GO:0048843

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Name negative regulation of axon extension involved in axon guidance
Categary Process
Go Slim No
Go Link GO:0048843
Unique Molecular Interactions 135
Total Molecular Interactions 203
Total Single Events 661
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of axon extension involved in axon guidance. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of axon extension involved in axon guidance. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2
2 INT96906 Plxna3 Regulation of Regulation of Prkaca 1 0.17 0.71 1.08
3 INT96905 Plxna3 Regulation of Regulation of Prkce 1 0.18 0.71 1.07
4 INT137441 Ngf Negative_regulation of Sema3a 1 0.46 2.07 1.01
5 INT334537 Sema3a Negative_regulation of Gene_expression of Plxna1 1 0.08 3.76 1
6 INT67908 Binding of Cck and Plxna3 1 0.04 0.54 0.84
7 INT260832 Binding of NRP2 and Nrp1 1 0.00 2.32 0.7
8 INT334526 Trpv1 Positive_regulation of Gene_expression of Sema3a 1 0.31 0.92 0.55
9 INT340609 Bdnf Regulation of Gene_expression of Wnt3a 1 0.53 0.31 0.36
10 INT137438 Ntf3 Regulation of Sema3a 1 0.06 0.82 0.35
11 INT137437 Nrtn Regulation of Sema3a 1 0.36 0.82 0.35
12 INT137439 Ntf3 Negative_regulation of Sema3a 1 0.02 0.77 0.34
13 INT137442 Nrtn Regulation of Sema3a 1 0.04 0.81 0.34
14 INT137440 Nrtn Negative_regulation of Sema3a 1 0.34 0.77 0.34
15 INT355038 NRP1 Negative_regulation of CKAP4 1 0.02 1.23 0.29
16 INT158733 Esr1 Regulation of Plxna3 1 0.03 0.27 0.29
17 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
18 INT334522 Ngf Positive_regulation of Nrp1 1 0.19 0.93 0.22
19 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 0.19 0.93 0.22
20 INT213561 Ngf Negative_regulation of Regulation of Sema3a 1 0.24 0.08 0.17
21 INT172232 CALCRL Positive_regulation of Gene_expression of NRP1 1 0.02 0.07 0.17
22 INT172237 TAS2R14 Positive_regulation of Gene_expression of NRP1 1 0.01 0.07 0.17
23 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 0.08 0.48 0.14
24 INT340608 Binding of Creb1 and Wnt3a 1 0.30 0.24 0.14
25 INT213555 Bdnf Negative_regulation of Gene_expression of Sema3a 1 0.31 0.09 0.14
26 INT334527 Sema3a Negative_regulation of Gene_expression of Il4 1 0.15 0.48 0.14
27 INT334534 Nrp1 Negative_regulation of Gene_expression of Sema3a 1 0.17 0.48 0.14
28 INT334530 Sema3a Regulation of Il18 1 0.18 1.61 0.13
29 INT334528 Nrp1 Negative_regulation of Sema3a 1 0.17 0.47 0.13
30 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
31 INT334524 Sema3a Regulation of Foxq1 1 0.04 1.61 0.13
32 INT221628 Sema3a Regulation of Gh 1 0.01 0.39 0.12
33 INT221625 Fer Regulation of Localization of Sema3a 1 0.24 0.29 0.1
34 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
35 INT146997 Binding of PLXNA3 and RLS 1 0.36 0.47 0.1
36 INT221668 Sema3a Positive_regulation of NPAT 1 0.36 0.47 0.09
37 INT221614 Binding of Sema3a and Fer 1 0.30 0.61 0.09
38 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
39 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
40 INT221619 Binding of Ngf and Sema3a 1 0.17 0.54 0.06
41 INT221658 Sema3a Positive_regulation of Phosphorylation of Crmp1 1 0.12 0.4 0.05
42 INT221657 Sema3a Positive_regulation of Binding of Plxna1 1 0.01 0.39 0.05
43 INT173051 Binding of VEGFA and NRP1 16 0.44 1.29 0.04
44 INT173056 Binding of NRP2 and NRP1 2 0.24 0.61 0.04
45 INT265771 NRP1 Positive_regulation of VEGFA 1 0.46 0 0.04
46 INT311925 Binding of NRP2 and SEMA3A 1 0.26 0.06 0.04
47 INT265764 NRP1 Positive_regulation of FLT1 1 0.45 0 0.04
48 INT315915 VEGFA Regulation of NRP1 1 0.22 0.32 0.04
49 INT265772 Binding of KDR and NRP1 1 0.29 0 0.04
50 INT311926 Binding of NRP1 and SEMA3A 1 0.26 0.48 0.04
51 INT265749 Binding of FLT1 and NRP1 1 0.43 0 0.04
52 INT221661 Sema3a Positive_regulation of Phosphorylation of Cdk5 1 0.19 0.28 0.03
53 INT221640 Sema3a Positive_regulation of Phosphorylation of Fyn 1 0.16 0.29 0.03
54 INT221626 Gopc Regulation of Sema3a 1 0.06 0.13 0.03
55 INT265744 VEGFA Regulation of Localization of NRP1 1 0.25 0 0
56 INT353192 Stat5a Positive_regulation of Plxna3 1 0.01 0 0
57 INT353189 Plxna3 Negative_regulation of Cyp4a8 1 0.01 0.35 0
58 INT221644 Binding of Nptx1 and Sema3a 1 0.12 0.19 0
59 INT276285 Binding of SEPHS1 and PLXNA3 1 0.00 0.41 0
60 INT265767 Positive_regulation of Binding of VEGFA and NRP1 1 0.46 0 0
61 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0
62 INT251072 Wnt3a Positive_regulation of Axin2 1 0.23 0.29 0
63 INT173054 NRP1 Positive_regulation of KDR 1 0.08 0.34 0
64 INT326893 Binding of Tcf4 and Wnt3a 1 0.13 0 0
65 INT311948 Binding of NRP1 and Plxna3 1 0.05 0.26 0
66 INT311947 Binding of SEMA3A and Plxna3 1 0.07 0.26 0
67 INT265752 NRP1 Negative_regulation of Gene_expression of FLT1 1 0.33 0 0
68 INT326896 Wnt3a Positive_regulation of Transcription of PLD2 1 0.24 0.06 0
69 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
70 INT251070 Wnt3a Positive_regulation of Cldn3 1 0.30 0.29 0
71 INT265765 Binding of NRP1 and GOPC 1 0.13 0 0
72 INT326894 Wnt3a Positive_regulation of Transcription of Pld1 1 0.24 0.06 0
73 INT351678 Nrp1 Regulation of Binding of Ecm1 1 0.00 1.55 0
74 INT265737 Binding of AR and NRP1 1 0.10 0 0
75 INT265751 NRP1 Negative_regulation of Localization of FLT1 1 0.33 0 0
76 INT265756 Positive_regulation of Binding of AR and NRP1 1 0.10 0 0
77 INT196185 Binding of SEMA3A and Nrp1 1 0.01 0.05 0
78 INT265757 Regulation of Binding of VEGFA and NRP1 1 0.41 0 0
79 INT221638 Binding of Nrp1 and Sema3a 1 0.05 0.38 0
80 INT265738 NRP1 Positive_regulation of KLKB1 1 0.03 0 0
81 INT265741 Negative_regulation of Binding of FLT1 and NRP1 1 0.38 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of axon extension involved in axon guidance. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of axon extension involved in axon guidance. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340600 Gene_expression of Wnt3a 1 0.68 2.14 9.14
2 INT32256 Gene_expression of PLXNA3 11 0.75 7.8 4.92
3 INT153189 Gene_expression of Sema3a 19 0.75 14.37 4.21
4 INT340603 Regulation of Gene_expression of Wnt3a 1 0.54 0.49 3.75
5 INT52184 Gene_expression of Sema3a 8 0.55 3.97 3.72
6 INT21156 Binding of PLXNA3 21 0.36 7.95 3.3
7 INT340595 Positive_regulation of Gene_expression of Wnt3a 1 0.61 0.86 3.11
8 INT82347 Regulation of PLXNA3 5 0.60 4.59 2.45
9 INT240113 Gene_expression of Nrp1 11 0.30 10.88 2.24
10 INT196176 Gene_expression of SEMA3A 3 0.75 4.75 2.17
11 INT64609 Negative_regulation of PLXNA3 5 0.57 3.64 1.94
12 INT153190 Negative_regulation of Sema3a 7 0.56 7.94 1.76
13 INT113676 Gene_expression of NRP1 22 0.72 10.81 1.71
14 INT16622 Positive_regulation of PLXNA3 6 0.67 5.2 1.69
15 INT153762 Positive_regulation of Gene_expression of Sema3a 6 0.49 4.56 1.65
16 INT174107 Binding of Plxna3 4 0.21 2.95 1.62
17 INT72647 Positive_regulation of Gene_expression of Sema3a 3 0.40 1.98 1.52
18 INT340596 Negative_regulation of Gene_expression of Wnt3a 1 0.51 0.38 1.4
19 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
20 INT340604 Regulation of Wnt3a 1 0.24 0 0.95
21 INT104079 Gene_expression of Plxna3 4 0.65 0.86 0.94
22 INT149291 Negative_regulation of NRP1 5 0.40 2.64 0.84
23 INT62760 Localization of PLXNA3 3 0.78 2.06 0.8
24 INT149298 Protein_catabolism of NRP1 2 0.82 1.52 0.77
25 INT139205 Binding of NRP1 27 0.45 4.34 0.71
26 INT3536 Positive_regulation of Nrp1 2 0.19 0.93 0.7
27 INT265800 Localization of NRP1 14 0.75 3.66 0.69
28 INT196155 Binding of Nrp1 5 0.16 2.38 0.69
29 INT260823 Positive_regulation of Gene_expression of Nrp1 3 0.19 2.14 0.65
30 INT104078 Localization of Plxna3 1 0.78 0.36 0.64
31 INT116175 Negative_regulation of Gene_expression of Sema3a 1 0.30 0.67 0.63
32 INT89067 Regulation of Gene_expression of Sema3a 2 0.31 0.84 0.61
33 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
34 INT134304 Positive_regulation of Sema3a 1 0.50 1.23 0.59
35 INT72648 Localization of Sema3a 1 0.28 0.38 0.58
36 INT158486 Negative_regulation of Gene_expression of Sema3a 4 0.41 2.49 0.57
37 INT311943 Negative_regulation of Gene_expression of SEMA3A 1 0.56 0.66 0.55
38 INT72646 Binding of Sema3a 2 0.15 0.52 0.54
39 INT221545 Binding of Sema3a 2 0.33 1.4 0.53
40 INT11847 Regulation of Plxna3 3 0.44 0.45 0.52
41 INT79935 Negative_regulation of Nrp1 3 0.17 1.36 0.46
42 INT135986 Negative_regulation of Sema3a 3 0.58 0.3 0.46
43 INT340598 Binding of Wnt3a 1 0.33 0.15 0.46
44 INT149293 Negative_regulation of Protein_catabolism of NRP1 1 0.05 0.93 0.44
45 INT135987 Regulation of Sema3a 2 0.60 0.57 0.43
46 INT213530 Regulation of Sema3a 3 0.29 0.84 0.42
47 INT340606 Positive_regulation of Wnt3a 1 0.61 0.49 0.4
48 INT46873 Positive_regulation of Plxna3 1 0.49 0 0.38
49 INT213538 Localization of Sema3a 2 0.56 1.12 0.32
50 INT104082 Negative_regulation of Plxna3 1 0.41 0.19 0.32
51 INT104084 Negative_regulation of Localization of Plxna3 1 0.57 0.19 0.32
52 INT221527 Positive_regulation of Sema3a 1 0.37 1.03 0.32
53 INT104080 Regulation of Localization of Plxna3 1 0.60 0.17 0.32
54 INT104083 Negative_regulation of Gene_expression of Plxna3 1 0.42 0.19 0.32
55 INT143442 Positive_regulation of NRP1 11 0.57 2.62 0.3
56 INT221579 Phosphorylation of Sema3a 1 0.46 0.82 0.3
57 INT158730 Gene_expression of Plxna3 4 0.65 1.82 0.29
58 INT158728 Regulation of Gene_expression of Plxna3 1 0.44 0.28 0.29
59 INT158731 Positive_regulation of Gene_expression of Plxna3 1 0.49 0.28 0.29
60 INT51514 Positive_regulation of Wnt3a 3 0.04 3.32 0.28
61 INT264305 Negative_regulation of Gene_expression of NRP1 3 0.40 1.4 0.25
62 INT227947 Regulation of Plxna3 1 0.07 0.2 0.19
63 INT265792 Regulation of Localization of NRP1 1 0.22 0.21 0.13
64 INT51512 Negative_regulation of Positive_regulation of Wnt3a 1 0.04 1.3 0.13
65 INT265797 Regulation of Protein_catabolism of NRP1 1 0.51 0.21 0.13
66 INT51513 Positive_regulation of Positive_regulation of Wnt3a 1 0.04 1.31 0.13
67 INT143446 Positive_regulation of Gene_expression of NRP1 1 0.45 1.02 0.12
68 INT89068 Transcription of Sema3a 1 0.14 0.27 0.11
69 INT162574 Gene_expression of Wnt5a 7 0.47 0.92 0.1
70 INT282594 Localization of WNT5A 2 0.18 0.89 0.1
71 INT221552 Positive_regulation of Localization of Sema3a 1 0.32 0.29 0.1
72 INT233483 Regulation of Gene_expression of Wnt5a 1 0.19 0.33 0.1
73 INT162576 Positive_regulation of Wnt5a 3 0.48 0.71 0.08
74 INT214463 Binding of Wnt3a 2 0.26 0.23 0.08
75 INT196181 Binding of SEMA3A 2 0.36 0.64 0.07
76 INT290078 Regulation of WNT5A 1 0.07 2.3 0.07
77 INT196164 Localization of SEMA3A 5 0.77 1.39 0.06
78 INT311940 Negative_regulation of SEMA3A 1 0.56 0.71 0.06
79 INT196179 Regulation of Gene_expression of SEMA3A 3 0.43 0.45 0
80 INT235629 Phosphorylation of NRP1 2 0.76 0.81 0
81 INT214465 Localization of Wnt3a 2 0.52 0.29 0
82 INT251053 Gene_expression of Wnt3a 2 0.47 0.5 0
83 INT326853 Positive_regulation of Gene_expression of Wnt3a 1 0.36 0.2 0
84 INT353172 Negative_regulation of Plxna3 1 0.01 0.14 0
85 INT113675 Regulation of Gene_expression of NRP1 1 0.00 1.62 0
86 INT315923 Negative_regulation of Positive_regulation of NRP1 1 0.40 0.19 0
87 INT335880 Regulation of Wnt5a 1 0.32 0.07 0
88 INT311924 Transcription of Plxna3 1 0.10 0 0
89 INT251054 Regulation of Localization of Wnt3a 1 0.27 0.07 0
90 INT311941 Transcription of SEMA3A 1 0.66 0.34 0
91 INT302041 Negative_regulation of Gene_expression of Nrp1 1 0.07 0.14 0
92 INT311933 Regulation of SEMA3A 1 0.43 0.33 0
93 INT196167 Positive_regulation of Gene_expression of SEMA3A 1 0.22 0.06 0
94 INT251066 Regulation of Gene_expression of Wnt3a 1 0.31 0.07 0
95 INT265785 Positive_regulation of Localization of NRP1 1 0.41 0 0
96 INT311938 Regulation of Transcription of SEMA3A 1 0.43 0.34 0
97 INT265793 Regulation of NRP1 1 0.22 0 0
98 INT296201 Binding of Plxna3 1 0.36 0.08 0
99 INT162572 Positive_regulation of Gene_expression of Wnt5a 1 0.02 0.3 0
100 INT265798 Positive_regulation of Binding of NRP1 1 0.41 0 0
101 INT188898 Negative_regulation of Localization of PLXNA3 1 0.09 0.47 0
102 INT326843 Negative_regulation of Gene_expression of Wnt3a 1 0.22 0.29 0
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