GO:0050717

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Name positive regulation of interleukin-1 alpha secretion
Categary Process
Go Slim No
Go Link GO:0050717
Unique Molecular Interactions 111
Total Molecular Interactions 125
Total Single Events 1216
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of interleukin-1 alpha secretion. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of interleukin-1 alpha secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
2 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
3 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
4 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
5 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
6 INT339293 Casp1 Regulation of Localization of Il1 1 0.07 1.87 0.83
7 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8
8 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
9 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
10 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
11 INT70161 Casp1 Regulation of Oprd1 1 0.03 0 0.65
12 INT70162 Casp1 Regulation of Penk 1 0.03 0 0.64
13 INT128811 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Casp1 1 0.06 0.35 0.61
14 INT66766 Casp1 Positive_regulation of Transcription of Pla2g10 1 0.06 0.19 0.6
15 INT128604 Casp1 Positive_regulation of Gene_expression of Fos 1 0.10 0.55 0.59
16 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
17 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
18 INT339290 Casp1 Regulation of Gene_expression of Il1 1 0.11 1.38 0.55
19 INT297311 Casp1 Positive_regulation of Il18 1 0.09 1.02 0.55
20 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
21 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
22 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
23 INT222284 Negative_regulation of Casp1 Negative_regulation of Il18 1 0.01 0.79 0.46
24 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46
25 INT90079 Ass1 Positive_regulation of Casp1 1 0.02 0.99 0.43
26 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
27 INT278389 Binding of Casp1 and Il1 2 0.09 0.82 0.36
28 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
29 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
30 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
31 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
32 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
33 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
34 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
35 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
36 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
37 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
38 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
39 INT69042 Negative_regulation of Casp1 Negative_regulation of Positive_regulation of IL1B 1 0.21 0.17 0.22
40 INT69041 Casp1 Negative_regulation of Gene_expression of IL1B 1 0.21 0.17 0.22
41 INT69040 Casp1 Negative_regulation of Gene_expression of IFNA1 1 0.07 0.17 0.22
42 INT69039 Negative_regulation of Casp1 Negative_regulation of Gene_expression of IFNA1 1 0.07 0.17 0.22
43 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
44 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
45 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
46 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
47 INT69038 Casp1 Regulation of Gene_expression of IFNA1 1 0.07 0.16 0.18
48 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
49 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
50 INT74504 Binding of P2rx7 and Rp2 1 0.02 0.19 0.11
51 INT205709 CAMP Positive_regulation of Positive_regulation of Casp1 1 0.00 0.27 0.11
52 INT270834 CBX1 Negative_regulation of Transcription of Panx1 1 0.06 0.13 0.1
53 INT270837 Negative_regulation of Panx1 Negative_regulation of Transcription of CBX1 1 0.07 0.13 0.1
54 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
55 INT270833 Binding of CASP1 and Panx1 1 0.02 0.14 0.09
56 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
57 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
58 INT270830 Panx1 Negative_regulation of CASP1 1 0.03 0.09 0.09
59 INT304464 Binding of P2rx7 and P2rx6 1 0.05 0 0.09
60 INT270832 Negative_regulation of Panx1 Negative_regulation of Gene_expression of CASP1 1 0.03 0.14 0.08
61 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 0.00 0.08 0.08
62 INT270829 P2rx7 Positive_regulation of Panx1 1 0.66 0.08 0.08
63 INT340420 Hmmr Regulation of P2rx7 1 0.01 1.12 0.08
64 INT278376 Negative_regulation of Casp1 Negative_regulation of Hps5 1 0.05 0.05 0.08
65 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
66 INT340427 Positive_regulation of P2rx7 Positive_regulation of Regulation of Pkhd1 1 0.01 1 0.05
67 INT270825 P2rx7 Positive_regulation of Slc37a4 1 0.01 0 0.04
68 INT278369 Ctsb Positive_regulation of Casp1 1 0.03 0 0
69 INT226045 Binding of Casp1 and Lta 1 0.04 0.73 0
70 INT217031 Binding of P2rx7 and Positive_regulation of Casp1 1 0.02 0 0
71 INT270831 Positive_regulation of Panx1 Positive_regulation of NLRP3 1 0.18 0.1 0
72 INT226042 Binding of Casp1 and Casp3 1 0.02 0.73 0
73 INT217032 Binding of P2rx7 and Positive_regulation of Il1 1 0.02 0 0
74 INT115239 Binding of Casp1 and EXOSC3 1 0.40 0.11 0
75 INT216942 Positive_regulation of P2rx7 Positive_regulation of Casp1 1 0.14 0 0
76 INT307460 P2rx7 Positive_regulation of Phosphorylation of Gsk3a 1 0.02 0 0
77 INT115240 Binding of Casp1 and TPPP3 1 0.52 0.11 0
78 INT270836 CBX1 Negative_regulation of Panx1 1 0.09 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of interleukin-1 alpha secretion. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of interleukin-1 alpha secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
2 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
3 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
4 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
5 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67
6 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
7 INT70848 Gene_expression of Casp1 24 0.77 10.97 8.52
8 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
9 INT69033 Negative_regulation of Casp1 21 0.58 13.15 7.52
10 INT81586 Negative_regulation of Casp1 11 0.57 6.55 6.45
11 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26
12 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
13 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
14 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
15 INT71220 Positive_regulation of Casp1 15 0.38 10.23 5.84
16 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
17 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
18 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
19 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
20 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
21 INT107433 Localization of Casp1 6 0.56 2.44 2.64
22 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
23 INT156876 Positive_regulation of Gene_expression of Casp1 10 0.50 10.25 2.58
24 INT205692 Positive_regulation of Positive_regulation of Casp1 5 0.46 3 2.44
25 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
26 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
27 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
28 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
29 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
30 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
31 INT69034 Regulation of Casp1 3 0.27 3.56 1.36
32 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
33 INT96073 Localization of Casp1 11 0.78 4.91 1.29
34 INT73590 Positive_regulation of Positive_regulation of Casp1 2 0.19 1.94 1.28
35 INT267750 Binding of Casp1 4 0.35 1.53 1.02
36 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
37 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
38 INT115238 Positive_regulation of Gene_expression of Casp1 5 0.68 1.78 0.88
39 INT96074 Negative_regulation of Gene_expression of Casp1 4 0.57 2.77 0.87
40 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
41 INT205685 Regulation of Positive_regulation of Casp1 3 0.11 1.62 0.78
42 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
43 INT182049 Protein_catabolism of Casp1 3 0.20 1.64 0.73
44 INT163783 Transcription of Casp1 1 0.58 0.88 0.73
45 INT163785 Positive_regulation of Transcription of Casp1 1 0.42 0.89 0.73
46 INT70156 Regulation of Casp1 2 0.15 0.79 0.7
47 INT138237 Negative_regulation of Negative_regulation of Casp1 1 0.30 0.56 0.69
48 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
49 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
50 INT71172 Negative_regulation of Gene_expression of Casp1 2 0.58 1.3 0.58
51 INT270809 Gene_expression of Panx1 1 0.69 0.59 0.55
52 INT138236 Positive_regulation of Localization of Casp1 2 0.48 0.82 0.54
53 INT90078 Negative_regulation of Positive_regulation of Casp1 2 0.42 1.38 0.53
54 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
55 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
56 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
57 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
58 INT107432 Negative_regulation of Localization of Casp1 1 0.03 0 0.42
59 INT117939 Transcription of Casp1 1 0.27 0.89 0.4
60 INT117938 Negative_regulation of Transcription of Casp1 1 0.22 0.89 0.4
61 INT270810 Localization of Panx1 1 0.67 0.33 0.34
62 INT121239 Regulation of Positive_regulation of P2rx7 2 0.61 1.32 0.32
63 INT216937 Regulation of Binding of P2rx7 1 0.44 0.08 0.29
64 INT298971 Positive_regulation of Localization of Casp1 2 0.06 0.97 0.28
65 INT270811 Negative_regulation of Panx1 1 0.52 0.4 0.27
66 INT317821 Regulation of Gene_expression of Casp1 1 0.05 1.74 0.24
67 INT216938 Negative_regulation of Localization of P2rx7 1 0.37 0.25 0.24
68 INT216940 Negative_regulation of Binding of P2rx7 1 0.37 0.15 0.2
69 INT270812 Transcription of Panx1 1 0.54 0.26 0.19
70 INT270803 Negative_regulation of Transcription of Panx1 1 0.33 0.26 0.19
71 INT216889 Phosphorylation of P2rx7 1 0.23 0 0.18
72 INT307467 Regulation of Binding of P2rx7 1 0.08 0 0.16
73 INT270813 Positive_regulation of Localization of P2rx7 1 0.46 0.24 0.15
74 INT267759 Negative_regulation of Binding of Casp1 1 0.04 0.09 0.1
75 INT307481 Phosphorylation of P2rx7 1 0.15 0.35 0.08
76 INT307480 Positive_regulation of Phosphorylation of P2rx7 1 0.09 0.35 0.08
77 INT270808 Positive_regulation of Gene_expression of Panx1 1 0.62 0.13 0.08
78 INT270807 Positive_regulation of Localization of Panx1 1 0.39 0.05 0.06
79 INT270806 Positive_regulation of Panx1 1 0.62 0.3 0.04
80 INT270801 Binding of Panx1 1 0.33 0 0.03
81 INT270805 Positive_regulation of Positive_regulation of Panx1 1 0.45 0.13 0
82 INT353117 Negative_regulation of Positive_regulation of Casp1 1 0.06 1.25 0
83 INT270799 Negative_regulation of Positive_regulation of Panx1 1 0.33 0 0
84 INT270802 Negative_regulation of Gene_expression of Panx1 1 0.33 0 0
85 INT270804 Regulation of Panx1 1 0.35 0.06 0
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