GO:0048791

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Name calcium ion-dependent exocytosis of neurotransmitter
Categary Process
Go Slim No
Go Link GO:0048791
Unique Molecular Interactions 76
Total Molecular Interactions 130
Total Single Events 918
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for calcium ion-dependent exocytosis of neurotransmitter. They are ordered first by their pain relevance and then by number of times they were reported for calcium ion-dependent exocytosis of neurotransmitter. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
2 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
3 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
4 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
5 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
6 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
7 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
8 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
9 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
10 INT122659 Binding of CACNA1A and SAR1B 1 0.06 1.38 1.35
11 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
12 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
13 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
14 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
15 INT252145 Binding of Napb and Snap25 9 0.19 0.85 0.75
16 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7
17 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
18 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
19 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
20 INT155752 Binding of CACNA1A and ATCAY 1 0.04 0.86 0.42
21 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
22 INT255283 Regulation of Binding of Napb and Snap25 1 0.24 0 0.39
23 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
24 INT268110 PRKCA Positive_regulation of Phosphorylation of SNAP25 1 0.32 0.11 0.35
25 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
26 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
27 INT255285 Binding of Snap25 and Stx1a 1 0.07 0 0.33
28 INT101551 Binding of CACNA1A and CACNA1F 1 0.07 1.51 0.33
29 INT151258 Binding of Cacna1a and FCMTE1 1 0.00 0.57 0.3
30 INT328185 Slc3a1 Negative_regulation of Snap25 1 0.00 0.07 0.3
31 INT252140 Binding of Cck and Snap25 1 0.30 0.39 0.3
32 INT255288 Binding of Snap25 and Vti1b 1 0.36 0 0.29
33 INT142003 Binding of Cacna1a and Etax2 1 0.00 1.02 0.26
34 INT142004 Binding of Cacna1a and TGM6 1 0.00 1.02 0.26
35 INT121807 CACNA1A Regulation of CAV2 1 0.01 0.25 0.2
36 INT94890 MBTPS1 Positive_regulation of SNAP25 1 0.16 0.39 0.2
37 INT71329 Cacna1a Regulation of Ea2 1 0.01 0.71 0.15
38 INT71328 Cacna1a Regulation of Atxn2 1 0.00 0.71 0.15
39 INT273441 Binding of Vamp1 and Snap25 1 0.02 0.13 0.14
40 INT249403 Binding of Snap25 and Napa 1 0.19 0 0.14
41 INT234104 Binding of Snap25 and DTNBP1 1 0.29 0.09 0.13
42 INT120559 Binding of Cacna1a and FCMTE1 1 0.02 0.25 0.1
43 INT255289 Snap25 Regulation of Gene_expression of Gnas 1 0.00 0 0.09
44 INT196213 REST Regulation of Gene_expression of CACNA1A 1 0.46 0.08 0.08
45 INT252141 Binding of Snap25 and Spata20 1 0.01 0 0.07
46 INT268111 Binding of MARCKS and SNAP25 1 0.09 0 0.05
47 INT273440 Positive_regulation of Binding of Vamp1 and Snap25 1 0.02 0.13 0.04
48 INT354983 Cacna1a Regulation of Mpo 1 0.02 0.41 0.04
49 INT249415 Binding of Snap25 and Dcaf12l2 1 0.01 0.07 0.04
50 INT249404 Binding of Snap25 and Vamp2 1 0.16 0 0.04
51 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03
52 INT196208 REST Regulation of CACNA1A 1 0.46 0.06 0
53 INT196216 Binding of CACNA1A and REST 1 0.28 0 0
54 INT273443 Positive_regulation of Binding of Snap25 and Napa 1 0.05 0 0
55 INT261963 Binding of Cacna1a and Tgm2 1 0.08 1.19 0
56 INT249401 Mbp Positive_regulation of Snap25 1 0.17 0.11 0
57 INT250496 Gopc Regulation of Positive_regulation of Cacna1a 1 0.37 0 0
58 INT320401 Dbn1 Regulation of Protein_catabolism of Snap25 1 0.02 0 0
59 INT249419 Mbp Positive_regulation of Localization of Snap25 1 0.17 0.33 0
60 INT320397 Tax1bp1 Regulation of Protein_catabolism of Snap25 1 0.04 0 0
61 INT130533 BACE1 Regulation of SNAP25 1 0.27 0.18 0
62 INT249420 Stx1a Positive_regulation of Binding of Snap25 1 0.13 0 0
63 INT130532 BACE2 Regulation of SNAP25 1 0.12 0.18 0
64 INT249425 Binding of Mbp and Snap25 1 0.16 0 0
65 INT273442 Binding of Snap25 and Napa 1 0.05 0 0
66 INT255290 Snap25 Positive_regulation of Gene_expression of Upf1 1 0.02 0 0
67 INT196209 Binding of REST and SNAP25 1 0.25 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for calcium ion-dependent exocytosis of neurotransmitter. They are ordered first by their pain relevance and then by number of times they were reported in calcium ion-dependent exocytosis of neurotransmitter. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
2 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
3 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
4 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
5 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
6 INT184844 Gene_expression of Snap25 130 0.78 14.32 12.13
7 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
8 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65
9 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
10 INT120335 Gene_expression of SNAP25 24 0.65 9.44 5.83
11 INT120339 Phosphorylation of SNAP25 5 0.51 2.97 5.3
12 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
13 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
14 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
15 INT287526 Negative_regulation of Gene_expression of CACNA1A 1 0.42 4.25 3.81
16 INT53516 Binding of CACNA1A 9 0.47 6.86 3.36
17 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
18 INT120334 Negative_regulation of Phosphorylation of SNAP25 4 0.37 1.71 3.21
19 INT78317 Regulation of CACNA1A 8 0.62 7.68 3.08
20 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
21 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
22 INT85885 Positive_regulation of SNAP25 8 0.69 2.74 2.84
23 INT252124 Transcription of Snap25 21 0.72 1.56 2.71
24 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
25 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26
26 INT81500 Protein_catabolism of Snap25 10 0.66 1.12 2.12
27 INT101582 Negative_regulation of SNAP25 9 0.57 4.34 2.12
28 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
29 INT115303 Localization of SNAP25 8 0.73 1.43 1.82
30 INT354979 Positive_regulation of Localization of Cacna1a 2 0.05 0.86 1.79
31 INT355239 Negative_regulation of Positive_regulation of Cacna1a 1 0.04 0 1.79
32 INT184843 Regulation of Gene_expression of Snap25 4 0.62 2.15 1.74
33 INT151790 Binding of SNAP25 11 0.24 1.09 1.73
34 INT71327 Localization of Cacna1a 3 0.60 2.51 1.7
35 INT148426 Gene_expression of Snap25 12 0.68 1.72 1.63
36 INT355242 Negative_regulation of Binding of Cacna1a 1 0.04 0.17 1.47
37 INT355245 Regulation of Localization of Cacna1a 1 0.04 0 1.43
38 INT139985 Negative_regulation of Snap25 20 0.59 3.73 1.41
39 INT252127 Negative_regulation of Gene_expression of Snap25 18 0.59 2.76 1.38
40 INT90740 Negative_regulation of Cacna1a 3 0.23 1.43 1.38
41 INT252133 Positive_regulation of Gene_expression of Snap25 19 0.70 2.36 1.35
42 INT82727 Positive_regulation of Transcription of Cacna1a 1 0.01 1.07 1.25
43 INT120337 Positive_regulation of Phosphorylation of SNAP25 2 0.29 0.11 1.19
44 INT85571 Positive_regulation of Cacna1a 3 0.50 2.06 1.18
45 INT355243 Negative_regulation of Regulation of Cacna1a 1 0.04 0 1.16
46 INT109443 Negative_regulation of Snap25 3 0.27 0.15 1.1
47 INT184841 Localization of Snap25 12 0.81 1.45 1.09
48 INT120336 Positive_regulation of Gene_expression of SNAP25 2 0.37 0 1.03
49 INT234076 Regulation of Snap25 8 0.62 1.85 1.02
50 INT81501 Negative_regulation of Protein_catabolism of Snap25 1 0.30 0.1 0.99
51 INT115304 Regulation of SNAP25 7 0.60 1.24 0.95
52 INT321650 Negative_regulation of Gene_expression of Cacna1a 2 0.04 0.13 0.95
53 INT94046 Protein_catabolism of Cacna1a 1 0.70 0.83 0.9
54 INT246311 Protein_catabolism of Snap25 6 0.66 1.15 0.89
55 INT234091 Binding of Snap25 13 0.37 0.24 0.86
56 INT131964 Positive_regulation of CACNA1A 5 0.61 0.73 0.85
57 INT109441 Transcription of Snap25 1 0.34 0 0.79
58 INT123757 Positive_regulation of Snap25 3 0.47 0.41 0.77
59 INT103336 Transcription of Cacna1a 2 0.69 1.17 0.68
60 INT246317 Positive_regulation of Snap25 10 0.50 0.74 0.67
61 INT148428 Binding of Snap25 6 0.37 0.22 0.67
62 INT141227 Phosphorylation of CACNA1A 1 0.55 0.78 0.66
63 INT148427 Positive_regulation of Gene_expression of Snap25 1 0.46 0.16 0.6
64 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55
65 INT122930 Positive_regulation of Gene_expression of CACNA1A 2 0.49 0.91 0.54
66 INT148429 Regulation of Snap25 2 0.27 0.15 0.53
67 INT148430 Regulation of Gene_expression of Snap25 1 0.27 0.15 0.53
68 INT120338 Regulation of Gene_expression of SNAP25 1 0.36 0 0.52
69 INT255274 Regulation of Transcription of Snap25 1 0.45 0 0.47
70 INT196247 Negative_regulation of Localization of SNAP25 2 0.29 0.76 0.37
71 INT99962 Positive_regulation of Gene_expression of Cacna1a 1 0.01 1.1 0.34
72 INT252134 Negative_regulation of Transcription of Snap25 4 0.43 0.54 0.33
73 INT268130 Regulation of Phosphorylation of SNAP25 1 0.28 0.07 0.32
74 INT155753 Regulation of Gene_expression of CACNA1A 1 0.27 0.66 0.32
75 INT255277 Positive_regulation of Transcription of Snap25 1 0.50 0 0.21
76 INT196239 Positive_regulation of Localization of SNAP25 1 0.47 0 0.13
77 INT94891 Protein_catabolism of SNAP25 2 0.55 0.19 0.1
78 INT293259 Negative_regulation of Gene_expression of SNAP25 4 0.49 5.08 0.09
79 INT255269 Negative_regulation of Regulation of Snap25 1 0.43 0 0.09
80 INT309563 Transcription of SNAP25 1 0.42 0 0.08
81 INT196235 Negative_regulation of Transcription of CACNA1A 1 0.36 0.1 0.07
82 INT196229 Transcription of CACNA1A 1 0.60 0.24 0.07
83 INT309389 Phosphorylation of Cacna1a 1 0.01 0.54 0.05
84 INT309386 Positive_regulation of Phosphorylation of Cacna1a 1 0.01 0.54 0.05
85 INT252125 Regulation of Regulation of Snap25 1 0.27 0.36 0.03
86 INT249392 Negative_regulation of Localization of Snap25 1 0.26 0 0.03
87 INT246318 Negative_regulation of Protein_catabolism of Snap25 2 0.19 0.34 0
88 INT115305 Regulation of Localization of SNAP25 1 0.44 0 0
89 INT249394 Phosphorylation of Snap25 1 0.49 0 0
90 INT293260 Negative_regulation of Protein_catabolism of SNAP25 1 0.07 0 0
91 INT196237 Positive_regulation of Transcription of CACNA1A 1 0.39 0.14 0
92 INT302015 Negative_regulation of Binding of SNAP25 1 0.27 0 0
93 INT249376 Positive_regulation of Phosphorylation of Snap25 1 0.30 0 0
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