GO:0048705

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Name skeletal system morphogenesis
Categary Process
Go Slim No
Go Link GO:0048705
Unique Molecular Interactions 362
Total Molecular Interactions 483
Total Single Events 4616
Pain Genes Associated 40

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for skeletal system morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for skeletal system morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT269444 Binding of RAB5A and HHIP 1 0.04 0 5.79
2 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
3 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81
4 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
5 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
6 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
7 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23
8 INT120313 Gnrhr Negative_regulation of Mmp2 1 0.03 0.85 1.07
9 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
10 INT269443 Positive_regulation of Binding of RAB5A and HHIP 1 0.04 0 1.06
11 INT204551 Binding of Col2a1 and Positive_regulation of Cia1 1 0.03 1.74 1.03
12 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
13 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 0.29 0.97 0.94
14 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
15 INT116269 Binding of Myc and Mycbp2 1 0.19 0.5 0.87
16 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
17 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
18 INT192158 Binding of Mmp2 and Mmp9 1 0.21 0.94 0.83
19 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
20 INT102161 Binding of TNF and Mmp2 1 0.10 0.88 0.78
21 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
22 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
23 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
24 INT269454 Positive_regulation of Binding of GOPC and HHIP 1 0.01 0 0.73
25 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
26 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
27 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
28 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
29 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
30 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
31 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
32 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
33 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
34 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 1 0.35 0.83 0.69
35 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
36 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
37 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
38 INT152299 Mmp2 Negative_regulation of Tsc22d1 1 0.16 0.16 0.66
39 INT152297 Mmp2 Negative_regulation of Mmp9 1 0.39 0.16 0.65
40 INT314051 THL Negative_regulation of Localization of Mmp2 1 0.14 1.1 0.62
41 INT95431 Il1a Regulation of Mmp2 1 0.48 0.25 0.61
42 INT95433 Mmp3 Regulation of Mmp2 1 0.17 0.24 0.6
43 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
44 INT342624 VEGFA Negative_regulation of Mmp2 1 0.09 1.54 0.58
45 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57
46 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
47 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53
48 INT314043 THL Negative_regulation of Mmp2 1 0.22 2.11 0.53
49 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
50 INT269442 Binding of GOPC and HHIP 1 0.01 0 0.52
51 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
52 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
53 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
54 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
55 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
56 INT150921 ZNF398 Negative_regulation of Gene_expression of Mmp2 1 0.00 0.46 0.5
57 INT230532 LILRB1 Positive_regulation of Gene_expression of Mmp2 1 0.14 1.04 0.5
58 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
59 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
60 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
61 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
62 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
63 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
64 INT314053 VEGFA Positive_regulation of Gene_expression of Mmp2 1 0.02 0.2 0.47
65 INT138152 IL6 Positive_regulation of Transcription of Mmp2 1 0.00 0.23 0.46
66 INT138154 IL1B Positive_regulation of Transcription of Mmp2 1 0.04 0.23 0.46
67 INT138149 Tgfb1 Regulation of Mmp2 1 0.00 0.23 0.46
68 INT314050 THL Negative_regulation of Transcription of Mmp2 1 0.16 0.81 0.44
69 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
70 INT314042 THL Negative_regulation of Gene_expression of Mmp2 1 0.19 2.97 0.42
71 INT269448 HHIP Positive_regulation of Binding of RAB5A 1 0.04 0 0.42
72 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
73 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
74 INT160245 Binding of Col11a1 and Crygs 1 0.00 0.17 0.4
75 INT179851 Il11 Positive_regulation of Mmp2 1 0.04 0 0.38
76 INT269456 RAB5A Regulation of Binding of HHIP 1 0.04 0 0.38
77 INT342622 Binding of MMP14 and Mmp2 1 0.39 1.15 0.37
78 INT342617 Binding of Col18a1 and Mmp2 1 0.11 1.15 0.37
79 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
80 INT254344 Binding of Col2a1 and Ncoa5 1 0.00 0.98 0.35
81 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
82 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
83 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
84 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
85 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
86 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
87 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
88 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
89 INT303446 Timp1 Negative_regulation of Mmp2 1 0.19 0.33 0.31
90 INT326090 Binding of Erbb2 and Mmp2 1 0.09 1.39 0.31
91 INT202313 Gene_expression of PDGFB Positive_regulation of Positive_regulation of Pdgfrb 1 0.14 1 0.29
92 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
93 INT56092 FGFR1 Positive_regulation of Transcription of SERPINE1 1 0.29 0.41 0.29
94 INT328224 Col2a1 Positive_regulation of Gene_expression of Mmp13 1 0.04 0.8 0.29
95 INT202314 Gene_expression of PDGFB Positive_regulation of Phosphorylation of Pdgfrb 1 0.14 1 0.29
96 INT354368 FGFR1 Positive_regulation of Tlr4 1 0.01 0.16 0.29
97 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
98 INT137014 Positive_regulation of Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
99 INT154044 Gm6983 Positive_regulation of Localization of FGFR1 1 0.00 0.06 0.28
100 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
101 INT137012 Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
102 INT328222 Mmp2 Regulation of Positive_regulation of Mmp13 1 0.05 0.69 0.28
103 INT269459 Binding of ISYNA1 and HHIP 1 0.00 0 0.27
104 INT269490 Binding of Racgap1 and HHIP 1 0.00 0 0.27
105 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26
106 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
107 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26
108 INT148223 CXCL14 Regulation of Localization of Mmp2 1 0.01 0.71 0.26
109 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
110 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
111 INT244687 Mmp14 Positive_regulation of Mmp2 1 0.23 0.48 0.25
112 INT327300 Binding of Hnrnpd and Myc 1 0.12 1.02 0.25
113 INT271446 Thy1 Regulation of Col1a1 1 0.05 0.61 0.25
114 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
115 INT256656 Binding of EP300 and HHIP 1 0.22 0 0.24
116 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
117 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
118 INT296372 Binding of IDUA and ACD 1 0.03 2.72 0.23
119 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
120 INT316810 Sparc Regulation of Col1a1 1 0.13 0.48 0.21
121 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
122 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
123 INT269446 Binding of EPHA3 and HHIP 1 0.01 0 0.2
124 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
125 INT201212 FGF2 Regulation of FGFR1 2 0.09 1.01 0.18
126 INT125550 FGFR1 Negative_regulation of Cyp2e1 1 0.02 0.06 0.18
127 INT337698 VEGFA Regulation of FGFR1 1 0.09 0.51 0.18
128 INT72325 Binding of Sigmar1 and WWOX 1 0.26 0 0.18
129 INT346305 Binding of ELANE and Col2a1 1 0.00 0.98 0.17
130 INT220531 Atf3 Negative_regulation of Gene_expression of Mmp2 1 0.02 1.09 0.16
131 INT244850 Lbx1 Negative_regulation of Hoxd8 1 0.01 0.09 0.16
132 INT332968 Hoxb4 Positive_regulation of Ppara 1 0.02 0.25 0.16
133 INT301121 Tgm7 Regulation of Gene_expression of Mmp2 1 0.52 2.53 0.16
134 INT116268 Binding of Myc and Acsl1 1 0.08 0.19 0.16
135 INT85274 SGCG Positive_regulation of Mmp2 1 0.09 0.46 0.16
136 INT220515 Il10 Negative_regulation of Gene_expression of Mmp2 1 0.01 1.1 0.16
137 INT250908 Binding of Mmp2 and Tsp1 1 0.04 0.09 0.15
138 INT269451 Negative_regulation of Binding of RAB5A and HHIP 1 0.03 0 0.15
139 INT75058 Negative_regulation of ACE Negative_regulation of HHIP 1 0.25 0.43 0.15
140 INT250906 Binding of Mmp2 and Thbs2 1 0.06 0.09 0.15
141 INT269452 RAB5A Regulation of Localization of HHIP 1 0.04 0 0.15
142 INT350713 MIR219-1 Negative_regulation of Pdgfra 1 0.00 0.4 0.15
143 INT336337 Glp2r Positive_regulation of Gene_expression of Col2a1 1 0.01 0.7 0.14
144 INT314039 THL Negative_regulation of Binding of Mmp2 1 0.16 1.62 0.14
145 INT144027 Binding of Slc6a4 and Pdgfrb 1 0.23 0.25 0.14
146 INT223963 Binding of Bglap and Runx2 1 0.14 1.74 0.13
147 INT250911 Thbs2 Regulation of Mmp2 1 0.05 0.3 0.13
148 INT201722 Myc Regulation of Gene_expression of Ccnd1 1 0.03 0.79 0.13
149 INT320261 Binding of Myc and Ntrk2 1 0.01 0.36 0.13
150 INT201791 JUP Regulation of Gene_expression of Myc 1 0.49 0.8 0.13
151 INT125551 Binding of FGFR1 and Cyp2e1 1 0.02 0.07 0.13
152 INT269445 Localization of HHIP Regulation of Gene_expression of RAB5A 1 0.03 0 0.13
153 INT269457 RAB5A Regulation of Regulation of HHIP 1 0.02 0 0.13
154 INT18230 Binding of HP and WWOX 1 0.19 0.17 0.13
155 INT125549 Binding of CYP2B6 and FGFR1 1 0.00 0.07 0.13
156 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
157 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
158 INT173200 PPA1 Positive_regulation of Myc 1 0.08 0.5 0.12
159 INT192330 UBR7 Negative_regulation of Positive_regulation of PDGFRB 1 0.01 0.54 0.12
160 INT343472 Epo Positive_regulation of Gene_expression of Mmp2 1 0.15 0.62 0.12
161 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
162 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
163 INT316813 Sparc Negative_regulation of Gene_expression of Col1a1 1 0.13 0.67 0.12
164 INT74504 Binding of P2rx7 and Rp2 1 0.02 0.19 0.11
165 INT269458 HHIP Regulation of Gene_expression of RAB5A 1 0.04 0 0.1
166 INT286046 Binding of Wwox and Creb1 1 0.14 1.67 0.1
167 INT286045 Binding of Jun and Wwox 1 0.12 2.33 0.1
168 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
169 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
170 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
171 INT346304 Col2a1 Positive_regulation of Localization of PTGER2 1 0.00 0.18 0.09
172 INT117838 FGFR1 Regulation of FGF2 1 0.33 0.17 0.09
173 INT304464 Binding of P2rx7 and P2rx6 1 0.05 0 0.09
174 INT221653 Binding of Myc and Gopc 2 0.12 0.51 0.08
175 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
176 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08
177 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
178 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 0.00 0.08 0.08
179 INT244639 AGK Negative_regulation of PDGFRB 1 0.01 0.69 0.08
180 INT270829 P2rx7 Positive_regulation of Panx1 1 0.66 0.08 0.08
181 INT340420 Hmmr Regulation of P2rx7 1 0.01 1.12 0.08
182 INT218710 MMP1 Regulation of Positive_regulation of Col1a1 1 0.00 0.15 0.07
183 INT298006 CHDM Positive_regulation of Gene_expression of PDGFRB 1 0.16 1.08 0.07
184 INT192329 UBR7 Negative_regulation of Phosphorylation of PDGFRB 1 0.01 0.06 0.07
185 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
186 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
187 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
188 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
189 INT279291 PDGFA Positive_regulation of PDGFRB 1 0.16 1.02 0.06
190 INT343480 Epo Positive_regulation of Mmp2 1 0.15 0.31 0.06
191 INT302980 Mmp2 Positive_regulation of Smpd3 1 0.29 0.78 0.05
192 INT346302 ELANE Regulation of Col2a1 1 0.00 0.3 0.05
193 INT180668 Edn1 Positive_regulation of Gene_expression of Col1a1 1 0.02 0 0.05
194 INT286049 Binding of MAPK8 and Wwox 1 0.31 0.26 0.05
195 INT279287 PDGFRB Regulation of CDCP1 1 0.01 0.98 0.05
196 INT66856 Rln1 Positive_regulation of Localization of Mmp2 1 0.30 0 0.05
197 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
198 INT340427 Positive_regulation of P2rx7 Positive_regulation of Regulation of Pkhd1 1 0.01 1 0.05
199 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
200 INT243783 FGFR1 Positive_regulation of FGF20 1 0.05 0 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for skeletal system morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in skeletal system morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
2 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68
3 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25
4 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
5 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73
6 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42
7 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
8 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
9 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
10 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57
11 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58
12 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76
13 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74
14 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
15 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41
16 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
17 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
18 INT111903 Regulation of Mmp2 9 0.61 3.95 7.98
19 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56
20 INT111398 Localization of Mmp2 37 0.76 23.78 7.17
21 INT81608 Gene_expression of Col11a1 13 0.15 1.58 6.87
22 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36
23 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
24 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
25 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
26 INT123551 Regulation of Mmp2 17 0.57 11.6 6
27 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
28 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82
29 INT87468 Negative_regulation of Mmp2 24 0.57 10.79 5.55
30 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
31 INT178763 Binding of HHIP 37 0.08 6.3 5.29
32 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
33 INT125478 Localization of HHIP 32 0.80 3.43 4.68
34 INT29502 Localization of Mmp2 18 0.79 3.49 4.64
35 INT97903 Negative_regulation of FGFR1 16 0.17 5.6 4.57
36 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
37 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
38 INT124815 Binding of Col2a1 9 0.37 10.27 3.93
39 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
40 INT86293 Positive_regulation of Gene_expression of Mmp2 21 0.64 11.69 3.79
41 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75
42 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
43 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
44 INT39867 Binding of Col2a1 9 0.35 7.65 3.18
45 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
46 INT54832 Negative_regulation of Gene_expression of Col2a1 6 0.50 2.53 3.16
47 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
48 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12
49 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09
50 INT171884 Positive_regulation of Gene_expression of Col2a1 11 0.23 8.04 3.02
51 INT138141 Transcription of Mmp2 10 0.64 6.52 2.99
52 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
53 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
54 INT36886 Transcription of Myc 6 0.69 3.16 2.86
55 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61
56 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
57 INT142908 Localization of FGFR1 18 0.38 11.46 2.57
58 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55
59 INT8890 Transcription of Col1a1 10 0.63 4.02 2.48
60 INT103603 Negative_regulation of Gene_expression of Mmp2 16 0.51 12.29 2.47
61 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45
62 INT163544 Binding of Psen1 40 0.36 15.28 2.42
63 INT163545 Gene_expression of PDGFRB 39 0.78 25.5 2.2
64 INT55090 Positive_regulation of Wnt7a 13 0.37 2.25 2.2
65 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18
66 INT180923 Negative_regulation of Localization of Mmp2 6 0.46 7.84 2.17
67 INT125480 Regulation of HHIP 17 0.38 6.16 2.16
68 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
69 INT263046 Negative_regulation of Gene_expression of Mmp2 7 0.34 5.98 2.09
70 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
71 INT46332 Binding of Mmp2 10 0.34 5.63 2
72 INT137906 Positive_regulation of Phosphorylation of Pdgfrb 6 0.50 2.55 1.94
73 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
74 INT120857 Localization of Col1a1 10 0.71 2.33 1.93
75 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92
76 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
77 INT164407 Negative_regulation of Gene_expression of Col2a1 6 0.39 4 1.78
78 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
79 INT152292 Regulation of Gene_expression of Mmp2 6 0.61 3.46 1.76
80 INT220992 Protein_catabolism of Col2a1 8 0.40 5.55 1.64
81 INT86294 Regulation of Gene_expression of Mmp2 3 0.60 1.12 1.62
82 INT133443 Transcription of Mmp2 8 0.69 2.48 1.61
83 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
84 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
85 INT164410 Negative_regulation of Col2a1 4 0.39 3.75 1.53
86 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
87 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52
88 INT142719 Binding of Col1a1 7 0.34 5.83 1.47
89 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
90 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
91 INT32184 Negative_regulation of Col2a1 9 0.42 3.05 1.43
92 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
93 INT86292 Positive_regulation of Positive_regulation of Mmp2 4 0.46 3.09 1.4
94 INT317979 Positive_regulation of Transcription of Mmp2 4 0.46 2.63 1.37
95 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36
96 INT116265 Binding of Myc 9 0.36 4.28 1.36
97 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
98 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34
99 INT38990 Negative_regulation of IDUA 12 0.59 5.04 1.33
100 INT238074 Negative_regulation of Positive_regulation of Mmp2 4 0.34 1.79 1.31
101 INT54831 Regulation of Gene_expression of Col2a1 4 0.39 2.3 1.31
102 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
103 INT112650 Positive_regulation of Col1a1 3 0.30 5.96 1.3
104 INT38989 Gene_expression of IDUA 22 0.78 16.99 1.26
105 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26
106 INT128714 Transcription of Col2a1 6 0.52 2.13 1.24
107 INT59473 Negative_regulation of Col1a1 4 0.25 1.33 1.24
108 INT71845 Positive_regulation of Positive_regulation of Col1a1 1 0.34 0.15 1.23
109 INT140033 Positive_regulation of Gene_expression of Col1a1 6 0.14 3.68 1.2
110 INT176463 Protein_catabolism of Col2a1 4 0.35 1.94 1.2
111 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
112 INT310164 Negative_regulation of Gene_expression of Tgfbr1 9 0.40 6.11 1.17
113 INT124008 Positive_regulation of Wwox 2 0.67 7.64 1.16
114 INT71848 Positive_regulation of Transcription of Myc 1 0.67 0.16 1.11
115 INT125476 Regulation of Gene_expression of HHIP 2 0.39 1.1 1.1
116 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
117 INT269487 Positive_regulation of Binding of HHIP 1 0.06 0 1.08
118 INT54835 Regulation of Col2a1 5 0.59 2.08 1.07
119 INT84511 Positive_regulation of Tfap2a 3 0.27 0.72 1.04
120 INT84235 Positive_regulation of Col11a1 2 0.01 0.09 1.03
121 INT74977 Binding of FGFR1 6 0.41 4.66 1.02
122 INT127647 Regulation of Wnt7a 3 0.07 1.28 1.01
123 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
124 INT168233 Positive_regulation of Transcription of Col2a1 2 0.45 1.78 0.99
125 INT129997 Protein_catabolism of Col1a1 5 0.96 3.43 0.96
126 INT102070 Regulation of Gene_expression of Myc 4 0.60 2.68 0.96
127 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
128 INT43484 Binding of Runx2 7 0.37 3.22 0.95
129 INT180925 Positive_regulation of Localization of Mmp2 4 0.54 3.21 0.95
130 INT29501 Positive_regulation of Localization of Mmp2 3 0.60 0.42 0.94
131 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
132 INT296385 Binding of IDUA 12 0.39 20.73 0.93
133 INT17894 Regulation of Myc 10 0.60 5.65 0.93
134 INT243974 Binding of Tfap2a 7 0.18 1.36 0.93
135 INT269485 Positive_regulation of Gene_expression of HHIP 9 0.41 1.08 0.92
136 INT29500 Regulation of Localization of Mmp2 3 0.53 0.47 0.92
137 INT97899 Positive_regulation of Gene_expression of FGFR1 7 0.62 5.99 0.9
138 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87
139 INT8888 Regulation of Col1a1 4 0.13 1.97 0.86
140 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
141 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
142 INT221796 Positive_regulation of Gene_expression of Tfap2a 2 0.10 1.19 0.83
143 INT192156 Negative_regulation of Col1a1 6 0.39 3.92 0.8
144 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
145 INT152290 Regulation of Transcription of Mmp2 1 0.27 0.15 0.8
146 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
147 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
148 INT173506 Positive_regulation of Col2a1 4 0.20 3.42 0.76
149 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76
150 INT123773 Positive_regulation of Positive_regulation of Mmp2 2 0.17 1.83 0.75
151 INT207535 Transcription of Tfap2a 3 0.31 0.98 0.74
152 INT265557 Protein_catabolism of Mmp2 3 0.55 3.15 0.73
153 INT164756 Negative_regulation of PDGFRB 32 0.57 21.69 0.72
154 INT37617 Regulation of Gene_expression of Col2a1 3 0.31 1.48 0.7
155 INT266797 Negative_regulation of Negative_regulation of Mmp2 1 0.05 0.96 0.7
156 INT135197 Gene_expression of Tfap2a 1 0.45 0.48 0.69
157 INT99239 Negative_regulation of Negative_regulation of FGFR1 1 0.06 0.3 0.69
158 INT171364 Localization of Pdgfrb 6 0.37 4.98 0.68
159 INT91172 Positive_regulation of Gene_expression of Pdgfrb 4 0.38 2.83 0.68
160 INT123443 Positive_regulation of WWOX 2 0.45 3.45 0.68
161 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
162 INT171380 Positive_regulation of Localization of Pdgfrb 1 0.21 0.48 0.66
163 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65
164 INT28958 Negative_regulation of Wnt7a 3 0.45 0.49 0.65
165 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
166 INT269461 Positive_regulation of Localization of HHIP 1 0.05 0 0.63
167 INT84250 Positive_regulation of IDUA 8 0.56 15.89 0.62
168 INT269465 Positive_regulation of Positive_regulation of HHIP 4 0.11 0.5 0.62
169 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
170 INT63389 Localization of Col2a1 7 0.68 1.95 0.6
171 INT207529 Localization of Tfap2a 2 0.34 0.13 0.6
172 INT223462 Binding of Hoxb4 1 0.01 0.08 0.58
173 INT144922 Gene_expression of TGFBR1 4 0.72 0.19 0.57
174 INT283569 Protein_catabolism of Mmp2 5 0.77 3.25 0.56
175 INT127648 Gene_expression of Wnt7a 2 0.13 1.11 0.56
176 INT243970 Phosphorylation of Tfap2a 2 0.25 0.56 0.56
177 INT97901 Regulation of FGFR1 5 0.24 2.56 0.55
178 INT145786 Binding of WWOX 2 0.35 0.59 0.55
179 INT97904 Negative_regulation of Gene_expression of FGFR1 1 0.38 0.92 0.55
180 INT244679 Binding of Mmp2 4 0.30 3.75 0.54
181 INT342614 Positive_regulation of Binding of Mmp2 1 0.46 0.6 0.54
182 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
183 INT156254 Gene_expression of Six1 7 0.67 1.52 0.51
184 INT144024 Negative_regulation of Phosphorylation of Pdgfrb 6 0.42 3.48 0.51
185 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
186 INT8886 Regulation of Transcription of Col1a1 1 0.04 0 0.5
187 INT32183 Positive_regulation of Negative_regulation of Col2a1 2 0.46 1.01 0.49
188 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
189 INT73200 Positive_regulation of PDGFRB 10 0.67 9.67 0.48
190 INT286021 Gene_expression of Wwox 1 0.61 6.15 0.47
191 INT145144 Positive_regulation of Negative_regulation of Mmp2 1 0.11 0.7 0.46
192 INT125840 Positive_regulation of Binding of Col2a1 1 0.43 1.21 0.45
193 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
194 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
195 INT267122 Negative_regulation of Positive_regulation of FGFR1 1 0.03 1.03 0.44
196 INT178766 Negative_regulation of HHIP 19 0.28 11.1 0.43
197 INT192342 Phosphorylation of PDGFRB 11 0.80 1.68 0.43
198 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
199 INT244683 Regulation of Positive_regulation of Mmp2 2 0.36 0.78 0.43
200 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
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