0
145 INT273770 VEGFA Negative_regulation of Localization of Twist1 1 0.07 0.58 0
146 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0
147 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
148 INT284302 Mir155 Regulation of Gnas 1 0.00 0.64 0
149 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0
150 INT350906 Twist1 Positive_regulation of Gene_expression of Cd4 1 0.10 1.49 0
151 INT230762 Binding of DAG1 and Tbx15 1 0.00 0.21 0
152 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
153 INT286988 Twist1 Positive_regulation of EGFR 1 0.17 2.01 0
154 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
155 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
156 INT269936 Smad2 Positive_regulation of Cdkn2b 1 0.15 0.07 0
157 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
158 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0
159 INT121479 Twist1 Negative_regulation of Ins1 1 0.10 0 0
160 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
161 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
162 INT314866 Binding of Six1 and Sall1 1 0.39 0.76 0
163 INT279884 Nipbl Regulation of Transcription of Pcdhb1 1 0.25 0.05 0
164 INT337914 sb Negative_regulation of Phosphorylation of Smad2 1 0.00 0.13 0
165 INT286188 Twist1 Positive_regulation of Serpina5 1 0.02 0 0
166 INT296999 Binding of EPS15 and TFAP2A 1 0.06 0.2 0
167 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
168 INT350907 Twist1 Positive_regulation of Gene_expression of Cd7 1 0.05 1.49 0
169 INT280166 Binding of MAPK8 and Twist1 1 0.19 0.78 0
170 INT245828 Binding of VEGFA and Tfap2a 1 0.01 0.64 0
171 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
172 INT218665 Olr811 Negative_regulation of Phosphorylation of Smad3 1 0.01 0.33 0
173 INT326728 Sox10 Regulation of Twist2 1 0.45 0.05 0
174 INT269929 Binding of Cdkn2b and Smad3 1 0.18 0.89 0
175 INT243623 Il12a Positive_regulation of Twist1 1 0.17 0 0
176 INT269935 Binding of Smad3 and Scn5a 1 0.13 0 0
177 INT277610 Binding of Runx2 and Hdac4 1 0.32 0.78 0
178 INT243624 Stat6 Negative_regulation of Gene_expression of Twist1 1 0.30 0 0
179 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
180 INT183410 Dnmt3b Positive_regulation of Tbx15 1 0.05 0.27 0
181 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
182 INT231169 Gnas Positive_regulation of Gene_expression of Dmd 1 0.00 0.19 0
183 INT185267 Egf Negative_regulation of Gene_expression of Dlx2 1 0.12 0.15 0
184 INT283201 Gm4658 Regulation of Gnas 1 0.00 0.56 0
185 INT268340 TGFBR2 Positive_regulation of Phosphorylation of TGFB1 1 0.25 0.68 0
186 INT337918 sb Positive_regulation of Negative_regulation of Smad2 1 0.00 0.15 0
187 INT310192 Tgfbr1 Positive_regulation of Regulation of Acvrl1 1 0.01 0 0
188 INT213556 Binding of Eya1 and Six1 1 0.41 0.48 0
189 INT280167 Twist1 Positive_regulation of MAPK8 1 0.29 0.94 0
190 INT218670 Olr811 Regulation of Phosphorylation of Smad2 1 0.00 0.33 0
191 INT269938 Smad2 Positive_regulation of Tpt1 1 0.14 0.07 0
192 INT185266 Egf Regulation of Gene_expression of Dlx2 1 0.12 0.07 0
193 INT279888 Binding of Rec8 and Nipbl 1 0.01 0.81 0
194 INT280163 Twist1 Positive_regulation of Mod2 1 0.07 1.67 0
195 INT269946 Binding of Smad3 and Gopc 1 0.08 0 0
196 INT214885 Binding of PDGFRA and Atcay 1 0.08 4.05 0
197 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
198 INT337917 Binding of sb and Tgfbr1 1 0.00 1.06 0
199 INT279890 Nipbl Regulation of Gene_expression of PCDHB@ 1 0.07 0.1 0
200 INT325836 Binding of Dnm2 and Gnas 1 0.00 0.22 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for embryonic cranial skeleton morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in embryonic cranial skeleton morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
2 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19
3 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
4 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
5 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
6 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
7 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
8 INT185252 Gene_expression of Dlx2 7 0.71 8.8 6.24
9 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
10 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
11 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
12 INT98357 Binding of Gnas 11 0.41 1.87 4.35
13 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
14 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
15 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4
16 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
17 INT116540 Binding of Twist1 35 0.48 16.32 2.85
18 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74
19 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55
20 INT127113 Positive_regulation of Phosphorylation of Smad2 1 0.68 2.38 2.51
21 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25
22 INT302340 Positive_regulation of Gene_expression of Dlx2 2 0.64 3.43 2.15
23 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
24 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
25 INT184676 Transcription of Prrx2 1 0.37 3.64 2.02
26 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98
27 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
28 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
29 INT183402 Positive_regulation of Gene_expression of Tbx15 7 0.49 4.87 1.62
30 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
31 INT127115 Regulation of Phosphorylation of Smad2 1 0.60 1.74 1.53
32 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51
33 INT184683 Gene_expression of Prrx2 1 0.37 7.9 1.5
34 INT121347 Binding of GNAS 8 0.13 3.99 1.47
35 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
36 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44
37 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
38 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
39 INT10873 Localization of Twist1 21 0.74 10.43 1.37
40 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
41 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34
42 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
43 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
44 INT310164 Negative_regulation of Gene_expression of Tgfbr1 9 0.40 6.11 1.17
45 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
46 INT84511 Positive_regulation of Tfap2a 3 0.27 0.72 1.04
47 INT184698 Positive_regulation of Prrx2 1 0.38 3.21 1.01
48 INT245514 Regulation of Gene_expression of Tbx15 3 0.01 2.83 0.98
49 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97
50 INT43484 Binding of Runx2 7 0.37 3.22 0.95
51 INT243974 Binding of Tfap2a 7 0.18 1.36 0.93
52 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92
53 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87
54 INT243611 Gene_expression of Twist2 5 0.67 2.85 0.86
55 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
56 INT107939 Regulation of TGFBR2 1 0.37 0.98 0.84
57 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
58 INT221796 Positive_regulation of Gene_expression of Tfap2a 2 0.10 1.19 0.83
59 INT258932 Positive_regulation of TBX1 3 0.39 2.73 0.82
60 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81
61 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
62 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8
63 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76
64 INT215783 Localization of Gnas 1 0.12 1.64 0.76
65 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75
66 INT207535 Transcription of Tfap2a 3 0.31 0.98 0.74
67 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72
68 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69
69 INT135197 Gene_expression of Tfap2a 1 0.45 0.48 0.69
70 INT137009 Negative_regulation of Gene_expression of SMAD2 4 0.42 1.76 0.66
71 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65
72 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65
73 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64
74 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
75 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
76 INT207529 Localization of Tfap2a 2 0.34 0.13 0.6
77 INT249551 Negative_regulation of Transcription of GNAS 1 0.06 0.16 0.6
78 INT80300 Gene_expression of TFAP2A 5 0.54 2.76 0.59
79 INT144922 Gene_expression of TGFBR1 4 0.72 0.19 0.57
80 INT243970 Phosphorylation of Tfap2a 2 0.25 0.56 0.56
81 INT279846 Gene_expression of Nipbl 1 0.68 11.1 0.56
82 INT3831 Negative_regulation of TGFBR2 4 0.28 4.99 0.55
83 INT156254 Gene_expression of Six1 7 0.67 1.52 0.51
84 INT158889 Gene_expression of Smad2 5 0.65 1.25 0.51
85 INT140436 Binding of TWIST1 5 0.39 2.34 0.47
86 INT81357 Regulation of Negative_regulation of Gnas 1 0.02 0.1 0.47
87 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
88 INT159221 Negative_regulation of TBX1 4 0.41 4.22 0.43
89 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
90 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
91 INT65606 Binding of TBX1 2 0.30 3.13 0.41
92 INT292484 Negative_regulation of TGFBR1 3 0.19 0.75 0.39
93 INT80302 Binding of TFAP2A 7 0.39 1.67 0.38
94 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
95 INT120899 Positive_regulation of Gene_expression of Tgfbr2 1 0.29 0.46 0.38
96 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
97 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
98 INT106402 Positive_regulation of TFAP2A 2 0.13 0.35 0.35
99 INT254816 Negative_regulation of Tgfbr1 20 0.55 9.24 0.34
100 INT173635 Negative_regulation of TFAP2A 3 0.34 2.93 0.33
101 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
102 INT156411 Gene_expression of Pdgfra 8 0.75 5.5 0.3
103 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3
104 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
105 INT137008 Positive_regulation of Gene_expression of SMAD2 2 0.49 0.51 0.3
106 INT224877 Positive_regulation of Gene_expression of Smad2 1 0.12 0.16 0.29
107 INT311881 Regulation of Positive_regulation of Tgfbr1 1 0.22 0.97 0.29
108 INT269082 Gene_expression of TBX1 1 0.14 0.36 0.28
109 INT172978 Negative_regulation of SMAD2 4 0.42 0.89 0.27
110 INT292207 Negative_regulation of Gene_expression of TFAP2A 1 0.05 1.2 0.27
111 INT156410 Positive_regulation of Pdgfra 3 0.08 1.51 0.25
112 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
113 INT121475 Regulation of Negative_regulation of Twist1 3 0.14 2.43 0.24
114 INT184670 Localization of Prrx2 1 0.35 0.23 0.24
115 INT184671 Positive_regulation of Localization of Prrx2 1 0.24 0.23 0.24
116 INT108902 Localization of GNAS 5 0.13 1.31 0.23
117 INT306427 Localization of TBX1 1 0.20 1.08 0.23
118 INT129907 Regulation of Smad2 1 0.40 0.87 0.23
119 INT310477 Positive_regulation of Dlx2 1 0.46 0.47 0.23
120 INT306428 Positive_regulation of Localization of TBX1 1 0.14 1.08 0.23
121 INT142117 Regulation of Runx2 6 0.61 2.75 0.22
122 INT265311 Localization of Smad2 5 0.50 1.57 0.21
123 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
124 INT265334 Regulation of Phosphorylation of Smad2 2 0.17 0.96 0.2
125 INT243604 Localization of Twist2 1 0.65 0.54 0.2
126 INT243599 Positive_regulation of Localization of Twist2 1 0.43 0.54 0.2
127 INT171614 Positive_regulation of Runx2 13 0.63 3.04 0.19
128 INT279853 Negative_regulation of Gene_expression of Nipbl 1 0.51 2.37 0.19
129 INT311886 Phosphorylation of Tgfbr1 1 0.40 0.7 0.19
130 INT208539 Positive_regulation of Gene_expression of Gnas 4 0.08 2.76 0.18
131 INT159231 Positive_regulation of PDGFRA 3 0.47 2.39 0.18
132 INT310492 Transcription of Dlx2 1 0.63 0.09 0.18
133 INT310468 Regulation of Gene_expression of Dlx2 1 0.42 0.1 0.18
134 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
135 INT171605 Negative_regulation of Runx2 4 0.46 2.14 0.17
136 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
137 INT268365 Binding of SMAD2 2 0.47 0.56 0.17
138 INT135054 Negative_regulation of Negative_regulation of Twist1 2 0.42 0.46 0.17
139 INT162939 Binding of Tfap2a 1 0.26 0.34 0.17
140 INT162940 Negative_regulation of Tfap2a 1 0.32 0.34 0.17
141 INT162941 Negative_regulation of Binding of Tfap2a 1 0.32 0.34 0.17
142 INT151741 Regulation of PDGFRA 2 0.44 0.78 0.16
143 INT310469 Negative_regulation of Gene_expression of Dlx2 1 0.39 0.66 0.16
144 INT102354 Localization of TWIST1 3 0.75 0.17 0.15
145 INT186632 Regulation of TWIST1 4 0.37 5.28 0.14
146 INT184674 Negative_regulation of Prrx2 1 0.23 3.14 0.14
147 INT135490 Localization of Smad2 1 0.51 0.08 0.14
148 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
149 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
150 INT302662 Negative_regulation of Negative_regulation of TGFBR1 1 0.14 0 0.13
151 INT158893 Negative_regulation of Gene_expression of Smad2 1 0.30 0.13 0.13
152 INT129616 Negative_regulation of Phosphorylation of Smad2 4 0.38 0.78 0.12
153 INT273333 Negative_regulation of Regulation of Twist1 1 0.18 0.3 0.12
154 INT311892 Regulation of Positive_regulation of Smad2 1 0.23 0.24 0.12
155 INT162568 Regulation of TBX1 3 0.35 1.54 0.11
156 INT258933 Protein_catabolism of TBX1 1 0.43 0.75 0.11
157 INT310465 Binding of Dlx2 1 0.34 0.33 0.11
158 INT260148 Negative_regulation of Gene_expression of TGFBR2 3 0.38 3.71 0.1
159 INT184669 Positive_regulation of Transcription of Prrx2 1 0.27 2.71 0.1
160 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
161 INT259802 Positive_regulation of Tbx15 2 0.45 1.87 0.09
162 INT254819 Regulation of Negative_regulation of Tgfbr1 1 0.15 1.2 0.09
163 INT325505 Transcription of Smad2 1 0.67 0.16 0.09
164 INT211942 Transcription of Runx2 3 0.69 2.46 0.08
165 INT136182 Negative_regulation of PDGFRA 3 0.43 2.43 0.08
166 INT107569 Transcription of Gnas 1 0.01 0 0.08
167 INT184689 Regulation of Prrx2 1 0.13 0.77 0.08
168 INT128091 Binding of TGFBR2 1 0.02 0.08 0.08
169 INT232713 Binding of PDGFRA 1 0.35 1.43 0.08
170 INT279840 Positive_regulation of Gene_expression of Nipbl 1 0.44 0.22 0.07
171 INT302964 Protein_catabolism of Tbx15 1 0.02 0.86 0.07
172 INT210243 Negative_regulation of Bmp4 1 0.55 0.55 0.07
173 INT311885 Positive_regulation of Gene_expression of Tgfbr1 2 0.44 0.35 0.06
174 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
175 INT97754 Regulation of Gene_expression of TFAP2A 1 0.36 0.13 0.06
176 INT179307 Regulation of GNAS 7 0.01 1.93 0.05
177 INT268389 Positive_regulation of TGFBR2 1 0.39 0.62 0.05
178 INT350900 Protein_catabolism of Twist1 1 0.22 0.78 0.05
179 INT254814 Positive_regulation of Phosphorylation of Smad2 7 0.33 3.74 0.04
180 INT196030 Positive_regulation of Bmp4 6 0.62 2.55 0.04
181 INT262799 Localization of Smad3 6 0.56 2.09 0.04
182 INT273406 Positive_regulation of Gene_expression of TWIST1 4 0.57 8.42 0.04
183 INT337908 Binding of Smad2 3 0.24 1.06 0.04
184 INT277277 Regulation of Gene_expression of Gnas 2 0.00 0.33 0.04
185 INT141476 Regulation of Gene_expression of TWIST1 2 0.50 2.57 0.04
186 INT210238 Positive_regulation of Negative_regulation of Bmp4 1 0.47 0 0.04
187 INT353261 Negative_regulation of Localization of Smad2 1 0.33 0 0.04
188 INT279862 Binding of Nipbl 1 0.36 1.22 0.04
189 INT253182 Positive_regulation of Positive_regulation of Bmp4 1 0.45 0.58 0.04
190 INT184682 Negative_regulation of Gene_expression of Prrx2 1 0.23 1.5 0.04
191 INT279851 Positive_regulation of Nipbl 1 0.44 0.19 0.04
192 INT353263 Positive_regulation of Localization of Smad2 1 0.33 0.15 0.04
193 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
194 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
195 INT254799 Transcription of Smad2 1 0.19 0.52 0.03
196 INT353266 Negative_regulation of Negative_regulation of Smad2 1 0.28 0 0.03
197 INT279869 Negative_regulation of Nipbl 1 0.43 4.3 0.03
198 INT296618 Negative_regulation of Smad2 1 0.37 1.42 0.03
199 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
200 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
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