GO:0050321

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Name tau-protein kinase activity
Categary Function
Go Slim No
Go Link GO:0050321
Unique Molecular Interactions 160
Total Molecular Interactions 184
Total Single Events 2412
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for tau-protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for tau-protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
2 INT338894 TNFSF14 Negative_regulation of Gsk3a 1 0.00 0.54 1.04
3 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
4 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
5 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58
6 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
7 INT273235 Binding of Cdk5 and Cdk5r1 1 0.24 6.06 0.46
8 INT288545 Gsk3b Negative_regulation of gr 1 0.25 0.38 0.38
9 INT152453 Gsk3b Regulation of Nfkb1 1 0.02 1.68 0.36
10 INT66369 Pomc Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
11 INT273234 Negative_regulation of Cdk5 Positive_regulation of Ptprs 1 0.14 1.26 0.34
12 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
13 INT342810 Binding of Adarb1 and Gsk3b 1 0.00 0.36 0.3
14 INT298995 Il18 Positive_regulation of Gene_expression of Cdk5 1 0.12 1.65 0.29
15 INT299008 Il18 Positive_regulation of Transcription of Cdk5 1 0.12 1.65 0.29
16 INT247949 Cdk5r1 Positive_regulation of Cdk5 1 0.26 1.12 0.28
17 INT325530 Positive_regulation of Gsk3b Negative_regulation of Gene_expression of Wnt2 1 0.03 0.63 0.28
18 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
19 INT337113 Ppp1r1b Negative_regulation of Phosphorylation of Cdk5 1 0.11 0.28 0.27
20 INT273232 Negative_regulation of Binding of Cdk5 and Cdk5r1 1 0.28 3.16 0.23
21 INT273237 Cdk5 Positive_regulation of Protein_catabolism of Grin2b 1 0.45 1.31 0.22
22 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21
23 INT326834 Cdk5r2 Positive_regulation of Cdk5 1 0.02 0.96 0.21
24 INT121583 Negative_regulation of GSK3A Negative_regulation of Gene_expression of GDF15 1 0.11 0.49 0.2
25 INT221956 CDK5R1 Regulation of Positive_regulation of CDK5 1 0.21 0.62 0.19
26 INT307453 Bdnf Positive_regulation of Phosphorylation of Gsk3a 1 0.06 0.16 0.18
27 INT261401 Binding of Gsk3b and ADHD1 1 0.00 1.62 0.18
28 INT298998 Il18 Positive_regulation of Cdk5 1 0.11 0.36 0.17
29 INT164791 Cdk5r1 Positive_regulation of Cdk5 1 0.30 0.25 0.17
30 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15
31 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14
32 INT273233 Negative_regulation of Cdk5 Negative_regulation of Positive_regulation of Ltp 1 0.20 0.39 0.13
33 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
34 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
35 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
36 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13
37 INT273239 Cdk5 Positive_regulation of Positive_regulation of GRIN1 1 0.51 0.37 0.12
38 INT289765 Akt1 Regulation of Phosphorylation of Gsk3a 1 0.05 0.45 0.11
39 INT268634 Ptpn2 Positive_regulation of Positive_regulation of Gsk3b 1 0.02 1.08 0.11
40 INT289768 Akt1 Regulation of Phosphorylation of Gsk3b 1 0.04 0.45 0.11
41 INT268626 Mpz Positive_regulation of Positive_regulation of Gsk3b 1 0.29 1.08 0.11
42 INT221958 CDK5R1 Positive_regulation of Positive_regulation of CDK5 1 0.36 0.38 0.1
43 INT32546 Gsk3b Negative_regulation of Localization of Gnrh1 1 0.05 0 0.1
44 INT32547 Gsk3b Negative_regulation of Localization of LH 1 0.04 0 0.1
45 INT273236 Cdk5 Positive_regulation of Car2 1 0.13 0.45 0.1
46 INT221959 Binding of CDK5 and CDK5R1 1 0.28 0.53 0.1
47 INT201751 Car2 Positive_regulation of Cdk5 1 0.00 0.67 0.09
48 INT221954 Binding of CDK5 and CDK5R2 1 0.02 0.36 0.09
49 INT157264 PPARA Positive_regulation of PRKAA1 1 0.03 0.92 0.08
50 INT157271 Adipor1 Positive_regulation of PRKAA1 1 0.01 0.89 0.08
51 INT268627 Ptpn2 Positive_regulation of Gsk3b 1 0.02 1.7 0.08
52 INT268630 Mpz Positive_regulation of Regulation of Gsk3b 1 0.18 0.57 0.07
53 INT354328 Gsk3b Regulation of Gs 1 0.16 0.84 0.07
54 INT354329 Gsk3b Regulation of Gene_expression of Gs 1 0.16 0.84 0.07
55 INT247948 Positive_regulation of Cdk5r1 Positive_regulation of Cdk5 1 0.26 0.16 0.07
56 INT221235 Akt1 Negative_regulation of Gsk3b 1 0.06 0.14 0.06
57 INT307454 Prkcg Regulation of Phosphorylation of Gsk3a 1 0.04 0.13 0.05
58 INT332329 Binding of Cdk5 and P2rx3 1 0.22 0.05 0.05
59 INT193966 AKT1 Negative_regulation of Gsk3b 1 0.05 0.75 0.05
60 INT193969 AKT1 Negative_regulation of Phosphorylation of Gsk3b 1 0.05 0.75 0.05
61 INT332331 Binding of Cdk5 and Rbm39 1 0.00 0.05 0.05
62 INT181814 Gsk3b Regulation of Gata4 1 0.06 0.37 0.05
63 INT193964 Mapk1 Negative_regulation of Gsk3b 1 0.00 0.74 0.05
64 INT307462 Gsk3a Regulation of Ntrk2 1 0.04 0.09 0.04
65 INT326830 Cdk5r1 Positive_regulation of Positive_regulation of Cdk5 1 0.09 0.16 0.04
66 INT213607 Binding of CSNK1D and CLOCK 1 0.27 0.65 0.04
67 INT307455 Gsk3a Regulation of Bdnf 1 0.06 0.09 0.04
68 INT290810 Gsk3b Regulation of Arntl 1 0.15 0 0.04
69 INT221639 Fyn Positive_regulation of Phosphorylation of Cdk5 1 0.14 0.28 0.03
70 INT303092 Gsk3b Positive_regulation of NEUROG2 1 0.01 0.16 0.03
71 INT221661 Sema3a Positive_regulation of Phosphorylation of Cdk5 1 0.19 0.28 0.03
72 INT332330 Cdk5 Negative_regulation of Pirt 1 0.00 0 0.03
73 INT290808 Gsk3b Positive_regulation of Arntl 1 0.25 0.17 0.03
74 INT234981 Binding of Dsg3 and Negative_regulation of Gsk3b 1 0.07 0.3 0.03
75 INT219352 CDK5 Negative_regulation of PAK1 1 0.22 0.72 0.03
76 INT303083 Rorb Regulation of Gsk3b 1 0.00 0.52 0.03
77 INT234975 Binding of Dsg3 and Negative_regulation of Gsk3a 1 0.03 0.3 0.03
78 INT268629 Mpz Regulation of Phosphorylation of Gsk3b 1 0.26 1.05 0.03
79 INT221613 Binding of Cdk5 and Fyn 1 0.10 0.29 0.03
80 INT303079 Gsk3b Positive_regulation of Cebpg 1 0.08 0.16 0.03
81 INT265906 IGF1 Regulation of Gsk3b 1 0.25 1.31 0.03
82 INT337811 Gene_expression of Gsk3b Positive_regulation of Phosphorylation of Akt1 1 0.37 0.37 0.03
83 INT221617 Fyn Positive_regulation of Cdk5 1 0.13 0.28 0.03
84 INT307458 Ntrk2 Positive_regulation of Phosphorylation of Gsk3a 1 0.05 0 0
85 INT290811 Binding of Mgst1 and Gsk3b 1 0.05 0 0
86 INT290807 Positive_regulation of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0
87 INT307457 Negative_regulation of Pik3cb Positive_regulation of Gsk3a 1 0.06 0.08 0
88 INT268628 Mpz Positive_regulation of Phosphorylation of Gsk3b 1 0.25 0.43 0
89 INT268635 Mpz Positive_regulation of Gsk3b 1 0.17 0.43 0
90 INT290809 Binding of Arntl and Gsk3b 1 0.20 0 0
91 INT201734 Binding of Akt1 and Cdk5 1 0.01 0.31 0
92 INT201738 Positive_regulation of Binding of Akt1 and Cdk5 1 0.01 0.31 0
93 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0
94 INT293979 Binding of CSNK1D and CSNK1E 1 0.21 0.18 0
95 INT235077 Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.07 0.53 0
96 INT307460 P2rx7 Positive_regulation of Phosphorylation of Gsk3a 1 0.02 0 0
97 INT307451 Fig4 Regulation of Phosphorylation of Gsk3a 1 0.01 0.06 0
98 INT281610 Positive_regulation of Akt1 Positive_regulation of Gsk3b 1 0.02 0.12 0
99 INT276212 Binding of Akt1 and Gsk3a 1 0.11 0 0
100 INT230713 Binding of Prkcd and Gsk3b 1 0.34 0 0
101 INT268632 Mpz Regulation of Gsk3b 1 0.22 0 0
102 INT290806 Gene_expression of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0
103 INT201731 Negative_regulation of Binding of Akt1 and Cdk5 1 0.01 0.31 0
104 INT268446 Cdk5 Positive_regulation of Cdk5r1 1 0.02 0.58 0
105 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0
106 INT303004 Adm Positive_regulation of Gsk3b 1 0.04 0.97 0
107 INT263319 Binding of Gsk3b and Uts2r 1 0.01 0 0
108 INT293980 Negative_regulation of Binding of CSNK1D and CSNK1E 1 0.24 0.18 0
109 INT307452 Negative_regulation of Pik3cb Positive_regulation of Phosphorylation of Gsk3a 1 0.06 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for tau-protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in tau-protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
2 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
3 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
4 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
5 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
6 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45
7 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
8 INT116641 Phosphorylation of Gsk3a 12 0.71 4.3 6.22
9 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95
10 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53
11 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
12 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
13 INT128746 Negative_regulation of Gsk3a 11 0.52 8.43 4.61
14 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
15 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
16 INT148495 Regulation of Cdk5 6 0.58 5.42 3.95
17 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83
18 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53
19 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07
20 INT196733 Gene_expression of Cdk5 25 0.76 18.25 2.64
21 INT138789 Gene_expression of Cdk5 6 0.76 5.19 2.62
22 INT92000 Gene_expression of Gsk3a 12 0.18 4.12 2.39
23 INT148494 Binding of Cdk5 6 0.40 5.97 2.31
24 INT112905 Phosphorylation of Cdk5 15 0.82 2.78 2.3
25 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22
26 INT157579 Binding of Cdk5 3 0.35 0.47 2.13
27 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87
28 INT148492 Positive_regulation of Binding of Cdk5 1 0.47 0.51 1.86
29 INT158710 Negative_regulation of Binding of Cdk5 1 0.40 0 1.84
30 INT261849 Positive_regulation of Phosphorylation of Gsk3a 3 0.14 1.15 1.57
31 INT109222 Positive_regulation of Negative_regulation of Cdk5 2 0.50 0.23 1.39
32 INT158709 Negative_regulation of Phosphorylation of Cdk5 1 0.40 0 1.39
33 INT163506 Binding of Gsk3a 4 0.32 1.41 1.31
34 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16
35 INT134036 Regulation of Gsk3b 4 0.60 1.42 1.15
36 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11
37 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11
38 INT273221 Positive_regulation of Negative_regulation of Cdk5 8 0.49 9.89 1.03
39 INT116646 Regulation of Negative_regulation of Gsk3b 2 0.44 0.39 0.99
40 INT203893 Positive_regulation of Gene_expression of Cdk5 2 0.49 7.12 0.92
41 INT253940 Gene_expression of Gsk3a 1 0.08 2.82 0.92
42 INT138788 Positive_regulation of Gene_expression of Cdk5 1 0.49 0.44 0.91
43 INT261360 Binding of Gsk3b 5 0.36 2.85 0.9
44 INT253938 Positive_regulation of Gsk3a 3 0.06 3.4 0.9
45 INT127452 Positive_regulation of CDK5 5 0.32 1.88 0.87
46 INT91995 Positive_regulation of Gsk3a 8 0.14 2.84 0.86
47 INT203892 Positive_regulation of Positive_regulation of Cdk5 4 0.49 4.02 0.85
48 INT307469 Regulation of Gsk3a 4 0.09 1.12 0.83
49 INT167285 Positive_regulation of Phosphorylation of Gsk3b 17 0.50 5.92 0.82
50 INT156945 Positive_regulation of Negative_regulation of Gsk3b 6 0.38 4.58 0.82
51 INT219358 Gene_expression of CDK5 9 0.58 5.65 0.81
52 INT66365 Positive_regulation of Gene_expression of Gsk3b 2 0.07 0.95 0.81
53 INT138787 Positive_regulation of Positive_regulation of Cdk5 1 0.49 0.38 0.81
54 INT116644 Phosphorylation of Gsk3b 4 0.61 0.68 0.78
55 INT204002 Negative_regulation of Gene_expression of Gsk3b 15 0.55 8.57 0.77
56 INT242137 Negative_regulation of Positive_regulation of Gsk3b 7 0.39 2.99 0.67
57 INT196790 Localization of Cdk5 6 0.74 2.6 0.67
58 INT204006 Negative_regulation of Localization of Gsk3b 6 0.40 1.66 0.6
59 INT230679 Positive_regulation of Binding of Gsk3b 3 0.42 1.42 0.58
60 INT127557 Positive_regulation of Phosphorylation of Cdk5 2 0.50 0.43 0.56
61 INT151663 Regulation of Gsk3a 3 0.16 1.03 0.54
62 INT208537 Regulation of Gene_expression of Gsk3b 4 0.36 2.15 0.52
63 INT85759 Localization of Gsk3a 3 0.55 0.43 0.52
64 INT163507 Negative_regulation of Phosphorylation of Gsk3a 3 0.51 0.96 0.45
65 INT307472 Regulation of Negative_regulation of Gsk3a 2 0.05 0.83 0.45
66 INT288540 Negative_regulation of Binding of Gsk3b 4 0.53 2.12 0.43
67 INT208552 Negative_regulation of Negative_regulation of Gsk3b 3 0.31 1.8 0.43
68 INT307464 Regulation of Phosphorylation of Gsk3a 1 0.12 0.42 0.43
69 INT235064 Regulation of Positive_regulation of Gsk3b 3 0.41 1.5 0.42
70 INT204012 Regulation of Negative_regulation of Gsk3b 4 0.42 4.51 0.39
71 INT208538 Regulation of Phosphorylation of Gsk3b 3 0.49 4.49 0.38
72 INT151662 Negative_regulation of Gsk3a 3 0.15 0.55 0.37
73 INT273218 Negative_regulation of Negative_regulation of Cdk5 1 0.42 3.06 0.37
74 INT221973 Negative_regulation of CDK5 4 0.57 2.26 0.36
75 INT66364 Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
76 INT226115 Positive_regulation of PRKAA1 2 0.15 0.45 0.29
77 INT268620 Regulation of Localization of Gsk3b 3 0.35 2.12 0.28
78 INT326820 Negative_regulation of Positive_regulation of Cdk5 1 0.36 1.27 0.28
79 INT298972 Transcription of Cdk5 1 0.15 1.63 0.28
80 INT345254 Positive_regulation of Localization of Gsk3b 2 0.01 0.91 0.24
81 INT164788 Regulation of Gene_expression of Cdk5 1 0.27 0.31 0.24
82 INT204021 Transcription of Gsk3b 8 0.57 2.75 0.23
83 INT268621 Positive_regulation of Localization of Gsk3b 4 0.40 1.54 0.22
84 INT116647 Positive_regulation of Phosphorylation of Gsk3b 1 0.37 0.18 0.22
85 INT121586 Positive_regulation of GSK3A 2 0.23 0.86 0.2
86 INT121585 Negative_regulation of Positive_regulation of GSK3A 1 0.11 0.49 0.2
87 INT219375 Localization of CDK5 4 0.52 2.8 0.19
88 INT221974 Phosphorylation of CDK5 1 0.56 0.99 0.19
89 INT273226 Negative_regulation of Gene_expression of Cdk5 2 0.42 0.79 0.17
90 INT157582 Regulation of Phosphorylation of Cdk5 1 0.26 0.25 0.16
91 INT221972 Regulation of CDK5 1 0.42 1.87 0.16
92 INT326822 Negative_regulation of Phosphorylation of Cdk5 1 0.36 0.43 0.12
93 INT259745 Phosphorylation of GSK3A 6 0.20 3 0.11
94 INT268617 Negative_regulation of Regulation of Gsk3b 3 0.28 1.84 0.11
95 INT289741 Phosphorylation of Gsk3a 1 0.24 0.45 0.11
96 INT341559 Positive_regulation of Gene_expression of CDK5 1 0.23 0.25 0.11
97 INT91997 Regulation of Gene_expression of Gsk3a 1 0.03 0.56 0.1
98 INT309869 Regulation of Binding of Gsk3b 1 0.12 0.66 0.1
99 INT312871 Positive_regulation of Transcription of Gsk3b 2 0.29 0.15 0.09
100 INT201655 Negative_regulation of Binding of Cdk5 1 0.06 0.9 0.09
101 INT234926 Protein_catabolism of Gsk3b 2 0.58 1.33 0.08
102 INT234906 Positive_regulation of Protein_catabolism of Gsk3b 2 0.33 1.33 0.08
103 INT307465 Positive_regulation of Positive_regulation of Gsk3a 1 0.10 0.24 0.07
104 INT341567 Negative_regulation of Gene_expression of CDK5 1 0.27 0.24 0.07
105 INT307482 Regulation of Regulation of Gsk3a 1 0.05 0 0.07
106 INT219355 Binding of CDK5 3 0.35 2.02 0.06
107 INT259746 Phosphorylation of CSNK1D 1 0.03 0.99 0.05
108 INT336062 Regulation of Localization of Gsk3b 1 0.03 0.48 0.04
109 INT268625 Regulation of Transcription of Gsk3b 2 0.15 0 0
110 INT268441 Regulation of Regulation of Gsk3b 1 0.07 0.72 0
111 INT258227 Positive_regulation of Regulation of GSK3A 1 0.15 0 0
112 INT268444 Regulation of Positive_regulation of Cdk5 1 0.08 0.66 0
113 INT260480 Transcription of Gsk3b 1 0.02 3.08 0
114 INT152449 Regulation of Protein_catabolism of Gsk3b 1 0.12 0.49 0
115 INT258225 Regulation of GSK3A 1 0.09 0 0
116 INT294005 Regulation of Negative_regulation of CSNK1D 1 0.28 0.19 0
117 INT307476 Negative_regulation of Gene_expression of Gsk3a 1 0.09 0.06 0
118 INT152451 Regulation of Gene_expression of Gsk3b 1 0.12 0.57 0
119 INT294021 Negative_regulation of CSNK1D 1 0.26 0.17 0
120 INT152448 Protein_catabolism of Gsk3b 1 0.28 0.49 0
121 INT238857 Phosphorylation of PRKAA1 1 0.01 1.73 0
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