GO:0048741

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Name skeletal muscle fiber development
Categary Process
Go Slim No
Go Link GO:0048741
Unique Molecular Interactions 94
Total Molecular Interactions 122
Total Single Events 1650
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for skeletal muscle fiber development. They are ordered first by their pain relevance and then by number of times they were reported for skeletal muscle fiber development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149743 Ean5 Positive_regulation of Gene_expression of P2rx2 1 0.10 1.54 1.5
2 INT158144 Binding of Gpx1 and Glyat 2 0.31 0 1.29
3 INT168866 Binding of RYR1 and Cd38 1 0.02 0.17 1.28
4 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
5 INT164607 Positive_regulation of GSR Positive_regulation of Gpx1 1 0.01 0.33 0.81
6 INT164606 GSR Positive_regulation of Gpx1 1 0.01 0.32 0.8
7 INT152949 Homer1 Regulation of Sgk1 1 0.28 0.18 0.76
8 INT152946 Homer1 Regulation of Cap1 1 0.32 0.18 0.76
9 INT152948 Homer1 Regulation of Gpr88 1 0.36 0.18 0.75
10 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
11 INT96282 Cav2 Regulation of Positive_regulation of Gabrg1 1 0.25 0 0.48
12 INT81064 Negative_regulation of Nts Negative_regulation of Gene_expression of Homer1 1 0.01 0 0.48
13 INT161654 Gsr Regulation of Gpx1 1 0.14 0.85 0.42
14 INT168435 Positive_regulation of Binding of GLRX and Gpx1 1 0.05 0.91 0.42
15 INT168434 Binding of GLRX and Gpx1 1 0.04 0.9 0.42
16 INT283714 Positive_regulation of Binding of Id2 and Homer1 1 0.08 1.34 0.42
17 INT283713 Binding of Id2 and Homer1 1 0.06 1.34 0.42
18 INT158104 Binding of Trpv1 and P2rx2 1 0.03 0.27 0.4
19 INT168461 Sult1a1 Positive_regulation of Gpx1 1 0.12 0.83 0.39
20 INT149221 Binding of Ryr1 and Trpc3 5 0.40 0 0.37
21 INT238261 pma Positive_regulation of Prkcg 1 0.01 0.33 0.34
22 INT334023 pma Positive_regulation of Gene_expression of CD36 1 0.04 0.31 0.28
23 INT238263 pma Positive_regulation of Gene_expression of Cd59 1 0.02 0.57 0.26
24 INT238260 Positive_regulation of pma Negative_regulation of Transcription of C3 1 0.02 0.12 0.23
25 INT150582 Creb1 Positive_regulation of Gene_expression of Homer1 1 0.00 0 0.22
26 INT174679 Homer1 Regulation of Luc7l3 1 0.02 0.67 0.21
27 INT283373 Pcbd1 Regulation of RYR1 1 0.00 1.45 0.21
28 INT131963 Binding of CAV2 and ATXN2 1 0.04 1.39 0.21
29 INT121807 CACNA1A Regulation of CAV2 1 0.01 0.25 0.2
30 INT121806 PHF21A Regulation of CAV2 1 0.00 0.24 0.2
31 INT343644 Grm5 Positive_regulation of Cav2 1 0.05 0 0.19
32 INT215167 Phosphorylation of Prkaca Positive_regulation of P2rx2 1 0.06 0.13 0.18
33 INT238264 pma Negative_regulation of Gene_expression of Cr1l 1 0.02 0.26 0.16
34 INT58179 Gtf3a Positive_regulation of Gene_expression of Homer1 1 0.07 0.1 0.16
35 INT271071 Binding of ACTA1 and Hypism 1 0.00 1.54 0.15
36 INT336665 Binding of P2rx1 and P2rx2 1 0.07 0 0.14
37 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14
38 INT252573 Rpe Negative_regulation of Gpx1 1 0.07 2.34 0.13
39 INT207785 Binding of RYR1 and Ap3d1 1 0.06 3.24 0.13
40 INT143661 Abl1 Regulation of Gpx1 1 0.19 0.56 0.12
41 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
42 INT265982 Homer1 Regulation of Grm5 1 0.04 0.38 0.12
43 INT143662 Rere Regulation of Gpx1 1 0.69 0.56 0.12
44 INT215169 Ptger2 Regulation of P2rx2 1 0.19 0.31 0.11
45 INT351427 Binding of PIK3C3 and RYR1 1 0.00 0 0.11
46 INT149219 Binding of Ryr1 and Trpc1 1 0.35 0 0.11
47 INT225740 RYR1 Positive_regulation of Binding of Entpd1 1 0.08 0.08 0.1
48 INT101880 Oxt Positive_regulation of Gene_expression of Homer1 1 0.23 0.14 0.1
49 INT265981 Homer1 Regulation of Localization of Grm5 1 0.04 0.06 0.09
50 INT265983 Homer1 Regulation of Ryr1 1 0.37 0.15 0.07
51 INT170517 Binding of Ryr1 and Qdpr 2 0.15 0.36 0.05
52 INT208432 Sms Negative_regulation of Negative_regulation of Gpx1 1 0.14 0.61 0.05
53 INT208433 Sms Positive_regulation of Gene_expression of Gpx1 1 0.25 0.53 0.05
54 INT334026 pma Regulation of Gene_expression of CD36 1 0.02 0.16 0.05
55 INT8928 Negative_regulation of Trpc4 Negative_regulation of Positive_regulation of Acta1 1 0.02 0.18 0.05
56 INT294311 Gene_expression of RCAN1 Positive_regulation of IL11 1 0.39 0 0.04
57 INT347414 Tlr4 Negative_regulation of Gpx1 1 0.01 0.36 0.04
58 INT294299 Gene_expression of RCAN1 Negative_regulation of PROK1 1 0.42 0 0.04
59 INT252767 CAT Regulation of Gpx1 1 0.00 0.25 0.04
60 INT294298 PROK1 Positive_regulation of Gene_expression of RCAN1 1 0.49 0 0.03
61 INT294293 Binding of RCAN1 and CABIN1 1 0.03 0 0.03
62 INT286268 Binding of GSR and Gpx1 2 0.02 0 0
63 INT327052 Gene_expression of Akt1 Positive_regulation of Gene_expression of Myod1 1 0.19 0.18 0
64 INT340560 Myog Positive_regulation of Mapk1 1 0.07 0.25 0
65 INT132849 Homer1 Regulation of Srf 1 0.01 0.15 0
66 INT294305 PROK1 Regulation of RCAN1 1 0.26 0 0
67 INT266704 Binding of RYR1 and TRDN 1 0.34 0 0
68 INT316647 Ryr1 Regulation of Qdpr 1 0.19 0.68 0
69 INT294304 RCAN1 Negative_regulation of PROK1 1 0.57 0 0
70 INT155123 Binding of Gpx1 and Cat 1 0.04 0.05 0
71 INT297212 Gene_expression of Ppp3ca Positive_regulation of Nfatc1 1 0.38 0.22 0
72 INT294307 Gene_expression of RCAN1 Negative_regulation of Gene_expression of IL11 1 0.36 0.09 0
73 INT287077 Chrm2 Positive_regulation of Homer1 1 0.05 0.08 0
74 INT283372 Binding of RYR1 and Pcbd1 1 0.00 0.28 0
75 INT155124 Positive_regulation of Binding of Gpx1 and Cat 1 0.05 0.05 0
76 INT340557 Myog Positive_regulation of Negative_regulation of Mapk1 1 0.16 0.25 0
77 INT340554 Myod1 Positive_regulation of Negative_regulation of Mapk1 1 0.28 0.25 0
78 INT340551 Myod1 Positive_regulation of Mapk1 1 0.19 0.25 0
79 INT281097 Binding of P2rx3 and P2rx2 1 0.06 0 0
80 INT299628 MSTN Negative_regulation of Gene_expression of MYOD1 1 0.09 0.15 0
81 INT214980 Binding of Cav2 and Sigmar1 1 0.02 0.07 0
82 INT88409 BMP7 Positive_regulation of Gene_expression of ACTA1 1 0.09 0 0
83 INT351596 Regulation of Binding of GSR and Gpx1 1 0.02 0 0
84 INT356290 pma Positive_regulation of Mapk1 1 0.00 0 0
85 INT297215 Gene_expression of Ppp3ca Positive_regulation of Ppp3r1 1 0.36 0.22 0
86 INT271027 Binding of RYR1 and Car2 1 0.03 0.46 0
87 INT296725 Binding of P2rx2 and Afm 1 0.10 0 0
88 INT340559 Myod1 Positive_regulation of Myog 1 0.12 0.25 0
89 INT206963 Lipg Regulation of Gpx1 1 0.00 0.5 0
90 INT266703 Binding of RYR1 and DIXDC1 1 0.26 0.1 0
91 INT296930 Casq1 Negative_regulation of RYR1 1 0.00 0.38 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for skeletal muscle fiber development. They are ordered first by their pain relevance and then by number of times they were reported in skeletal muscle fiber development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16
2 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67
3 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4
4 INT7899 Positive_regulation of Gene_expression of Homer1 41 0.70 7.29 25.98
5 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05
6 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07
7 INT91285 Negative_regulation of P2rx2 29 0.57 12.74 15.48
8 INT92839 Regulation of P2rx2 36 0.45 13.19 15.38
9 INT78234 Positive_regulation of Gene_expression of P2rx2 18 0.69 12.86 12.75
10 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77
11 INT60995 Negative_regulation of Positive_regulation of Homer1 9 0.38 1.63 9.63
12 INT105304 Negative_regulation of Gene_expression of P2rx2 11 0.28 11.07 9.53
13 INT116705 Positive_regulation of Positive_regulation of P2rx2 13 0.49 9.44 9.47
14 INT15242 Regulation of Gene_expression of Homer1 14 0.62 4.33 9.28
15 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83
16 INT18393 Negative_regulation of Ryr1 15 0.43 3.63 7.57
17 INT120261 Binding of P2rx2 19 0.28 5.8 6.72
18 INT105306 Regulation of Gene_expression of P2rx2 7 0.21 6.92 5.22
19 INT59555 Binding of RYR1 39 0.42 8.65 4.92
20 INT53974 Regulation of Homer1 14 0.39 4.71 4.9
21 INT148649 Transcription of P2rx2 8 0.43 8.11 4.79
22 INT9798 Negative_regulation of Gene_expression of Homer1 10 0.41 2.04 3.77
23 INT215163 Phosphorylation of P2rx2 19 0.60 1.43 3.62
24 INT53584 Regulation of Gpx1 19 0.62 14.38 3.48
25 INT60714 Regulation of Positive_regulation of Homer1 3 0.04 0.64 3.46
26 INT18396 Positive_regulation of Ryr1 10 0.58 2.45 3.38
27 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26
28 INT18394 Regulation of Ryr1 6 0.60 0.28 3.26
29 INT81830 Localization of P2rx2 14 0.73 5.42 3.16
30 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11
31 INT90289 Positive_regulation of Gene_expression of Gpx1 10 0.17 8.07 3.05
32 INT292058 Positive_regulation of Cav2 7 0.67 3.43 2.89
33 INT58173 Negative_regulation of Homer1 5 0.43 1 2.79
34 INT149314 Negative_regulation of CAV2 5 0.42 1.21 2.76
35 INT82278 Positive_regulation of Positive_regulation of Homer1 5 0.13 2.32 2.73
36 INT282270 Gene_expression of Cav2 11 0.57 3.53 2.72
37 INT151878 Gene_expression of CAV2 18 0.66 9.26 2.17
38 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04
39 INT287525 Localization of CAV2 5 0.47 5.32 2
40 INT148648 Negative_regulation of Transcription of P2rx2 3 0.29 3.54 1.94
41 INT292051 Negative_regulation of Cav2 6 0.41 2.52 1.9
42 INT61845 Transcription of Homer1 9 0.72 2.28 1.85
43 INT94848 Negative_regulation of Gene_expression of Gpx1 11 0.30 4.91 1.7
44 INT11713 Localization of RYR1 22 0.76 10.42 1.64
45 INT63520 Localization of Homer1 4 0.75 0.38 1.63
46 INT67869 Transcription of Gpx1 3 0.68 0.67 1.56
47 INT71918 Gene_expression of ACTA1 16 0.75 7.73 1.45
48 INT168726 Negative_regulation of Positive_regulation of P2rx2 1 0.07 0.09 1.44
49 INT168727 Negative_regulation of Negative_regulation of P2rx2 1 0.07 0.09 1.43
50 INT82279 Regulation of Negative_regulation of Homer1 1 0.02 0 1.36
51 INT55305 Regulation of RYR1 14 0.45 5.27 1.33
52 INT142815 Regulation of Regulation of P2rx2 4 0.33 0.69 1.33
53 INT154813 Regulation of Transcription of P2rx2 2 0.26 2.38 1.17
54 INT215499 Positive_regulation of Phosphorylation of P2rx2 3 0.37 0.57 1.07
55 INT89887 Regulation of Gene_expression of Gpx1 3 0.32 0.8 1.02
56 INT292059 Positive_regulation of Gene_expression of Cav2 3 0.42 0.88 0.92
57 INT116831 Binding of Ryr1 11 0.47 0.12 0.9
58 INT9797 Binding of Homer1 2 0.48 1.14 0.9
59 INT116314 Gene_expression of Myod1 38 0.70 16.6 0.89
60 INT38446 Localization of Ryr1 3 0.64 0.28 0.86
61 INT121774 Binding of ACTA1 4 0.47 2.31 0.85
62 INT168432 Negative_regulation of Positive_regulation of Gpx1 4 0.40 2.89 0.75
63 INT152326 Regulation of Gene_expression of CAV2 2 0.36 0.44 0.74
64 INT151877 Positive_regulation of Gene_expression of CAV2 2 0.40 0.39 0.72
65 INT76315 Gene_expression of Myog 15 0.41 6.79 0.6
66 INT148230 Positive_regulation of Regulation of Gpx1 1 0.31 0.58 0.6
67 INT65977 Gene_expression of RCAN1 6 0.70 3.72 0.59
68 INT76505 Positive_regulation of Transcription of Homer1 3 0.21 0.48 0.59
69 INT18395 Negative_regulation of Negative_regulation of Ryr1 1 0.00 0 0.59
70 INT21087 Negative_regulation of Ppp3ca 2 0.32 0.31 0.58
71 INT121810 Positive_regulation of CAV2 2 0.28 0.55 0.57
72 INT84854 Regulation of Transcription of Homer1 1 0.00 0.15 0.57
73 INT215501 Positive_regulation of Binding of P2rx2 3 0.37 0.61 0.56
74 INT57201 Localization of ACTA1 2 0.73 1.53 0.56
75 INT107819 Positive_regulation of Localization of P2rx2 1 0.24 0.66 0.55
76 INT146784 Gene_expression of MYOD1 13 0.74 4.41 0.54
77 INT315028 Regulation of Cav2 2 0.43 0.86 0.54
78 INT92523 Phosphorylation of Homer1 3 0.63 0.15 0.52
79 INT238239 Positive_regulation of pma 3 0.03 0.5 0.51
80 INT73301 Positive_regulation of ACTA1 2 0.01 0.58 0.51
81 INT298539 Binding of CAV2 2 0.39 0.95 0.48
82 INT15647 Regulation of Positive_regulation of RYR1 1 0.26 0.23 0.45
83 INT73302 Transcription of ACTA1 2 0.02 0.55 0.43
84 INT88005 Binding of MYOD1 6 0.30 2.08 0.42
85 INT343628 Regulation of Positive_regulation of Cav2 1 0.19 0 0.4
86 INT8923 Positive_regulation of Acta1 1 0.18 0.96 0.39
87 INT238241 Negative_regulation of Positive_regulation of pma 1 0.02 0.35 0.39
88 INT217405 Regulation of Positive_regulation of P2rx2 1 0.32 0 0.33
89 INT215492 Negative_regulation of Phosphorylation of P2rx2 1 0.31 0 0.31
90 INT137586 Binding of Gpx1 8 0.23 2.76 0.29
91 INT80636 Positive_regulation of Localization of RYR1 2 0.47 0.78 0.29
92 INT116703 Negative_regulation of Negative_regulation of Gpx1 3 0.18 0.81 0.28
93 INT292064 Positive_regulation of Positive_regulation of Cav2 1 0.49 0.5 0.28
94 INT34275 Positive_regulation of Ppp3ca 2 0.31 0.24 0.27
95 INT280603 Transcription of Myod1 4 0.67 1.22 0.24
96 INT160516 Positive_regulation of Transcription of P2rx2 1 0.13 0.2 0.24
97 INT185719 Regulation of Gene_expression of MYOD1 1 0.07 0 0.24
98 INT59650 Regulation of Binding of RYR1 1 0.04 0 0.23
99 INT1594 Binding of Ppp3ca 1 0.29 0 0.22
100 INT272484 Negative_regulation of Myod1 8 0.39 6.77 0.2
101 INT274775 Regulation of Positive_regulation of Gpx1 1 0.04 0.76 0.2
102 INT121809 Regulation of Positive_regulation of CAV2 1 0.25 0.26 0.2
103 INT49908 Regulation of Gene_expression of RYR1 3 0.45 0.32 0.19
104 INT272940 Positive_regulation of Gene_expression of Myog 3 0.37 1.57 0.18
105 INT177568 Localization of Gpx1 5 0.49 1.82 0.16
106 INT60209 Transcription of RYR1 3 0.69 3.06 0.16
107 INT329386 Positive_regulation of Localization of CAV2 1 0.17 0.19 0.16
108 INT272949 Positive_regulation of Myod1 6 0.36 5.31 0.14
109 INT73303 Positive_regulation of Transcription of ACTA1 1 0.01 0.29 0.14
110 INT143657 Phosphorylation of Gpx1 1 0.82 0.97 0.14
111 INT143658 Regulation of Phosphorylation of Gpx1 1 0.45 0.97 0.14
112 INT145096 Negative_regulation of ACTA1 1 0.43 0.28 0.14
113 INT143659 Positive_regulation of Phosphorylation of Gpx1 1 0.50 0.98 0.14
114 INT158175 Positive_regulation of Gene_expression of RYR1 2 0.48 1.35 0.13
115 INT88416 Positive_regulation of Gene_expression of ACTA1 2 0.67 1.05 0.13
116 INT314341 Positive_regulation of Localization of Gpx1 1 0.08 0.82 0.13
117 INT170514 Gene_expression of Ryr1 4 0.49 0.56 0.12
118 INT219214 Positive_regulation of Gene_expression of MYOD1 1 0.35 0.21 0.12
119 INT8926 Negative_regulation of Positive_regulation of Acta1 1 0.11 0.33 0.12
120 INT327036 Transcription of Myog 2 0.16 0.51 0.11
121 INT252568 Negative_regulation of Regulation of Gpx1 1 0.08 1.11 0.09
122 INT294346 Positive_regulation of Gene_expression of RCAN1 1 0.63 0.34 0.09
123 INT8922 Positive_regulation of Positive_regulation of Acta1 1 0.13 0.13 0.09
124 INT214973 Binding of Cav2 2 0.03 0.57 0.08
125 INT272945 Protein_catabolism of Myod1 1 0.35 2.1 0.08
126 INT272469 Negative_regulation of Gene_expression of Myod1 5 0.39 2.82 0.07
127 INT8924 Regulation of Positive_regulation of Acta1 1 0.12 0.18 0.07
128 INT229652 Regulation of Myog 2 0.25 0.88 0.06
129 INT214968 Localization of Cav2 1 0.05 0.08 0.05
130 INT271024 Negative_regulation of Binding of RYR1 3 0.05 1.07 0.04
131 INT340544 Binding of Myog 1 0.16 0.81 0.04
132 INT340173 Positive_regulation of Transcription of Myod1 1 0.14 0.26 0.04
133 INT340536 Negative_regulation of Myog 1 0.24 2.39 0.04
134 INT316641 Positive_regulation of Localization of Ryr1 1 0.42 0 0.04
135 INT340166 Positive_regulation of Transcription of Myog 1 0.11 0.26 0.04
136 INT294322 Binding of RCAN1 1 0.32 0 0.03
137 INT327034 Negative_regulation of Gene_expression of Myog 4 0.31 1.08 0
138 INT272946 Localization of Myod1 3 0.56 1.6 0
139 INT301729 Positive_regulation of Gene_expression of Myod1 2 0.24 1.53 0
140 INT327027 Regulation of Gene_expression of Myog 2 0.24 0.86 0
141 INT203677 Negative_regulation of Gene_expression of RCAN1 2 0.39 1.31 0
142 INT327021 Phosphorylation of Myog 2 0.33 1.26 0
143 INT299630 Negative_regulation of Gene_expression of MYOD1 1 0.16 0.15 0
144 INT203676 Localization of RCAN1 1 0.06 1.11 0
145 INT227665 Transcription of MYOD1 1 0.23 0.3 0
146 INT297186 Negative_regulation of Gene_expression of Ppp3ca 1 0.30 0.24 0
147 INT211904 Negative_regulation of Localization of RYR1 1 0.37 0.64 0
148 INT239147 Regulation of Binding of Gpx1 1 0.28 0.53 0
149 INT294328 Regulation of RCAN1 1 0.41 0 0
150 INT282279 Regulation of Gene_expression of Cav2 1 0.05 0.39 0
151 INT332316 Negative_regulation of Positive_regulation of Cav2 1 0.22 0 0
152 INT268724 Positive_regulation of Negative_regulation of Gpx1 1 0.04 0.13 0
153 INT332317 Negative_regulation of Gene_expression of Cav2 1 0.25 0 0
154 INT297195 Positive_regulation of Gene_expression of Ppp3ca 1 0.35 0.22 0
155 INT297194 Protein_catabolism of Ppp3ca 1 0.46 0.3 0
156 INT327032 Negative_regulation of Phosphorylation of Myog 1 0.23 0.22 0
157 INT332315 Positive_regulation of Negative_regulation of Cav2 1 0.26 0 0
158 INT272948 Negative_regulation of Localization of Myod1 1 0.15 1.43 0
159 INT297203 Gene_expression of Ppp3ca 1 0.55 0.74 0
160 INT204718 Localization of MYOD1 1 0.29 0 0
161 INT272944 Positive_regulation of Localization of Myod1 1 0.17 1.44 0
162 INT340549 Positive_regulation of Myog 1 0.21 0.27 0
163 INT272950 Regulation of Gene_expression of Myod1 1 0.41 0.7 0
164 INT335757 Positive_regulation of Positive_regulation of Gpx1 1 0.07 0.66 0
165 INT238240 Localization of pma 1 0.04 0 0
166 INT347402 Negative_regulation of Binding of Gpx1 1 0.05 0 0
167 INT340534 Regulation of Myod1 1 0.14 0.61 0
168 INT80635 Regulation of Localization of RYR1 1 0.04 0.1 0
169 INT272939 Positive_regulation of Negative_regulation of Myod1 1 0.16 0.78 0
170 INT211903 Negative_regulation of Gene_expression of RYR1 1 0.37 0.06 0
171 INT351593 Positive_regulation of Binding of Gpx1 1 0.08 0 0
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