GO:0048754

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Name branching morphogenesis of a tube
Categary Process
Go Slim No
Go Link GO:0048754
Unique Molecular Interactions 855
Total Molecular Interactions 1255
Total Single Events 7782
Pain Genes Associated 51

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for branching morphogenesis of a tube. They are ordered first by their pain relevance and then by number of times they were reported for branching morphogenesis of a tube. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
3 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
4 INT273120 NOVA2 Regulation of Gene_expression of MET 1 0.23 1.17 2.11
5 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
6 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81
7 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
8 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
9 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
10 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
11 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
12 INT30128 Binding of MET and Gast 1 0.06 0.18 1.25
13 INT220751 EGF Regulation of GOPC 1 0.08 0 1.18
14 INT220752 Negative_regulation of EGF Regulation of NAV1 1 0.26 0 1.18
15 INT220753 Negative_regulation of EGF Regulation of GOPC 1 0.08 0 1.18
16 INT220748 EGF Regulation of NAV1 1 0.28 0 1.17
17 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
18 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
19 INT136989 EGF Negative_regulation of Positive_regulation of KCNJ2 1 0.04 1.09 1.1
20 INT136988 EGF Negative_regulation of KCNJ2 1 0.04 1.09 1.04
21 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
22 INT148327 Binding of Pkd1 and Trpv1 1 0.52 2.23 1.01
23 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
24 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
25 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
26 INT137920 Binding of Kdr and Oprm1 1 0.23 0 0.97
27 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
28 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
29 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
30 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
31 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
32 INT220744 EGF Positive_regulation of Gene_expression of KRT20 1 0.01 1.26 0.9
33 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
34 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
35 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
36 INT260842 Binding of NRP2 and Kdr 1 0.00 2.28 0.85
37 INT46085 Binding of MET and Penk 1 0.02 0.06 0.83
38 INT220739 EGF Positive_regulation of Transcription of NAV1 1 0.31 0.16 0.83
39 INT46076 Binding of MET and SELL 1 0.39 0.06 0.83
40 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8
41 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8
42 INT141605 Gene_expression of Ctsl Positive_regulation of Positive_regulation of MET 1 0.34 0 0.8
43 INT220747 Binding of PCa and EGF 1 0.05 1.42 0.8
44 INT42797 Egf Regulation of Gene_expression of Penk 1 0.21 0.07 0.8
45 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
46 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
47 INT231031 Egf Positive_regulation of Sec22b 1 0.03 0.05 0.76
48 INT113472 TNF Positive_regulation of Localization of MMP14 1 0.47 0.45 0.75
49 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
50 INT220746 EGF Positive_regulation of Gene_expression of GOPC 1 0.13 0 0.72
51 INT123300 Mks1 Positive_regulation of Creb1 1 0.01 0.35 0.7
52 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
53 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
54 INT224678 Binding of Mmp14 and Mmp23 1 0.00 0.85 0.69
55 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
56 INT194857 Positive_regulation of Adora2a Positive_regulation of Gene_expression of Vegfa 1 0.23 0.74 0.67
57 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
58 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
59 INT224683 Mmp14 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
60 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
61 INT224684 Binding of Mmp14 and Mmp9 1 0.01 0.81 0.64
62 INT113473 RETNLB Positive_regulation of MMP14 1 0.01 0.37 0.64
63 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
64 INT169287 EGF Positive_regulation of Localization of IL8 1 0.15 0.13 0.61
65 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
66 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
67 INT144071 TRPV1 Positive_regulation of Gene_expression of MMP14 1 0.21 0.5 0.58
68 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
69 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
70 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
71 INT199976 EGF Regulation of ITGB3BP 1 0.02 0.77 0.57
72 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
73 INT339335 Binding of MET and TACR1 1 0.06 0.06 0.57
74 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
75 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
76 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
77 INT121993 Binding of EGF and SGCG 1 0.40 0 0.55
78 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
79 INT129270 Binding of Wnt4 and Efs 1 0.00 0 0.55
80 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
81 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
82 INT220745 EGF Positive_regulation of Positive_regulation of PCa 1 0.05 0.79 0.52
83 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
84 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
85 INT98734 Egf Negative_regulation of Tk1 1 0.13 0.15 0.49
86 INT295708 Binding of EGF and CCL2 1 0.01 0.79 0.49
87 INT14993 MET Positive_regulation of Localization of FPR1 1 0.50 0.44 0.49
88 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48
89 INT108329 EGF Positive_regulation of Phosphorylation of EPHB2 4 0.48 3.96 0.48
90 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
91 INT345306 Binding of MMP14 and TIMP2 1 0.04 0.21 0.48
92 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
93 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
94 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
95 INT345305 MMP14 Positive_regulation of MMP13 1 0.00 0.33 0.45
96 INT345304 MMP14 Positive_regulation of MMP2 1 0.08 0.2 0.45
97 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
98 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
99 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
100 INT295406 Egf Regulation of Gene_expression of Oprk1 1 0.01 0.72 0.43
101 INT311590 EGF Regulation of Gene_expression of CXCL10 1 0.23 0.51 0.43
102 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43
103 INT113471 RETNLB Regulation of Localization of MMP14 1 0.01 0.24 0.43
104 INT311591 CXCL10 Regulation of Gene_expression of EGF 1 0.23 0.51 0.43
105 INT13281 Egf Regulation of Ngf 1 0.66 0.12 0.42
106 INT13279 Ngf Regulation of Egf 1 0.49 0.12 0.42
107 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
108 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
109 INT13283 Egf Regulation of Fgf2 1 0.49 0.11 0.41
110 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
111 INT13284 Fgf2 Regulation of Egf 1 0.49 0.11 0.41
112 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
113 INT222180 Binding of HNF1B and TFAM 1 0.01 1.48 0.4
114 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
115 INT135015 MGP Negative_regulation of Cabin1 1 0.01 0.26 0.4
116 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
117 INT90807 EGF Positive_regulation of Oprd1 1 0.00 0.39 0.39
118 INT304319 Ptger1 Positive_regulation of Gene_expression of Vegfa 1 0.37 1.19 0.39
119 INT283840 Binding of Egf and hb 1 0.21 1.34 0.38
120 INT330519 Binding of CD8A and DICER1 1 0.08 0.99 0.38
121 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38
122 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37
123 INT342622 Binding of MMP14 and Mmp2 1 0.39 1.15 0.37
124 INT342606 Binding of MMP14 and VEGFA 1 0.08 1.16 0.37
125 INT311616 Binding of MET and Comt 1 0.01 0.2 0.37
126 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37
127 INT356274 Egf Positive_regulation of Localization of Stat3 1 0.13 0.22 0.36
128 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
129 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
130 INT295407 Egf Positive_regulation of Localization of Oprk1 1 0.02 0.67 0.36
131 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
132 INT329449 IL17A Regulation of Gene_expression of Vegfa 1 0.28 0.63 0.36
133 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
134 INT94875 Binding of Calca and Egf 1 0.25 0 0.35
135 INT337156 Kdr Positive_regulation of Gtf3a 1 0.01 0.77 0.35
136 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
137 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34
138 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
139 INT188193 Negative_regulation of EGF Positive_regulation of MAPK1 1 0.28 0.54 0.34
140 INT352232 VEGFA Negative_regulation of Vegfa 1 0.02 0.21 0.34
141 INT113476 IL1A Positive_regulation of Localization of MMP14 1 0.10 0.22 0.34
142 INT156831 EGF Positive_regulation of MAPK1 2 0.45 0.27 0.33
143 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
144 INT26193 OPRD1 Positive_regulation of MET 1 0.47 0 0.33
145 INT329448 IL17A Positive_regulation of Gene_expression of Vegfa 1 0.45 0.59 0.32
146 INT220740 EGF Positive_regulation of Regulation of NAV1 1 0.31 0.61 0.32
147 INT220749 EGF Positive_regulation of Positive_regulation of KRT20 1 0.01 0.61 0.32
148 INT299549 Binding of TGFB1 and Egf 1 0.02 0.32 0.32
149 INT113475 RETNLB Positive_regulation of Localization of MMP14 1 0.01 0.18 0.32
150 INT75769 Egf Positive_regulation of Cpox 1 0.26 0.76 0.31
151 INT173947 Il6 Positive_regulation of Gene_expression of IGF1 1 0.05 1.02 0.31
152 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3
153 INT170496 Egf Positive_regulation of Mapk1 3 0.21 0.5 0.3
154 INT356288 Egf Positive_regulation of Trib3 1 0.00 0.17 0.3
155 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
156 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
157 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
158 INT328223 Mmp14 Regulation of Positive_regulation of Mmp13 1 0.07 0.69 0.29
159 INT83967 Binding of MGP and OPRD1 1 0.16 0 0.29
160 INT142885 Positive_regulation of IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.29
161 INT303440 Egf Positive_regulation of Gene_expression of Col7a1 1 0.07 0.92 0.28
162 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
163 INT337162 Binding of Kdr and Iqgap1 1 0.32 0.98 0.28
164 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28
165 INT173949 Binding of IGF1 and Atp6v1e1 1 0.01 0.89 0.28
166 INT142884 IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.28
167 INT149898 Ihh Regulation of Localization of Mmp14 1 0.03 1.29 0.27
168 INT56892 Binding of MGP and Oprd1 1 0.05 0 0.27
169 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
170 INT193027 EGF Positive_regulation of Positive_regulation of MRGPRX1 1 0.02 0 0.27
171 INT285243 EGF Positive_regulation of Egf 1 0.00 1.55 0.27
172 INT285238 EGF Positive_regulation of VEGFA 1 0.01 1.55 0.27
173 INT144255 EGF Regulation of Positive_regulation of NFKB1 1 0.41 0.66 0.27
174 INT195898 Negative_regulation of Egf Negative_regulation of Gene_expression of Cpox 1 0.03 0.3 0.26
175 INT171384 Egf Negative_regulation of Positive_regulation of Mapk1 1 0.16 0.24 0.26
176 INT68872 Ghrh Regulation of IGF1 1 0.09 0.18 0.26
177 INT244687 Mmp14 Positive_regulation of Mmp2 1 0.23 0.48 0.25
178 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
179 INT332242 Binding of Egf and Pdgfa 1 0.07 0.97 0.25
180 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
181 INT9720 Binding of TGFB1 and Egf 1 0.01 0 0.23
182 INT7869 Gh Negative_regulation of IGF1 1 0.39 0.47 0.23
183 INT220750 EGF Positive_regulation of PCa 1 0.05 0.45 0.23
184 INT323436 VEGFA Regulation of Kdr 1 0.03 0.77 0.23
185 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
186 INT173294 LPA Positive_regulation of EGF 1 0.01 0.07 0.23
187 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
188 INT173292 F2 Positive_regulation of EGF 1 0.00 0.07 0.23
189 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
190 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
191 INT118838 Gene_expression of Vegfa Positive_regulation of Gene_expression of Mb 1 0.44 0.4 0.22
192 INT9717 Binding of Egf and Fgfr1 1 0.15 0 0.22
193 INT9716 Binding of Egf and Pdgfc 1 0.20 0 0.22
194 INT193033 Binding of CHRM1 and EGF 1 0.01 1.96 0.22
195 INT149900 Gli1 Regulation of Localization of Mmp14 1 0.02 1.17 0.22
196 INT137611 Crh Positive_regulation of Vegfa 1 0.43 0.49 0.21
197 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21
198 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
199 INT9718 Binding of Egf and Ngf 1 0.30 0 0.21
200 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21

Single Events

The table below shows the top 100 pain related interactions that have been reported for branching morphogenesis of a tube. They are ordered first by their pain relevance and then by number of times they were reported in branching morphogenesis of a tube. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
2 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
3 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
4 INT14823 Gene_expression of MET 103 0.75 51.92 32.48
5 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47
6 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
7 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
8 INT11157 Binding of EGF 88 0.48 53.73 21.25
9 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
10 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
11 INT99898 Gene_expression of Mmp14 37 0.56 28.54 16.39
12 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89
13 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
14 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68
15 INT12464 Binding of MET 38 0.47 10.3 13.15
16 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
17 INT13823 Gene_expression of Egf 97 0.78 39.99 12.99
18 INT12156 Positive_regulation of MET 43 0.67 17.75 12.64
19 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
20 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09
21 INT2036 Localization of EGF 42 0.77 21.5 9.74
22 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
23 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42
24 INT22771 Positive_regulation of Egf 44 0.70 16.45 8.64
25 INT34777 Localization of IGF1 82 0.80 42.68 8.62
26 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
27 INT9398 Localization of MET 15 0.78 2.34 7.69
28 INT9397 Regulation of MET 17 0.60 8.36 7.04
29 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81
30 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
31 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63
32 INT13822 Localization of Egf 30 0.81 13.79 6.4
33 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
34 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
35 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
36 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
37 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
38 INT151032 Localization of Igf1 49 0.76 26.32 5.71
39 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
40 INT213741 Gene_expression of Kdr 60 0.75 44.24 5.35
41 INT37227 Regulation of EGF 19 0.45 11.16 5.17
42 INT21901 Negative_regulation of Egf 25 0.58 10.46 4.99
43 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
44 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49
45 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
46 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
47 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38
48 INT49360 Localization of Igf1 22 0.76 6.96 4.26
49 INT113485 Localization of MMP14 11 0.77 3.44 4.19
50 INT65926 Positive_regulation of Gene_expression of Egf 26 0.70 12.91 4.18
51 INT12915 Gene_expression of MGP 18 0.75 7.53 4.15
52 INT23653 Binding of Egf 22 0.36 11.34 4.12
53 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
54 INT118835 Positive_regulation of Vegfa 18 0.59 11.2 3.91
55 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
56 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
57 INT4922 Negative_regulation of MET 19 0.57 13.97 3.7
58 INT31758 Positive_regulation of Egf 32 0.66 19.42 3.64
59 INT20936 Binding of MGP 13 0.40 3.55 3.59
60 INT18920 Binding of Egf 24 0.48 9.43 3.57
61 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
62 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47
63 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
64 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
65 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
66 INT215926 Regulation of Gene_expression of Mmp14 1 0.45 5.33 3.15
67 INT31955 Protein_catabolism of MET 7 0.96 2.95 3.06
68 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
69 INT137609 Localization of Vegfa 22 0.78 14.67 3.01
70 INT16130 Binding of IGF1 67 0.48 27.43 2.95
71 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94
72 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87
73 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
74 INT99895 Positive_regulation of Mmp14 10 0.58 6.64 2.72
75 INT190280 Gene_expression of DICER1 12 0.65 9.54 2.67
76 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
77 INT43719 Positive_regulation of Vegfa 21 0.69 5.15 2.64
78 INT28878 Negative_regulation of Localization of Egf 6 0.49 10.34 2.57
79 INT77636 Phosphorylation of Egf 11 0.61 1.69 2.56
80 INT99897 Positive_regulation of Gene_expression of Mmp14 7 0.36 6.33 2.51
81 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
82 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
83 INT66544 Binding of Igf1 23 0.46 8.33 2.44
84 INT123528 Negative_regulation of Gene_expression of Vegfa 10 0.57 7.08 2.31
85 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29
86 INT43723 Regulation of Vegfa 9 0.34 4.96 2.28
87 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
88 INT82226 Negative_regulation of Gene_expression of EGF 11 0.58 6.36 2.13
89 INT108335 Phosphorylation of EGF 17 0.80 7.3 2.09
90 INT105247 Positive_regulation of Gene_expression of Vegfa 12 0.67 12.07 2.05
91 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
92 INT19114 Negative_regulation of MGP 2 0.32 0.15 2
93 INT215914 Localization of Mmp14 4 0.59 2.26 1.98
94 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
95 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
96 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
97 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
98 INT14822 Positive_regulation of Binding of MET 3 0.49 1.35 1.94
99 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86
100 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
101 INT148326 Gene_expression of Pkd1 7 0.76 5.38 1.85
102 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
103 INT107607 Negative_regulation of MMP14 10 0.37 6.05 1.83
104 INT172961 Localization of Egf 26 0.71 16.74 1.81
105 INT73721 Negative_regulation of Gene_expression of Egf 5 0.43 2.28 1.8
106 INT162725 Binding of Kdr 13 0.42 8.86 1.79
107 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
108 INT90800 Negative_regulation of Positive_regulation of EGF 5 0.40 2.78 1.77
109 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
110 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
111 INT192152 Negative_regulation of Mmp14 3 0.24 1.69 1.72
112 INT118833 Positive_regulation of Gene_expression of Vegfa 11 0.65 8.14 1.7
113 INT113479 Transcription of MMP14 3 0.51 1.81 1.7
114 INT215921 Regulation of Mmp14 1 0.33 2.8 1.7
115 INT19747 Regulation of Egf 14 0.46 4.67 1.68
116 INT12442 Localization of Vegfa 11 0.73 4.85 1.68
117 INT125245 Positive_regulation of Mmp14 4 0.44 4.38 1.67
118 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
119 INT337100 Gene_expression of Mgp 3 0.71 45.04 1.64
120 INT105248 Negative_regulation of Vegfa 8 0.47 6.19 1.61
121 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
122 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
123 INT176468 Transcription of Mmp14 3 0.52 2.47 1.51
124 INT114525 Negative_regulation of Positive_regulation of Egf 4 0.35 2.93 1.5
125 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
126 INT140245 Binding of Gli3 3 0.36 2.65 1.46
127 INT86382 Negative_regulation of Localization of EGF 5 0.43 1.75 1.44
128 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
129 INT109536 Negative_regulation of Vegfa 15 0.46 10.35 1.39
130 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
131 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
132 INT20937 Regulation of MGP 4 0.43 0.62 1.37
133 INT90491 Binding of Igf1 25 0.44 9.75 1.36
134 INT199567 Binding of Kdr 18 0.47 13.81 1.34
135 INT130098 Negative_regulation of NOTCH1 11 0.42 5.45 1.33
136 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
137 INT68057 Negative_regulation of Binding of MGP 1 0.03 0 1.28
138 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
139 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22
140 INT27108 Positive_regulation of Localization of Egf 5 0.50 2.91 1.21
141 INT148321 Positive_regulation of Gene_expression of Pkd1 5 0.68 2.93 1.21
142 INT105270 Positive_regulation of KDR 25 0.49 11.49 1.2
143 INT110780 Localization of Notch1 2 0.06 0.47 1.19
144 INT137607 Positive_regulation of Localization of Vegfa 7 0.49 3.72 1.18
145 INT188376 Negative_regulation of Gene_expression of Vegfa 5 0.30 5.29 1.18
146 INT330526 Positive_regulation of Gene_expression of DICER1 5 0.30 3.34 1.18
147 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
148 INT58311 Regulation of Localization of EGF 3 0.54 1.06 1.16
149 INT28110 Transcription of MET 9 0.67 9.43 1.15
150 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14
151 INT162124 Positive_regulation of Phosphorylation of Egf 3 0.45 0.77 1.14
152 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
153 INT22770 Regulation of Gene_expression of Egf 5 0.44 2.56 1.12
154 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11
155 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
156 INT21670 Localization of Lama5 1 0.31 1.11 1.1
157 INT37207 Positive_regulation of Positive_regulation of Egf 4 0.50 0.76 1.07
158 INT125248 Negative_regulation of Mmp14 1 0.06 3.06 1.07
159 INT134859 Gene_expression of Lama5 3 0.39 4.47 1.06
160 INT13817 Protein_catabolism of EGF 3 1.00 1.44 1.06
161 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05
162 INT105860 Positive_regulation of Positive_regulation of EGF 6 0.64 2.37 1.05
163 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
164 INT152404 Regulation of PKD1 2 0.45 2.02 1.04
165 INT200556 Regulation of Kdr 8 0.28 6.04 1.01
166 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01
167 INT260471 Positive_regulation of Gene_expression of Kdr 9 0.61 8.37 0.99
168 INT119674 Localization of GLI2 6 0.52 2.84 0.99
169 INT184240 Positive_regulation of Localization of Egf 2 0.27 3.58 0.99
170 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
171 INT14999 Negative_regulation of Positive_regulation of MET 2 0.41 0.44 0.98
172 INT6833 Binding of Notch1 4 0.36 0.05 0.94
173 INT192155 Negative_regulation of Negative_regulation of Mmp14 1 0.17 0.88 0.94
174 INT90370 Gene_expression of Mmp14 3 0.49 3.71 0.93
175 INT340119 Regulation of Regulation of MET 1 0.10 0.93 0.93
176 INT32977 Negative_regulation of Binding of MET 1 0.41 0 0.91
177 INT262109 Positive_regulation of Mgp 2 0.63 42.44 0.9
178 INT32978 Regulation of Binding of MET 1 0.26 0 0.9
179 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
180 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
181 INT118290 Regulation of Phosphorylation of EGF 1 0.32 0.72 0.87
182 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
183 INT171372 Positive_regulation of Gene_expression of Egf 16 0.66 9.82 0.84
184 INT160918 Negative_regulation of Gene_expression of MGP 1 0.07 0 0.83
185 INT167424 Positive_regulation of Pak1 1 0.14 1.43 0.83
186 INT202241 Positive_regulation of Negative_regulation of IGF1 5 0.48 1.56 0.82
187 INT173100 Binding of KDR 39 0.39 22.48 0.81
188 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
189 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
190 INT297469 Regulation of Binding of Kdr 1 0.54 2.01 0.8
191 INT200855 Positive_regulation of Kdr 14 0.45 11.14 0.77
192 INT31759 Negative_regulation of Gene_expression of Egf 6 0.53 5.33 0.77
193 INT141150 Localization of BMP7 4 0.56 2.84 0.76
194 INT84726 Gene_expression of NKX3-1 4 0.75 2.1 0.75
195 INT129174 Gene_expression of PKD1 24 0.67 14.91 0.74
196 INT353854 Positive_regulation of Gene_expression of Mgp 1 0.63 13.92 0.73
197 INT104840 Binding of GLI2 6 0.08 1.89 0.72
198 INT144073 Positive_regulation of Gene_expression of MMP14 4 0.24 6.13 0.72
199 INT12443 Regulation of Localization of Vegfa 2 0.20 0 0.72
200 INT123290 Phosphorylation of Mks1 1 0.02 0.36 0.72
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