GO:0048854

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Name brain morphogenesis
Categary Process
Go Slim No
Go Link GO:0048854
Unique Molecular Interactions 76
Total Molecular Interactions 98
Total Single Events 1431
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for brain morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for brain morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT145940 Binding of Gad1 and Abat 2 0.14 1.44 1.78
2 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
3 INT1619 Binding of Gad1 and Oprl1 1 0.14 0 1.13
4 INT1620 Negative_regulation of Binding of Gad1 and Oprl1 1 0.16 0 1.13
5 INT12137 Ngf Regulation of Gad1 1 0.27 0.67 0.83
6 INT103535 Obfc1 Negative_regulation of Positive_regulation of Gad1 1 0.03 0.07 0.49
7 INT12139 Ins1 Regulation of Gad1 1 0.15 0.33 0.42
8 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
9 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
10 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
11 INT28237 BBS2 Positive_regulation of Localization of Cck 1 0.04 0.33 0.39
12 INT79504 Binding of Gad1 and Chat 1 0.35 0 0.38
13 INT55087 Binding of Gad1 and Penk 1 0.08 0 0.32
14 INT309366 Pax2 Negative_regulation of Transcription of Slc6a5 1 0.03 0 0.31
15 INT309369 Ptf1a Positive_regulation of Pax2 1 0.10 0 0.3
16 INT42253 Bbx Regulation of Gad1 1 0.15 0 0.3
17 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
18 INT356231 Binding of Gabrb3 and Gad1 1 0.32 1.25 0.23
19 INT180247 Binding of Gad1 and Tbca 1 0.02 0.22 0.22
20 INT180248 Binding of Gad1 and Plp1 1 0.08 0.22 0.21
21 INT338443 Binding of Gad1 and Slc32a1 1 0.31 0.64 0.18
22 INT354968 Shank3 Positive_regulation of Gene_expression of Gria2 1 0.05 0 0.15
23 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
24 INT180252 Negative_regulation of Gad1 Positive_regulation of CP 1 0.03 0.75 0.14
25 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
26 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
27 INT177490 Binding of Gad1 and Gad2 1 0.10 0.19 0.11
28 INT309372 Lhx5 Positive_regulation of Gene_expression of Pax2 1 0.09 0.07 0.11
29 INT354962 Gene_expression of Shank3 Positive_regulation of Gusb 1 0.10 0.45 0.08
30 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
31 INT322969 Binding of Gad1 and Fos 1 0.23 0.23 0.08
32 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
33 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
34 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
35 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
36 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
37 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
38 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
39 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
40 INT299368 Mkks Positive_regulation of Mapk8 1 0.41 0.17 0.03
41 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
42 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
43 INT200058 Binding of Ndn and Bbs4 1 0.30 0.29 0
44 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0
45 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
46 INT244839 Lbx1 Positive_regulation of Pax2 1 0.39 0 0
47 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
48 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
49 INT200062 Binding of Ngfr and Bbs4 1 0.30 0.3 0
50 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0
51 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
52 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
53 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
54 INT186401 Binding of MKKS and MKS1 1 0.09 0.07 0
55 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
56 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 0.22 0.07 0
57 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0
58 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
59 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
60 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
61 INT297691 Binding of Fut1 and Pax2 1 0.03 0 0
62 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0
63 INT302368 Binding of Arx and Pafah1b1 1 0.27 1.25 0
64 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
65 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
66 INT193957 Binding of Bcl2l1 and Psen2 1 0.07 0.66 0
67 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
68 INT257826 PAFAH1B1 Positive_regulation of Paf 1 0.02 1.02 0
69 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
70 INT334645 Binding of PSEN1 and HM13 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for brain morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in brain morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT26788 Gene_expression of Gad1 93 0.78 27.05 42.71
2 INT10453 Positive_regulation of Gad1 65 0.70 10.75 31.9
3 INT1616 Regulation of Gad1 46 0.61 10.2 28.64
4 INT16326 Transcription of Gad1 58 0.71 15.78 20.45
5 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
6 INT22143 Gene_expression of Gad1 35 0.76 14.4 15.4
7 INT336 Negative_regulation of Gad1 19 0.58 7.71 9.51
8 INT26789 Positive_regulation of Gene_expression of Gad1 22 0.70 7.39 9.02
9 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
10 INT49011 Regulation of Gene_expression of Gad1 10 0.62 0.55 6.07
11 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
12 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
13 INT66388 Positive_regulation of Transcription of Gad1 14 0.67 2.45 4.67
14 INT9349 Gene_expression of BBS2 15 0.49 12.77 4.22
15 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
16 INT42251 Regulation of Gad1 10 0.44 5.25 3.45
17 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
18 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
19 INT67952 Regulation of Transcription of Gad1 6 0.51 1.23 2.98
20 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
21 INT54170 Positive_regulation of Positive_regulation of Gad1 5 0.69 0 2.89
22 INT199798 Positive_regulation of BBS2 2 0.50 5.85 2.55
23 INT42255 Negative_regulation of Gad1 7 0.56 4.83 2.54
24 INT163544 Binding of Psen1 40 0.36 15.28 2.42
25 INT90566 Positive_regulation of Gene_expression of Gad1 5 0.48 1.46 2.42
26 INT67951 Negative_regulation of Gene_expression of Gad1 4 0.43 1.08 2.13
27 INT42256 Positive_regulation of Gad1 4 0.66 1.1 2.09
28 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
29 INT60723 Localization of Psen2 5 0.68 2.11 2.02
30 INT44109 Localization of Gad1 7 0.74 1.06 1.97
31 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
32 INT55587 Negative_regulation of Positive_regulation of Gad1 6 0.49 1.1 1.82
33 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
34 INT257820 Positive_regulation of PAFAH1B1 1 0.68 11.09 1.69
35 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
36 INT103531 Regulation of Positive_regulation of Gad1 3 0.61 0.31 1.43
37 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
38 INT90567 Negative_regulation of Gene_expression of Gad1 4 0.41 2.88 1.36
39 INT96641 Transcription of Gad1 3 0.60 0.84 1.36
40 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
41 INT53548 Negative_regulation of Transcription of Gad1 3 0.43 0.46 1.32
42 INT1618 Binding of Gad1 6 0.37 2.01 1.3
43 INT227150 Localization of Gad1 4 0.49 0.15 1.22
44 INT165513 Negative_regulation of Regulation of Gad1 1 0.41 1.59 1.11
45 INT177481 Negative_regulation of BBS2 6 0.31 5.34 1.06
46 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
47 INT257824 Localization of PAFAH1B1 1 0.74 6.58 1
48 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
49 INT90568 Regulation of Gene_expression of Gad1 3 0.27 0.46 0.89
50 INT180240 Binding of Gad1 7 0.47 2.99 0.86
51 INT28236 Localization of BBS2 2 0.54 1.9 0.83
52 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
53 INT274178 Binding of BBS2 1 0.27 2.12 0.82
54 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
55 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
56 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
57 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
58 INT180752 Gene_expression of PAFAH1B1 3 0.66 9.89 0.75
59 INT78649 Binding of Psen2 7 0.36 5.9 0.73
60 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
61 INT257817 Regulation of PAFAH1B1 1 0.60 4.93 0.7
62 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
63 INT354944 Negative_regulation of Shank3 1 0.59 1.18 0.59
64 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
65 INT123645 Negative_regulation of Transcription of Gad1 2 0.42 0.76 0.52
66 INT274177 Positive_regulation of Gene_expression of BBS2 2 0.36 1.55 0.49
67 INT257816 Negative_regulation of PAFAH1B1 1 0.58 3.66 0.49
68 INT354955 Gene_expression of Shank3 1 0.78 3.23 0.45
69 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
70 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
71 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
72 INT193856 Localization of Psen1 19 0.73 9.79 0.41
73 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
74 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
75 INT213507 Gene_expression of Pax2 10 0.67 1.41 0.34
76 INT346261 Gene_expression of MKKS 1 0.40 0.66 0.34
77 INT14382 Regulation of BBS2 3 0.43 2.07 0.33
78 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
79 INT346249 Phosphorylation of MKKS 1 0.43 0.61 0.31
80 INT274176 Negative_regulation of Gene_expression of BBS2 1 0.31 0.94 0.29
81 INT309354 Regulation of Pax2 1 0.10 0 0.29
82 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
83 INT309339 Negative_regulation of Localization of Pax2 1 0.15 0 0.28
84 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
85 INT354948 Regulation of Shank3 1 0.45 0.69 0.26
86 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
87 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
88 INT257802 Positive_regulation of Transcription of Gad1 1 0.44 0 0.23
89 INT284157 Regulation of Negative_regulation of BBS2 1 0.08 1.08 0.21
90 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
91 INT180242 Positive_regulation of Binding of Gad1 1 0.49 0.86 0.17
92 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
93 INT257825 Binding of PAFAH1B1 1 0.37 0.89 0.17
94 INT272845 Transcription of BBS2 1 0.04 0.42 0.16
95 INT257818 Regulation of Gene_expression of PAFAH1B1 1 0.44 0.76 0.15
96 INT104557 Positive_regulation of Binding of Gad1 1 0.50 0.76 0.15
97 INT309352 Localization of Pax2 1 0.27 0 0.14
98 INT257821 Transcription of PAFAH1B1 1 0.61 1.11 0.14
99 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
100 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
101 INT101575 Negative_regulation of Negative_regulation of Gad1 1 0.07 0.24 0.13
102 INT163225 Gene_expression of Bbs4 1 0.60 0.09 0.13
103 INT163230 Gene_expression of Mkks 1 0.48 0.09 0.13
104 INT176595 Negative_regulation of Gene_expression of PSEN2 1 0.24 1.01 0.11
105 INT177493 Phosphorylation of Gad1 1 0.45 0.19 0.11
106 INT193841 Regulation of Gene_expression of Psen2 1 0.40 1.66 0.11
107 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
108 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
109 INT109131 Regulation of PSEN2 3 0.44 0.55 0.08
110 INT193862 Positive_regulation of Positive_regulation of Psen1 3 0.49 0.9 0.08
111 INT193872 Positive_regulation of Localization of Psen1 3 0.49 1.39 0.08
112 INT354949 Positive_regulation of Gene_expression of Shank3 1 0.70 0.45 0.08
113 INT261678 Positive_regulation of Positive_regulation of PSEN1 1 0.42 0.62 0.08
114 INT354958 Localization of Shank3 1 0.80 0.4 0.08
115 INT193890 Regulation of Positive_regulation of Psen1 1 0.44 0.66 0.08
116 INT193938 Phosphorylation of PSEN1 5 0.79 1.6 0.07
117 INT229469 Gene_expression of Pafah1b1 1 0.15 0.32 0.07
118 INT354959 Regulation of Gene_expression of Shank3 1 0.27 1.11 0.06
119 INT244741 Positive_regulation of Gene_expression of Pax2 1 0.38 0 0.06
120 INT176592 Transcription of PSEN2 5 0.33 0.41 0.05
121 INT193859 Negative_regulation of Binding of Psen1 3 0.42 1.85 0.05
122 INT177498 Positive_regulation of Localization of Gad1 2 0.40 0.48 0.05
123 INT331406 Negative_regulation of Regulation of Psen1 1 0.04 0.09 0.05
124 INT183818 Positive_regulation of MKKS 1 0.01 1.82 0.05
125 INT193865 Protein_catabolism of Psen1 10 0.97 0.37 0.04
126 INT79982 Positive_regulation of Negative_regulation of Gad1 1 0.05 0.41 0.04
127 INT224302 Negative_regulation of Transcription of PSEN2 3 0.26 0.08 0
128 INT265229 Binding of PSEN2 2 0.16 1.37 0
129 INT354953 Negative_regulation of Gene_expression of Shank3 1 0.59 0.36 0
130 INT286327 Regulation of Binding of Psen1 1 0.33 0.16 0
131 INT234250 Positive_regulation of Negative_regulation of PSEN1 1 0.41 0 0
132 INT244782 Negative_regulation of Pax2 1 0.44 0 0
133 INT354960 Binding of Shank3 1 0.32 0 0
134 INT193886 Regulation of Protein_catabolism of Psen1 1 0.44 0.06 0
135 INT193934 Positive_regulation of Binding of PSEN1 1 0.49 0.92 0
136 INT224297 Regulation of Transcription of PSEN2 1 0.20 0.06 0
137 INT331407 Negative_regulation of Transcription of Psen1 1 0.04 0.08 0
138 INT177774 Transcription of PSEN1 1 0.33 0.09 0
139 INT177482 Negative_regulation of Negative_regulation of BBS2 1 0.03 0.73 0
140 INT354892 Negative_regulation of Psen2 1 0.37 0.95 0
141 INT176248 Binding of Pafah1b1 1 0.07 0.45 0
142 INT180232 Protein_catabolism of Gad1 1 0.87 0.52 0
143 INT193844 Positive_regulation of Protein_catabolism of Psen1 1 0.49 0.05 0
144 INT213529 Negative_regulation of Gene_expression of Pax2 1 0.37 0.23 0
145 INT331463 Regulation of Gene_expression of PSEN2 1 0.04 0 0
146 INT234258 Negative_regulation of Phosphorylation of PSEN1 1 0.35 0.49 0
147 INT354946 Positive_regulation of Shank3 1 0.50 0 0
148 INT354938 Transcription of Shank3 1 0.69 0 0
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