GO:0048706

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Name embryonic skeletal system development
Categary Process
Go Slim No
Go Link GO:0048706
Unique Molecular Interactions 276
Total Molecular Interactions 369
Total Single Events 2450
Pain Genes Associated 37

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for embryonic skeletal system development. They are ordered first by their pain relevance and then by number of times they were reported for embryonic skeletal system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
2 INT157540 Binding of SP1 and YY1 1 0.41 2.55 1.42
3 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
4 INT121802 DEAF1 Negative_regulation of HTR1A 1 0.46 0.88 1.29
5 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
6 INT134970 Positive_regulation of Binding of OPRK1 and SP1 1 0.00 0 1.05
7 INT134969 Binding of OPRK1 and SP1 1 0.00 0 1.04
8 INT200323 Binding of Oprm1 and Sp3 1 0.39 0 0.99
9 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 0.01 1.64 0.93
10 INT222978 Binding of COL1A1 and FN1 1 0.01 1.64 0.92
11 INT77254 Binding of gr and Sp1 1 0.04 0.4 0.9
12 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
13 INT103611 Mdk Negative_regulation of Phosphorylation of Sp1 1 0.01 0.28 0.88
14 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85
15 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
16 INT157539 Binding of SP1 and Regulation of Gene_expression of OPRM1 1 0.36 1.2 0.72
17 INT98956 Positive_regulation of Binding of NR5A2 and SP1 1 0.00 0 0.7
18 INT98951 Positive_regulation of Binding of NR5A2 and SP3 1 0.00 0 0.7
19 INT207542 Sp1 Regulation of Oprm1 1 0.15 0.06 0.7
20 INT98957 Binding of NR5A2 and SP3 1 0.00 0 0.7
21 INT98958 Binding of NR5A2 and SP1 1 0.00 0 0.7
22 INT287099 Binding of Bdnf and T 1 0.10 1.1 0.69
23 INT207547 Sp1 Regulation of Qsox1 1 0.05 0.06 0.67
24 INT123416 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.60 0 0.63
25 INT98955 Positive_regulation of Binding of SP3 and CFHR4 1 0.00 0 0.62
26 INT98953 Positive_regulation of Binding of SP1 and CFHR4 1 0.00 0 0.62
27 INT98954 Binding of SP1 and CFHR4 1 0.00 0 0.61
28 INT98952 Binding of SP3 and CFHR4 1 0.00 0 0.61
29 INT200348 Sp3 Negative_regulation of Gene_expression of Oprm1 1 0.48 0.4 0.55
30 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
31 INT302369 Binding of Arx and Dlx1 1 0.34 0 0.43
32 INT89332 Binding of SP1 and SP3 1 0.30 0.76 0.39
33 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
34 INT200313 Sp3 Regulation of Oprm1 1 0.10 0.07 0.38
35 INT200301 Sp3 Regulation of Rorb 1 0.00 0.07 0.38
36 INT167558 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.03 0.07 0.36
37 INT302371 Dlx1 Regulation of Gene_expression of Arx 1 0.28 0 0.35
38 INT278766 HOXA9 Positive_regulation of Gene_expression of PTGS2 1 0.43 1.28 0.35
39 INT167551 Binding of MECP2 and SP3 1 0.01 0.06 0.35
40 INT200333 Binding of Rest and Sp1 1 0.24 0.07 0.35
41 INT200316 Sp1 Regulation of Gene_expression of Rest 1 0.31 0 0.35
42 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
43 INT280926 Hoxa3 Positive_regulation of Gene_expression of Ccl2 1 0.53 2.61 0.32
44 INT253576 Binding of Lpl and Sp3 1 0.22 0.85 0.32
45 INT200351 Sp1 Positive_regulation of Gene_expression of Rest 1 0.34 0.07 0.3
46 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
47 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
48 INT137014 Positive_regulation of Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
49 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
50 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
51 INT137012 Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
52 INT96788 Binding of SP3 and NR2F2 1 0.24 0.27 0.27
53 INT96789 Binding of SP1 and NR2F2 1 0.24 0.27 0.27
54 INT96787 SP1 Positive_regulation of GDF15 1 0.08 0.27 0.27
55 INT96790 SP3 Positive_regulation of GDF15 1 0.20 0.26 0.27
56 INT125515 SP1 Regulation of GDF15 1 0.14 0.47 0.26
57 INT169837 Sp1 Positive_regulation of Gene_expression of Kcnq3 1 0.04 0.08 0.26
58 INT126886 Protein_catabolism of SP1 Negative_regulation of Gene_expression of VEGFA 1 0.03 0.49 0.26
59 INT169836 Sp1 Positive_regulation of Gene_expression of Kcnq2 1 0.05 0.08 0.26
60 INT271446 Thy1 Regulation of Col1a1 1 0.05 0.61 0.25
61 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25
62 INT200309 Positive_regulation of Binding of Rest and Sp3 1 0.41 0.88 0.24
63 INT252784 ROS1 Positive_regulation of Gene_expression of COL1A1 1 0.05 1.86 0.24
64 INT287098 Binding of FL and T 1 0.10 0.66 0.23
65 INT302367 Dlx2 Regulation of Gene_expression of Arx 1 0.59 0.23 0.22
66 INT312517 Rapgef1 Negative_regulation of Rbp4 1 0.01 0.9 0.22
67 INT253568 Negative_regulation of Binding of Lpl and Sp3 1 0.19 0.37 0.22
68 INT316810 Sparc Regulation of Col1a1 1 0.13 0.48 0.21
69 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
70 INT189196 RASGRP1 Positive_regulation of SP1 1 0.05 0.63 0.21
71 INT225099 ZNF630 Positive_regulation of Gene_expression of COL1A1 1 0.00 0.17 0.2
72 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
73 INT136462 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Sp1 1 0.01 0.65 0.19
74 INT287097 T Positive_regulation of Ntrk2 1 0.21 0.6 0.19
75 INT256586 Binding of RBP4 and TTR 1 0.07 1.92 0.18
76 INT310494 Gene_expression of Dlx2 Positive_regulation of Fate1 1 0.04 0.1 0.18
77 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18
78 INT244844 Lbx1 Negative_regulation of Hoxd9 1 0.01 0.09 0.16
79 INT238825 LTF Regulation of Localization of RBP4 1 0.05 1.08 0.16
80 INT190633 Binding of Lmo2 and Deaf1 1 0.18 0.59 0.16
81 INT253564 Binding of Lpl and Sp1 1 0.13 0.9 0.14
82 INT327877 Itgb1 Negative_regulation of Gene_expression of Dlk1 1 0.02 0.99 0.13
83 INT200328 Sp3 Positive_regulation of Gene_expression of Oprm1 1 0.38 0 0.13
84 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
85 INT157602 Binding of COL1A1 and COL3A1 1 0.04 0 0.13
86 INT200315 Binding of Sp1 and Sp3 1 0.29 0 0.12
87 INT68802 Sp1 Regulation of Gene_expression of Pebp1 1 0.24 0 0.12
88 INT226532 T Positive_regulation of Gene_expression of IFNA1 1 0.01 0.15 0.12
89 INT316813 Sparc Negative_regulation of Gene_expression of Col1a1 1 0.13 0.67 0.12
90 INT253572 Binding of Csnk2a2 and Sp1 1 0.17 0 0.11
91 INT273018 Binding of FGF9 and PDE1A 1 0.18 0.3 0.11
92 INT273020 Binding of FGF9 and PDE11A 1 0.22 0.3 0.11
93 INT200320 Binding of Sp3 and Negative_regulation of Gene_expression of Oprm1 1 0.35 0.4 0.1
94 INT294445 KLK4 Negative_regulation of COL1A1 1 0.01 0 0.1
95 INT210992 Binding of KCNMA1 and SP3 1 0.00 0.17 0.1
96 INT210989 Binding of FSCN1 and SP3 1 0.00 0.17 0.1
97 INT179869 COL1A1 Positive_regulation of SOCS3 1 0.04 0.99 0.1
98 INT171163 Creb1 Regulation of Sp1 1 0.03 0.62 0.1
99 INT194822 Negative_regulation of MAPK1 Negative_regulation of Binding of Sp1 1 0.04 0.05 0.1
100 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
101 INT210988 Binding of SP3 and PKDREJ 1 0.01 0.17 0.1
102 INT210994 Binding of SEA and SP3 1 0.00 0.17 0.1
103 INT253571 Positive_regulation of Binding of Lpl and Sp1 1 0.17 0.42 0.09
104 INT253579 Negative_regulation of Binding of Lpl and Sp1 1 0.15 0.42 0.09
105 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
106 INT58630 Calca Negative_regulation of Positive_regulation of COL1A1 1 0.02 0.23 0.08
107 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
108 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
109 INT313509 Binding of ALOX5 and SP1 1 0.07 1.51 0.08
110 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
111 INT222983 TNF Positive_regulation of Positive_regulation of COL1A1 1 0.01 0.71 0.08
112 INT218710 MMP1 Regulation of Positive_regulation of Col1a1 1 0.00 0.15 0.07
113 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
114 INT253570 Binding of Csnk2a2 and Sp3 1 0.16 0.2 0.07
115 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
116 INT253577 Csnk2a2 Positive_regulation of Phosphorylation of Sp1 1 0.17 0.37 0.06
117 INT180668 Edn1 Positive_regulation of Gene_expression of Col1a1 1 0.02 0 0.05
118 INT220081 Binding of COL1A1 and MMRN1 1 0.00 0.36 0.05
119 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
120 INT295718 Binding of PTGER2 and Positive_regulation of Positive_regulation of SP1 1 0.02 0.58 0.04
121 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
122 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
123 INT222980 TNF Positive_regulation of Localization of COL1A1 1 0.01 0.56 0.04
124 INT199526 Ceacam1 Negative_regulation of Col1a1 1 0.01 0.06 0.03
125 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
126 INT253574 Sp3 Positive_regulation of Lpl 1 0.22 0 0.03
127 INT222977 Positive_regulation of COL1A1 Positive_regulation of MMP1 1 0.01 0.61 0.03
128 INT222987 Positive_regulation of COL1A1 Positive_regulation of Protein_catabolism of MMP1 1 0.01 0.61 0.03
129 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
130 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
131 INT170329 Binding of Col4a1 and Col1a1 1 0.03 0.14 0.03
132 INT180565 HEYL Positive_regulation of Negative_regulation of COL1A1 1 0.01 0 0.03
133 INT180571 HEYL Positive_regulation of Protein_catabolism of COL1A1 1 0.01 0 0.03
134 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
135 INT170331 Binding of Col7a1 and Col1a1 1 0.00 0.14 0.03
136 INT314052 Binding of VEGFA and Sp1 1 0.02 1.25 0.03
137 INT253566 Sp1 Positive_regulation of Lpl 1 0.18 0 0.03
138 INT252820 ELANE Positive_regulation of Gene_expression of COL1A1 1 0.01 0.58 0
139 INT312224 INPP5K Regulation of Negative_regulation of COL1A1 1 0.08 0 0
140 INT233280 Binding of PBX1 and Emx2 1 0.19 0.68 0
141 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
142 INT320529 HOXA9 Regulation of Gene_expression of KRBA1 1 0.01 0.48 0
143 INT278747 Binding of HOXA9 and PLN 1 0.33 0 0
144 INT250132 Binding of Hoxa3 and Gopc 1 0.07 0 0
145 INT278756 Binding of RUNX1 and HOXA9 1 0.02 0.26 0
146 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
147 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
148 INT238819 Binding of LTF and RBP4 1 0.04 0.26 0
149 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0
150 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
151 INT183090 Gene_expression of SULF1 Positive_regulation of Phosphorylation of FGF2 1 0.19 0.42 0
152 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0
153 INT278772 NUP98 Regulation of HOXA9 1 0.42 0 0
154 INT252796 ELANE Regulation of COL1A1 1 0.01 0.57 0
155 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
156 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0
157 INT278763 Binding of HOXA9 and GOPC 1 0.14 0 0
158 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
159 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
160 INT180847 Binding of COL1A1 and NID2 1 0.05 0.91 0
161 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
162 INT233284 Regulation of Binding of PBX1 and Hoxa10 1 0.21 0.35 0
163 INT278748 HOXA9 Negative_regulation of Gene_expression of RAP1A 1 0.38 0.44 0
164 INT222539 Negative_regulation of Binding of Inhba and Acvr2a 1 0.01 0 0
165 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0
166 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
167 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
168 INT183093 SULF1 Negative_regulation of Binding of FGF2 1 0.17 0.41 0
169 INT233281 Binding of PBX1 and Hoxa10 1 0.28 0.35 0
170 INT77956 Binding of PENK and DEAF1 1 0.21 0.22 0
171 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
172 INT312214 INPP5K Regulation of Gene_expression of COL1A1 1 0.08 0 0
173 INT70770 Fga Regulation of TAPT1 1 0.00 0.65 0
174 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
175 INT238822 TF Regulation of Localization of RBP4 1 0.14 0.28 0
176 INT252773 ROS1 Positive_regulation of COL1A1 1 0.05 0.57 0
177 INT222504 Binding of Inhba and Acvr2a 1 0.01 0 0
178 INT238827 RBP4 Positive_regulation of Gene_expression of INS 1 0.14 1.15 0
179 INT278750 HOXA9 Regulation of NUP98 1 0.11 0 0
180 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
181 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
182 INT252800 ROS1 Regulation of COL1A1 1 0.05 0.57 0
183 INT233282 Binding of HOXA9 and Meis1 1 0.41 0.21 0
184 INT215344 Binding of Sp1 and Vdac1 1 0.02 0.1 0
185 INT252813 ELANE Positive_regulation of COL1A1 1 0.01 0.57 0
186 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
187 INT118660 Binding of COL1A1 and GAPDH 1 0.16 0.09 0
188 INT233283 Binding of HOXA9 and target gene promoter 1 0.01 0.23 0
189 INT238818 LTF Positive_regulation of RBP4 1 0.06 0.29 0
190 INT238826 Binding of INS and RBP4 1 0.10 2.07 0
191 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
192 INT335022 Fgf15 Regulation of Pbx1 1 0.15 0.17 0
193 INT77957 Binding of RUNX1T1 and DEAF1 1 0.20 0.36 0
194 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
195 INT342558 FGF9 Positive_regulation of MAPK3 1 0.03 1.21 0
196 INT96782 FAM176C Regulation of Gene_expression of COL1A1 1 0.32 0.05 0
197 INT180859 Binding of COL1A1 and NID1 1 0.01 0.9 0
198 INT278767 NUP98 Regulation of Gene_expression of HOXA9 1 0.42 0.23 0
199 INT340561 Mapk1 Negative_regulation of Gene_expression of Pax7 1 0.23 0.25 0
200 INT278751 OR51S1 Regulation of HOXA9 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for embryonic skeletal system development. They are ordered first by their pain relevance and then by number of times they were reported in embryonic skeletal system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15
2 INT41558 Localization of Sp1 9 0.48 0.56 14.9
3 INT24082 Negative_regulation of Sp1 13 0.40 1.19 13.11
4 INT48555 Binding of SP1 30 0.46 11.38 6.53
5 INT185252 Gene_expression of Dlx2 7 0.71 8.8 6.24
6 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98
7 INT41604 Negative_regulation of Localization of Sp1 2 0.30 0.32 5.86
8 INT183119 Gene_expression of SULF1 1 0.75 46.71 5.44
9 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
10 INT204449 Gene_expression of T 17 0.32 9.77 4.77
11 INT198736 Binding of Sp3 23 0.40 4.77 4.42
12 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38
13 INT123411 Gene_expression of Sp1 15 0.69 4.2 3.79
14 INT81229 Binding of COL1A1 24 0.35 12.07 3.3
15 INT41559 Positive_regulation of Sp1 7 0.45 2.65 3.24
16 INT123409 Binding of Sp1 20 0.39 3.18 3.15
17 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12
18 INT103607 Binding of Sp1 7 0.42 1.26 2.92
19 INT93213 Phosphorylation of Sp1 5 0.67 0.93 2.84
20 INT89336 Binding of SP3 6 0.47 1.75 2.63
21 INT24902 Gene_expression of SP1 17 0.71 8.11 2.58
22 INT68091 Localization of COL1A1 19 0.66 9.13 2.56
23 INT23998 Positive_regulation of Sp1 4 0.40 0.51 2.56
24 INT8890 Transcription of Col1a1 10 0.63 4.02 2.48
25 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45
26 INT103609 Transcription of Sp1 1 0.11 0.97 2.42
27 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3
28 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18
29 INT302340 Positive_regulation of Gene_expression of Dlx2 2 0.64 3.43 2.15
30 INT103608 Negative_regulation of Binding of Sp1 4 0.35 0.69 2.1
31 INT53434 Positive_regulation of T 7 0.07 3.67 2.09
32 INT41495 Regulation of Sp1 7 0.42 2.96 2.05
33 INT41557 Gene_expression of Sp1 5 0.68 1.17 2.04
34 INT113717 Negative_regulation of Gene_expression of COL1A1 21 0.41 6.14 2.01
35 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
36 INT120857 Localization of Col1a1 10 0.71 2.33 1.93
37 INT96116 Transcription of COL1A1 10 0.44 4.57 1.81
38 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81
39 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
40 INT24906 Negative_regulation of SP1 8 0.40 4.48 1.77
41 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
42 INT41605 Positive_regulation of Localization of Sp1 1 0.05 0 1.58
43 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52
44 INT142719 Binding of Col1a1 7 0.34 5.83 1.47
45 INT136459 Gene_expression of Sp3 6 0.64 1.97 1.47
46 INT250114 Gene_expression of Hoxa3 36 0.77 23.04 1.46
47 INT218313 Localization of RBP4 5 0.79 15.68 1.4
48 INT123414 Transcription of Sp1 5 0.48 2.2 1.38
49 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34
50 INT112650 Positive_regulation of Col1a1 3 0.30 5.96 1.3
51 INT94692 Positive_regulation of Gene_expression of Sp1 3 0.17 0.39 1.28
52 INT24000 Regulation of Sp1 2 0.22 1.25 1.27
53 INT59473 Negative_regulation of Col1a1 4 0.25 1.33 1.24
54 INT71845 Positive_regulation of Positive_regulation of Col1a1 1 0.34 0.15 1.23
55 INT48554 Positive_regulation of SP1 12 0.49 3.64 1.2
56 INT140033 Positive_regulation of Gene_expression of Col1a1 6 0.14 3.68 1.2
57 INT226407 Negative_regulation of T 2 0.21 1.81 1.18
58 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
59 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
60 INT207183 Binding of Bmi1 1 0.01 16.24 1.14
61 INT93216 Negative_regulation of Phosphorylation of Sp1 2 0.14 0.4 1.13
62 INT183127 Localization of SULF1 1 0.77 3.45 1.13
63 INT208427 Regulation of T 3 0.25 3.28 1.08
64 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
65 INT177615 Gene_expression of PAX7 20 0.65 13.5 1.03
66 INT156614 Regulation of Gene_expression of COL1A1 6 0.33 2.51 0.99
67 INT129997 Protein_catabolism of Col1a1 5 0.96 3.43 0.96
68 INT123408 Positive_regulation of Gene_expression of Sp1 2 0.62 0.9 0.96
69 INT123407 Negative_regulation of Binding of Sp1 6 0.47 0.72 0.93
70 INT136458 Negative_regulation of Sp3 3 0.39 1.53 0.93
71 INT200272 Localization of Sp1 3 0.57 0.06 0.93
72 INT312362 Gene_expression of PBX1 1 0.56 4.48 0.87
73 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
74 INT8888 Regulation of Col1a1 4 0.13 1.97 0.86
75 INT287093 Positive_regulation of Gene_expression of T 1 0.28 1.47 0.86
76 INT287090 Regulation of Gene_expression of T 1 0.18 2.77 0.86
77 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85
78 INT53660 Positive_regulation of Pcsk5 2 0.49 0.29 0.85
79 INT123410 Negative_regulation of Gene_expression of Sp1 3 0.38 1.01 0.82
80 INT294805 Gene_expression of Dlx1 4 0.70 0.45 0.81
81 INT312364 Positive_regulation of PBX1 1 0.43 4.69 0.81
82 INT192156 Negative_regulation of Col1a1 6 0.39 3.92 0.8
83 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
84 INT287094 Transcription of T 1 0.29 1.41 0.8
85 INT114604 Positive_regulation of Acvr2a 2 0.41 0 0.73
86 INT161471 Gene_expression of Bmi1 9 0.76 11.47 0.72
87 INT226411 Binding of T 2 0.15 1.56 0.68
88 INT89520 Regulation of COL1A1 8 0.32 3.21 0.66
89 INT98967 Localization of SP1 2 0.60 0.15 0.66
90 INT24905 Negative_regulation of Gene_expression of SP1 4 0.39 2.05 0.65
91 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
92 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
93 INT183133 Negative_regulation of Localization of SULF1 1 0.41 1.34 0.59
94 INT238828 Regulation of RBP4 6 0.60 2.7 0.58
95 INT126899 Regulation of SP1 5 0.43 2.53 0.57
96 INT68092 Negative_regulation of Localization of COL1A1 1 0.48 0 0.53
97 INT89334 Negative_regulation of Binding of SP1 2 0.47 1.05 0.5
98 INT8886 Regulation of Transcription of Col1a1 1 0.04 0 0.5
99 INT200264 Localization of Sp3 1 0.62 0 0.47
100 INT206484 Localization of Shh 2 0.75 1.14 0.46
101 INT253558 Negative_regulation of Binding of Sp3 1 0.39 1.09 0.46
102 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
103 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
104 INT126896 Positive_regulation of Protein_catabolism of SP1 1 0.13 0.99 0.44
105 INT308493 Positive_regulation of Positive_regulation of Pcsk5 1 0.27 0 0.44
106 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
107 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
108 INT98969 Regulation of Binding of SP3 1 0.26 0 0.41
109 INT287095 Negative_regulation of Gene_expression of T 1 0.24 0.47 0.41
110 INT207182 Positive_regulation of Bmi1 1 0.02 6.81 0.41
111 INT320812 Positive_regulation of Localization of COL1A1 1 0.05 1.04 0.4
112 INT302352 Positive_regulation of Binding of Dlx1 1 0.45 0 0.4
113 INT231524 Localization of PAX7 5 0.56 4.2 0.39
114 INT89333 Negative_regulation of SP3 1 0.38 0.77 0.39
115 INT302357 Binding of Dlx1 1 0.33 0 0.39
116 INT89335 Negative_regulation of Binding of SP3 1 0.38 0.77 0.39
117 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
118 INT126895 Protein_catabolism of SP1 3 0.96 3.59 0.38
119 INT183114 Positive_regulation of Gene_expression of SULF1 1 0.48 7.61 0.37
120 INT98963 Positive_regulation of Binding of SP1 1 0.43 0 0.37
121 INT98960 Positive_regulation of Binding of SP3 1 0.67 0 0.37
122 INT166959 Positive_regulation of Positive_regulation of SP1 3 0.46 2.23 0.35
123 INT200265 Regulation of Sp3 2 0.37 0.25 0.34
124 INT183116 Positive_regulation of SULF1 1 0.67 3.22 0.34
125 INT163709 Regulation of Negative_regulation of COL1A1 1 0.29 0.93 0.34
126 INT218314 Binding of RBP4 9 0.36 6.27 0.33
127 INT254811 Localization of Col1a1 3 0.29 1.39 0.3
128 INT136460 Negative_regulation of Sp1 2 0.30 0.99 0.3
129 INT218316 Positive_regulation of RBP4 2 0.68 7.54 0.3
130 INT291615 Negative_regulation of Localization of Col1a1 1 0.06 1.28 0.3
131 INT312360 Positive_regulation of Gene_expression of PBX1 1 0.43 2 0.3
132 INT200276 Positive_regulation of Sp3 1 0.42 0.17 0.28
133 INT126512 Negative_regulation of Gene_expression of Col1a1 3 0.39 2.2 0.27
134 INT93215 Positive_regulation of Phosphorylation of Sp1 1 0.11 0.09 0.27
135 INT181808 Gene_expression of Pax7 18 0.54 6.22 0.26
136 INT250126 Localization of Hoxa3 4 0.74 1.5 0.26
137 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
138 INT176464 Protein_catabolism of Col1a1 1 0.19 0.83 0.26
139 INT161464 Regulation of Gene_expression of Bmi1 1 0.44 3.01 0.26
140 INT253556 Phosphorylation of Sp1 6 0.44 2.93 0.24
141 INT200251 Phosphorylation of Sp3 2 0.67 0.42 0.24
142 INT271432 Positive_regulation of Regulation of Col1a1 1 0.10 0.61 0.24
143 INT310477 Positive_regulation of Dlx2 1 0.46 0.47 0.23
144 INT225109 Regulation of Localization of COL1A1 1 0.05 0.41 0.23
145 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
146 INT178280 Regulation of PAX7 4 0.44 1.34 0.21
147 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
148 INT254040 Regulation of FGF9 2 0.57 1.04 0.21
149 INT218694 Binding of Col1a1 2 0.21 1.52 0.21
150 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
151 INT136457 Negative_regulation of Negative_regulation of Sp1 1 0.30 0.65 0.2
152 INT253542 Positive_regulation of Phosphorylation of Sp1 1 0.27 1.16 0.2
153 INT136452 Negative_regulation of Negative_regulation of Sp3 1 0.28 0.65 0.2
154 INT250111 Negative_regulation of Gene_expression of Hoxa3 2 0.43 1.3 0.19
155 INT161469 Regulation of Bmi1 1 0.61 2.41 0.19
156 INT120859 Positive_regulation of Localization of Col1a1 1 0.16 0.05 0.18
157 INT310492 Transcription of Dlx2 1 0.63 0.09 0.18
158 INT310468 Regulation of Gene_expression of Dlx2 1 0.42 0.1 0.18
159 INT139662 Gene_expression of FGF9 7 0.65 2.26 0.17
160 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
161 INT233570 Gene_expression of Rbp4 4 0.66 3.4 0.17
162 INT187816 Positive_regulation of Transcription of Col1a1 1 0.06 0.82 0.17
163 INT244740 Positive_regulation of Hoxd9 1 0.01 0.09 0.17
164 INT190588 Localization of Deaf1 1 0.22 0.6 0.17
165 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
166 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
167 INT294809 Positive_regulation of Gene_expression of Dlx1 2 0.37 0.21 0.16
168 INT340373 Negative_regulation of Rbp4 1 0.17 1.96 0.16
169 INT310469 Negative_regulation of Gene_expression of Dlx2 1 0.39 0.66 0.16
170 INT136454 Positive_regulation of Gene_expression of Sp3 1 0.33 0.44 0.16
171 INT178673 Positive_regulation of Gene_expression of SP1 1 0.08 0.14 0.16
172 INT233260 Gene_expression of HOXA9 37 0.67 3.45 0.15
173 INT177614 Positive_regulation of PAX7 8 0.54 2.14 0.15
174 INT130000 Positive_regulation of Protein_catabolism of Col1a1 1 0.49 1.15 0.15
175 INT187815 Transcription of Col1a1 1 0.09 0.76 0.15
176 INT238831 Regulation of Localization of RBP4 1 0.27 1.71 0.15
177 INT73297 Positive_regulation of Transcription of Col1a1 2 0.32 3.12 0.14
178 INT257290 Negative_regulation of Transcription of COL1A1 3 0.27 1.64 0.13
179 INT253190 Localization of Shh 2 0.77 1.06 0.13
180 INT183125 Negative_regulation of SULF1 2 0.42 2.26 0.13
181 INT192056 Binding of Pbx1 2 0.31 0.46 0.13
182 INT200261 Positive_regulation of Transcription of Sp3 1 0.42 0 0.13
183 INT200280 Transcription of Sp3 1 0.57 0 0.13
184 INT327856 Gene_expression of Dlk1 1 0.45 0.97 0.13
185 INT161470 Regulation of Negative_regulation of Bmi1 1 0.27 1.49 0.13
186 INT327860 Positive_regulation of Gene_expression of Dlk1 1 0.35 1.04 0.13
187 INT161473 Negative_regulation of Bmi1 1 0.42 1.49 0.13
188 INT222585 Transcription of Acvr2a 1 0.16 0 0.13
189 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
190 INT286293 Binding of Rbp4 3 0.17 0.61 0.12
191 INT192060 Gene_expression of Hoxd9 2 0.54 0.25 0.12
192 INT280917 Regulation of Gene_expression of Hoxa3 1 0.45 2.12 0.12
193 INT310465 Binding of Dlx2 1 0.34 0.33 0.11
194 INT162574 Gene_expression of Wnt5a 7 0.47 0.92 0.1
195 INT200268 Positive_regulation of Binding of Sp3 2 0.39 0.8 0.1
196 INT282594 Localization of WNT5A 2 0.18 0.89 0.1
197 INT233483 Regulation of Gene_expression of Wnt5a 1 0.19 0.33 0.1
198 INT183124 Regulation of Gene_expression of SULF1 1 0.59 1.92 0.1
199 INT173632 Transcription of SP1 7 0.41 1.42 0.09
200 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
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