GO:0050649

From wiki-pain
Jump to: navigation, search
Name testosterone 6-beta-hydroxylase activity
Categary Function
Go Slim No
Go Link GO:0050649
Unique Molecular Interactions 85
Total Molecular Interactions 106
Total Single Events 993
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for testosterone 6-beta-hydroxylase activity. They are ordered first by their pain relevance and then by number of times they were reported for testosterone 6-beta-hydroxylase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
2 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
3 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
4 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
5 INT81583 Cyp3a23/3a1 Positive_regulation of st 1 0.04 0 1.08
6 INT81580 Cyp3a23/3a1 Positive_regulation of Nudt14 1 0.01 0 1.08
7 INT130282 Cyp3a23/3a1 Positive_regulation of Gene_expression of Npy 1 0.15 0 0.94
8 INT279166 Binding of Cyp3a23/3a1 and Nr3c2 1 0.00 0.61 0.9
9 INT253995 Binding of Cxcl12 and Cyp3a23/3a1 1 0.06 1.28 0.85
10 INT65807 Nr3c1 Positive_regulation of Cyp3a23/3a1 1 0.14 0 0.82
11 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
12 INT130283 Cyp3a23/3a1 Positive_regulation of Transcription of Npy 1 0.10 0 0.79
13 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
14 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
15 INT218933 Cyp3a23/3a1 Regulation of Alpi 1 0.00 1.07 0.73
16 INT253994 Cyp3a23/3a1 Positive_regulation of Localization of Mif 1 0.09 0.96 0.69
17 INT113685 Binding of Cyp3a23/3a1 and Cyp2c11 1 0.35 0 0.65
18 INT52816 Cyp3a23/3a1 Regulation of Localization of LH 1 0.03 0.16 0.6
19 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
20 INT43692 Cyp3a23/3a1 Negative_regulation of Gh1 1 0.04 0 0.59
21 INT43693 Cyp3a23/3a1 Positive_regulation of Localization of Prl 1 0.10 0 0.57
22 INT253998 Cyp3a23/3a1 Positive_regulation of Binding of Cxcl12 1 0.10 0.65 0.55
23 INT253990 Cyp3a23/3a1 Positive_regulation of Cxcl12 1 0.09 0.65 0.55
24 INT281982 Cyp3a23/3a1 Negative_regulation of Gene_expression of MDK 1 0.00 0.67 0.47
25 INT218932 Cyp3a23/3a1 Regulation of Gene_expression of Alpi 1 0.00 0.53 0.46
26 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
27 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
28 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
29 INT78064 Cyp3a23/3a1 Regulation of Localization of Il6 1 0.08 0.07 0.32
30 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
31 INT281970 Cyp3a23/3a1 Negative_regulation of Gene_expression of Tie1 1 0.00 0.46 0.3
32 INT218934 Cyp3a23/3a1 Negative_regulation of Ephb1 1 0.01 0.95 0.28
33 INT218928 Cyp3a23/3a1 Regulation of Transcription of Bcl2 1 0.00 0.56 0.28
34 INT78065 Cyp3a23/3a1 Negative_regulation of Gene_expression of Il6 1 0.12 0.07 0.27
35 INT218931 Cyp3a23/3a1 Regulation of Gene_expression of Akp3 1 0.00 0.55 0.27
36 INT78061 Cyp3a23/3a1 Negative_regulation of Localization of Il6 1 0.12 0.07 0.27
37 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
38 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
39 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24
40 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
41 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2
42 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
43 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18
44 INT151895 Binding of CYP3A4 and GBE1 1 0.01 0.24 0.18
45 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
46 INT151894 NR1I2 Positive_regulation of CYP3A4 1 0.19 0.23 0.16
47 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
48 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14
49 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14
50 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14
51 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13
52 INT254002 Binding of Cyp3a23/3a1 and Positive_regulation of Gene_expression of Mif 1 0.08 0.56 0.13
53 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12
54 INT97081 CYP3A4 Regulation of HAGH 1 0.02 0 0.11
55 INT155221 Binding of CYP3A4 and PNPLA4 1 0.09 0 0.1
56 INT264085 CYP2C19 Regulation of CYP3A4 1 0.02 0 0.09
57 INT177296 Binding of CXADR and CYP3A4 1 0.30 0 0.09
58 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
59 INT264105 Cyp2e1 Regulation of CYP3A4 1 0.02 0 0.09
60 INT99476 Binding of CYP3A4 and ABCB1 2 0.28 0 0.08
61 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
62 INT339695 Binding of CYP3A4 and TRO 1 0.06 0.57 0.05
63 INT319578 CYP3A4 Regulation of ALPPL2 1 0.00 0.56 0.05
64 INT235313 Cyp3a23/3a1 Positive_regulation of Ins1 1 0.14 0.82 0.05
65 INT177274 Binding of CYP3A4 and TNFRSF25 1 0.19 0 0.04
66 INT177273 Binding of CYP3A4 and FAUP1 1 0.02 0 0.04
67 INT339707 TRO Positive_regulation of CYP3A4 1 0.12 0.97 0.04
68 INT199406 Binding of CYP3A4 and PPIB 1 0.40 0 0.04
69 INT294894 CYP3A4 Negative_regulation of CYP2C19 1 0.08 0.13 0
70 INT125648 Cyp2c11 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.42 0 0
71 INT96893 Binding of CYP3A4 and Orm2 1 0.07 0 0
72 INT262225 Binding of CYP3A4 and Nr1i2 1 0.13 0 0
73 INT96894 Binding of CYP3A4 and Orm1 1 0.00 0 0
74 INT135130 Binding of CYP3A4 and NR1I2 1 0.34 0.31 0
75 INT294895 CYP3A4 Negative_regulation of CYP2C9 1 0.09 0.13 0
76 INT177290 GOPC Positive_regulation of CYP3A4 1 0.15 0 0
77 INT125659 Cyp2b2 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.06 0 0
78 INT339700 CYP2B6 Positive_regulation of CYP3A4 1 0.13 0.3 0
79 INT96892 Negative_regulation of Binding of CYP3A4 and Orm2 1 0.08 0 0
80 INT199719 2610029G23Rik Regulation of CYP3A4 1 0.01 0.45 0
81 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0
82 INT96895 Negative_regulation of Binding of CYP3A4 and Orm1 1 0.00 0 0
83 INT135129 NR1I2 Regulation of Transcription of CYP3A4 1 0.58 0.6 0
84 INT125654 Cyp2e1 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.43 0 0
85 INT125649 Cyp2c6 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.40 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for testosterone 6-beta-hydroxylase activity. They are ordered first by their pain relevance and then by number of times they were reported in testosterone 6-beta-hydroxylase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
2 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
3 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
4 INT8765 Positive_regulation of Cyp3a23/3a1 63 0.67 22.28 20.39
5 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
6 INT32706 Gene_expression of Cyp3a23/3a1 51 0.65 19.48 15.06
7 INT18191 Negative_regulation of Cyp3a23/3a1 48 0.57 10.21 13.38
8 INT28014 Localization of Cyp3a23/3a1 34 0.77 9.8 12.96
9 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
10 INT28015 Regulation of Cyp3a23/3a1 19 0.40 6.32 5.79
11 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
12 INT140199 Positive_regulation of Gene_expression of Cyp3a23/3a1 9 0.45 4.91 4.56
13 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
14 INT8764 Positive_regulation of Positive_regulation of Cyp3a23/3a1 5 0.45 1.62 3.33
15 INT69564 Binding of Cyp3a23/3a1 11 0.34 4.67 3.2
16 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
17 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
18 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
19 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
20 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
21 INT113683 Positive_regulation of Negative_regulation of Cyp3a23/3a1 2 0.49 0.48 1.94
22 INT113684 Negative_regulation of Gene_expression of Cyp3a23/3a1 5 0.36 2.04 1.71
23 INT117897 Negative_regulation of Protein_catabolism of CYP3A4 1 0.55 0 1.28
24 INT125541 Transcription of CYP3A4 7 0.69 2.14 1.02
25 INT207325 Positive_regulation of Localization of Cyp3a23/3a1 1 0.42 0.61 0.98
26 INT207326 Regulation of Localization of Cyp3a23/3a1 1 0.43 0.74 0.65
27 INT53396 Regulation of Gene_expression of Cyp3a23/3a1 7 0.38 3.04 0.63
28 INT115823 Transcription of Cyp3a23/3a1 3 0.54 0.82 0.61
29 INT139306 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.45 0.31 0.52
30 INT199410 Negative_regulation of Binding of CYP3A4 4 0.43 0.96 0.5
31 INT80929 Negative_regulation of Positive_regulation of Cyp3a23/3a1 3 0.43 0.83 0.48
32 INT135131 Regulation of Gene_expression of CYP3A4 8 0.59 4.32 0.44
33 INT28016 Negative_regulation of Localization of Cyp3a23/3a1 2 0.04 0 0.43
34 INT199409 Positive_regulation of Negative_regulation of CYP3A4 7 0.50 2.54 0.41
35 INT155222 Positive_regulation of Transcription of CYP3A4 2 0.50 0.13 0.34
36 INT158581 Negative_regulation of Positive_regulation of CYP3A4 7 0.43 1.83 0.29
37 INT248664 Phosphorylation of Cyp3a23/3a1 2 0.14 0.94 0.24
38 INT345946 Negative_regulation of Localization of CYP3A4 1 0.09 0.56 0.16
39 INT70583 Negative_regulation of Binding of Cyp3a23/3a1 1 0.30 0.09 0.12
40 INT100094 Regulation of Positive_regulation of CYP3A4 3 0.45 0.31 0.1
41 INT115832 Negative_regulation of Transcription of Cyp3a23/3a1 1 0.34 0.51 0.09
42 INT115836 Regulation of Regulation of Cyp3a23/3a1 1 0.17 0.49 0.09
43 INT262138 Positive_regulation of Regulation of CYP3A4 1 0.15 0.06 0.07
44 INT123100 Positive_regulation of Positive_regulation of CYP3A4 2 0.54 0 0
45 INT277007 Negative_regulation of Transcription of CYP3A4 1 0.39 0.34 0
46 INT253980 Positive_regulation of Binding of Cyp3a23/3a1 1 0.08 0 0
47 INT277008 Regulation of Transcription of CYP3A4 1 0.41 0.67 0
48 INT248670 Negative_regulation of Regulation of Cyp3a23/3a1 1 0.08 0.16 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox