GO:0048863

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Name stem cell differentiation
Categary Process
Go Slim No
Go Link GO:0048863
Unique Molecular Interactions 102
Total Molecular Interactions 147
Total Single Events 924
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for stem cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for stem cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
2 INT90385 EXTL3 Regulation of Ctsl 1 0.00 1.1 0.98
3 INT141605 Gene_expression of Ctsl Positive_regulation of Positive_regulation of MET 1 0.34 0 0.8
4 INT152925 Aanat Positive_regulation of Nanog 1 0.02 0.42 0.67
5 INT106074 IL1B Positive_regulation of Gene_expression of A2M 1 0.03 0.75 0.49
6 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
7 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
8 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
9 INT309366 Pax2 Negative_regulation of Transcription of Slc6a5 1 0.03 0 0.31
10 INT309369 Ptf1a Positive_regulation of Pax2 1 0.10 0 0.3
11 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
12 INT94849 A2M Negative_regulation of Gene_expression of COL7A1 1 0.01 0.27 0.28
13 INT26669 Nanog Regulation of Binding of Tlyr1 1 0.02 0 0.28
14 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26
15 INT168203 Binding of Mc1r and Msx1 1 0.19 0.64 0.25
16 INT41950 Ptger1 Positive_regulation of Localization of A2m 1 0.19 0.46 0.24
17 INT41949 Ptger1 Positive_regulation of Gene_expression of A2m 1 0.19 0.46 0.24
18 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2
19 INT97547 KITLG Negative_regulation of Msx1 1 0.00 0.08 0.15
20 INT97542 Pomc Negative_regulation of Msx1 1 0.13 0.07 0.15
21 INT97545 Gtf3a Negative_regulation of Msx1 1 0.02 0.08 0.15
22 INT243524 Positive_regulation of Binding of NTF3 and SOX10 1 0.01 0.54 0.14
23 INT243525 Binding of NTF3 and SOX10 1 0.01 0.54 0.14
24 INT94850 A2M Negative_regulation of Gene_expression of PIP 1 0.01 0.14 0.14
25 INT223963 Binding of Bglap and Runx2 1 0.14 1.74 0.13
26 INT323430 Binding of Vhl and Osr1 1 0.02 0.78 0.13
27 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
28 INT323434 Osr1 Regulation of Hif1a 1 0.01 0.79 0.13
29 INT323435 Binding of Osr1 and Gtf3a 1 0.00 0.78 0.13
30 INT323433 Osr1 Regulation of Protein_catabolism of Hif1a 1 0.01 0.8 0.13
31 INT214150 Binding of Mc3r and Msx1 1 0.03 0.5 0.12
32 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12
33 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
34 INT309372 Lhx5 Positive_regulation of Gene_expression of Pax2 1 0.09 0.07 0.11
35 INT214152 Binding of Mc4r and Msx1 1 0.03 0.24 0.11
36 INT190684 Binding of A2M and IGF1 1 0.16 1.54 0.1
37 INT214168 Msx1 Positive_regulation of Gene_expression of DST 1 0.00 0.13 0.09
38 INT288374 Binding of MLANA and Msx1 1 0.09 0 0.08
39 INT201173 Sox2 Positive_regulation of Localization of Ryr2 1 0.40 0.9 0.07
40 INT201172 Sox2 Positive_regulation of Localization of Ca2 1 0.47 0.9 0.07
41 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06
42 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
43 INT213562 Ctnnd2 Regulation of Gene_expression of Sox2 1 0.35 0.07 0.05
44 INT287223 Pdx1 Regulation of Transcription of Insig1 1 0.03 0.56 0.05
45 INT214146 Msx1 Positive_regulation of Gene_expression of Nucb2 1 0.05 0.19 0.05
46 INT133983 Pou2f1 Regulation of Pdx1 1 0.06 0 0.04
47 INT133989 Pdx1 Regulation of Kcnip3 1 0.07 0 0.04
48 INT133981 Pdx1 Regulation of Pou1f1 1 0.05 0 0.04
49 INT133982 Pou1f1 Regulation of Pdx1 1 0.05 0 0.04
50 INT133990 Meis1 Regulation of Pdx1 1 0.05 0 0.04
51 INT134000 Pdx1 Regulation of Gene_expression of Npff 1 0.46 0 0.04
52 INT133978 Pdx1 Regulation of Pou2f1 1 0.06 0 0.04
53 INT134001 Kcnip3 Regulation of Pdx1 1 0.07 0 0.04
54 INT133996 Pdx1 Regulation of Meis1 1 0.05 0 0.04
55 INT349287 A2m Negative_regulation of Prtn3 1 0.00 0.4 0.03
56 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
57 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
58 INT244839 Lbx1 Positive_regulation of Pax2 1 0.39 0 0
59 INT127731 Binding of A2m and Mif 1 0.19 0 0
60 INT262172 Nr1i2 Regulation of Msx2 1 0.12 0.53 0
61 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
62 INT269948 Sox17 Positive_regulation of Gene_expression of Ccnd1 1 0.61 0.19 0
63 INT314773 Glp1r Positive_regulation of Gene_expression of Pdx1 1 0.01 0.57 0
64 INT269940 Binding of Sox17 and Scn4a 1 0.17 0.15 0
65 INT272977 Osr1 Regulation of ADHD1 1 0.01 1.79 0
66 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
67 INT49943 Binding of Th and Pdx1 1 0.02 0.17 0
68 INT269928 Binding of Sox17 and Mgst1 1 0.12 0 0
69 INT272978 Binding of Osr1 and ADHD1 1 0.00 1.91 0
70 INT269949 Sox17 Positive_regulation of Ccnd1 1 0.61 0.96 0
71 INT269954 Sox17 Regulation of Gene_expression of Foxa2 1 0.43 0 0
72 INT269950 Sox17 Negative_regulation of Gene_expression of Cdkn2b 1 0.27 0.24 0
73 INT269947 Sox17 Positive_regulation of Gene_expression of Atxn1 1 0.08 0 0
74 INT269957 Sox17 Negative_regulation of Gene_expression of TGFB1 1 0.04 0 0
75 INT269941 Sox17 Regulation of Gene_expression of Foxa1 1 0.56 0 0
76 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
77 INT269934 Sox17 Regulation of Gopc 1 0.12 0 0
78 INT161358 Binding of SOX10 and Nes 1 0.02 0.11 0
79 INT217151 Gene_expression of MIR98 Negative_regulation of HMGA2 1 0.24 1.08 0
80 INT269951 Binding of Sox17 and Gopc 1 0.11 0 0
81 INT277610 Binding of Runx2 and Hdac4 1 0.32 0.78 0
82 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
83 INT269945 Sox17 Positive_regulation of Localization of Ccnd1 1 0.39 0 0
84 INT268600 Mirlet7a-1 Regulation of HMGA2 1 0.01 0.72 0
85 INT297691 Binding of Fut1 and Pax2 1 0.03 0 0
86 INT352841 Binding of Miox and Lin28a 1 0.00 0 0
87 INT269922 Sox17 Regulation of Ccnd1 1 0.47 0 0
88 INT269931 Binding of Ccnd1 and Sox17 1 0.33 0.19 0
89 INT217142 MIR98 Regulation of Gene_expression of HMGA2 1 0.40 2.22 0
90 INT269918 Binding of Scn5a and Sox17 1 0.18 0.15 0
91 INT352842 Binding of Lin28a and Mirlet7a-1 1 0.03 0 0
92 INT269916 Sox17 Positive_regulation of Pcna 1 0.16 0 0
93 INT331090 Binding of Ctsl and Itga2 1 0.10 0.2 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for stem cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in stem cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT47301 Gene_expression of Ctsl 27 0.76 7.72 9.32
2 INT50767 Positive_regulation of Nanog 14 0.67 3.63 8.56
3 INT28358 Gene_expression of Nanog 25 0.70 3.52 7.85
4 INT47298 Localization of Ctsl 13 0.79 3.77 4.08
5 INT41942 Gene_expression of A2m 9 0.36 9.98 3.96
6 INT64825 Negative_regulation of Nanog 8 0.57 2.59 3.47
7 INT148190 Positive_regulation of Transcription of Nanog 1 0.49 0.2 3.17
8 INT122787 Transcription of Nanog 4 0.67 0.78 2.81
9 INT122782 Negative_regulation of Positive_regulation of Nanog 3 0.57 1.15 2.81
10 INT10141 Gene_expression of A2M 11 0.35 9.37 2.75
11 INT27412 Regulation of Nanog 7 0.58 0.81 2.59
12 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55
13 INT699 Positive_regulation of A2M 16 0.66 10.49 2.5
14 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42
15 INT23352 Negative_regulation of A2M 10 0.33 8.35 2.16
16 INT47303 Regulation of Ctsl 10 0.56 2.64 2.04
17 INT58208 Negative_regulation of Ctsl 8 0.53 3.49 1.91
18 INT62692 Localization of Nanog 3 0.73 0.82 1.85
19 INT47302 Regulation of Gene_expression of Ctsl 2 0.53 0.54 1.77
20 INT41639 Positive_regulation of A2m 7 0.46 4.52 1.74
21 INT3249 Regulation of A2M 7 0.39 3.29 1.61
22 INT41944 Positive_regulation of Gene_expression of A2m 2 0.23 2.56 1.29
23 INT138726 Positive_regulation of Gene_expression of Msx1 5 0.53 1.73 1.2
24 INT41947 Regulation of A2m 2 0.29 1.08 1.14
25 INT47305 Positive_regulation of Gene_expression of Ctsl 5 0.59 2.06 1.12
26 INT86931 Gene_expression of A2m 3 0.16 4.81 1.04
27 INT133842 Binding of SOX10 3 0.38 5.79 1.02
28 INT43484 Binding of Runx2 7 0.37 3.22 0.95
29 INT243533 Positive_regulation of SOX10 1 0.35 3.93 0.92
30 INT41946 Localization of A2m 1 0.38 1.81 0.89
31 INT304863 Negative_regulation of Gene_expression of Nanog 4 0.41 0.91 0.84
32 INT133841 Gene_expression of SOX10 18 0.67 9.96 0.8
33 INT120046 Negative_regulation of Localization of Ctsl 2 0.40 0.31 0.8
34 INT41943 Positive_regulation of Positive_regulation of A2m 2 0.22 1.19 0.74
35 INT95617 Regulation of Msx1 2 0.56 1.05 0.73
36 INT41945 Negative_regulation of A2m 2 0.27 0.35 0.68
37 INT54497 Binding of Nanog 1 0.35 0 0.67
38 INT189322 Binding of A2M 7 0.29 12.1 0.66
39 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65
40 INT75043 Binding of Msx1 6 0.35 2.36 0.65
41 INT88987 Gene_expression of HMGA2 8 0.77 10.46 0.64
42 INT62732 Positive_regulation of Gene_expression of Nanog 2 0.45 0.27 0.63
43 INT185244 Gene_expression of Sox2 27 0.65 4.71 0.61
44 INT32921 Positive_regulation of Msx1 4 0.47 0.99 0.57
45 INT133968 Binding of Pdx1 1 0.32 0.16 0.55
46 INT160148 Positive_regulation of Ctsl 2 0.43 0.74 0.52
47 INT167366 Positive_regulation of A2m 1 0.02 0.43 0.49
48 INT88170 Positive_regulation of HMGA2 2 0.69 2 0.48
49 INT243538 Regulation of SOX10 1 0.31 3.27 0.48
50 INT304861 Regulation of Gene_expression of Nanog 3 0.43 0.13 0.46
51 INT230623 Negative_regulation of SOX10 2 0.36 0.46 0.46
52 INT185255 Positive_regulation of Sox2 3 0.26 1.22 0.42
53 INT247307 Negative_regulation of Msx1 3 0.22 0.11 0.42
54 INT84326 Protein_catabolism of Nanog 1 0.02 0 0.41
55 INT288336 Positive_regulation of Gene_expression of A2m 1 0.12 1.73 0.37
56 INT224637 Protein_catabolism of Ctsl 1 0.12 0.76 0.37
57 INT48772 Localization of A2M 3 0.78 2.83 0.35
58 INT88167 Negative_regulation of Positive_regulation of HMGA2 1 0.41 0.16 0.35
59 INT213507 Gene_expression of Pax2 10 0.67 1.41 0.34
60 INT156399 Regulation of Pdx1 1 0.00 0.96 0.33
61 INT309354 Regulation of Pax2 1 0.10 0 0.29
62 INT88988 Positive_regulation of Gene_expression of HMGA2 1 0.69 4.05 0.29
63 INT309339 Negative_regulation of Localization of Pax2 1 0.15 0 0.28
64 INT201143 Regulation of Sox2 6 0.44 2.71 0.26
65 INT49942 Positive_regulation of Pdx1 5 0.02 1.24 0.26
66 INT214128 Negative_regulation of Gene_expression of Msx1 3 0.53 1.25 0.26
67 INT332230 Regulation of Pdx1 1 0.01 0.99 0.25
68 INT316448 Positive_regulation of Lin28a 1 0.26 0.53 0.24
69 INT46524 Negative_regulation of Gene_expression of A2M 2 0.02 1.45 0.23
70 INT41948 Negative_regulation of Localization of A2m 1 0.20 0.46 0.23
71 INT142117 Regulation of Runx2 6 0.61 2.75 0.22
72 INT220862 Negative_regulation of Transcription of Ctsl 1 0.05 0.41 0.21
73 INT220859 Transcription of Ctsl 1 0.09 0.41 0.21
74 INT171614 Positive_regulation of Runx2 13 0.63 3.04 0.19
75 INT171605 Negative_regulation of Runx2 4 0.46 2.14 0.17
76 INT3248 Positive_regulation of Positive_regulation of A2M 1 0.46 0.25 0.17
77 INT23708 Regulation of Regulation of A2M 1 0.02 0.68 0.17
78 INT243532 Positive_regulation of Gene_expression of SOX10 1 0.55 0.86 0.15
79 INT243529 Regulation of Gene_expression of SOX10 1 0.31 1.27 0.15
80 INT167367 Binding of A2m 1 0.01 0.13 0.15
81 INT47304 Regulation of Localization of Ctsl 1 0.23 0.14 0.15
82 INT309352 Localization of Pax2 1 0.27 0 0.14
83 INT47300 Negative_regulation of Gene_expression of Ctsl 1 0.57 0.14 0.14
84 INT214127 Localization of Msx1 1 0.06 0.21 0.13
85 INT323417 Protein_catabolism of Osr1 1 0.07 0.84 0.13
86 INT47299 Positive_regulation of Localization of Ctsl 1 0.40 0.15 0.12
87 INT146139 Gene_expression of ETV4 11 0.12 8.43 0.11
88 INT201144 Regulation of Gene_expression of Sox2 3 0.44 0.82 0.11
89 INT201140 Transcription of Sox2 4 0.67 1.31 0.1
90 INT193490 Negative_regulation of Gene_expression of A2m 1 0.06 0.56 0.1
91 INT123875 Localization of Pdx1 1 0.80 0.28 0.09
92 INT70606 Positive_regulation of Positive_regulation of Pdx1 1 0.02 0.4 0.09
93 INT202629 Gene_expression of Pdx1 8 0.60 4.09 0.08
94 INT211942 Transcription of Runx2 3 0.69 2.46 0.08
95 INT202649 Positive_regulation of Pdx1 3 0.45 1.45 0.07
96 INT88990 Binding of HMGA2 1 0.48 0.95 0.07
97 INT244741 Positive_regulation of Gene_expression of Pax2 1 0.38 0 0.06
98 INT185260 Positive_regulation of Positive_regulation of Sox2 1 0.15 0 0.05
99 INT213537 Positive_regulation of Gene_expression of Sox2 3 0.48 1.34 0.04
100 INT213528 Negative_regulation of Gene_expression of Sox2 1 0.30 0.07 0.04
101 INT199219 Negative_regulation of Positive_regulation of A2M 1 0.29 1.94 0.03
102 INT323421 Gene_expression of Osr1 1 0.05 0.46 0.03
103 INT97829 Gene_expression of Pdx1 7 0.32 1.14 0
104 INT206911 Gene_expression of Msx2 4 0.71 1.26 0
105 INT201142 Negative_regulation of Sox2 4 0.57 0.59 0
106 INT201141 Binding of Sox2 3 0.36 0.53 0
107 INT206909 Negative_regulation of Gene_expression of Msx2 2 0.53 0.29 0
108 INT142118 Regulation of Gene_expression of Runx2 2 0.61 2.92 0
109 INT200864 Positive_regulation of Sox17 2 0.50 0.07 0
110 INT272974 Negative_regulation of Gene_expression of Osr1 1 0.04 1.58 0
111 INT243531 Localization of SOX10 1 0.52 0.31 0
112 INT211944 Regulation of Transcription of Runx2 1 0.34 0.32 0
113 INT269903 Localization of Sox17 1 0.75 0.07 0
114 INT206916 Positive_regulation of Gene_expression of Msx2 1 0.40 0.36 0
115 INT132735 Positive_regulation of Gene_expression of Pdx1 1 0.29 0 0
116 INT220772 Transcription of Msx2 1 0.46 0.08 0
117 INT161357 Transcription of SOX10 1 0.25 0.17 0
118 INT202631 Transcription of Pdx1 1 0.48 0 0
119 INT269907 Positive_regulation of Localization of Sox17 1 0.50 0.2 0
120 INT244782 Negative_regulation of Pax2 1 0.44 0 0
121 INT300344 Localization of HMGA2 1 0.42 1.75 0
122 INT269904 Regulation of Sox17 1 0.45 0 0
123 INT217195 Negative_regulation of HMGA2 1 0.55 3.54 0
124 INT49941 Negative_regulation of Pdx1 1 0.02 0.07 0
125 INT269876 Binding of Sox17 1 0.48 0.72 0
126 INT352833 Binding of Lin28a 1 0.19 0.54 0
127 INT236257 Regulation of Gene_expression of A2m 1 0.14 0 0
128 INT49938 Negative_regulation of Positive_regulation of Pdx1 1 0.02 0.07 0
129 INT245175 Transcription of ETV4 1 0.03 1.21 0
130 INT201146 Negative_regulation of Binding of Sox2 1 0.41 0.28 0
131 INT269885 Negative_regulation of Sox17 1 0.42 0.32 0
132 INT269891 Positive_regulation of Gene_expression of Sox17 1 0.69 0.4 0
133 INT268581 Regulation of HMGA2 1 0.18 0.72 0
134 INT202644 Regulation of Gene_expression of Pdx1 1 0.41 0 0
135 INT269878 Negative_regulation of Gene_expression of Sox17 1 0.42 0 0
136 INT272976 Regulation of Osr1 1 0.04 1.54 0
137 INT269892 Transcription of Sox17 1 0.71 0 0
138 INT49940 Positive_regulation of Negative_regulation of Pdx1 1 0.02 0.07 0
139 INT272973 Gene_expression of Osr1 1 0.06 5.27 0
140 INT265814 Localization of Runx2 1 0.75 0.84 0
141 INT201139 Localization of Sox2 1 0.73 0.15 0
142 INT217225 Negative_regulation of Negative_regulation of HMGA2 1 0.55 2.4 0
143 INT213529 Negative_regulation of Gene_expression of Pax2 1 0.37 0.23 0
144 INT272975 Negative_regulation of Osr1 1 0.05 1.51 0
145 INT277589 Regulation of Negative_regulation of Runx2 1 0.36 0.78 0
146 INT245169 Regulation of Gene_expression of ETV4 1 0.01 0.26 0
147 INT269898 Positive_regulation of Binding of Sox17 1 0.44 0 0
148 INT265813 Regulation of Binding of Runx2 1 0.27 0.19 0
149 INT269869 Gene_expression of Sox17 1 0.77 2.48 0
150 INT269882 Regulation of Gene_expression of Sox17 1 0.61 0.14 0
151 INT171613 Positive_regulation of Positive_regulation of Runx2 1 0.01 0 0
152 INT245170 Positive_regulation of Gene_expression of ETV4 1 0.02 0.93 0
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