GO:0050667

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Name homocysteine metabolic process
Categary Process
Go Slim No
Go Link GO:0050667
Unique Molecular Interactions 109
Total Molecular Interactions 155
Total Single Events 1084
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for homocysteine metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for homocysteine metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
2 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
3 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
4 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
5 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
6 INT255317 Binding of Dpep1 and Nav1 1 0.01 0 2.42
7 INT255318 Binding of Dpep1 and Nrcam 1 0.00 0 2.16
8 INT158762 Binding of Vwf and Mthfr 1 0.05 1.85 1.37
9 INT27425 Mtr Positive_regulation of Gene_expression of Il1f5 1 0.06 0 1.3
10 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
11 INT107563 Penk Regulation of Mtr 1 0.00 0.1 1.04
12 INT107565 Hps4 Regulation of Mtr 1 0.00 0.1 1.04
13 INT103933 Cps1 Negative_regulation of Gene_expression of Cd69 1 0.03 0.25 0.93
14 INT103930 Cps1 Negative_regulation of Gene_expression of Il2ra 1 0.02 0.25 0.93
15 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
16 INT14626 Binding of Dpep1 and Pax3 1 0.01 0 0.87
17 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
18 INT87490 CALCA Positive_regulation of Gene_expression of CCL5 1 0.30 0.14 0.81
19 INT149493 PNOC Negative_regulation of CCL5 1 0.14 0.16 0.77
20 INT54669 Mtr Regulation of Gene_expression of Il1 1 0.02 0.2 0.77
21 INT54668 Mtr Regulation of Gene_expression of Il1f5 1 0.00 0.2 0.76
22 INT258644 Binding of CCL2 and CCL5 1 0.36 1.6 0.74
23 INT258643 Positive_regulation of Binding of CCL2 and CCL5 1 0.49 1.61 0.74
24 INT255324 Negative_regulation of Binding of Dpep1 and 2E 1 0.02 0 0.73
25 INT255325 Binding of Dpep1 and 2E 1 0.02 0 0.73
26 INT46657 Mtr Regulation of Gnrh1 1 0.01 0 0.71
27 INT46656 Mtr Regulation of Prl 1 0.05 0 0.7
28 INT38820 Binding of MTR and PDYN 1 0.03 0.19 0.65
29 INT27426 Mtr Positive_regulation of Localization of Il1f5 1 0.06 0 0.63
30 INT127778 Mthfd1 Regulation of Positive_regulation of Mthfr 1 0.01 0.71 0.62
31 INT255319 Binding of Dpep1 and Kcnq2 1 0.01 0 0.6
32 INT255320 Binding of Dpep1 and Kcnq3 1 0.01 0 0.6
33 INT255326 Binding of Dpep1 and AIS 1 0.00 0 0.6
34 INT316831 CCL5 Positive_regulation of Gene_expression of MMP2 1 0.02 0.51 0.59
35 INT160780 Cps1 Positive_regulation of Positive_regulation of FAS 1 0.01 1 0.55
36 INT50935 Mtr Regulation of Gene_expression of Il6 1 0.00 0 0.53
37 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
38 INT103937 Cps1 Negative_regulation of Gene_expression of Cd28 1 0.03 0.19 0.51
39 INT103932 Cps1 Negative_regulation of Gene_expression of Trav6-3 1 0.01 0.19 0.5
40 INT261498 CBS Positive_regulation of DSE 1 0.00 0 0.5
41 INT176010 Binding of MTHFR and ZNF677 1 0.00 0.7 0.5
42 INT103934 Cps1 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.2 0.49
43 INT171278 TNFSF12 Positive_regulation of CCL5 1 0.02 0.93 0.48
44 INT280189 Binding of Cbs and P2rx3 1 0.01 1.03 0.47
45 INT280188 Binding of Cbs and Trpv1 1 0.26 1.03 0.47
46 INT103929 Cps1 Negative_regulation of Gene_expression of Icam1 1 0.01 0.13 0.47
47 INT103936 Cps1 Negative_regulation of Il2ra 1 0.02 0.07 0.46
48 INT103931 Cps1 Negative_regulation of Icam1 1 0.01 0.07 0.46
49 INT103935 Cps1 Negative_regulation of Cd69 1 0.03 0.07 0.46
50 INT28863 Mtr Negative_regulation of Dhfr 1 0.04 0.87 0.45
51 INT326514 Sugt1 Negative_regulation of MTHFR 1 0.01 0.77 0.42
52 INT316830 TNF Regulation of CCL5 1 0.02 1.02 0.39
53 INT261499 CBS Positive_regulation of CNR1 1 0.01 0.48 0.35
54 INT280190 Cbs Regulation of Gene_expression of Hist1h1t 1 0.04 0.58 0.32
55 INT188789 Binding of pad and Mthfr 1 0.06 4.6 0.31
56 INT255322 Binding of Dpep1 and Csnk2b 1 0.01 0 0.29
57 INT103279 PGR Negative_regulation of Gene_expression of CCL5 1 0.32 0.31 0.27
58 INT266802 Dlst Positive_regulation of CCL5 1 0.00 0.95 0.25
59 INT252815 Binding of CCL5 and TNF 1 0.02 0.75 0.25
60 INT80286 IFNG Positive_regulation of Gene_expression of CCL5 1 0.24 0.37 0.23
61 INT80287 IL4 Positive_regulation of Gene_expression of CCL5 1 0.21 0.37 0.23
62 INT255316 Csnk2b Regulation of Binding of Dpep1 1 0.01 0 0.22
63 INT196635 CFTR Positive_regulation of Gene_expression of CCL5 1 0.07 0.44 0.21
64 INT295713 PTGER2 Positive_regulation of Regulation of CCL5 1 0.01 0.82 0.21
65 INT50934 Mtr Positive_regulation of Gene_expression of Il6 1 0.00 0 0.2
66 INT170995 Binding of IFNA1 and Positive_regulation of Localization of CCL5 1 0.03 0.34 0.19
67 INT220243 IL1RN Negative_regulation of Gene_expression of DPEP1 1 0.20 0.22 0.19
68 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
69 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
70 INT226344 Gene_expression of IL9 Positive_regulation of CCL5 1 0.07 1.03 0.18
71 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
72 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17
73 INT318306 Binding of DPEP1 and NLRP3 1 0.03 1.77 0.15
74 INT171295 CXCL10 Positive_regulation of CCL5 1 0.04 0.06 0.12
75 INT25285 CBS Negative_regulation of Localization of IL1RL1 1 0.05 0 0.09
76 INT220244 IL1B Regulation of Gene_expression of DPEP1 1 0.17 0 0.08
77 INT220241 IL1RN Regulation of Gene_expression of DPEP1 1 0.24 0 0.08
78 INT220238 IL1RN Regulation of Protein_catabolism of DPEP1 1 0.14 0 0.08
79 INT220247 IL1B Regulation of Protein_catabolism of DPEP1 1 0.10 0 0.08
80 INT171297 TNF Positive_regulation of Localization of CCL5 1 0.17 0.66 0.07
81 INT245985 Binding of MTR and Mtrr 1 0.06 0.8 0.07
82 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
83 INT245986 MTR Regulation of Mthfr 1 0.07 0.18 0.05
84 INT245981 Negative_regulation of TCN1 Regulation of Mthfr 1 0.03 0.18 0.05
85 INT245966 TCN1 Regulation of MTR 1 0.02 0.18 0.05
86 INT27738 CBS Positive_regulation of EGF 1 0.33 0.85 0.05
87 INT245982 TCN1 Regulation of Mthfr 1 0.04 0.18 0.05
88 INT27737 CBS Positive_regulation of Positive_regulation of EGF 1 0.36 0.85 0.05
89 INT245967 Negative_regulation of TCN1 Regulation of MTR 1 0.02 0.18 0.05
90 INT245974 Mtrr Regulation of Mthfr 1 0.07 0.18 0.05
91 INT122216 IL1B Positive_regulation of CCL5 3 0.67 0.53 0.04
92 INT171279 IL6 Positive_regulation of CCL5 1 0.04 0.38 0.04
93 INT171301 TNF Positive_regulation of CCL5 1 0.16 0.38 0.04
94 INT245987 Binding of MTR and Mthfr 1 0.11 0.48 0.03
95 INT324836 Nox4 Regulation of Gene_expression of ROS1 1 0.01 0.13 0.03
96 INT324800 Binding of Tlr4 and Nox4 1 0.12 0.14 0.03
97 INT122217 IL1B Positive_regulation of Gene_expression of CCL5 2 0.52 0.08 0
98 INT127690 TNF Positive_regulation of Regulation of CCL5 1 0.33 0.17 0
99 INT171282 TNFSF12 Positive_regulation of Gene_expression of CCL5 1 0.01 0 0
100 INT269062 Nox4 Negative_regulation of Localization of Cyba 1 0.17 0 0
101 INT269067 Nox4 Negative_regulation of Localization of Ncf1 1 0.17 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for homocysteine metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in homocysteine metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09
2 INT78901 Localization of CCL5 67 0.78 40.79 20.59
3 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62
4 INT1672 Gene_expression of Mtr 18 0.67 3.39 13.32
5 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65
6 INT78895 Regulation of CCL5 30 0.46 20.45 10.18
7 INT87495 Positive_regulation of Gene_expression of CCL5 26 0.69 13.85 9.46
8 INT130497 Gene_expression of Cbs 5 0.77 16.93 9.34
9 INT9802 Positive_regulation of Mtr 9 0.60 3.69 7.43
10 INT89589 Negative_regulation of Ccl5 9 0.40 4.62 7.39
11 INT261511 Localization of CBS 1 0.02 5.06 7.27
12 INT46518 Localization of Mtr 12 0.65 1.31 6.55
13 INT138833 Binding of MTHFR 12 0.46 16.08 6.4
14 INT92470 Negative_regulation of Gene_expression of CCL5 15 0.50 5.46 5.86
15 INT10006 Regulation of Mtr 9 0.23 3.56 5.42
16 INT12250 Negative_regulation of Mtr 19 0.50 6.9 5.35
17 INT82887 Positive_regulation of Ccl5 10 0.40 3.4 4.91
18 INT89590 Negative_regulation of Gene_expression of Ccl5 8 0.36 3.97 4.67
19 INT121954 Binding of Mthfr 17 0.44 13.47 4.66
20 INT4283 Positive_regulation of Cbs 10 0.46 6.85 4.44
21 INT9803 Positive_regulation of Gene_expression of Mtr 3 0.60 1.45 4.36
22 INT4239 Negative_regulation of CCL5 15 0.40 10.92 4.26
23 INT280193 Positive_regulation of Gene_expression of Cbs 1 0.69 6.59 3.81
24 INT103281 Transcription of CCL5 10 0.67 5.95 3.7
25 INT89592 Localization of Ccl5 10 0.61 7.65 3.62
26 INT124123 Positive_regulation of Localization of CCL5 12 0.67 7 3.37
27 INT14625 Binding of Dpep1 2 0.02 0 3.36
28 INT24751 Gene_expression of Mtr 8 0.36 1.34 3.34
29 INT82879 Regulation of Ccl5 9 0.30 6.19 3.17
30 INT78898 Regulation of Gene_expression of CCL5 9 0.42 5.7 3.11
31 INT109448 Negative_regulation of MTHFR 8 0.58 7.62 3.11
32 INT115617 Binding of Ccl5 5 0.33 0.58 3.11
33 INT138652 Negative_regulation of Mthfr 13 0.54 7.3 2.88
34 INT194661 Binding of CCL5 9 0.46 6.07 2.73
35 INT124063 Gene_expression of MTHFR 9 0.65 6.22 2.67
36 INT124417 Gene_expression of Mthfr 8 0.60 8.65 2.53
37 INT54540 Negative_regulation of Cps1 7 0.58 2.64 2.26
38 INT127777 Positive_regulation of Mthfr 4 0.38 3.8 2.09
39 INT115616 Positive_regulation of Binding of Ccl5 3 0.25 0.59 2.04
40 INT142049 Regulation of Mthfr 6 0.41 4.73 2
41 INT103061 Positive_regulation of Gene_expression of Ccl5 4 0.35 1.67 1.9
42 INT25582 Regulation of Mtr 2 0.03 0.4 1.76
43 INT194660 Positive_regulation of Binding of CCL5 1 0.42 2.74 1.72
44 INT78896 Negative_regulation of Localization of CCL5 8 0.57 2.43 1.59
45 INT171015 Positive_regulation of Positive_regulation of CCL5 3 0.42 3.63 1.51
46 INT38043 Gene_expression of Cps1 6 0.56 0.82 1.46
47 INT47446 Regulation of Localization of Mtr 1 0.05 0.07 1.42
48 INT9217 Negative_regulation of MTR 17 0.58 1.13 1.32
49 INT115895 Phosphorylation of Ccl5 1 0.55 0 1.31
50 INT34626 Binding of Cbs 2 0.37 3.27 1.27
51 INT2595 Binding of Mtr 1 0.29 0 1.24
52 INT144645 Localization of Cbs 2 0.64 1.02 1.22
53 INT22353 Positive_regulation of Cps1 6 0.17 0.98 1.14
54 INT149554 Transcription of Ccl5 2 0.59 0.55 1.14
55 INT115893 Negative_regulation of Binding of Ccl5 1 0.37 0 1.14
56 INT176609 Gene_expression of Dpep1 8 0.03 2.37 1.07
57 INT47131 Negative_regulation of Localization of Mtr 1 0.41 0 1.06
58 INT157361 Localization of MTR 2 0.31 1.4 1.05
59 INT24750 Negative_regulation of Mtr 1 0.22 0.06 1.04
60 INT208244 Regulation of Gene_expression of Ccl5 1 0.26 1.92 1.01
61 INT123536 Positive_regulation of MTHFR 7 0.57 4.74 1
62 INT4971 Regulation of Cbs 2 0.44 1.66 1
63 INT77856 Binding of Cps1 6 0.30 2.32 0.95
64 INT220249 Gene_expression of DPEP1 1 0.40 0.99 0.95
65 INT255304 Regulation of Binding of Dpep1 1 0.02 0 0.95
66 INT261514 Positive_regulation of Localization of CBS 1 0.01 0.67 0.91
67 INT103285 Regulation of Localization of CCL5 3 0.44 1.11 0.89
68 INT202190 Gene_expression of CBS 7 0.32 4.19 0.88
69 INT46483 Localization of Dpep1 4 0.06 1.58 0.88
70 INT149555 Negative_regulation of Positive_regulation of Ccl5 1 0.15 0 0.88
71 INT152474 Phosphorylation of Cps1 1 0.06 0 0.78
72 INT280194 Regulation of Gene_expression of Cbs 1 0.61 1.54 0.73
73 INT24584 Positive_regulation of MTR 4 0.44 0.07 0.7
74 INT157186 Regulation of Cps1 4 0.22 0.54 0.67
75 INT115897 Positive_regulation of Phosphorylation of Ccl5 1 0.41 0 0.66
76 INT155639 Regulation of Negative_regulation of Mthfr 1 0.56 0.76 0.66
77 INT176013 Negative_regulation of Binding of MTHFR 2 0.42 1.18 0.63
78 INT153699 Regulation of MTHFR 2 0.45 1.54 0.63
79 INT10007 Regulation of Gene_expression of Mtr 2 0.23 1.17 0.61
80 INT255306 Positive_regulation of Dpep1 1 0.02 0 0.61
81 INT261508 Negative_regulation of CBS 1 0.01 0.39 0.61
82 INT14109 Positive_regulation of Mtr 1 0.03 0.49 0.6
83 INT253325 Positive_regulation of Negative_regulation of MTHFR 2 0.44 1.22 0.49
84 INT255308 Negative_regulation of Binding of Dpep1 1 0.02 0 0.46
85 INT194658 Positive_regulation of Transcription of CCL5 1 0.45 0.68 0.44
86 INT220254 Positive_regulation of Gene_expression of DPEP1 1 0.22 0.56 0.44
87 INT267606 Protein_catabolism of CCL5 2 0.48 1.39 0.43
88 INT24583 Protein_catabolism of MTR 1 0.57 0 0.42
89 INT199078 Gene_expression of Nox4 3 0.59 3.83 0.41
90 INT261515 Positive_regulation of CBS 2 0.47 2.63 0.41
91 INT188788 Negative_regulation of Gene_expression of Mthfr 2 0.33 1.3 0.39
92 INT322698 Protein_catabolism of Ccl5 1 0.49 0.33 0.38
93 INT54952 Binding of Mtr 1 0.03 0.58 0.37
94 INT111345 Negative_regulation of Cbs 2 0.30 2.82 0.36
95 INT259859 Regulation of CBS 1 0.01 1.26 0.34
96 INT195733 Phosphorylation of CCL5 2 0.10 1.04 0.33
97 INT26194 Regulation of MTR 1 0.19 1.1 0.33
98 INT166893 Negative_regulation of Gene_expression of Mtr 1 0.03 0.57 0.33
99 INT227514 Regulation of Dpep1 1 0.02 0.06 0.3
100 INT103283 Negative_regulation of Transcription of CCL5 1 0.50 0.28 0.27
101 INT259857 Regulation of Gene_expression of CBS 1 0.01 1.07 0.27
102 INT282213 Negative_regulation of Regulation of Mtr 1 0.01 0.82 0.27
103 INT322710 Positive_regulation of Transcription of Ccl5 1 0.43 0.56 0.26
104 INT176012 Localization of MTHFR 1 0.74 0.38 0.24
105 INT69801 Positive_regulation of DPEP1 3 0.49 0.89 0.23
106 INT282377 Regulation of Positive_regulation of CCL5 1 0.05 1.12 0.22
107 INT70913 Gene_expression of MTR 2 0.12 0.44 0.21
108 INT138653 Positive_regulation of Negative_regulation of Mthfr 1 0.45 0.53 0.2
109 INT38044 Regulation of Gene_expression of Cps1 1 0.38 0 0.19
110 INT223333 Negative_regulation of Gene_expression of MTR 1 0.07 0.16 0.16
111 INT220251 Regulation of DPEP1 1 0.12 0.33 0.15
112 INT89593 Negative_regulation of Localization of Ccl5 1 0.03 0.46 0.15
113 INT55773 Binding of MTR 2 0.30 0.74 0.14
114 INT259858 Protein_catabolism of CBS 1 0.03 1.46 0.14
115 INT195730 Negative_regulation of Binding of CCL5 1 0.05 0.51 0.13
116 INT220259 Protein_catabolism of DPEP1 1 0.34 0 0.11
117 INT253327 Negative_regulation of Positive_regulation of MTHFR 1 0.41 1.17 0.09
118 INT69802 Binding of DPEP1 1 0.02 0 0.09
119 INT12251 Regulation of Negative_regulation of Mtr 1 0.19 0 0.09
120 INT220263 Negative_regulation of DPEP1 1 0.22 0.28 0.09
121 INT270815 Localization of DPEP1 1 0.06 0.08 0.07
122 INT55772 Negative_regulation of Negative_regulation of MTR 1 0.41 0 0.07
123 INT270819 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
124 INT288754 Negative_regulation of Positive_regulation of Mtr 1 0.11 0.1 0.05
125 INT143346 Localization of Mthfr 2 0.54 0.4 0.04
126 INT288765 Positive_regulation of Negative_regulation of Mtr 1 0.12 0.09 0.04
127 INT220258 Negative_regulation of Gene_expression of DPEP1 1 0.22 0 0.03
128 INT142048 Transcription of Mthfr 1 0.51 0.18 0
129 INT47058 Positive_regulation of Negative_regulation of MTR 1 0.41 0 0
130 INT47059 Positive_regulation of Positive_regulation of MTR 1 0.44 0 0
131 INT169661 Localization of Cps1 1 0.62 0.09 0
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