GO:0050708

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Name regulation of protein secretion
Categary Process
Go Slim No
Go Link GO:0050708
Unique Molecular Interactions 713
Total Molecular Interactions 943
Total Single Events 11769
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of protein secretion. They are ordered first by their pain relevance and then by number of times they were reported for regulation of protein secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
2 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
3 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
4 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
5 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
6 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
7 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
8 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
9 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
10 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
11 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
12 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
13 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
14 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
15 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
16 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
17 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
18 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
19 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
20 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
21 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
22 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
23 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
24 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
25 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
26 INT220751 EGF Regulation of GOPC 1 0.08 0 1.18
27 INT220752 Negative_regulation of EGF Regulation of NAV1 1 0.26 0 1.18
28 INT220753 Negative_regulation of EGF Regulation of GOPC 1 0.08 0 1.18
29 INT220748 EGF Regulation of NAV1 1 0.28 0 1.17
30 INT136989 EGF Negative_regulation of Positive_regulation of KCNJ2 1 0.04 1.09 1.1
31 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
32 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
33 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
34 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
35 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
36 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
37 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
38 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
39 INT136988 EGF Negative_regulation of KCNJ2 1 0.04 1.09 1.04
40 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
41 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
42 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
43 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
44 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
45 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
46 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
47 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
48 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
49 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
50 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
51 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
52 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
53 INT220744 EGF Positive_regulation of Gene_expression of KRT20 1 0.01 1.26 0.9
54 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
55 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
56 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
57 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
58 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
59 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
60 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
61 INT116556 Olr1627 Negative_regulation of Regulation of Tnf 1 0.01 1.52 0.87
62 INT152868 Tnf Regulation of Gene_expression of Trpv1 1 0.27 0.25 0.86
63 INT146919 Tnf Positive_regulation of Gene_expression of Ccl2 1 0.16 1.44 0.84
64 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
65 INT220739 EGF Positive_regulation of Transcription of NAV1 1 0.31 0.16 0.83
66 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
67 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8
68 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8
69 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
70 INT220747 Binding of PCa and EGF 1 0.05 1.42 0.8
71 INT42797 Egf Regulation of Gene_expression of Penk 1 0.21 0.07 0.8
72 INT126555 Binding of Ighg1 and Tnf 1 0.35 2.2 0.8
73 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
74 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
75 INT110518 Tnf Positive_regulation of Prkce 1 0.26 1.43 0.78
76 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
77 INT152869 Tnf Positive_regulation of Gene_expression of Trpv1 1 0.46 0.48 0.77
78 INT231031 Egf Positive_regulation of Sec22b 1 0.03 0.05 0.76
79 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
80 INT354455 Il11 Negative_regulation of Gene_expression of Tnf 1 0.31 1.21 0.74
81 INT96301 Olr1742 Negative_regulation of Gene_expression of Tnf 1 0.14 0 0.74
82 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
83 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
84 INT150992 Sfpq Negative_regulation of Gene_expression of Tnf 1 0.03 0.69 0.72
85 INT220746 EGF Positive_regulation of Gene_expression of GOPC 1 0.13 0 0.72
86 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
87 INT83625 Tnf Positive_regulation of Gene_expression of Cd59 1 0.15 1.08 0.69
88 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
89 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
90 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67
91 INT148139 Phosphorylation of Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.46 0.98 0.66
92 INT148138 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.64 0.98 0.66
93 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
94 INT120146 seb Positive_regulation of Gene_expression of Tnf 1 0.40 0.86 0.66
95 INT120145 seb Positive_regulation of Tnf 1 0.40 0.85 0.65
96 INT132689 Tnf Regulation of Dnajc13 1 0.01 1.27 0.65
97 INT165047 Mapk14 Positive_regulation of Gene_expression of Tnf 1 0.73 0.8 0.63
98 INT165048 Trib3 Positive_regulation of Gene_expression of Tnf 1 0.08 0.8 0.63
99 INT148137 Tnf Positive_regulation of Positive_regulation of Mapk14 1 0.46 1 0.63
100 INT60328 Il1b Positive_regulation of Tnf 2 0.29 1.84 0.62
101 INT9163 Tnf Regulation of Gene_expression of Glul 1 0.12 1.99 0.62
102 INT61826 Tnf Negative_regulation of Il1b 1 0.39 0.89 0.62
103 INT158362 Tnf Positive_regulation of Steap4 1 0.55 1.6 0.61
104 INT169287 EGF Positive_regulation of Localization of IL8 1 0.15 0.13 0.61
105 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
106 INT314197 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.48 1.16 0.61
107 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
108 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59
109 INT96241 Il13 Negative_regulation of Tnf 1 0.08 0.6 0.59
110 INT56451 Ifng Positive_regulation of Tnf 1 0.00 1.92 0.59
111 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
112 INT61827 Tnf Regulation of Lta 1 0.40 1.5 0.58
113 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
114 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
115 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
116 INT199976 EGF Regulation of ITGB3BP 1 0.02 0.77 0.57
117 INT94506 Tnf Positive_regulation of Gene_expression of Avp 1 0.31 0.98 0.57
118 INT94507 Tnf Positive_regulation of Gene_expression of AVP 1 0.39 0.98 0.57
119 INT8402 Tnf Regulation of Gene_expression of Vip 1 0.02 0.38 0.56
120 INT8400 Tnf Regulation of Gene_expression of Nts 1 0.00 0.38 0.56
121 INT148922 Pdia4 Negative_regulation of Tnf 1 0.09 1.01 0.56
122 INT146112 Binding of Il1b and Tnf 1 0.32 1.19 0.56
123 INT94499 Tnf Positive_regulation of Gene_expression of Crh 1 0.27 0.97 0.56
124 INT131316 Tnf Positive_regulation of Mpo 1 0.29 0.65 0.55
125 INT352270 Tnf Positive_regulation of GZMA 1 0.13 2.43 0.55
126 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
127 INT121993 Binding of EGF and SGCG 1 0.40 0 0.55
128 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 0.18 0.76 0.55
129 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54
130 INT352268 Tnf Positive_regulation of Arl6ip6 1 0.02 2.42 0.54
131 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
132 INT8397 Tnf Regulation of Nts 1 0.00 0.38 0.53
133 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
134 INT8398 Tnf Regulation of Vip 1 0.01 0.38 0.53
135 INT220745 EGF Positive_regulation of Positive_regulation of PCa 1 0.05 0.79 0.52
136 INT311767 INS Negative_regulation of Gene_expression of SLC1A3 1 0.52 0 0.52
137 INT206960 Lipg Regulation of Tnf 1 0.02 0.85 0.51
138 INT23090 Tnf Positive_regulation of Localization of Prl 1 0.18 0.15 0.5
139 INT23091 Tnf Positive_regulation of Localization of Ggh 1 0.05 0.15 0.5
140 INT23092 Tnf Positive_regulation of Prl 1 0.08 0.15 0.5
141 INT93740 Ddc Positive_regulation of Tnf 1 0.00 1.45 0.5
142 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
143 INT23089 Tnf Positive_regulation of Ggh 1 0.04 0.15 0.5
144 INT285344 Il10 Negative_regulation of Gene_expression of Tnf 1 0.15 1.91 0.49
145 INT161227 Binding of Ngfr and Tnf 1 0.06 0.41 0.49
146 INT98734 Egf Negative_regulation of Tk1 1 0.13 0.15 0.49
147 INT339275 Il6 Regulation of KRT20 1 0.00 3.11 0.49
148 INT155621 Tnf Regulation of Transcription of Il1b 1 0.51 0.77 0.49
149 INT295708 Binding of EGF and CCL2 1 0.01 0.79 0.49
150 INT108329 EGF Positive_regulation of Phosphorylation of EPHB2 4 0.48 3.96 0.48
151 INT187796 Binding of Tnf and Il1 1 0.09 1.85 0.48
152 INT67440 Pdyn Regulation of Gene_expression of Tnf 1 0.23 0.19 0.48
153 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
154 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
155 INT187795 Positive_regulation of Binding of Tnf and Il1 1 0.13 1.87 0.48
156 INT137416 Binding of SDC1 and Tnf 1 0.00 1.19 0.47
157 INT101001 GHRH Regulation of Localization of INS 1 0.28 0 0.47
158 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46
159 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46
160 INT161652 Gsr Regulation of Gene_expression of Tnf 1 0.17 0.98 0.46
161 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
162 INT96245 Negative_regulation of Tnf Positive_regulation of KNG1 1 0.01 0.59 0.45
163 INT96246 Tnf Positive_regulation of KNG1 1 0.01 0.59 0.45
164 INT148635 Abat Negative_regulation of Gene_expression of Tnf 1 0.10 0.53 0.44
165 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
166 INT295406 Egf Regulation of Gene_expression of Oprk1 1 0.01 0.72 0.43
167 INT311590 EGF Regulation of Gene_expression of CXCL10 1 0.23 0.51 0.43
168 INT126019 Binding of Ltbr and Tnf 1 0.18 1.61 0.43
169 INT126020 Binding of fc and Tnf 1 0.22 1.61 0.43
170 INT107694 Tnf Positive_regulation of Gene_expression of Cxcl1 1 0.60 0.63 0.43
171 INT142273 KITLG Positive_regulation of Gene_expression of Tnf 1 0.07 0.9 0.43
172 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43
173 INT51475 Binding of Il6 and Tnf 1 0.15 0.61 0.43
174 INT126018 Binding of Lifr and Tnf 1 0.06 1.61 0.43
175 INT311591 CXCL10 Regulation of Gene_expression of EGF 1 0.23 0.51 0.43
176 INT13281 Egf Regulation of Ngf 1 0.66 0.12 0.42
177 INT13279 Ngf Regulation of Egf 1 0.49 0.12 0.42
178 INT13283 Egf Regulation of Fgf2 1 0.49 0.11 0.41
179 INT147977 Tnf Positive_regulation of Il4 1 0.01 1.12 0.41
180 INT165568 Tnf Regulation of Gene_expression of Il1b 1 0.41 1.26 0.41
181 INT13284 Fgf2 Regulation of Egf 1 0.49 0.11 0.41
182 INT157650 Phosphorylation of Prkcc Positive_regulation of Pik3c3 1 0.51 0 0.41
183 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
184 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
185 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
186 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
187 INT230500 Il1 Positive_regulation of Gene_expression of Tnf 1 0.07 1.83 0.4
188 INT134761 Ghrl Regulation of Localization of Tnf 1 0.20 0.76 0.4
189 INT154756 Tnf Positive_regulation of Nfkb1 1 0.31 0.78 0.4
190 INT157647 Positive_regulation of Oprd1 Positive_regulation of Pik3c3 1 0.01 0 0.4
191 INT29052 Binding of INS and INSRR 1 0.02 0.23 0.4
192 INT168458 Sult1a1 Negative_regulation of Tnf 1 0.09 1 0.4
193 INT29053 Regulation of Binding of INS and INSRR 1 0.01 0.24 0.4
194 INT78621 PRL Positive_regulation of Localization of INS 2 0.06 0.5 0.39
195 INT165565 Tnf Regulation of Gene_expression of Sdf2l1 1 0.26 1.15 0.39
196 INT165567 Tnf Regulation of Gene_expression of Tgfb1 1 0.41 1.15 0.39
197 INT157649 Prkcc Regulation of Pik3c3 1 0.30 0 0.39
198 INT291256 INS Negative_regulation of Positive_regulation of Mdk 1 0.01 1.65 0.39
199 INT90807 EGF Positive_regulation of Oprd1 1 0.00 0.39 0.39
200 INT228761 Tnf Positive_regulation of Gene_expression of Ccl17 1 0.20 0.66 0.39

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of protein secretion. They are ordered first by their pain relevance and then by number of times they were reported in regulation of protein secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
2 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
3 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
4 INT812 Localization of INS 1026 0.81 515.6 145.31
5 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
6 INT10166 Localization of Tnf 237 0.81 153.95 88.64
7 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
8 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
9 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
10 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
11 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
12 INT251 Regulation of INS 398 0.62 232.47 55.04
13 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
14 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
15 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
16 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
17 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
18 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
19 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
20 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
21 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88
22 INT35406 Localization of Tnf 94 0.81 64.63 31.65
23 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47
24 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
25 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
26 INT11157 Binding of EGF 88 0.48 53.73 21.25
27 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
28 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
29 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
30 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
31 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
32 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
33 INT10173 Binding of Tnf 45 0.48 35.6 14.32
34 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
35 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68
36 INT14572 Binding of INS 205 0.48 175.43 13.38
37 INT13823 Gene_expression of Egf 97 0.78 39.99 12.99
38 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
39 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
40 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
41 INT2036 Localization of EGF 42 0.77 21.5 9.74
42 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42
43 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
44 INT22771 Positive_regulation of Egf 44 0.70 16.45 8.64
45 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
46 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07
47 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
48 INT68299 Binding of Tnf 17 0.39 12.55 7.49
49 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
50 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81
51 INT13822 Localization of Egf 30 0.81 13.79 6.4
52 INT38672 Binding of KRT20 69 0.39 48.01 6.31
53 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
54 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6
55 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55
56 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
57 INT37227 Regulation of EGF 19 0.45 11.16 5.17
58 INT92054 Positive_regulation of Transcription of Tnf 8 0.50 4.93 5.05
59 INT21901 Negative_regulation of Egf 25 0.58 10.46 4.99
60 INT65926 Positive_regulation of Gene_expression of Egf 26 0.70 12.91 4.18
61 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15
62 INT23653 Binding of Egf 22 0.36 11.34 4.12
63 INT66754 Negative_regulation of Transcription of Tnf 11 0.43 8.43 3.93
64 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
65 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82
66 INT25464 Binding of SAA1 11 0.42 6.89 3.72
67 INT31758 Positive_regulation of Egf 32 0.66 19.42 3.64
68 INT18920 Binding of Egf 24 0.48 9.43 3.57
69 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47
70 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31
71 INT60174 Positive_regulation of Pik3c3 12 0.67 1.05 3.23
72 INT65427 Regulation of Positive_regulation of Tnf 7 0.60 3.49 3.22
73 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94
74 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
75 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
76 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87
77 INT95049 Negative_regulation of Regulation of Tnf 4 0.42 1.64 2.84
78 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77
79 INT75736 Regulation of Localization of Tnf 6 0.62 4.61 2.67
80 INT28878 Negative_regulation of Localization of Egf 6 0.49 10.34 2.57
81 INT77636 Phosphorylation of Egf 11 0.61 1.69 2.56
82 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
83 INT66804 Negative_regulation of Negative_regulation of Tnf 4 0.56 2.79 2.26
84 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
85 INT38674 Regulation of KRT20 32 0.44 19 2.15
86 INT161382 Localization of KRT20 25 0.61 12.97 2.13
87 INT82226 Negative_regulation of Gene_expression of EGF 11 0.58 6.36 2.13
88 INT108335 Phosphorylation of EGF 17 0.80 7.3 2.09
89 INT122649 Positive_regulation of Regulation of Tnf 2 0.49 2.78 1.96
90 INT111143 Regulation of Gene_expression of KRT20 22 0.26 5.65 1.93
91 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86
92 INT172961 Localization of Egf 26 0.71 16.74 1.81
93 INT73721 Negative_regulation of Gene_expression of Egf 5 0.43 2.28 1.8
94 INT77801 Negative_regulation of Binding of Tnf 5 0.42 3.93 1.77
95 INT90800 Negative_regulation of Positive_regulation of EGF 5 0.40 2.78 1.77
96 INT19747 Regulation of Egf 14 0.46 4.67 1.68
97 INT159957 Positive_regulation of Phosphorylation of Tnf 3 0.49 2.63 1.65
98 INT114525 Negative_regulation of Positive_regulation of Egf 4 0.35 2.93 1.5
99 INT61967 Positive_regulation of Negative_regulation of Tnf 3 0.50 2.46 1.49
100 INT192762 Localization of SAA1 10 0.78 12.63 1.44
101 INT86382 Negative_regulation of Localization of EGF 5 0.43 1.75 1.44
102 INT83659 Negative_regulation of Binding of Tnf 3 0.37 1.57 1.42
103 INT94572 Negative_regulation of Pik3c3 5 0.13 1.37 1.41
104 INT101653 Negative_regulation of SAA1 7 0.39 7 1.33
105 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29
106 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24
107 INT27108 Positive_regulation of Localization of Egf 5 0.50 2.91 1.21
108 INT148027 Localization of Pik3c3 1 0.24 0.34 1.17
109 INT58311 Regulation of Localization of EGF 3 0.54 1.06 1.16
110 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15
111 INT162124 Positive_regulation of Phosphorylation of Egf 3 0.45 0.77 1.14
112 INT183046 Transcription of INS 25 0.70 11.14 1.13
113 INT22770 Regulation of Gene_expression of Egf 5 0.44 2.56 1.12
114 INT157642 Gene_expression of Pik3c3 7 0.75 0.68 1.08
115 INT129587 Protein_catabolism of Tnf 2 0.86 1.41 1.08
116 INT168276 Negative_regulation of Phosphorylation of Tnf 1 0.19 1.3 1.08
117 INT37207 Positive_regulation of Positive_regulation of Egf 4 0.50 0.76 1.07
118 INT13817 Protein_catabolism of EGF 3 1.00 1.44 1.06
119 INT105860 Positive_regulation of Positive_regulation of EGF 6 0.64 2.37 1.05
120 INT135027 Regulation of Positive_regulation of Tnf 3 0.38 2.84 1.05
121 INT5006 Transcription of KRT20 9 0.46 7.11 1.03
122 INT58470 Negative_regulation of Binding of INS 14 0.43 7.2 1.01
123 INT184240 Positive_regulation of Localization of Egf 2 0.27 3.58 0.99
124 INT150942 Regulation of Pik3c3 2 0.18 0.96 0.94
125 INT168377 Negative_regulation of Binding of KRT20 3 0.35 2.14 0.89
126 INT122813 Binding of Krt20 11 0.32 13.77 0.88
127 INT134307 Negative_regulation of Protein_catabolism of Tnf 1 0.41 0.57 0.88
128 INT115822 Regulation of Transcription of Tnf 3 0.35 1.96 0.87
129 INT118290 Regulation of Phosphorylation of EGF 1 0.32 0.72 0.87
130 INT134310 Positive_regulation of Protein_catabolism of Tnf 1 0.49 0.57 0.87
131 INT171372 Positive_regulation of Gene_expression of Egf 16 0.66 9.82 0.84
132 INT192761 Positive_regulation of Gene_expression of SAA1 5 0.40 7.45 0.82
133 INT167833 Positive_regulation of Ins2 4 0.50 6.52 0.82
134 INT157643 Phosphorylation of Pik3c3 1 0.78 0 0.79
135 INT136690 Regulation of Negative_regulation of Tnf 5 0.45 3.58 0.78
136 INT102199 Regulation of Transcription of Tnf 2 0.45 2.25 0.78
137 INT31759 Negative_regulation of Gene_expression of Egf 6 0.53 5.33 0.77
138 INT12057 Regulation of Negative_regulation of INS 7 0.40 3.92 0.76
139 INT237158 Negative_regulation of Negative_regulation of Tnf 2 0.13 1.37 0.74
140 INT22772 Positive_regulation of Negative_regulation of Egf 1 0.50 1.48 0.71
141 INT70652 Negative_regulation of Binding of EGF 7 0.43 4.23 0.7
142 INT110854 Phosphorylation of Egf 8 0.75 5.62 0.67
143 INT206139 Phosphorylation of KRT20 8 0.48 9.1 0.66
144 INT312830 Regulation of Ins2 2 0.39 1.45 0.66
145 INT228279 Regulation of Gene_expression of Egf 7 0.43 6.64 0.65
146 INT183789 Positive_regulation of Phosphorylation of INS 5 0.50 4.87 0.64
147 INT14570 Regulation of Positive_regulation of INS 8 0.45 4.97 0.62
148 INT260422 Positive_regulation of Localization of EGF 3 0.10 1.58 0.56
149 INT219610 Protein_catabolism of SAA1 2 0.90 4.47 0.54
150 INT192765 Negative_regulation of Gene_expression of SAA1 1 0.34 4.55 0.54
151 INT105782 Positive_regulation of Krt20 9 0.20 9.62 0.53
152 INT77258 Regulation of SAA1 4 0.54 1.93 0.53
153 INT14571 Regulation of Binding of INS 2 0.23 2.44 0.53
154 INT115532 Negative_regulation of Positive_regulation of Egf 3 0.28 1.38 0.52
155 INT157638 Positive_regulation of Gene_expression of Pik3c3 2 0.48 0.46 0.52
156 INT205200 Positive_regulation of Pik3c3 7 0.08 2.76 0.51
157 INT46311 Regulation of Gene_expression of SAA1 4 0.27 1.51 0.51
158 INT157645 Negative_regulation of Pik3c3 6 0.41 2.88 0.5
159 INT141194 Regulation of Negative_regulation of Tnf 3 0.42 1.57 0.47
160 INT312821 Binding of Ins2 2 0.37 2.13 0.46
161 INT213286 Positive_regulation of Binding of INS 6 0.50 4.85 0.45
162 INT53667 Gene_expression of Ins2 10 0.65 5.65 0.44
163 INT213272 Negative_regulation of Phosphorylation of INS 7 0.40 9.13 0.44
164 INT138003 Positive_regulation of Negative_regulation of Tnf 2 0.49 2.07 0.43
165 INT157639 Negative_regulation of Positive_regulation of Pik3c3 1 0.41 0 0.41
166 INT157644 Negative_regulation of Phosphorylation of Pik3c3 1 0.41 0 0.4
167 INT72086 Regulation of Regulation of Tnf 1 0.45 0.3 0.4
168 INT312829 Positive_regulation of Positive_regulation of Ins2 1 0.50 1.73 0.4
169 INT157640 Positive_regulation of Phosphorylation of Pik3c3 1 0.48 0 0.4
170 INT157641 Regulation of Pik3c3 1 0.59 0 0.39
171 INT14569 Positive_regulation of Negative_regulation of INS 4 0.36 3.52 0.37
172 INT159782 Phosphorylation of Tnf 2 0.79 1.51 0.36
173 INT82763 Regulation of Positive_regulation of Egf 1 0.26 0.68 0.35
174 INT183066 Positive_regulation of Transcription of INS 8 0.49 5.31 0.34
175 INT102597 Regulation of Localization of Egf 2 0.62 0.1 0.34
176 INT225248 Positive_regulation of Phosphorylation of Egf 2 0.32 2.02 0.34
177 INT13824 Transcription of Egf 6 0.56 0.94 0.33
178 INT143535 Protein_catabolism of Tnf 2 0.86 3.43 0.33
179 INT72107 Positive_regulation of Protein_catabolism of Egf 2 0.16 0.34 0.32
180 INT72106 Protein_catabolism of Egf 2 0.31 0.34 0.32
181 INT178301 Regulation of Egf 9 0.58 4.96 0.31
182 INT116034 Negative_regulation of Transcription of Tnf 2 0.41 0.17 0.29
183 INT277711 Regulation of Localization of KRT20 1 0.37 0.87 0.28
184 INT13818 Negative_regulation of Protein_catabolism of EGF 1 0.59 0.37 0.27
185 INT207293 Negative_regulation of Negative_regulation of INS 12 0.49 6 0.26
186 INT130886 Regulation of Krt20 1 0.02 0.91 0.23
187 INT214557 Regulation of Binding of KRT20 3 0.37 2.25 0.22
188 INT192763 Transcription of SAA1 1 0.57 1.73 0.22
189 INT222130 Gene_expression of Pik3c3 3 0.12 0.62 0.21
190 INT276186 Negative_regulation of Gene_expression of Pik3c3 1 0.07 0.3 0.21
191 INT159783 Positive_regulation of Phosphorylation of Tnf 1 0.12 0.39 0.19
192 INT92586 Negative_regulation of PIK3C3 2 0.03 0.73 0.18
193 INT312822 Regulation of Transcription of Ins2 1 0.45 0.71 0.18
194 INT312825 Transcription of Ins2 1 0.69 0.7 0.18
195 INT111291 Transcription of EGF 2 0.52 0.35 0.17
196 INT274662 Positive_regulation of Binding of KRT20 3 0.39 4.32 0.15
197 INT185256 Positive_regulation of Binding of Egf 3 0.32 2.17 0.15
198 INT265905 Regulation of Localization of SAA1 1 0.60 1 0.14
199 INT170142 Regulation of Protein_catabolism of Tnf 1 0.44 1.53 0.13
200 INT217718 Positive_regulation of Localization of KRT20 4 0.16 1.24 0.12
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