GO:0050700

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Name CARD domain binding
Categary Function
Go Slim No
Go Link GO:0050700
Unique Molecular Interactions 32
Total Molecular Interactions 33
Total Single Events 321
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for CARD domain binding. They are ordered first by their pain relevance and then by number of times they were reported for CARD domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
2 INT116771 Binding of MAVS and MRGPRX1 1 0.00 0.51 0.89
3 INT116020 Positive_regulation of Binding of Il4 and Mavs 1 0.02 0.08 0.7
4 INT116021 Binding of Il4 and Mavs 1 0.02 0.08 0.7
5 INT116019 Negative_regulation of Binding of Il4 and Mavs 1 0.02 0.08 0.7
6 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
7 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
8 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
9 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
10 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31
11 INT290378 NOD2 Negative_regulation of TLR2 1 0.27 0.83 0.23
12 INT290377 NOD2 Negative_regulation of Positive_regulation of TLR2 1 0.24 0.95 0.23
13 INT55252 Binding of CCK and RIPK2 1 0.40 0 0.2
14 INT204791 Binding of Spg7 and Nod2 1 0.03 0.5 0.16
15 INT204789 Binding of Tlr2 and Nod2 1 0.23 0.44 0.16
16 INT318305 Binding of NOD2 and NLRP3 1 0.08 1.76 0.15
17 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14
18 INT290314 MAVS Positive_regulation of DDX58 1 0.06 0.63 0.13
19 INT145830 Mdp1 Positive_regulation of Nod2 1 0.34 0.52 0.13
20 INT201766 Binding of RIPK2 and Ngfr 1 0.02 0.41 0.04
21 INT244129 Binding of RNGTT and NOD1 1 0.11 0 0.04
22 INT244132 DDB1 Regulation of Transcription of NOD1 1 0.01 0.09 0.03
23 INT222259 EIF4E Regulation of Negative_regulation of NOD2 1 0.13 0.1 0
24 INT238627 Binding of Cadm1 and Card14 1 0.00 0.08 0
25 INT204997 Ppp1r15b Regulation of Mavs 1 0.00 0.87 0
26 INT238629 Binding of Sdc2 and Card14 1 0.00 0.08 0
27 INT217314 IFNA1 Positive_regulation of MAVS 1 0.01 1.47 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for CARD domain binding. They are ordered first by their pain relevance and then by number of times they were reported in CARD domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
2 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
3 INT37976 Binding of Ripk2 6 0.47 0.27 5.01
4 INT20459 Regulation of Ripk2 5 0.44 0 4.53
5 INT103910 Binding of NOD2 19 0.47 12.24 2.93
6 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
7 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
8 INT162792 Gene_expression of NOD1 19 0.71 6.11 2.71
9 INT61004 Negative_regulation of Regulation of Ripk2 1 0.41 0 2.68
10 INT37977 Negative_regulation of Ripk2 3 0.42 0.92 2.03
11 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83
12 INT162793 Regulation of NOD2 6 0.45 7.61 1.78
13 INT37978 Localization of Ripk2 4 0.78 0.57 1.73
14 INT55511 Positive_regulation of Binding of Ripk2 1 0.49 0.19 1.69
15 INT117219 Positive_regulation of NOD2 9 0.69 4.66 1.31
16 INT204766 Gene_expression of Nod2 4 0.75 4.14 1.3
17 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27
18 INT38502 Gene_expression of Ripk2 3 0.65 0.17 1.16
19 INT154227 Regulation of Gene_expression of NOD2 3 0.44 3.38 0.99
20 INT19422 Protein_catabolism of RIPK2 2 0.86 0.62 0.97
21 INT36850 Negative_regulation of Negative_regulation of RIPK2 1 0.57 0 0.97
22 INT38426 Regulation of RIPK2 3 0.60 0.62 0.91
23 INT42076 Regulation of Negative_regulation of RIPK2 1 0.44 0.91 0.91
24 INT55512 Positive_regulation of Localization of Ripk2 1 0.67 0.09 0.85
25 INT40227 Regulation of Positive_regulation of Ripk2 1 0.44 0 0.82
26 INT37975 Negative_regulation of Binding of Ripk2 1 0.57 0 0.75
27 INT116007 Negative_regulation of Mavs 1 0.03 0.08 0.69
28 INT244153 Positive_regulation of Gene_expression of NOD1 1 0.46 1.36 0.63
29 INT244161 Positive_regulation of NOD1 4 0.64 1.83 0.62
30 INT162791 Regulation of NOD1 2 0.13 0.58 0.55
31 INT19420 Positive_regulation of Positive_regulation of RIPK2 1 0.49 0.59 0.5
32 INT84573 Regulation of Mavs 1 0.01 1.37 0.49
33 INT204781 Positive_regulation of Nod2 6 0.45 2.79 0.46
34 INT38738 Localization of RIPK2 2 0.68 0.07 0.45
35 INT166728 Regulation of MAVS 1 0.32 0.15 0.44
36 INT222266 Transcription of NOD2 5 0.68 0.76 0.43
37 INT171764 Localization of NOD2 2 0.74 0.86 0.37
38 INT183240 Negative_regulation of NOD2 6 0.43 1.52 0.33
39 INT346492 Protein_catabolism of MAVS 1 0.06 1.74 0.31
40 INT244143 Positive_regulation of Positive_regulation of NOD1 1 0.46 0.68 0.31
41 INT244148 Positive_regulation of Positive_regulation of NOD2 1 0.47 0.68 0.31
42 INT244171 Negative_regulation of NOD1 3 0.47 0 0.28
43 INT222270 Regulation of Localization of NOD2 1 0.45 0.63 0.28
44 INT346895 Positive_regulation of Gene_expression of Nod2 1 0.33 0.74 0.28
45 INT346896 Binding of Nod2 1 0.21 0.72 0.26
46 INT318992 Localization of NOD1 1 0.11 1.1 0.23
47 INT346899 Regulation of Positive_regulation of Nod2 1 0.18 0.75 0.22
48 INT222271 Transcription of NOD1 2 0.66 0.32 0.21
49 INT201691 Binding of RIPK2 2 0.18 1.51 0.17
50 INT204974 Positive_regulation of Mavs 1 0.02 3.77 0.16
51 INT204989 Gene_expression of Mavs 3 0.02 0.86 0.15
52 INT240596 Negative_regulation of Gene_expression of RIPK2 1 0.06 0.91 0.15
53 INT136002 Positive_regulation of Gene_expression of RIPK2 1 0.67 0.52 0.15
54 INT346493 Binding of MAVS 1 0.03 0.54 0.15
55 INT222274 Regulation of Regulation of NOD2 1 0.27 0.45 0.13
56 INT279781 Gene_expression of MAVS 4 0.15 3.51 0.12
57 INT144094 Negative_regulation of Localization of Ripk2 1 0.42 0.49 0.09
58 INT204777 Negative_regulation of Localization of Nod2 1 0.28 0.61 0.09
59 INT204779 Localization of Nod2 1 0.48 0.6 0.08
60 INT217383 Regulation of Regulation of Mavs 1 0.01 0.79 0.08
61 INT204770 Regulation of Nod2 1 0.29 0.66 0.07
62 INT222267 Regulation of Transcription of NOD2 1 0.45 0 0.05
63 INT217374 Positive_regulation of Regulation of Mavs 1 0.01 0.37 0.05
64 INT346893 Negative_regulation of Gene_expression of Nod2 1 0.28 0.13 0.04
65 INT244158 Regulation of Gene_expression of NOD1 1 0.56 0 0.03
66 INT204980 Regulation of Gene_expression of Mavs 1 0.01 0.3 0.03
67 INT284053 Positive_regulation of Positive_regulation of Nod2 1 0.25 0.08 0
68 INT343496 Negative_regulation of Gene_expression of NOD1 1 0.12 0 0
69 INT273927 Transcription of Mavs 1 0.00 0 0
70 INT343493 Protein_catabolism of NOD1 1 0.25 0 0
71 INT222273 Positive_regulation of Regulation of NOD2 1 0.46 0.09 0
72 INT321753 Regulation of Card14 1 0.01 0.06 0
73 INT343495 Negative_regulation of Protein_catabolism of NOD1 1 0.12 0 0
74 INT238565 Binding of Card14 1 0.00 0.09 0
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