GO:0050662

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Name coenzyme binding
Categary Function
Go Slim No
Go Link GO:0050662
Unique Molecular Interactions 70
Total Molecular Interactions 124
Total Single Events 1038
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for coenzyme binding. They are ordered first by their pain relevance and then by number of times they were reported for coenzyme binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84
3 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
4 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
5 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
6 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
7 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2
8 INT48751 Binding of Nqo1 and Npy 1 0.28 0 0.82
9 INT144449 Plscr1 Positive_regulation of Gene_expression of Nqo1 1 0.15 0.18 0.8
10 INT144451 Napa Positive_regulation of Gene_expression of Nqo1 1 0.07 0.18 0.8
11 INT31776 Positive_regulation of Gclc Positive_regulation of G6pd 1 0.29 0.19 0.75
12 INT288323 Glyr1 Regulation of Sds 1 0.05 0.2 0.72
13 INT288326 Sds Positive_regulation of Glyr1 1 0.10 0.12 0.68
14 INT288324 Sds Positive_regulation of Gene_expression of Glyr1 1 0.10 0.12 0.68
15 INT147040 Hmbs Negative_regulation of Nppa 1 0.07 0.95 0.55
16 INT309370 Positive_regulation of Glyr1 Positive_regulation of Positive_regulation of Gphn 1 0.01 0 0.47
17 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
18 INT80053 Negative_regulation of Binding of ACAT1 and NA 1 0.01 0.25 0.45
19 INT80052 Binding of ACAT1 and NA 1 0.01 0.24 0.44
20 INT148465 Positive_regulation of Ccl4 Positive_regulation of Gclc 1 0.32 0.06 0.38
21 INT148467 Ccl4 Positive_regulation of Gclc 1 0.32 0.05 0.37
22 INT105768 Binding of Nos1 and Nqo1 1 0.00 0.26 0.34
23 INT144448 Nqo1 Regulation of Nos1 1 0.11 0.09 0.34
24 INT144450 Regulation of Nqo1 Regulation of Nos1 1 0.11 0.1 0.34
25 INT235971 Positive_regulation of Binding of Nqo1 and NMO-IgG 1 0.00 1.86 0.32
26 INT147041 Hmbs Negative_regulation of Negative_regulation of Nppa 1 0.05 0.51 0.3
27 INT288325 Binding of Glyr1 and Sds 1 0.07 0 0.3
28 INT36306 HADH Positive_regulation of NKG7 1 0.07 1.07 0.28
29 INT235959 Nqo1 Positive_regulation of Localization of Aqp4 1 0.02 1.39 0.26
30 INT206763 Binding of CSF2 and Nqo1 1 0.00 1.7 0.25
31 INT162931 TXNRD1 Negative_regulation of Phosphorylation of NQO1 1 0.13 0.5 0.23
32 INT235967 Binding of Ighm and Nqo1 1 0.00 1.45 0.23
33 INT302978 Nqo1 Positive_regulation of Smpd2 1 0.01 1.1 0.22
34 INT263366 Dlat Regulation of Glyr1 1 0.03 0 0.22
35 INT79511 Negative_regulation of NOS1 Regulation of Negative_regulation of Nqo1 1 0.05 0.08 0.19
36 INT101812 Binding of KEAP1 and Positive_regulation of Gene_expression of GCLC 1 0.54 0.1 0.19
37 INT101808 Binding of NFE2L2 and Positive_regulation of Gene_expression of GCLC 1 0.54 0.1 0.19
38 INT175596 Binding of ACAT1 and HGF 1 0.01 1.58 0.18
39 INT72325 Binding of Sigmar1 and WWOX 1 0.26 0 0.18
40 INT263365 Glyr1 Regulation of Dlat 1 0.03 0.18 0.17
41 INT327790 Binding of Nqo1 and Alms1 1 0.00 1.1 0.17
42 INT235441 HMBS Regulation of PPARA 1 0.03 0.76 0.16
43 INT189796 Binding of EHHADH and Cd14 1 0.13 0.9 0.14
44 INT235961 Binding of Nqo1 and Aqp4 1 0.02 0.9 0.14
45 INT18230 Binding of HP and WWOX 1 0.19 0.17 0.13
46 INT332581 Binding of Nqo1 and MRI1 1 0.01 1.68 0.12
47 INT101809 Gene_expression of NFE2L2 Positive_regulation of Gene_expression of GCLC 1 0.75 0 0.12
48 INT101811 NFE2L2 Regulation of Gene_expression of GCLC 1 0.67 0.06 0.12
49 INT101807 Gene_expression of KEAP1 Negative_regulation of Positive_regulation of GCLC 1 0.46 0 0.08
50 INT89724 RYBP Positive_regulation of Gclc 1 0.01 0.21 0.07
51 INT235969 Binding of Ighg1 and Nqo1 1 0.01 2.63 0.04
52 INT302981 Nqo1 Positive_regulation of Positive_regulation of Smpd2 1 0.00 0.45 0.04
53 INT302974 Nqo1 Positive_regulation of Jag2 1 0.00 0.45 0.04
54 INT235968 NMO-IgG Positive_regulation of Nqo1 1 0.00 2.11 0.03
55 INT301310 GALE Positive_regulation of GPR17 1 0.00 0 0.03
56 INT241031 Gopc Positive_regulation of Hmbs 1 0.04 0.83 0
57 INT285996 Binding of ACAT1 and IL1RL1 1 0.00 0 0
58 INT47720 Gpr143 Regulation of Nqo1 1 0.01 0 0
59 INT303251 HMBS Positive_regulation of Protein_catabolism of Dlgap1 1 0.01 0 0
60 INT241019 Positive_regulation of Mapk1 Positive_regulation of Protein_catabolism of Hmbs 1 0.07 0.05 0
61 INT317316 Park7 Positive_regulation of Protein_catabolism of Hmbs 1 0.11 0.68 0
62 INT262750 GLYR1 Positive_regulation of THBS1 1 0.01 0.99 0
63 INT315541 ACO1 Negative_regulation of Gene_expression of ALAS2 1 0.17 0.18 0
64 INT197552 GSTK1 Positive_regulation of NQO1 1 0.09 1.06 0
65 INT315533 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of ALAS2 1 0.38 1.06 0
66 INT241029 Agtrap Positive_regulation of Hmbs 1 0.07 0.83 0
67 INT241018 Hmbs Positive_regulation of Protein_catabolism of Sypl 1 0.00 0.44 0
68 INT191413 Tert Positive_regulation of Nqo1 1 0.02 0.84 0
69 INT147067 Binding of Aqp4 and Nqo1 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for coenzyme binding. They are ordered first by their pain relevance and then by number of times they were reported in coenzyme binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
2 INT10384 Positive_regulation of Nqo1 62 0.70 14.27 11.08
3 INT41627 Gene_expression of Nqo1 33 0.65 4.58 10.48
4 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
5 INT140411 Gene_expression of Nqo1 45 0.60 62.35 8.7
6 INT152347 Binding of GCH1 8 0.37 6.13 7.36
7 INT140170 Binding of Nqo1 24 0.38 36.16 6.79
8 INT73382 Regulation of Nqo1 13 0.58 1.58 6.16
9 INT163776 Regulation of GCH1 7 0.27 4.58 6.16
10 INT112873 Gene_expression of Glyr1 28 0.76 2.88 5.94
11 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65
12 INT38251 Negative_regulation of Gclc 7 0.57 1.37 5.06
13 INT35599 Negative_regulation of Nqo1 25 0.54 4.6 4.42
14 INT84703 Negative_regulation of Nqo1 8 0.38 7.1 4.05
15 INT112872 Negative_regulation of Glyr1 9 0.42 2.4 3.59
16 INT69943 Regulation of Gene_expression of Nqo1 3 0.26 0.98 3.56
17 INT135815 Transcription of Gch1 1 0.60 0 3.32
18 INT18744 Localization of Nqo1 7 0.69 1.06 3.19
19 INT89229 Positive_regulation of Gene_expression of Nqo1 2 0.06 0.1 2.81
20 INT15509 Negative_regulation of HMBS 14 0.58 13.13 2.78
21 INT150933 Negative_regulation of Positive_regulation of GCH1 3 0.58 1.8 2.77
22 INT150932 Positive_regulation of Gene_expression of GCH1 3 0.70 2.07 2.57
23 INT206760 Localization of Nqo1 8 0.09 15.76 2.4
24 INT105532 Positive_regulation of Glyr1 2 0.34 1.29 2.36
25 INT283973 Transcription of GCH1 1 0.61 1.99 2.33
26 INT48750 Binding of Nqo1 5 0.29 0.1 2.31
27 INT100886 Gene_expression of GCLC 16 0.76 5.63 2.29
28 INT283975 Negative_regulation of Localization of GCH1 1 0.38 1.99 2.27
29 INT5998 Negative_regulation of Glyr1 4 0.32 0.47 2.2
30 INT135827 Positive_regulation of Transcription of Gch1 1 0.58 0 2.2
31 INT3784 Regulation of Hmbs 4 0.38 2.79 2.11
32 INT258637 Regulation of Gene_expression of GCH1 1 0.62 1.77 2.02
33 INT100897 Positive_regulation of Gene_expression of GCLC 9 0.68 1.84 1.99
34 INT117799 Positive_regulation of Glyr1 4 0.46 0.42 1.98
35 INT135820 Regulation of Gch1 1 0.59 0 1.88
36 INT122300 Negative_regulation of Positive_regulation of Nqo1 2 0.59 1.07 1.84
37 INT8556 Positive_regulation of NQO1 12 0.70 5.11 1.78
38 INT22591 Negative_regulation of Hmbs 6 0.51 5.04 1.74
39 INT47714 Regulation of Nqo1 12 0.24 11.12 1.71
40 INT41395 Positive_regulation of Gclc 9 0.61 1.34 1.66
41 INT105531 Positive_regulation of Positive_regulation of Glyr1 2 0.31 0.74 1.6
42 INT5997 Regulation of Glyr1 3 0.38 0.34 1.38
43 INT74178 Gene_expression of HMBS 24 0.76 9.62 1.36
44 INT135822 Gene_expression of Gch1 2 0.50 0.77 1.35
45 INT102747 Gene_expression of Hmbs 17 0.78 10.53 1.34
46 INT93702 Localization of Hmbs 1 0.81 4.84 1.26
47 INT72997 Negative_regulation of GLYR1 2 0.41 1.03 1.2
48 INT122891 Negative_regulation of Gch1 4 0.16 1.83 1.15
49 INT130437 Phosphorylation of Nqo1 3 0.25 0.97 1.14
50 INT132972 Gene_expression of HADH 3 0.65 4.75 1.13
51 INT283974 Negative_regulation of Transcription of GCH1 1 0.38 0.99 1.13
52 INT283972 Localization of GCH1 1 0.67 0.99 1.13
53 INT283976 Positive_regulation of Binding of GCH1 1 0.45 1.27 1.13
54 INT100892 Positive_regulation of GCLC 8 0.68 3.44 1.08
55 INT69421 Positive_regulation of ACAT1 5 0.23 1.56 1.08
56 INT5999 Gene_expression of Glyr1 2 0.20 0.74 1.08
57 INT150931 Negative_regulation of GCH1 6 0.59 1.23 1.05
58 INT3320 Regulation of ALAS2 3 0.33 0.93 1.05
59 INT107653 Gene_expression of ACAT1 9 0.60 4.74 1.03
60 INT16186 Negative_regulation of HADH 2 0.42 1.17 0.91
61 INT130438 Negative_regulation of Phosphorylation of Nqo1 1 0.01 0.47 0.91
62 INT288317 Positive_regulation of Gene_expression of Glyr1 2 0.13 0.36 0.9
63 INT309353 Positive_regulation of Positive_regulation of Glyr1 1 0.03 0 0.9
64 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87
65 INT22592 Positive_regulation of Hmbs 2 0.48 2.27 0.87
66 INT94194 Transcription of Gclc 1 0.58 0.53 0.87
67 INT105530 Regulation of Negative_regulation of Glyr1 1 0.28 0.06 0.85
68 INT31775 Positive_regulation of Gclc 3 0.38 0.52 0.84
69 INT165684 Localization of HADH 3 0.73 0.91 0.82
70 INT57135 Gene_expression of Hmbs 1 0.32 0.55 0.82
71 INT102745 Positive_regulation of Hmbs 17 0.61 12.41 0.78
72 INT102746 Negative_regulation of Hmbs 11 0.59 8.35 0.77
73 INT251224 Negative_regulation of Gene_expression of Glyr1 3 0.12 0.17 0.75
74 INT125270 Regulation of Binding of Nqo1 1 0.01 0.1 0.74
75 INT50291 Positive_regulation of HMBS 10 0.67 8.89 0.73
76 INT137555 Regulation of GLYR1 2 0.37 0.69 0.73
77 INT49137 Negative_regulation of Positive_regulation of Nqo1 1 0.14 0.33 0.73
78 INT72995 Gene_expression of GLYR1 2 0.75 0.16 0.71
79 INT327776 Negative_regulation of Gene_expression of Nqo1 2 0.02 2.39 0.69
80 INT123443 Positive_regulation of WWOX 2 0.45 3.45 0.68
81 INT61226 Binding of Gclc 1 0.14 0 0.67
82 INT41394 Regulation of Gclc 5 0.43 1.78 0.64
83 INT22593 Negative_regulation of Positive_regulation of Hmbs 1 0.41 1.58 0.64
84 INT56207 Positive_regulation of Positive_regulation of Nqo1 7 0.47 1.08 0.62
85 INT134951 Gene_expression of NQO1 14 0.78 7.87 0.61
86 INT94423 Binding of ALAS2 4 0.32 2.1 0.61
87 INT130184 Positive_regulation of Regulation of Nqo1 1 0.14 0 0.6
88 INT122410 Transcription of Nqo1 4 0.68 1.42 0.58
89 INT73771 Regulation of EHHADH 1 0.44 0.94 0.58
90 INT106246 Positive_regulation of GLYR1 2 0.23 0.29 0.57
91 INT226176 Protein_catabolism of Hmbs 15 0.61 13.17 0.56
92 INT145786 Binding of WWOX 2 0.35 0.59 0.55
93 INT118549 Negative_regulation of Phosphorylation of Glyr1 1 0.32 0.35 0.54
94 INT118550 Phosphorylation of Glyr1 1 0.61 0.35 0.53
95 INT309344 Regulation of Glyr1 2 0.13 0.36 0.51
96 INT309340 Negative_regulation of Negative_regulation of Glyr1 1 0.03 0.47 0.49
97 INT309336 Localization of Glyr1 1 0.05 0.09 0.48
98 INT147960 Negative_regulation of GCLC 8 0.28 4.4 0.45
99 INT69420 Positive_regulation of Positive_regulation of ACAT1 1 0.23 0.17 0.45
100 INT130436 Positive_regulation of Phosphorylation of Nqo1 1 0.01 0.2 0.44
101 INT235471 Regulation of HMBS 6 0.13 1.8 0.43
102 INT68850 Negative_regulation of NQO1 2 0.19 0.19 0.43
103 INT158463 Regulation of Hmbs 7 0.31 4.87 0.4
104 INT102744 Positive_regulation of Gene_expression of Hmbs 4 0.70 2.97 0.35
105 INT167696 Positive_regulation of Gene_expression of NQO1 3 0.45 1.22 0.35
106 INT309356 Binding of Glyr1 1 0.02 0.36 0.34
107 INT118264 Binding of Hmbs 6 0.37 4.87 0.33
108 INT68851 Localization of NQO1 2 0.62 0.05 0.33
109 INT3321 Positive_regulation of ALAS2 10 0.51 3.08 0.32
110 INT74177 Positive_regulation of Gene_expression of HMBS 6 0.49 2.77 0.3
111 INT346132 Regulation of HADH 1 0.01 0.89 0.29
112 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28
113 INT325209 Localization of Gch1 1 0.25 0.72 0.28
114 INT325214 Positive_regulation of Localization of Gch1 1 0.17 0.73 0.28
115 INT325216 Positive_regulation of Gch1 2 0.23 1.5 0.27
116 INT325218 Negative_regulation of Positive_regulation of Gch1 2 0.14 1.51 0.27
117 INT263352 Positive_regulation of Gene_expression of Glyr1 1 0.07 0 0.26
118 INT72996 Binding of GLYR1 2 0.03 0 0.25
119 INT131132 Protein_catabolism of HMBS 5 0.86 1.02 0.24
120 INT120656 Localization of HMBS 3 0.16 2.6 0.23
121 INT101822 Negative_regulation of Positive_regulation of GCLC 1 0.57 0.07 0.23
122 INT162933 Phosphorylation of NQO1 1 0.69 0.5 0.23
123 INT263357 Regulation of Gene_expression of Glyr1 1 0.04 0 0.22
124 INT122414 Positive_regulation of Transcription of Nqo1 1 0.44 0.15 0.22
125 INT3323 Gene_expression of ALAS2 10 0.58 7.51 0.21
126 INT334150 Positive_regulation of Gene_expression of Nqo1 1 0.01 0.41 0.2
127 INT131133 Binding of HMBS 9 0.36 2.13 0.19
128 INT325205 Positive_regulation of Gene_expression of Gch1 1 0.17 0.77 0.19
129 INT157172 Gene_expression of WWOX 2 0.65 1.99 0.18
130 INT79510 Regulation of Negative_regulation of Nqo1 1 0.32 0.08 0.18
131 INT96951 Positive_regulation of Gene_expression of Gclc 5 0.34 1.45 0.16
132 INT142420 Negative_regulation of Gene_expression of Nqo1 2 0.41 0.26 0.15
133 INT101819 Positive_regulation of Positive_regulation of GCLC 2 0.59 1.47 0.15
134 INT189792 Binding of EHHADH 1 0.36 0.79 0.14
135 INT288311 Transcription of Glyr1 1 0.14 0 0.11
136 INT242263 Regulation of ACAT1 4 0.09 0.66 0.1
137 INT309349 Regulation of Binding of Glyr1 1 0.02 0.28 0.1
138 INT235464 Regulation of Gene_expression of HMBS 1 0.44 0.23 0.1
139 INT158692 Negative_regulation of Gene_expression of HMBS 1 0.25 0.67 0.09
140 INT120657 Positive_regulation of Localization of HMBS 1 0.00 0.83 0.09
141 INT341574 Localization of WWOX 1 0.42 0.66 0.08
142 INT213624 Localization of ALAS2 1 0.05 0 0.07
143 INT265987 Protein_catabolism of ALAS2 1 0.01 2.77 0.07
144 INT235472 Negative_regulation of Binding of HMBS 1 0.09 0.28 0.07
145 INT235465 Regulation of Binding of HMBS 1 0.10 0.28 0.07
146 INT242264 Binding of ACAT1 3 0.12 1.05 0.06
147 INT261026 Localization of Gclc 3 0.36 0.88 0.06
148 INT261017 Regulation of Gclc 2 0.22 0.88 0.06
149 INT288315 Regulation of Gene_expression of Glyr1 1 0.12 0 0.06
150 INT341546 Negative_regulation of Positive_regulation of WWOX 1 0.26 0.75 0.06
151 INT320587 Localization of Glyr1 1 0.07 0.2 0.06
152 INT313475 Regulation of NQO1 1 0.04 0.42 0.05
153 INT242265 Negative_regulation of Gene_expression of ACAT1 3 0.14 0 0.04
154 INT341576 Regulation of WWOX 1 0.42 0.76 0.04
155 INT200983 Transcription of EHHADH 1 0.01 0.17 0.03
156 INT3322 Positive_regulation of Gene_expression of ALAS2 4 0.43 3.25 0
157 INT186262 Transcription of GCLC 3 0.23 1.19 0
158 INT39570 Localization of ACAT1 2 0.75 0.44 0
159 INT336004 Positive_regulation of HADH 2 0.45 0.17 0
160 INT319631 Positive_regulation of Transcription of Gclc 1 0.17 0 0
161 INT315551 Negative_regulation of Gene_expression of ALAS2 1 0.37 1.11 0
162 INT241017 Positive_regulation of Protein_catabolism of Hmbs 1 0.07 0.05 0
163 INT271725 Regulation of Protein_catabolism of Hmbs 1 0.31 0.22 0
164 INT261016 Regulation of Positive_regulation of Gclc 1 0.22 0.23 0
165 INT204358 Negative_regulation of Transcription of HADH 1 0.11 0.07 0
166 INT286001 Phosphorylation of ACAT1 1 0.09 0 0
167 INT213625 Regulation of Gene_expression of ALAS2 1 0.03 0.06 0
168 INT319621 Transcription of Gclc 1 0.20 0 0
169 INT235463 Regulation of Protein_catabolism of HMBS 1 0.10 0.2 0
170 INT261006 Positive_regulation of Positive_regulation of Gclc 1 0.24 0.23 0
171 INT286003 Negative_regulation of ACAT1 1 0.05 0 0
172 INT313321 Negative_regulation of Transcription of GCLC 1 0.15 0 0
173 INT315556 Positive_regulation of Binding of ALAS2 1 0.43 1.05 0
174 INT159743 Protein_catabolism of EHHADH 1 0.86 0.11 0
175 INT159742 Positive_regulation of EHHADH 1 0.49 0.12 0
176 INT246068 Regulation of GCLC 1 0.24 0.11 0
177 INT336003 Binding of HADH 1 0.07 0.35 0
178 INT240993 Positive_regulation of Positive_regulation of Hmbs 1 0.07 0.26 0
179 INT237437 Phosphorylation of Hmbs 1 0.15 0 0
180 INT313476 Binding of NQO1 1 0.03 0 0
181 INT312976 Protein_catabolism of ACAT1 1 0.02 0.46 0
182 INT241000 Transcription of Hmbs 1 0.10 0.82 0
183 INT163775 Negative_regulation of Regulation of GCH1 1 0.43 0 0
184 INT271740 Negative_regulation of Binding of Hmbs 1 0.30 0.59 0
185 INT285999 Transcription of ACAT1 1 0.08 0 0
186 INT286000 Positive_regulation of Phosphorylation of ACAT1 1 0.06 0 0
187 INT204362 Transcription of HADH 1 0.18 0.07 0
188 INT261005 Regulation of Localization of Gclc 1 0.13 0.39 0
189 INT261027 Binding of Gclc 1 0.18 0 0
190 INT279975 Regulation of Gene_expression of Nqo1 1 0.02 0.1 0
191 INT261022 Regulation of Gene_expression of Gclc 1 0.22 0.23 0
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