GO:0050435

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Name beta-amyloid metabolic process
Categary Process
Go Slim No
Go Link GO:0050435
Unique Molecular Interactions 198
Total Molecular Interactions 288
Total Single Events 4591
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for beta-amyloid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for beta-amyloid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
2 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
3 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
4 INT165929 Binding of MME and WSN 1 0.01 0.99 1.16
5 INT60134 MME Negative_regulation of GRP 1 0.20 0 1.12
6 INT60133 MME Negative_regulation of SST 1 0.10 0 1.12
7 INT45665 Fpr1 Negative_regulation of Mme 1 0.13 0 1
8 INT34837 Maob Regulation of Negative_regulation of Mme 1 0.48 0.15 0.92
9 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
10 INT159995 Prkcg Regulation of Gene_expression of Bace1 1 0.39 0.32 0.91
11 INT56500 Ide Regulation of Maoa 1 0.21 0 0.89
12 INT92423 EC3 Negative_regulation of Mme 1 0.02 0.28 0.86
13 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
14 INT110578 PENK Positive_regulation of Gene_expression of MME 1 0.35 0.1 0.76
15 INT4875 TNF Regulation of MME 1 0.51 0.71 0.74
16 INT355815 BACE1 Regulation of Positive_regulation of NAV1 1 0.32 0.26 0.72
17 INT355814 BACE1 Regulation of Gene_expression of NAV1 1 0.37 0.24 0.72
18 INT36219 Mme Positive_regulation of Protein_catabolism of Penk 1 0.39 0 0.72
19 INT31243 Binding of Mme and Cpe 1 0.01 0 0.72
20 INT29380 Binding of gp and Mme 1 0.01 0 0.71
21 INT110577 MME Positive_regulation of Protein_catabolism of POMC 1 0.49 0.06 0.71
22 INT14613 Negative_regulation of MME Negative_regulation of Positive_regulation of POMC 1 0.06 0.24 0.65
23 INT29381 gp Regulation of Mme 1 0.01 0 0.65
24 INT29382 Positive_regulation of gp Regulation of Mme 1 0.02 0 0.65
25 INT14614 Negative_regulation of MME Negative_regulation of POMC 1 0.06 0.24 0.65
26 INT79210 Hps4 Negative_regulation of Mme 1 0.00 0 0.62
27 INT47284 Binding of Mme and Ctsa 1 0.21 0 0.57
28 INT54239 Binding of Mme and Nts 1 0.21 0 0.54
29 INT55445 Positive_regulation of Ahr Regulation of Mme 1 0.23 0 0.53
30 INT88696 Tac1 Regulation of Regulation of Mme 1 0.00 0.39 0.48
31 INT145954 Binding of BSG and MME 1 0.00 0.81 0.47
32 INT41039 Thop1 Positive_regulation of Mme 1 0.01 0 0.45
33 INT355817 BACE1 Regulation of NAV1 1 0.37 0.7 0.45
34 INT92422 Mme Negative_regulation of EC3 1 0.01 0.14 0.43
35 INT189309 Binding of MME and PENK 1 0.15 1.16 0.42
36 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
37 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
38 INT4876 Regulation of TNF Regulation of MME 1 0.37 0.36 0.37
39 INT37328 Binding of PDYN and Mme 1 0.02 0 0.34
40 INT24127 Cast Positive_regulation of Mme 1 0.15 0 0.33
41 INT15141 MME Negative_regulation of IL1B 1 0.39 0.19 0.32
42 INT246690 exf Regulation of Localization of Ide 1 0.00 0.17 0.3
43 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
44 INT15142 MME Regulation of IL1B 1 0.40 0.16 0.28
45 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
46 INT246689 Zglp1 Positive_regulation of Ide 1 0.06 0.28 0.27
47 INT246693 Zglp1 Positive_regulation of Localization of Ide 1 0.08 0.34 0.27
48 INT141545 Binding of Bace1 and Rtn4 1 0.00 0.45 0.27
49 INT141552 Binding of RTN3 and Bace1 1 0.00 0.45 0.27
50 INT141546 Binding of Bace1 and Rtn4r 1 0.00 0.46 0.27
51 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
52 INT160464 Binding of Mme and Lnpep 1 0.31 0.37 0.24
53 INT124383 ACOT1 Positive_regulation of MME 1 0.01 0.17 0.22
54 INT246686 Ide Regulation of Ros1 1 0.03 0.41 0.22
55 INT139848 Binding of Bace1 and Bace2 2 0.28 0.31 0.18
56 INT237418 Binding of Hif1a and Bace1 1 0.06 1.18 0.15
57 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
58 INT139849 Binding of App and Bace1 7 0.41 0.85 0.13
59 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13
60 INT270355 Vcsa1 Positive_regulation of Negative_regulation of Mme 1 0.13 0.52 0.12
61 INT43095 Binding of Ace and Mme 1 0.26 0 0.12
62 INT308647 Ager Positive_regulation of Gene_expression of Bace1 1 0.09 1.01 0.12
63 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
64 INT26316 Binding of MME and KRT20 1 0.16 0.57 0.12
65 INT262702 Bace1 Positive_regulation of Aplp2 1 0.14 0.25 0.09
66 INT36128 Binding of Scd1 and Mme 1 0.00 0 0.09
67 INT262704 Bace1 Positive_regulation of Aplp1 1 0.15 0.25 0.09
68 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
69 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
70 INT312547 Akt1 Positive_regulation of Phosphorylation of Ide 1 0.01 0.6 0.08
71 INT168549 Binding of MME and NCAM1 1 0.00 1.43 0.08
72 INT220629 Gene_expression of Bace1 Positive_regulation of Localization of Il1r2 1 0.17 0.19 0.07
73 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
74 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
75 INT330487 Binding of MME and HPSE 1 0.35 0 0.06
76 INT209611 Binding of Mme and Cd34 1 0.00 1.05 0.06
77 INT246691 Ide Positive_regulation of Gene_expression of Nos3 1 0.03 0.26 0.05
78 INT331227 Binding of Becn1 and Pink1 1 0.03 1.13 0.05
79 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
80 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
81 INT191980 Ide Regulation of Sit1 1 0.17 0 0.04
82 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
83 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
84 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
85 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
86 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0
87 INT220630 Binding of Bace1 and Gga1 3 0.25 0.07 0
88 INT220631 Gene_expression of Gga1 Positive_regulation of Bace1 2 0.24 0 0
89 INT220626 Thim Negative_regulation of Positive_regulation of Bace1 2 0.00 0 0
90 INT220634 Binding of Bace1 and Pawr 2 0.06 0.2 0
91 INT220636 Binding of Lrp1 and Bace1 2 0.32 0.62 0
92 INT230134 Binding of SORL1 and BACE1 1 0.19 0.09 0
93 INT283001 Binding of Becn1 and Om 1 0.00 0.1 0
94 INT317393 Binding of Car2 and Ide 1 0.03 0.3 0
95 INT220625 Negative_regulation of Binding of App and Bace1 1 0.44 0.09 0
96 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
97 INT331226 Binding of Becn1 and Pik3c3 1 0.02 0.47 0
98 INT130531 BACE1 Regulation of Gene_expression of BACE2 1 0.40 0.18 0
99 INT333770 Bace1 Regulation of Gene_expression of App 1 0.57 0 0
100 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0
101 INT312372 Binding of MME and TCHP 1 0.06 1.56 0
102 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
103 INT217402 Binding of Bace1 and PSENEN 1 0.02 0.72 0
104 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
105 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
106 INT217399 Binding of Bace1 and Ncstn 1 0.05 0.72 0
107 INT191982 Sit1 Regulation of Gene_expression of Ide 1 0.25 0.09 0
108 INT205393 MME Regulation of Gene_expression of ANPEP 1 0.26 1.49 0
109 INT205388 Binding of HSPB1 and MME 1 0.22 1.36 0
110 INT283000 Negative_regulation of Binding of Bcl2 and Becn1 1 0.03 0.71 0
111 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0
112 INT262706 Uts2r Positive_regulation of Bace1 1 0.10 0.39 0
113 INT331230 Binding of Mapk8 and Becn1 1 0.02 0.77 0
114 INT225536 Ncoa6 Positive_regulation of Localization of Ide 1 0.02 0.41 0
115 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
116 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
117 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
118 INT333774 sal Positive_regulation of Bace1 1 0.18 0.07 0
119 INT191981 Ide Positive_regulation of Positive_regulation of Sit1 1 0.28 0.06 0
120 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
121 INT283010 Regulation of Binding of Bcl2 and Becn1 1 0.03 1.45 0
122 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 0.22 0.07 0
123 INT283004 Binding of Becn1 and Pdss2 1 0.00 0.57 0
124 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0
125 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
126 INT130533 BACE1 Regulation of SNAP25 1 0.27 0.18 0
127 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
128 INT262703 Mapk14 Positive_regulation of Bace1 1 0.29 0.39 0
129 INT191984 Ide Positive_regulation of Nppc 1 0.04 0.13 0
130 INT283008 Igkv1-131 Regulation of Binding of Becn1 1 0.01 0 0
131 INT262708 Bace1 Positive_regulation of Gene_expression of App 1 0.44 2.82 0
132 INT163614 POMC Regulation of MME 1 0.08 0.39 0
133 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
134 INT283014 Becn1 Regulation of Bcl2 1 0.03 0.88 0
135 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0
136 INT142955 Positive_regulation of Binding of APP and BACE1 1 0.48 0.5 0
137 INT262713 App Regulation of Transcription of Bace1 1 0.45 0.31 0
138 INT262700 Uts2r Regulation of Gene_expression of Bace1 1 0.12 0.21 0
139 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
140 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
141 INT193957 Binding of Bcl2l1 and Psen2 1 0.07 0.66 0
142 INT305632 Binding of BCL6 and MME 1 0.00 1.37 0
143 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
144 INT307210 Ide Positive_regulation of Ppara 1 0.02 0.18 0
145 INT333773 Bace1 Regulation of App 1 0.25 0 0
146 INT205391 MME Regulation of ANPEP 1 0.26 1.36 0
147 INT225582 Asc2 Positive_regulation of Localization of Ide 1 0.01 0.41 0
148 INT142954 Binding of APP and BACE1 1 0.37 0.5 0
149 INT97223 Gm9902 Regulation of Negative_regulation of Mme 1 0.00 0.61 0
150 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
151 INT307212 Ide Regulation of Lep 1 0.00 0.51 0
152 INT217397 Binding of Bace1 and Alph1 1 0.02 0.73 0
153 INT334645 Binding of PSEN1 and HM13 1 0.01 0 0
154 INT262707 Bace2 Positive_regulation of Bace1 1 0.33 0.15 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for beta-amyloid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in beta-amyloid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9
2 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84
3 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85
4 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1
5 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65
6 INT4877 Gene_expression of MME 184 0.78 122.82 24.78
7 INT9490 Regulation of Mme 44 0.56 6.69 19.21
8 INT15237 Protein_catabolism of Mme 31 0.96 10.26 16.69
9 INT15166 Positive_regulation of Mme 40 0.70 13.01 16.24
10 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
11 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79
12 INT14453 Localization of Mme 44 0.80 2.46 14.75
13 INT56494 Localization of Ide 73 0.68 22.9 11.26
14 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63
15 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
16 INT4880 Regulation of MME 17 0.61 7.78 8.2
17 INT8603 Binding of Mme 28 0.48 1.42 7.64
18 INT126200 Negative_regulation of Bace1 73 0.58 50.19 7.44
19 INT156489 Positive_regulation of Gene_expression of Bace1 67 0.69 41.07 7.02
20 INT107070 Gene_expression of BACE1 11 0.68 8.63 6.16
21 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
22 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
23 INT15143 Protein_catabolism of MME 16 1.00 4.56 5.54
24 INT11062 Positive_regulation of MME 24 0.63 14.37 5.26
25 INT34358 Binding of MME 13 0.37 7.25 5.14
26 INT56495 Positive_regulation of Localization of Ide 20 0.53 3.53 4.92
27 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47
28 INT137795 Positive_regulation of BACE1 3 0.68 4.74 4.31
29 INT111066 Regulation of Bace1 40 0.61 31.47 4.28
30 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
31 INT220594 Localization of Bace1 48 0.79 20.22 4.16
32 INT126197 Transcription of Bace1 13 0.72 7.34 3.87
33 INT56493 Regulation of Localization of Ide 15 0.47 3.53 3.82
34 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45
35 INT217389 Negative_regulation of Gene_expression of Bace1 43 0.59 18.57 3.27
36 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
37 INT35910 Binding of Mme 8 0.37 4.79 3.16
38 INT37111 Regulation of Negative_regulation of Mme 7 0.44 2.61 3.13
39 INT156488 Binding of Bace1 46 0.48 15.64 3.04
40 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
41 INT35548 Regulation of Mme 9 0.45 10.62 2.97
42 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
43 INT12887 Positive_regulation of Mme 9 0.60 15.41 2.93
44 INT11291 Positive_regulation of Gene_expression of Mme 6 0.61 5.93 2.81
45 INT133674 Gene_expression of Bace1 3 0.61 1.11 2.78
46 INT7148 Negative_regulation of Negative_regulation of Mme 6 0.42 2.19 2.74
47 INT191974 Regulation of Ide 16 0.38 9.54 2.52
48 INT4879 Positive_regulation of Gene_expression of MME 17 0.69 12.48 2.46
49 INT163544 Binding of Psen1 40 0.36 15.28 2.42
50 INT111072 Protein_catabolism of Bace1 26 0.98 14.07 2.41
51 INT26434 Localization of MME 17 0.81 8.67 2.3
52 INT26514 Regulation of Gene_expression of Mme 2 0.41 1.18 2.27
53 INT107068 Negative_regulation of BACE1 5 0.42 1.81 2.2
54 INT51980 Protein_catabolism of Mme 6 0.89 2.49 2.06
55 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
56 INT60723 Localization of Psen2 5 0.68 2.11 2.02
57 INT71870 Positive_regulation of Gene_expression of Mme 6 0.48 4.27 2
58 INT137797 Positive_regulation of Gene_expression of BACE1 2 0.59 2.15 1.99
59 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
60 INT187789 Positive_regulation of Positive_regulation of Bace1 18 0.50 16.18 1.87
61 INT110579 Negative_regulation of Gene_expression of MME 15 0.58 12.8 1.81
62 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
63 INT217382 Regulation of Gene_expression of Bace1 26 0.61 17 1.76
64 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
65 INT56497 Negative_regulation of Localization of Ide 12 0.44 5.34 1.42
66 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
67 INT191970 Positive_regulation of Ide 29 0.51 12.94 1.4
68 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
69 INT133672 Regulation of Bace1 2 0.25 0.56 1.33
70 INT156564 Negative_regulation of Gene_expression of BACE1 2 0.36 0.36 1.32
71 INT126198 Negative_regulation of Transcription of Bace1 3 0.43 1.95 1.27
72 INT43941 Transcription of Mme 6 0.68 0.78 1.26
73 INT166628 Positive_regulation of Gene_expression of Becn1 2 0.67 1.03 1.23
74 INT166632 Gene_expression of Becn1 2 0.75 1.02 1.22
75 INT43940 Regulation of Transcription of Mme 1 0.44 0 1.22
76 INT64948 Positive_regulation of Negative_regulation of MME 1 0.43 0 1.21
77 INT34704 Positive_regulation of Negative_regulation of Mme 6 0.47 0.17 1.17
78 INT142957 Binding of BACE1 3 0.37 0.83 1.17
79 INT107071 Localization of BACE1 3 0.64 0.19 1.16
80 INT25401 Negative_regulation of Gene_expression of Mme 2 0.43 0.08 1.1
81 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
82 INT7149 Phosphorylation of Mme 3 0.60 0.34 0.97
83 INT21842 Regulation of Protein_catabolism of Mme 1 0.19 0.58 0.97
84 INT43648 Positive_regulation of Binding of Mme 3 0.50 0.24 0.94
85 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
86 INT37377 Negative_regulation of Binding of Mme 2 0.38 1.79 0.88
87 INT166630 Negative_regulation of Localization of Becn1 1 0.41 0.51 0.88
88 INT166626 Localization of Becn1 1 0.76 0.5 0.87
89 INT166633 Binding of Becn1 1 0.45 0.5 0.86
90 INT166629 Negative_regulation of Binding of Becn1 1 0.41 0.5 0.86
91 INT166631 Positive_regulation of Becn1 1 0.41 0.52 0.84
92 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
93 INT133673 Transcription of Bace1 1 0.53 0.52 0.82
94 INT133671 Positive_regulation of Bace1 1 0.46 0.53 0.82
95 INT220600 Regulation of Transcription of Bace1 2 0.42 0.95 0.81
96 INT47740 Regulation of Regulation of Mme 2 0.24 0.52 0.8
97 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
98 INT220615 Positive_regulation of Negative_regulation of Bace1 2 0.49 1.65 0.79
99 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
100 INT111071 Positive_regulation of Protein_catabolism of Bace1 6 0.50 2.52 0.77
101 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
102 INT220614 Regulation of Positive_regulation of Bace1 5 0.45 5.32 0.76
103 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
104 INT355827 Protein_catabolism of BACE1 1 0.76 0.24 0.74
105 INT78649 Binding of Psen2 7 0.36 5.9 0.73
106 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
107 INT286615 Phosphorylation of Ide 7 0.31 5.22 0.7
108 INT15055 Regulation of Negative_regulation of Mme 2 0.42 0.24 0.67
109 INT220580 Regulation of Localization of Bace1 6 0.61 3.12 0.66
110 INT48592 Positive_regulation of Regulation of MME 1 0.40 0.32 0.66
111 INT191978 Positive_regulation of Gene_expression of Ide 16 0.63 6.8 0.65
112 INT4878 Regulation of Gene_expression of MME 6 0.53 5.38 0.65
113 INT37329 Regulation of Binding of Mme 1 0.27 0 0.65
114 INT355820 Positive_regulation of Positive_regulation of BACE1 1 0.49 0.26 0.64
115 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
116 INT37517 Negative_regulation of Protein_catabolism of MME 1 0.43 0.1 0.62
117 INT355826 Positive_regulation of Localization of BACE1 1 0.43 0 0.62
118 INT28402 Negative_regulation of Negative_regulation of MME 3 0.43 1.51 0.57
119 INT210522 Protein_catabolism of Ide 16 0.79 7.73 0.55
120 INT156567 Negative_regulation of Gene_expression of Bace1 1 0.32 0.22 0.54
121 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
122 INT210539 Binding of Ide 11 0.29 6.09 0.52
123 INT37094 Positive_regulation of Negative_regulation of Mme 2 0.50 1.15 0.51
124 INT237410 Positive_regulation of Transcription of Bace1 3 0.69 1.53 0.5
125 INT191968 Negative_regulation of Gene_expression of Ide 9 0.39 7.14 0.47
126 INT217393 Negative_regulation of Gene_expression of Mme 3 0.43 5.98 0.46
127 INT77688 Transcription of Mme 2 0.53 4.01 0.45
128 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
129 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
130 INT35545 Negative_regulation of Protein_catabolism of Mme 1 0.31 0 0.43
131 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
132 INT193856 Localization of Psen1 19 0.73 9.79 0.41
133 INT77687 Regulation of Gene_expression of Mme 3 0.44 2.75 0.4
134 INT137796 Regulation of BACE1 3 0.41 2.92 0.4
135 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
136 INT71869 Localization of Mme 2 0.70 2.13 0.37
137 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
138 INT220592 Negative_regulation of Positive_regulation of Bace1 6 0.42 6.22 0.35
139 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
140 INT110365 Negative_regulation of Positive_regulation of Mme 1 0.39 0.09 0.32
141 INT37120 Negative_regulation of Localization of Mme 1 0.42 0.07 0.32
142 INT237038 Gene_expression of Becn1 18 0.36 13.68 0.31
143 INT220609 Positive_regulation of Localization of Bace1 6 0.50 2.6 0.3
144 INT220612 Negative_regulation of Protein_catabolism of Bace1 3 0.51 2.67 0.29
145 INT130535 Regulation of Gene_expression of BACE1 2 0.54 2.61 0.29
146 INT127877 Regulation of Negative_regulation of MME 1 0.45 0.37 0.29
147 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
148 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
149 INT84037 Negative_regulation of Regulation of Mme 1 0.37 0.64 0.26
150 INT37518 Regulation of Protein_catabolism of MME 1 0.27 0 0.25
151 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
152 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
153 INT251557 Negative_regulation of Negative_regulation of Bace1 2 0.37 2.68 0.22
154 INT210525 Transcription of Ide 3 0.40 1.93 0.21
155 INT191971 Regulation of Gene_expression of Ide 5 0.45 1.97 0.2
156 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
157 INT110883 Positive_regulation of Localization of MME 1 0.40 0.74 0.19
158 INT220584 Phosphorylation of Bace1 9 0.81 1.31 0.17
159 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
160 INT210533 Negative_regulation of Binding of Ide 3 0.25 1.93 0.16
161 INT220599 Positive_regulation of Binding of Bace1 3 0.50 0.66 0.16
162 INT204171 Negative_regulation of Positive_regulation of Ide 2 0.06 1.73 0.16
163 INT242135 Regulation of Transcription of Ide 1 0.03 0.62 0.14
164 INT197135 Transcription of MME 4 0.69 3.23 0.13
165 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
166 INT242147 Positive_regulation of Transcription of Ide 1 0.03 0.63 0.13
167 INT242133 Negative_regulation of Transcription of Ide 1 0.03 0.62 0.13
168 INT329792 Positive_regulation of Positive_regulation of Mme 1 0.23 1.17 0.13
169 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
170 INT130539 Transcription of BACE1 1 0.47 1.35 0.12
171 INT57731 Negative_regulation of Positive_regulation of MME 1 0.38 0.05 0.12
172 INT331058 Regulation of Phosphorylation of Ide 1 0.03 0.36 0.12
173 INT137794 Regulation of Transcription of BACE1 1 0.19 1.18 0.12
174 INT176595 Negative_regulation of Gene_expression of PSEN2 1 0.24 1.01 0.11
175 INT193841 Regulation of Gene_expression of Psen2 1 0.40 1.66 0.11
176 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
177 INT204168 Positive_regulation of Negative_regulation of Ide 2 0.29 1.34 0.1
178 INT188120 Regulation of Negative_regulation of Bace1 2 0.45 2.6 0.1
179 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
180 INT220597 Positive_regulation of Regulation of Bace1 1 0.43 0.65 0.09
181 INT109131 Regulation of PSEN2 3 0.44 0.55 0.08
182 INT193862 Positive_regulation of Positive_regulation of Psen1 3 0.49 0.9 0.08
183 INT193872 Positive_regulation of Localization of Psen1 3 0.49 1.39 0.08
184 INT262689 Regulation of Protein_catabolism of Bace1 1 0.53 1.81 0.08
185 INT207663 Localization of Bace1 1 0.51 0.13 0.08
186 INT237412 Regulation of Regulation of Bace1 1 0.20 0.45 0.08
187 INT261678 Positive_regulation of Positive_regulation of PSEN1 1 0.42 0.62 0.08
188 INT193890 Regulation of Positive_regulation of Psen1 1 0.44 0.66 0.08
189 INT193938 Phosphorylation of PSEN1 5 0.79 1.6 0.07
190 INT210532 Positive_regulation of Protein_catabolism of Ide 2 0.40 0.86 0.07
191 INT207679 Binding of Bace1 1 0.25 0.12 0.07
192 INT282981 Positive_regulation of Gene_expression of Becn1 8 0.13 6.2 0.06
193 INT176592 Transcription of PSEN2 5 0.33 0.41 0.05
194 INT193859 Negative_regulation of Binding of Psen1 3 0.42 1.85 0.05
195 INT331406 Negative_regulation of Regulation of Psen1 1 0.04 0.09 0.05
196 INT354322 Negative_regulation of Regulation of Ide 1 0.16 0.69 0.05
197 INT282985 Negative_regulation of Becn1 11 0.20 7.72 0.04
198 INT193865 Protein_catabolism of Psen1 10 0.97 0.37 0.04
199 INT282977 Regulation of Becn1 4 0.25 2.29 0.04
200 INT352210 Negative_regulation of Transcription of Mme 1 0.43 1.16 0.04
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