GO:0050709

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Name negative regulation of protein secretion
Categary Process
Go Slim No
Go Link GO:0050709
Unique Molecular Interactions 383
Total Molecular Interactions 504
Total Single Events 7237
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein secretion. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of protein secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
2 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
3 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
4 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
5 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
6 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
7 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
8 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
9 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
10 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
11 INT111211 Binding of Drd4 and Chdh 1 0.01 1.34 1.26
12 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
13 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
14 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
15 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
16 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
17 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
18 INT166842 Binding of ANXA1 and Nfkb1 1 0.37 1.64 0.95
19 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
20 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
21 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
22 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
23 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
24 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
25 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
26 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
27 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
28 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
29 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
30 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
31 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
32 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
33 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
34 INT127056 Ddc Positive_regulation of Transcription of Drd3 1 0.10 0.06 0.63
35 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
36 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
37 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59
38 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
39 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
40 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
41 INT166840 Binding of Anxa1 and Nfkb1 1 0.26 0.82 0.56
42 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
43 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
44 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
45 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
46 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
47 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
48 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
49 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
50 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
51 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
52 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
53 INT311767 INS Negative_regulation of Gene_expression of SLC1A3 1 0.52 0 0.52
54 INT165043 Drd2 Regulation of Cck 1 0.20 0 0.52
55 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
56 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
57 INT172207 Binding of Drd4 and ADHD1 2 0.03 1.56 0.48
58 INT101001 GHRH Regulation of Localization of INS 1 0.28 0 0.47
59 INT296237 Anxa1 Regulation of Gene_expression of Trpm8 1 0.03 0.57 0.43
60 INT296231 Anxa1 Regulation of Gene_expression of Trpa1 1 0.03 0.57 0.43
61 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43
62 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
63 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
64 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42
65 INT296235 Trpm8 Regulation of Positive_regulation of Anxa1 1 0.03 0.62 0.41
66 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
67 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
68 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
69 INT29052 Binding of INS and INSRR 1 0.02 0.23 0.4
70 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
71 INT29053 Regulation of Binding of INS and INSRR 1 0.01 0.24 0.4
72 INT78621 PRL Positive_regulation of Localization of INS 2 0.06 0.5 0.39
73 INT291256 INS Negative_regulation of Positive_regulation of Mdk 1 0.01 1.65 0.39
74 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
75 INT81506 Drd3 Regulation of Positive_regulation of Fos 1 0.28 0 0.37
76 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
77 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
78 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
79 INT353392 Binding of DRD4 and NCK1 1 0.37 0.62 0.37
80 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
81 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
82 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
83 INT138515 Drd3 Negative_regulation of Localization of Tnf 1 0.06 0.4 0.36
84 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
85 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35
86 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34
87 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34
88 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
89 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34
90 INT183785 INS Positive_regulation of Gene_expression of NFKBIB 1 0.03 1.83 0.34
91 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34
92 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
93 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34
94 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
95 INT51629 Binding of DRD3 and OPRK1 1 0.15 0 0.33
96 INT334836 Ncs1 Regulation of Drd2 1 0.02 0.48 0.33
97 INT51628 Binding of ACHE and DRD3 1 0.15 0 0.33
98 INT51631 Binding of DRD3 and PENK 1 0.08 0 0.33
99 INT109894 Drd2 Positive_regulation of FOS 1 0.01 0 0.33
100 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
101 INT238895 Binding of CRP and INS 1 0.00 0.93 0.32
102 INT258764 Binding of Drd4 and ADHD1 1 0.08 1.11 0.31
103 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3
104 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
105 INT287747 Anxa1 Positive_regulation of Lpar1 1 0.04 0 0.29
106 INT287748 Positive_regulation of Anxa1 Positive_regulation of Lpar1 1 0.04 0 0.29
107 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
108 INT71550 GTPBP4 Regulation of Localization of INS 1 0.00 0.16 0.28
109 INT291201 Regulation of INS Positive_regulation of GOPC 1 0.00 0.35 0.28
110 INT273130 Negative_regulation of Binding of Drd2 and Hp 1 0.05 0 0.28
111 INT273129 Binding of Drd2 and Hp 1 0.04 0 0.28
112 INT97594 Penk Regulation of Gene_expression of Drd2 1 0.15 0.1 0.28
113 INT291200 INS Positive_regulation of GOPC 1 0.01 0.3 0.28
114 INT242878 INS Negative_regulation of Gene_expression of SPI1 1 0.04 1.81 0.27
115 INT224406 INS Regulation of Localization of PYY 1 0.11 0.27 0.27
116 INT224405 INS Regulation of Localization of CCK 1 0.12 0.27 0.27
117 INT105004 Binding of DRD3 and PDYN 1 0.23 0.49 0.26
118 INT74433 Binding of INS and Cpe 2 0.03 0 0.25
119 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25
120 INT291261 INS Positive_regulation of Phosphorylation of Mdk 1 0.01 0.28 0.25
121 INT309888 INS Positive_regulation of Gene_expression of FAAH 1 0.04 1.19 0.25
122 INT242875 INS Negative_regulation of Gene_expression of TLR4 1 0.11 1.41 0.24
123 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23
124 INT87750 IGFBP3 Negative_regulation of INS 1 0.11 0.86 0.23
125 INT63196 INS Positive_regulation of IL2 1 0.10 0.3 0.23
126 INT63203 INS Positive_regulation of ESR1 1 0.09 0.3 0.23
127 INT63195 INS Positive_regulation of CD8A 1 0.19 0.3 0.23
128 INT63199 INS Positive_regulation of PGR 1 0.11 0.3 0.23
129 INT328382 Positive_regulation of Ghrl Positive_regulation of Localization of INS 1 0.03 1.08 0.23
130 INT108808 Binding of IAPP and INS 1 0.32 1.36 0.23
131 INT207845 Binding of INS and Hypism 3 0.04 2.88 0.22
132 INT255044 GLP1R Positive_regulation of Localization of INS 3 0.49 1.47 0.22
133 INT332481 ANXA1 Regulation of SGPP2 1 0.45 1.01 0.22
134 INT46400 Negative_regulation of Drd3 Positive_regulation of Localization of Prl 1 0.15 0.09 0.22
135 INT214481 ROS1 Negative_regulation of Gene_expression of INS 1 0.00 0.37 0.22
136 INT46399 Negative_regulation of Drd3 Positive_regulation of Prl 1 0.15 0.09 0.22
137 INT164136 Binding of DRD2 and Prl 1 0.09 0 0.22
138 INT39263 POMC Negative_regulation of INS 1 0.23 0.6 0.22
139 INT164135 Binding of Drd2 and Prl 1 0.04 0 0.22
140 INT148345 Binding of Drd3 and Adra1a 1 0.18 0.12 0.21
141 INT257397 Binding of FGD1 and INS 1 0.07 0.27 0.21
142 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
143 INT355103 Binding of Ins2 and Ins1 1 0.12 2 0.21
144 INT74437 Negative_regulation of Cpe Positive_regulation of Localization of INS 1 0.06 0 0.2
145 INT69254 Drd2 Regulation of Gene_expression of Pomc 1 0.01 0 0.2
146 INT78622 POMC Positive_regulation of Localization of INS 1 0.07 0 0.2
147 INT3592 INS Positive_regulation of AVP 1 0.05 0.28 0.2
148 INT339901 Binding of INS and SCN5A 1 0.01 0.18 0.2
149 INT3591 Negative_regulation of INS Positive_regulation of AVP 1 0.04 0.28 0.2
150 INT74439 Negative_regulation of Cpe Positive_regulation of INS 1 0.06 0 0.2
151 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19
152 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19
153 INT110717 CGA Positive_regulation of Localization of INS 1 0.03 0.5 0.19
154 INT32395 POMC Positive_regulation of INS 1 0.41 0.52 0.19
155 INT191609 Binding of Drd3 and Flna 1 0.06 0.42 0.17
156 INT44903 Binding of EIF2S1 and Sergef 1 0.02 0.32 0.17
157 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17
158 INT15523 INS Negative_regulation of FFAR1 1 0.02 0.35 0.16
159 INT206059 IL6 Positive_regulation of INS 1 0.02 1.16 0.16
160 INT311227 INS Negative_regulation of HBA1 1 0.01 0.52 0.16
161 INT71548 ADRA2C Negative_regulation of Localization of INS 1 0.04 0.13 0.16
162 INT157097 Ddc Positive_regulation of Drd3 1 0.30 0.88 0.16
163 INT240620 Binding of INS and SHBG 4 0.12 3.35 0.15
164 INT207253 INS Negative_regulation of TXNIP 1 0.45 1.2 0.15
165 INT194136 Binding of HLA-E and INS 1 0.01 0.95 0.15
166 INT31641 POMC Regulation of Gene_expression of INS 1 0.26 0.25 0.15
167 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14
168 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
169 INT141001 Negative_regulation of CPOX Regulation of Localization of INS 1 0.17 0.07 0.14
170 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14
171 INT296233 Binding of Anxa1 and Trpa1 1 0.03 0.78 0.14
172 INT332485 SGPP2 Regulation of ANXA1 1 0.27 0.69 0.13
173 INT227956 Drd2 Regulation of Chrm2 1 0.07 0.38 0.13
174 INT227957 Chrm4 Regulation of Localization of Drd2 1 0.19 0.38 0.13
175 INT227960 Drd2 Regulation of Chrm5 1 0.26 0.38 0.13
176 INT321408 INS Positive_regulation of EGR1 1 0.03 2.36 0.13
177 INT227958 Chrm2 Regulation of Localization of Drd2 1 0.17 0.38 0.13
178 INT117371 SUCLA2 Positive_regulation of Localization of INS 1 0.03 0 0.13
179 INT227959 Drd2 Regulation of Chrm4 1 0.08 0.38 0.13
180 INT117372 SUCLA2 Regulation of Localization of INS 1 0.02 0 0.13
181 INT321414 INS Positive_regulation of Transcription of EGR1 1 0.03 2.36 0.13
182 INT202255 Binding of DRD2 and TCN1 1 0.16 0 0.12
183 INT255710 Binding of INS and LOC691138 1 0.00 0.51 0.12
184 INT352501 PRKAB1 Positive_regulation of INS 1 0.04 1.36 0.12
185 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11
186 INT164923 INS Positive_regulation of GIP 1 0.43 0.18 0.11
187 INT258767 Binding of Drd2 and ADHD1 1 0.11 1.14 0.11
188 INT267124 IGF1 Negative_regulation of Gene_expression of INS 2 0.14 0.18 0.1
189 INT26176 POMC Negative_regulation of Localization of INS 1 0.36 0.06 0.1
190 INT352500 Binding of FAT1 and INS 1 0.01 1.38 0.1
191 INT102248 INS Positive_regulation of Binding of HIF1A 1 0.13 0.96 0.1
192 INT350820 INS Regulation of SELS 1 0.13 1.11 0.1
193 INT27844 Binding of INS and Gh 1 0.03 0.1 0.1
194 INT311738 Binding of Anxa1 and Plat 1 0.19 0.63 0.1
195 INT262996 ADIPOQ Regulation of INS 1 0.13 1.25 0.1
196 INT102246 Binding of HIF1A and INS 1 0.07 0.96 0.1
197 INT27841 Binding of INS and GAL 1 0.04 0.1 0.1
198 INT267684 Binding of INS and ARID1B 3 0.10 6.08 0.09
199 INT164925 GIP Positive_regulation of Localization of INS 2 0.59 0.86 0.09
200 INT8046 SORT1 Negative_regulation of Drd2 1 0.00 0 0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein secretion. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of protein secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT812 Localization of INS 1026 0.81 515.6 145.31
2 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
3 INT251 Regulation of INS 398 0.62 232.47 55.04
4 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
5 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
6 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
7 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
8 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
9 INT13501 Binding of Drd2 65 0.48 23.76 35.6
10 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
11 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
12 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
13 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
14 INT12484 Binding of Drd2 45 0.48 15.17 24.72
15 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
16 INT49774 Binding of DRD2 48 0.48 17.42 20.73
17 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
18 INT14572 Binding of INS 205 0.48 175.43 13.38
19 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
20 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
21 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
22 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
23 INT75955 Gene_expression of Drd3 19 0.77 4.39 10.07
24 INT62544 Gene_expression of Anxa1 21 0.47 13.56 9.71
25 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
26 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
27 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
28 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
29 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
30 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
31 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
32 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
33 INT64215 Gene_expression of Drd3 16 0.78 5.27 6.71
34 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
35 INT24460 Localization of Drd2 12 0.73 2.96 6.46
36 INT86772 Localization of Drd2 14 0.80 1.93 6.17
37 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
38 INT42799 Positive_regulation of Drd3 11 0.69 1.1 5.92
39 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
40 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
41 INT50330 Positive_regulation of Drd3 7 0.70 0.76 5.08
42 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
43 INT24011 Binding of Drd3 13 0.47 3.03 4.64
44 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
45 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
46 INT88274 Positive_regulation of Drd4 7 0.69 3.48 4.1
47 INT76714 Binding of Drd3 9 0.37 2.33 4.09
48 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
49 INT85497 Gene_expression of Anxa1 6 0.77 4.7 3.68
50 INT89329 Regulation of Gene_expression of Drd3 4 0.61 0.72 3.56
51 INT62547 Positive_regulation of Gene_expression of Anxa1 5 0.42 4.52 3.27
52 INT48042 Positive_regulation of Anxa1 5 0.50 3.64 3.19
53 INT109095 Binding of Drd4 7 0.40 3.6 3.18
54 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
55 INT88273 Gene_expression of Drd4 6 0.54 1.84 3.01
56 INT134798 Gene_expression of ANXA1 15 0.75 13.94 2.99
57 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
58 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
59 INT82992 Gene_expression of DRD3 3 0.50 2.12 2.88
60 INT99419 Regulation of Drd3 7 0.48 1.89 2.81
61 INT147412 Binding of DRD4 11 0.47 7.57 2.77
62 INT189863 Gene_expression of DRD4 11 0.68 7.65 2.66
63 INT89327 Positive_regulation of Gene_expression of Drd3 4 0.54 0.32 2.64
64 INT89326 Transcription of Drd3 4 0.37 0.67 2.58
65 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
66 INT165726 Positive_regulation of Anxa1 7 0.29 3.16 2.57
67 INT88272 Gene_expression of Drd4 5 0.66 1.07 2.53
68 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
69 INT51047 Regulation of Drd3 4 0.53 2 2.2
70 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
71 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
72 INT166838 Positive_regulation of ANXA1 4 0.64 4.88 2.16
73 INT105008 Binding of DRD3 5 0.36 3.15 2.05
74 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
75 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86
76 INT89330 Positive_regulation of Binding of Drd3 1 0.31 0.16 1.81
77 INT85498 Positive_regulation of Gene_expression of Anxa1 3 0.50 2.12 1.7
78 INT267108 Negative_regulation of Gene_expression of DRD3 2 0.26 1.53 1.69
79 INT138083 Positive_regulation of Gene_expression of Drd4 2 0.40 1.34 1.55
80 INT85499 Regulation of Anxa1 1 0.27 1.88 1.52
81 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
82 INT112063 Regulation of Gene_expression of Drd3 2 0.09 1.84 1.31
83 INT69498 Positive_regulation of DRD4 3 0.50 0.95 1.3
84 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
85 INT82991 Regulation of Gene_expression of DRD3 1 0.23 0.59 1.26
86 INT82988 Regulation of Transcription of DRD3 1 0.38 0.59 1.26
87 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
88 INT82987 Transcription of DRD3 1 0.58 0.59 1.25
89 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24
90 INT89328 Regulation of Transcription of Drd3 2 0.22 0.51 1.21
91 INT4570 Negative_regulation of Drd3 4 0.39 0.09 1.2
92 INT77216 Localization of DRD2 3 0.75 0 1.19
93 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15
94 INT183046 Transcription of INS 25 0.70 11.14 1.13
95 INT60441 Positive_regulation of Positive_regulation of Drd3 1 0.21 0 1.07
96 INT71233 Negative_regulation of Anxa1 1 0.07 0.15 1.05
97 INT58470 Negative_regulation of Binding of INS 14 0.43 7.2 1.01
98 INT88083 Negative_regulation of Drd3 3 0.58 0.88 1.01
99 INT228871 Negative_regulation of Gene_expression of Anxa1 2 0.03 1.92 1.01
100 INT127052 Transcription of Drd3 2 0.37 0.06 1
101 INT122151 Localization of Anxa1 1 0.75 0.53 1
102 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
103 INT82989 Regulation of DRD3 1 0.23 0.45 0.99
104 INT89331 Positive_regulation of Transcription of Drd3 1 0.21 0.09 0.85
105 INT11086 Regulation of Positive_regulation of Drd2 2 0.45 1.22 0.84
106 INT119491 Positive_regulation of Positive_regulation of Drd3 1 0.46 0.17 0.83
107 INT167833 Positive_regulation of Ins2 4 0.50 6.52 0.82
108 INT88271 Positive_regulation of Drd4 2 0.19 0.5 0.82
109 INT295239 Negative_regulation of Anxa1 2 0.02 1.6 0.81
110 INT13692 Negative_regulation of Positive_regulation of Drd2 1 0.01 0 0.79
111 INT103879 Regulation of Binding of DRD2 1 0.23 0.13 0.79
112 INT16434 Regulation of Positive_regulation of Drd2 1 0.30 0 0.78
113 INT12057 Regulation of Negative_regulation of INS 7 0.40 3.92 0.76
114 INT12885 Negative_regulation of Binding of Drd2 2 0.53 0.26 0.71
115 INT326603 Regulation of Positive_regulation of DRD2 1 0.44 0.8 0.69
116 INT15662 Positive_regulation of Transcription of Drd2 3 0.39 0 0.68
117 INT312830 Regulation of Ins2 2 0.39 1.45 0.66
118 INT184840 Positive_regulation of Transcription of Drd2 2 0.35 1.03 0.65
119 INT183789 Positive_regulation of Phosphorylation of INS 5 0.50 4.87 0.64
120 INT14570 Regulation of Positive_regulation of INS 8 0.45 4.97 0.62
121 INT127050 Positive_regulation of Transcription of Drd3 1 0.26 0.06 0.62
122 INT166836 Negative_regulation of Positive_regulation of ANXA1 2 0.39 1.15 0.57
123 INT12483 Regulation of Binding of Drd2 1 0.38 0 0.57
124 INT122149 Binding of Anxa1 1 0.36 0.22 0.57
125 INT37750 Localization of ANXA1 2 0.74 1.72 0.56
126 INT47933 Positive_regulation of Localization of Drd2 1 0.10 0.23 0.56
127 INT135534 Regulation of Gene_expression of Drd4 1 0.30 0.18 0.56
128 INT47934 Negative_regulation of Localization of Drd2 1 0.10 0.22 0.56
129 INT14571 Regulation of Binding of INS 2 0.23 2.44 0.53
130 INT37749 Positive_regulation of Localization of ANXA1 1 0.01 0.67 0.53
131 INT89285 Positive_regulation of Gene_expression of Drd3 2 0.60 0.09 0.52
132 INT206876 Positive_regulation of Gene_expression of ANXA1 3 0.39 1.68 0.51
133 INT166837 Binding of ANXA1 2 0.34 0.85 0.51
134 INT156210 Regulation of Positive_regulation of Drd4 1 0.45 0.72 0.49
135 INT202581 Positive_regulation of Gene_expression of DRD2 2 0.49 0.81 0.47
136 INT66984 Regulation of Binding of Drd2 1 0.60 0 0.47
137 INT312821 Binding of Ins2 2 0.37 2.13 0.46
138 INT213286 Positive_regulation of Binding of INS 6 0.50 4.85 0.45
139 INT206858 Regulation of ANXA1 3 0.56 2.4 0.45
140 INT53667 Gene_expression of Ins2 10 0.65 5.65 0.44
141 INT213272 Negative_regulation of Phosphorylation of INS 7 0.40 9.13 0.44
142 INT122150 Positive_regulation of Localization of Anxa1 1 0.47 0.28 0.44
143 INT166839 Negative_regulation of ANXA1 1 0.37 0.88 0.43
144 INT119492 Positive_regulation of Negative_regulation of Drd3 1 0.69 0.07 0.43
145 INT124636 Negative_regulation of Positive_regulation of Drd3 1 0.43 0.09 0.41
146 INT184866 Positive_regulation of Binding of Drd4 1 0.20 0.87 0.41
147 INT312829 Positive_regulation of Positive_regulation of Ins2 1 0.50 1.73 0.4
148 INT124635 Localization of Drd3 1 0.75 0.08 0.39
149 INT172201 Localization of Drd4 1 0.58 0.18 0.38
150 INT14569 Positive_regulation of Negative_regulation of INS 4 0.36 3.52 0.37
151 INT317624 Regulation of Phosphorylation of Drd3 1 0.05 0.46 0.36
152 INT317616 Phosphorylation of Drd3 1 0.12 0.46 0.36
153 INT261442 Negative_regulation of Gene_expression of Drd3 1 0.04 0.7 0.35
154 INT88082 Negative_regulation of Drd4 1 0.18 0.65 0.35
155 INT183066 Positive_regulation of Transcription of INS 8 0.49 5.31 0.34
156 INT117968 Regulation of Anxa1 1 0.39 1.36 0.31
157 INT105005 Positive_regulation of Positive_regulation of DRD3 1 0.48 0.5 0.28
158 INT105006 Positive_regulation of DRD3 1 0.48 0.5 0.27
159 INT24010 Negative_regulation of Binding of Drd3 1 0.39 0 0.27
160 INT353393 Transcription of DRD4 1 0.63 0.57 0.27
161 INT207293 Negative_regulation of Negative_regulation of INS 12 0.49 6 0.26
162 INT137662 Negative_regulation of Drd4 2 0.39 0.86 0.23
163 INT326600 Negative_regulation of Gene_expression of DRD2 1 0.53 0.35 0.23
164 INT89286 Positive_regulation of Binding of Drd3 1 0.69 0 0.23
165 INT172200 Transcription of Drd4 1 0.41 0.73 0.21
166 INT172199 Positive_regulation of Transcription of Drd4 1 0.36 0.73 0.21
167 INT89284 Regulation of Binding of Drd3 1 0.45 0 0.2
168 INT344112 Regulation of Transcription of Drd3 1 0.04 0 0.2
169 INT300559 Positive_regulation of Gene_expression of Drd4 1 0.43 0.15 0.19
170 INT312822 Regulation of Transcription of Ins2 1 0.45 0.71 0.18
171 INT312825 Transcription of Ins2 1 0.69 0.7 0.18
172 INT224096 Positive_regulation of Negative_regulation of DRD2 1 0.05 0.38 0.15
173 INT287734 Binding of Anxa1 1 0.03 0.18 0.14
174 INT312828 Negative_regulation of Gene_expression of Ins2 1 0.37 0.8 0.12
175 INT296223 Regulation of Localization of Anxa1 1 0.03 0.35 0.11
176 INT296227 Localization of Anxa1 1 0.05 0.34 0.11
177 INT355099 Localization of Ins2 1 0.44 0.83 0.09
178 INT312832 Negative_regulation of Ins2 1 0.37 0.64 0.09
179 INT290117 Negative_regulation of Gene_expression of ANXA1 1 0.57 1.15 0.08
180 INT228295 Negative_regulation of Transcription of INS 2 0.43 1.1 0.07
181 INT271054 Regulation of DRD4 1 0.12 0.61 0.07
182 INT44894 Positive_regulation of Sergef 1 0.04 0.13 0.05
183 INT206862 Regulation of Gene_expression of ANXA1 2 0.18 1.76 0.04
184 INT332510 Protein_catabolism of ANXA1 1 0.60 0.08 0.04
185 INT297867 Positive_regulation of Gene_expression of Ins2 1 0.48 2.86 0.04
186 INT172202 Binding of Drd4 1 0.28 0.05 0.03
187 INT296228 Positive_regulation of Positive_regulation of Anxa1 1 0.03 0.34 0.03
188 INT199086 Binding of Sergef 2 0.08 0.28 0
189 INT183060 Regulation of Transcription of INS 2 0.44 0.34 0
190 INT44893 Gene_expression of Sergef 1 0.06 0.07 0
191 INT202574 Negative_regulation of DRD4 1 0.42 0.29 0
192 INT337102 Protein_catabolism of Drd2 1 0.88 0 0
193 INT202583 Negative_regulation of Binding of DRD4 1 0.42 0.29 0
194 INT301391 Protein_catabolism of Anxa1 1 0.01 1.03 0
195 INT263506 Regulation of Regulation of Drd2 1 0.26 0.34 0
196 INT202576 Regulation of Gene_expression of DRD4 1 0.44 0.45 0
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