GO:0050220

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Name prostaglandin-E synthase activity
Categary Function
Go Slim No
Go Link GO:0050220
Unique Molecular Interactions 85
Total Molecular Interactions 112
Total Single Events 1078
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for prostaglandin-E synthase activity. They are ordered first by their pain relevance and then by number of times they were reported for prostaglandin-E synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT155139 Binding of MC1R and PTGES 3 0.09 0 0.7
2 INT312106 EGR1 Regulation of Gene_expression of PTGES 1 0.31 1.06 0.64
3 INT147071 NFKB1 Regulation of Gene_expression of PTGES 1 0.36 0.35 0.57
4 INT136758 TNF Positive_regulation of Gene_expression of PTGES 1 0.05 0.52 0.55
5 INT312118 ELANE Regulation of PTGES 1 0.22 0.92 0.49
6 INT162329 Tmc1 Negative_regulation of Gene_expression of Ptges2 1 0.03 0.58 0.47
7 INT314263 Binding of CPOX and PTGES3 1 0.01 1.7 0.44
8 INT220193 PTGER2 Regulation of PTGES 1 0.06 0.66 0.41
9 INT144047 IL4 Positive_regulation of PTGES 1 0.29 0.43 0.37
10 INT144044 IRF6 Positive_regulation of PTGES 1 0.10 0.43 0.37
11 INT144043 IL13 Positive_regulation of PTGES 1 0.32 0.43 0.37
12 INT106511 Binding of Cpox and Ptges3 2 0.01 0.7 0.36
13 INT144046 IL13 Negative_regulation of Gene_expression of PTGES 1 0.30 0.48 0.35
14 INT312124 EGR1 Regulation of Binding of PTGES 1 0.31 0.41 0.35
15 INT144045 IFNG Negative_regulation of Gene_expression of PTGES 1 0.63 0.47 0.35
16 INT144050 IL4 Negative_regulation of Gene_expression of PTGES 1 0.27 0.48 0.35
17 INT144049 IL10 Negative_regulation of Gene_expression of PTGES 1 0.35 0.47 0.35
18 INT144048 IRF6 Positive_regulation of Gene_expression of PTGES 1 0.12 0.46 0.35
19 INT312119 ELANE Positive_regulation of Gene_expression of PTGES 1 0.18 0.74 0.33
20 INT188521 Binding of Hsp90aa1 and Ptges3 1 0.02 0.61 0.33
21 INT188517 Il1a Negative_regulation of Gene_expression of Ptges 1 0.00 0.17 0.28
22 INT136759 TNF Positive_regulation of PTGES 1 0.03 0.29 0.28
23 INT188524 Il1a Positive_regulation of Ptges 1 0.00 0.31 0.28
24 INT107615 IL1B Positive_regulation of PTGES 2 0.55 0.05 0.26
25 INT3507 Ptges Regulation of Localization of LH 1 0.21 0 0.26
26 INT139357 Nr1h2 Regulation of Gene_expression of Ptges 1 0.07 0.5 0.25
27 INT312115 ELANE Positive_regulation of Transcription of PTGES 1 0.25 0.53 0.25
28 INT105542 PTGES Positive_regulation of DNTT 1 0.00 0.62 0.25
29 INT184162 Egr1 Positive_regulation of Transcription of Ptges2 1 0.08 0.42 0.22
30 INT149882 Binding of Ptgs1 and Ptges 1 0.01 0.15 0.22
31 INT184160 Binding of Egr1 and Ptges2 1 0.07 0.4 0.22
32 INT184159 Egr1 Positive_regulation of Ptges2 1 0.07 0.34 0.19
33 INT184161 Negative_regulation of Egr1 Positive_regulation of Ptges2 1 0.07 0.34 0.19
34 INT165555 Hypt Regulation of Gene_expression of Ptges2 1 0.30 0.87 0.19
35 INT139877 CPOX Regulation of Gene_expression of PTGES 1 0.17 0.07 0.18
36 INT139881 CPOX Regulation of Transcription of PTGES 1 0.17 0.07 0.18
37 INT314269 Binding of PTGES and PTGES3 1 0.12 0.68 0.18
38 INT312090 EGR1 Regulation of Positive_regulation of PTGES 1 0.42 0.21 0.18
39 INT139878 PTGES Regulation of Gene_expression of CPOX 1 0.17 0.07 0.18
40 INT139879 PTGES Regulation of Transcription of CPOX 1 0.17 0.07 0.18
41 INT168807 Binding of Nfkb1 and Ptges 1 0.04 0.35 0.16
42 INT312111 ELANE Regulation of Transcription of PTGES 1 0.22 0.23 0.16
43 INT234604 Tlr4 Positive_regulation of Ptges 1 0.04 0 0.14
44 INT350097 Gtf3a Regulation of Gene_expression of PTGES 1 0.00 0.25 0.13
45 INT147072 NFKB1 Regulation of PTGES 1 0.36 0 0.11
46 INT184163 Binding of Ptges2 and Glis1 1 0.02 0.2 0.11
47 INT312094 ELANE Positive_regulation of PTGES 1 0.29 0.34 0.11
48 INT116788 Bsg Negative_regulation of Gene_expression of Ptges 1 0.00 0.17 0.09
49 INT314267 Binding of CPOX and PTGES 1 0.03 0.34 0.09
50 INT217271 Cpox Regulation of Gene_expression of Ptges 1 0.01 0.14 0.08
51 INT314265 PTGER2 Positive_regulation of Gene_expression of PTGES2 1 0.00 0.19 0.08
52 INT168808 Tlr4 Positive_regulation of Gene_expression of Ptges 1 0.02 0.13 0.08
53 INT188520 Ptges Positive_regulation of Cpox 1 0.01 0.05 0.06
54 INT217278 Kitl Regulation of Gene_expression of Ptges 1 0.02 0.1 0.05
55 INT312104 Binding of ALOX5 and PTGES 1 0.13 0.14 0.04
56 INT217277 Cpox Negative_regulation of Gene_expression of Ptges 1 0.01 0.09 0.04
57 INT106515 Binding of Ptges and Cpox 1 0.00 0.17 0.04
58 INT188525 Il1a Regulation of Ptges 1 0.00 0.07 0.04
59 INT217273 Avp Negative_regulation of Gene_expression of Ptges 1 0.01 0.09 0.04
60 INT310804 SFTPA1 Negative_regulation of Gene_expression of Ptges2 1 0.00 0.14 0.03
61 INT195836 Tlr4 Regulation of Gene_expression of Ptges 1 0.00 0.52 0.03
62 INT312125 Binding of ELANE and PTGES 1 0.13 0.07 0.03
63 INT195835 Tlr4 Regulation of Ptges 1 0.00 0.52 0.03
64 INT352066 Binding of PTGS2 and PTGES2 1 0.04 0 0
65 INT312114 EGR1 Positive_regulation of Positive_regulation of PTGES 1 0.32 0 0
66 INT217272 Cpox Regulation of Positive_regulation of Ptges 1 0.00 0 0
67 INT340917 Binding of Ptges3 and Ptplad1 1 0.14 0.17 0
68 INT152541 CBX1 Negative_regulation of Gene_expression of PTGES 1 0.15 0.3 0
69 INT152542 ACF Negative_regulation of Gene_expression of PTGES 1 0.23 0.3 0
70 INT310805 MAPK8 Regulation of Regulation of Ptges2 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for prostaglandin-E synthase activity. They are ordered first by their pain relevance and then by number of times they were reported in prostaglandin-E synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT63419 Gene_expression of PTGES 109 0.77 40.83 23.67
2 INT134298 Gene_expression of Ptges2 96 0.54 56.52 17.19
3 INT91413 Negative_regulation of PTGES 35 0.58 17.94 12.03
4 INT106510 Gene_expression of Ptges 70 0.75 36.18 9.75
5 INT104679 Gene_expression of Ptges 33 0.41 10.14 7.89
6 INT91417 Positive_regulation of PTGES 36 0.68 18.45 7.64
7 INT142904 Negative_regulation of Ptges2 14 0.47 9.49 6.15
8 INT162328 Regulation of Ptges2 21 0.19 12.07 5.56
9 INT98685 Positive_regulation of Gene_expression of PTGES 28 0.68 9.46 5.55
10 INT143925 Negative_regulation of Ptges 18 0.42 10.5 5.18
11 INT134297 Positive_regulation of Gene_expression of Ptges2 22 0.41 13.12 4.97
12 INT62291 Gene_expression of PTGES2 14 0.68 8.34 4.75
13 INT118926 Regulation of PTGES 17 0.51 5.79 4.69
14 INT107620 Binding of PTGES 25 0.48 5.49 4.24
15 INT134296 Positive_regulation of Ptges2 20 0.19 14.85 3.8
16 INT108814 Regulation of Gene_expression of PTGES 8 0.59 3.62 3.54
17 INT104678 Positive_regulation of Ptges 18 0.34 6.29 3.39
18 INT139355 Regulation of Gene_expression of Ptges2 11 0.17 6.37 3.19
19 INT117582 Positive_regulation of Gene_expression of Ptges 12 0.27 4.22 2.98
20 INT108813 Negative_regulation of Ptges 8 0.57 2.79 2.85
21 INT130506 Regulation of Ptges 7 0.12 2.56 2.77
22 INT134145 Negative_regulation of Gene_expression of PTGES 11 0.51 5.32 2.73
23 INT103238 Localization of PTGES 7 0.68 4.16 2.59
24 INT139354 Negative_regulation of Gene_expression of Ptges2 11 0.23 4.28 2.51
25 INT106513 Gene_expression of Ptges3 7 0.73 3.57 2.42
26 INT106508 Positive_regulation of Gene_expression of Ptges 12 0.20 5.37 2.06
27 INT62290 Positive_regulation of Gene_expression of PTGES2 5 0.28 3.14 1.88
28 INT158772 Negative_regulation of Regulation of Ptges 1 0.03 0.07 1.81
29 INT184154 Transcription of Ptges2 4 0.20 2.4 1.71
30 INT118700 Positive_regulation of Ptges 12 0.49 5.04 1.68
31 INT118699 Binding of Ptges 4 0.33 1.15 1.5
32 INT139886 Gene_expression of PTGES3 11 0.72 1.5 1.27
33 INT146381 Localization of Ptges 3 0.10 5.55 1.26
34 INT106509 Negative_regulation of Gene_expression of Ptges 6 0.17 1.95 1.25
35 INT93619 Localization of PTGES2 2 0.04 1.88 1.17
36 INT117579 Regulation of Gene_expression of Ptges 4 0.24 1.41 1.13
37 INT139885 Transcription of PTGES 4 0.68 1.46 1.12
38 INT71314 Regulation of Ptges3 1 0.13 0.84 1.02
39 INT117580 Positive_regulation of Positive_regulation of Ptges 3 0.20 1.48 0.93
40 INT117581 Positive_regulation of Gene_expression of Ptges3 1 0.39 0.93 0.93
41 INT117584 Regulation of Gene_expression of Ptges3 1 0.21 0.93 0.93
42 INT134299 Localization of Ptges2 4 0.60 5.93 0.89
43 INT91416 Negative_regulation of Positive_regulation of PTGES 3 0.40 1.88 0.82
44 INT184157 Gene_expression of Ptges3 6 0.45 2.93 0.71
45 INT139353 Regulation of Gene_expression of Ptges 3 0.18 2.05 0.71
46 INT184151 Negative_regulation of Transcription of Ptges2 1 0.12 0.96 0.66
47 INT104677 Transcription of Ptges 3 0.49 0.36 0.61
48 INT117583 Positive_regulation of Ptges3 1 0.36 0.59 0.57
49 INT130507 Negative_regulation of Ptges3 1 0.35 0.81 0.53
50 INT234588 Transcription of Ptges 1 0.06 0.9 0.51
51 INT146382 Positive_regulation of Localization of Ptges 1 0.00 0.36 0.45
52 INT139890 Regulation of Gene_expression of PTGES3 2 0.50 0.82 0.43
53 INT104676 Positive_regulation of Transcription of Ptges 1 0.34 0.3 0.42
54 INT144052 Positive_regulation of Regulation of PTGES 1 0.45 0.42 0.37
55 INT234585 Negative_regulation of Positive_regulation of Ptges 1 0.04 0.91 0.37
56 INT162899 Regulation of Negative_regulation of Ptges2 1 0.03 0.72 0.37
57 INT162900 Regulation of Negative_regulation of PTGES 1 0.14 0.72 0.37
58 INT169236 Negative_regulation of Binding of PTGES 2 0.36 0.37 0.36
59 INT234594 Positive_regulation of Transcription of Ptges 1 0.04 0.9 0.36
60 INT62293 Negative_regulation of PTGES2 2 0.06 1.05 0.34
61 INT134300 Positive_regulation of Localization of Ptges2 1 0.00 0.74 0.33
62 INT151718 Regulation of Ptges 3 0.27 1.63 0.31
63 INT147074 Positive_regulation of Transcription of PTGES 2 0.44 0.33 0.3
64 INT62292 Positive_regulation of PTGES2 2 0.02 0.51 0.27
65 INT188510 Negative_regulation of Negative_regulation of Ptges 1 0.03 0 0.26
66 INT310797 Positive_regulation of Gene_expression of PTGES3 1 0.17 0.7 0.23
67 INT310800 Positive_regulation of PTGES3 1 0.24 0.7 0.23
68 INT252169 Negative_regulation of Gene_expression of Ptges3 1 0.16 0.5 0.21
69 INT330901 Phosphorylation of PTGES 1 0.29 0.3 0.2
70 INT199309 Positive_regulation of Positive_regulation of Ptges2 1 0.03 1 0.2
71 INT91414 Regulation of Positive_regulation of PTGES 1 0.14 0.28 0.19
72 INT188509 Negative_regulation of Gene_expression of Ptges 3 0.04 0.15 0.18
73 INT167419 Regulation of Localization of Ptges2 1 0.36 0.22 0.15
74 INT184152 Positive_regulation of Regulation of Ptges2 1 0.14 0.23 0.13
75 INT184153 Regulation of Regulation of Ptges2 1 0.12 0.23 0.13
76 INT312134 Regulation of Transcription of PTGES 1 0.40 0.18 0.13
77 INT188508 Positive_regulation of Localization of Ptges 1 0.04 0 0.1
78 INT188504 Localization of Ptges 1 0.06 0 0.1
79 INT164486 Positive_regulation of Negative_regulation of PTGES 1 0.41 0.15 0.07
80 INT154601 Protein_catabolism of PTGES 1 0.65 0.07 0.07
81 INT310796 Transcription of PTGES3 1 0.27 0.05 0.03
82 INT203614 Positive_regulation of Negative_regulation of PTGES2 1 0.07 0.3 0
83 INT352070 Binding of PTGES2 1 0.05 0 0
84 INT199306 Phosphorylation of Ptges2 1 0.04 1.06 0
85 INT217263 Negative_regulation of Transcription of Ptges 1 0.04 0 0
86 INT199307 Binding of Ptges2 1 0.02 1.06 0
87 INT217264 Regulation of Positive_regulation of Ptges 1 0.03 0 0
88 INT195827 Phosphorylation of Ptges 1 0.02 1.3 0
89 INT310799 Negative_regulation of Gene_expression of PTGES3 1 0.17 0 0
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