GO:0050750

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Name low-density lipoprotein particle receptor binding
Categary Function
Go Slim No
Go Link GO:0050750
Unique Molecular Interactions 257
Total Molecular Interactions 361
Total Single Events 2920
Pain Genes Associated 26

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for low-density lipoprotein particle receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for low-density lipoprotein particle receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
2 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87
3 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
4 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77
5 INT162241 Binding of COL7A1 and MMP13 2 0.03 0.86 0.73
6 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
7 INT297344 Apoe Regulation of Binding of Alms1 1 0.08 1.1 0.61
8 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
9 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
10 INT345303 MMP15 Positive_regulation of MMP13 1 0.00 1.18 0.58
11 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
12 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
13 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52
14 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5
15 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
16 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
17 INT173597 Negative_regulation of Binding of MMP2 and Mmp13 1 0.14 0.83 0.48
18 INT173595 Binding of MMP2 and Mmp13 1 0.12 0.83 0.48
19 INT173596 Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
20 INT173598 Negative_regulation of Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
21 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
22 INT345305 MMP14 Positive_regulation of MMP13 1 0.00 0.33 0.45
23 INT224686 S100a4 Positive_regulation of Gene_expression of Mmp13 1 0.05 0.85 0.45
24 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44
25 INT254760 Igh-Dex Positive_regulation of Gene_expression of Apoe 1 0.00 0 0.42
26 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42
27 INT312086 ELANE Positive_regulation of MMP13 1 0.13 0.64 0.39
28 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38
29 INT288164 Jun Regulation of Gene_expression of Mmp13 1 0.02 0.41 0.35
30 INT288167 Ugcg Negative_regulation of Gene_expression of Mmp13 1 0.06 0.46 0.35
31 INT194859 IL1B Positive_regulation of Gene_expression of MMP13 2 0.52 0.86 0.33
32 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
33 INT146893 TNF Negative_regulation of Dkk1 1 0.01 1.27 0.3
34 INT328224 Col2a1 Positive_regulation of Gene_expression of Mmp13 1 0.04 0.8 0.29
35 INT328223 Mmp14 Regulation of Positive_regulation of Mmp13 1 0.07 0.69 0.29
36 INT254759 Igh-Dex Positive_regulation of Localization of Apoe 1 0.00 0.32 0.28
37 INT254769 Binding of LDLR and Apoe 1 0.03 0 0.28
38 INT336335 Glp2r Regulation of Mmp13 1 0.06 0.68 0.28
39 INT328222 Mmp2 Regulation of Positive_regulation of Mmp13 1 0.05 0.69 0.28
40 INT297338 Apoe Regulation of Gnb5 1 0.06 1.12 0.27
41 INT194977 Binding of Alox5 and Syt1 1 0.04 0.65 0.27
42 INT141635 Binding of APOB and Alb 1 0.02 0.3 0.26
43 INT180964 PLG Positive_regulation of MMP13 1 0.24 0.45 0.25
44 INT254772 DNMT1 Positive_regulation of Apoe 1 0.02 0 0.25
45 INT78293 Binding of Apoe and Ldlr 1 0.20 0.25 0.24
46 INT78295 Binding of Ptpra and Apoe 1 0.42 0.25 0.24
47 INT297334 Gnb5 Regulation of Apoe 1 0.09 0.83 0.24
48 INT78294 Negative_regulation of Binding of Ptpra and Apoe 1 0.48 0.25 0.24
49 INT254773 PPARA Positive_regulation of Gene_expression of Apoe 1 0.01 0.07 0.24
50 INT78292 Negative_regulation of Binding of Apoe and Ldlr 1 0.23 0.25 0.24
51 INT175324 Hsp90b1 Positive_regulation of TLR2 1 0.00 0.65 0.23
52 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
53 INT175317 Hsp90b1 Positive_regulation of Tlr4 1 0.02 0.66 0.23
54 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
55 INT254774 DNMT1 Positive_regulation of Localization of Apoe 1 0.01 0.31 0.23
56 INT283857 APOA5 Positive_regulation of Positive_regulation of MAPK1 1 0.00 0.6 0.22
57 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
58 INT264526 PTGDS Negative_regulation of Gene_expression of MMP13 1 0.12 0.5 0.22
59 INT283858 Binding of PTK2 and APOA5 1 0.00 0.67 0.21
60 INT283860 APOA5 Negative_regulation of MAPK1 1 0.00 0.59 0.21
61 INT254687 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Mmp13 1 0.06 0.2 0.2
62 INT134494 Binding of APOE and Alb 1 0.11 0.45 0.2
63 INT256706 Binding of Hsp90b1 and Wfs1 1 0.43 5.02 0.2
64 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
65 INT303058 Akt1 Negative_regulation of Gene_expression of Syt1 1 0.21 0.43 0.18
66 INT308518 HSP90B1 Positive_regulation of Positive_regulation of SOAT1 1 0.00 0.65 0.18
67 INT108663 Lrpap1 Negative_regulation of Positive_regulation of Ephb1 1 0.11 0.28 0.17
68 INT324820 Hsp90b1 Positive_regulation of Tlr2 1 0.16 0.42 0.17
69 INT208360 Binding of Abca1 and Apoe 1 0.15 0.74 0.17
70 INT197499 Binding of Apoe and Tfrc 1 0.14 1.54 0.17
71 INT108664 Lrpap1 Negative_regulation of Positive_regulation of Trpv1 1 0.26 0.28 0.17
72 INT122528 Apoe Regulation of Eno2 1 0.05 0.29 0.16
73 INT122529 Apoe Regulation of S100B 1 0.18 0.29 0.16
74 INT297345 Apoe Negative_regulation of Csf2 1 0.17 0.66 0.16
75 INT329850 APOA5 Negative_regulation of Transcription of APOC3 1 0.24 0.85 0.15
76 INT220213 Mmp13 Regulation of Protein_catabolism of COL2A1 1 0.49 0.29 0.14
77 INT297333 Apoe Negative_regulation of Positive_regulation of Tlr4 1 0.10 1.02 0.14
78 INT297343 Binding of Apoe and Tlr4 1 0.09 0.94 0.14
79 INT297339 Tlr4 Negative_regulation of Gene_expression of Apoe 1 0.10 0.73 0.13
80 INT342518 HSP90B1 Positive_regulation of Gene_expression of TLR4 1 0.04 0.4 0.13
81 INT264399 Binding of IL1B and MMP13 1 0.39 0.08 0.13
82 INT324807 Binding of Tlr4 and Hsp90b1 1 0.10 0.36 0.13
83 INT342520 HSP90B1 Positive_regulation of Gene_expression of TLR2 1 0.06 0.4 0.13
84 INT311912 Gene_expression of Smad1 Positive_regulation of Gene_expression of Mmp13 1 0.08 0.51 0.12
85 INT264397 MMP9 Regulation of Positive_regulation of MMP13 1 0.20 0.06 0.12
86 INT264389 MMP14 Regulation of Positive_regulation of MMP13 1 0.31 0.06 0.12
87 INT264381 MMP3 Regulation of Positive_regulation of MMP13 1 0.21 0.06 0.12
88 INT323886 BMI1 Regulation of Gene_expression of MMP13 1 0.01 1.13 0.12
89 INT214953 Syt1 Regulation of Rims1 1 0.25 0 0.12
90 INT323882 Binding of BMI1 and MMP13 1 0.01 1.26 0.11
91 INT214955 Binding of Syt1 and Vamp2 1 0.22 0 0.1
92 INT208361 Positive_regulation of Binding of Apoe and Hdl1 1 0.12 1.22 0.1
93 INT297346 Apoe Negative_regulation of Localization of TNF 1 0.48 0.26 0.1
94 INT214951 Binding of Syt1 and Vamp1 1 0.22 0 0.1
95 INT352555 DKK1 Positive_regulation of Wnt2 1 0.01 0.25 0.1
96 INT308585 Binding of APOB and PLA2G7 1 0.07 0.69 0.09
97 INT337888 Ins1 Positive_regulation of Gene_expression of Ldlrap1 1 0.06 0 0.08
98 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
99 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08
100 INT337889 Binding of Ins1 and Ldlrap1 1 0.06 0.27 0.08
101 INT300641 Binding of APOE and CRP 1 0.41 0.81 0.07
102 INT297330 Apoe Positive_regulation of Gene_expression of Nos2 1 0.26 0.34 0.07
103 INT335890 Binding of Dkk1 and Lrp4 1 0.37 0.64 0.07
104 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07
105 INT303055 Akt1 Negative_regulation of Syt1 1 0.21 0 0.07
106 INT308663 Apoe Regulation of Car2 1 0.02 0.44 0.07
107 INT138133 Nfkb1 Regulation of Positive_regulation of Mmp13 1 0.00 0.31 0.07
108 INT50078 Binding of APOE and NPPA 1 0.30 0.42 0.07
109 INT326067 APOA1 Positive_regulation of Localization of APOE 1 0.61 4.22 0.07
110 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
111 INT311903 Acvrl1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
112 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
113 INT323878 Binding of LEP and MMP13 1 0.17 0.77 0.05
114 INT303086 Binding of Mafk and Syt1 1 0.23 0.18 0.05
115 INT303057 Binding of Syn1 and Syt1 1 0.07 0.19 0.05
116 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05
117 INT251468 Binding of APOE and DBT 1 0.03 1.18 0.05
118 INT303059 Binding of Syt1 and Sdcbp 1 0.04 0.19 0.05
119 INT231395 Binding of HSD11B1 and Apob 1 0.27 1.18 0.04
120 INT242167 Binding of Dkk1 and Kremen2 1 0.01 0.06 0.04
121 INT208356 Hdl1 Positive_regulation of Apoe 1 0.12 1.25 0.04
122 INT220239 IL1B Positive_regulation of MMP13 1 0.23 0 0.04
123 INT295477 Binding of TLR4 and LANCL1 1 0.01 0.16 0.04
124 INT293899 UPF1 Positive_regulation of Gene_expression of APOB 1 0.01 0 0.04
125 INT235551 Gene_expression of Hras1 Negative_regulation of Positive_regulation of Apoe 1 0.03 0.57 0.04
126 INT240623 Binding of CRP and Apob 1 0.01 0.52 0.04
127 INT290180 Binding of APOB and PLTP 1 0.19 0.6 0.04
128 INT180956 PLG Regulation of Positive_regulation of MMP13 1 0.32 0.38 0.04
129 INT208357 Hdl1 Positive_regulation of Localization of Apoe 1 0.12 1.26 0.04
130 INT180957 Binding of PLG and Regulation of Positive_regulation of MMP13 1 0.14 0.38 0.04
131 INT208350 Positive_regulation of Hdl1 Positive_regulation of Apoe 1 0.12 1.27 0.04
132 INT290181 Binding of APOE and PLTP 1 0.17 1.61 0.04
133 INT198919 Binding of Lrp1 and Lrpap1 1 0.07 0 0.04
134 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04
135 INT264393 MMP1 Positive_regulation of Gene_expression of MMP13 1 0.29 0.14 0.04
136 INT220909 GNS Negative_regulation of Gene_expression of MMP13 1 0.00 0 0.03
137 INT303054 Rorb Positive_regulation of Gene_expression of Syt1 1 0.01 0 0.03
138 INT194483 Binding of Apoe and Chol1 1 0.24 0.51 0.03
139 INT269838 Binding of Hsp90b1 and Tlr2 1 0.26 1.75 0.03
140 INT342512 Hsp90b1 Positive_regulation of Gene_expression of HSP90B1 1 0.24 0.62 0.03
141 INT208352 Apoe Regulation of Localization of Em 1 0.04 1.15 0.03
142 INT194481 Binding of Apoe and Apob 1 0.07 0.51 0.03
143 INT308658 Binding of Apoa2 and Apoe 1 0.17 0.15 0.03
144 INT194486 Binding of SNRNP70 and Apob 1 0.00 0.64 0.03
145 INT220915 GNS Negative_regulation of MMP13 1 0.00 0 0.03
146 INT247435 Binding of APOB and SNRNP70 1 0.04 2.2 0
147 INT198920 Binding of Ldlr and Lrpap1 1 0.05 0.06 0
148 INT353795 Binding of Cd320 and Apob 1 0.08 0.82 0
149 INT264380 Binding of JUN and MMP13 1 0.05 0 0
150 INT171598 Binding of APOB and Lipg 1 0.01 0.63 0
151 INT341487 Binding of APOE and TLR2 1 0.00 0.3 0
152 INT256703 Negative_regulation of Hsp90b1 Positive_regulation of Wfs1 1 0.42 0.24 0
153 INT316774 Hsp90b1 Positive_regulation of Localization of Ddit3 1 0.12 0.17 0
154 INT326065 APOE Positive_regulation of LCAT 1 0.53 0.84 0
155 INT256700 Negative_regulation of Binding of Hsp90b1 and Wfs1 1 0.52 0 0
156 INT145336 Binding of PYGO1 and Positive_regulation of Transcription of DKK1 1 0.07 0 0
157 INT353798 Binding of Hdl1 and Apob 1 0.01 0.82 0
158 INT209987 Binding of APOE and LDLR 1 0.24 0 0
159 INT145333 Binding of BCL9 and Positive_regulation of Transcription of DKK1 1 0.41 0 0
160 INT316770 Hsp90b1 Positive_regulation of Ddit3 1 0.12 0.17 0
161 INT208349 Regulation of Binding of Apoc3 and Apoe 1 0.01 0.38 0
162 INT90283 Binding of APOE and Il1a 1 0.01 0 0
163 INT298849 Binding of APOB and MCC 1 0.00 0.38 0
164 INT346755 Atf6 Positive_regulation of Hsp90b1 1 0.00 0 0
165 INT201080 Binding of APOE and HLA-C 1 0.41 0.31 0
166 INT283865 Binding of MAPK1 and APOA5 1 0.00 0.22 0
167 INT353802 Binding of APOE and Apob 1 0.05 0.83 0
168 INT210417 APOB Negative_regulation of CYP2D6 1 0.01 0 0
169 INT283866 Binding of SVIL and APOA5 1 0.00 0.22 0
170 INT208355 Binding of Apoc3 and Apoe 1 0.01 0.76 0
171 INT298856 Binding of APOB and MTG1 1 0.00 0.38 0
172 INT302584 Binding of Lpl and Apoa5 1 0.20 0.63 0
173 INT198933 Binding of Apoe and App 1 0.33 0.19 0
174 INT256701 Binding of Hsp90aa1 and Hsp90b1 1 0.12 0.34 0
175 INT286444 PCSK9 Positive_regulation of Apob 1 0.02 0.49 0
176 INT277047 Binding of APOB and LDLR 1 0.25 0.82 0
177 INT353801 Binding of APOE and Cd320 1 0.22 0.83 0
178 INT335891 Binding of Dkk1 and Lrp5 1 0.39 0.57 0
179 INT293981 MYC Negative_regulation of DKK1 1 0.07 0.62 0
180 INT264407 Binding of DR1 and MMP13 1 0.08 0 0
181 INT344723 Niacr1 Positive_regulation of Binding of APOB 1 0.31 1.05 0
182 INT353796 Binding of Ldlr and Apob 1 0.06 0.82 0
183 INT250152 Binding of APOE and UBE4B 1 0.21 1.2 0
184 INT247438 Binding of APOB and SACM1L 1 0.28 2 0
185 INT267974 APOB Negative_regulation of HSD11B1 1 0.01 0.75 0
186 INT326059 APOA1 Positive_regulation of Gene_expression of APOE 1 0.61 0.38 0
187 INT302594 Binding of CETP and Apoa5 1 0.26 0.63 0
188 INT300199 PCSK9 Regulation of Gene_expression of LDLR 1 0.13 0.88 0
189 INT335882 Dkk1 Negative_regulation of Wnt2 1 0.02 0.15 0
190 INT353804 Binding of APOE and Ldlr 1 0.16 0.84 0
191 INT326057 APOA1 Regulation of Localization of APOE 1 0.54 1.36 0
192 INT191258 Binding of LRPAP1 and GOPC 1 0.01 0 0
193 INT264383 MMP1 Regulation of Binding of MMP13 1 0.28 0 0
194 INT201082 Binding of APOE and HLA-B 1 0.54 1.54 0
195 INT264378 MMP1 Regulation of Transcription of MMP13 1 0.28 0 0
196 INT302595 Binding of Apoa5 and HDLCQ1 1 0.02 0.16 0
197 INT247440 Binding of APOA1 and APOB 1 0.28 1.02 0
198 INT352794 Binding of APOB and FGF21 1 0.01 1.98 0
199 INT284093 VWF Negative_regulation of APOE 1 0.40 2.32 0
200 INT302586 Binding of Lipc and Apoa5 1 0.26 0.63 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for low-density lipoprotein particle receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in low-density lipoprotein particle receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
2 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98
3 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18
4 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91
5 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52
6 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45
7 INT244490 Gene_expression of HSP90B1 4 0.33 41.16 10.37
8 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71
9 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54
10 INT197493 Localization of Apoe 61 0.79 27.48 7.06
11 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
12 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
13 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27
14 INT141751 Localization of Syt1 21 0.78 11.19 5.98
15 INT63042 Binding of Apoe 59 0.48 31.23 5.88
16 INT141146 Gene_expression of Mmp13 18 0.38 8.61 5.54
17 INT141750 Positive_regulation of Localization of Syt1 10 0.67 5.53 5.28
18 INT1285 Localization of Mmp13 12 0.78 8.98 4.93
19 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
20 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27
21 INT129964 Negative_regulation of MMP13 23 0.55 6.48 4.21
22 INT106274 Positive_regulation of Syt1 16 0.67 9.76 4.1
23 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95
24 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
25 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
26 INT22578 Gene_expression of Syt1 43 0.77 11.02 3.66
27 INT149614 Localization of MMP13 13 0.81 6.12 3.65
28 INT32464 Regulation of Mmp13 12 0.44 6.46 3.61
29 INT129960 Negative_regulation of Gene_expression of MMP13 19 0.53 7.17 3.55
30 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
31 INT32517 Positive_regulation of LRPAP1 13 0.49 7.4 3.44
32 INT116281 Negative_regulation of Gene_expression of Mmp13 15 0.41 9.96 3.41
33 INT72141 Binding of Apoe 11 0.37 10.91 3.27
34 INT97710 Localization of Apoe 1 0.79 7.18 3.2
35 INT244512 Positive_regulation of Gene_expression of HSP90B1 2 0.30 12.08 3.12
36 INT151268 Phosphorylation of Syt1 4 0.61 1.65 2.95
37 INT195978 Gene_expression of Hsp90b1 26 0.65 11.28 2.88
38 INT141752 Negative_regulation of Localization of Syt1 5 0.42 4.96 2.68
39 INT50080 Binding of APOE 38 0.45 29.61 2.67
40 INT111153 Positive_regulation of Dkk1 13 0.68 10.56 2.58
41 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
42 INT188255 Gene_expression of DKK1 19 0.60 12.69 2.39
43 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
44 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
45 INT120106 Negative_regulation of Mmp13 8 0.51 2.25 2.08
46 INT116280 Transcription of Mmp13 11 0.67 6.52 2.06
47 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
48 INT145235 Protein_catabolism of Mmp13 3 0.89 2.46 2.03
49 INT195968 Positive_regulation of Gene_expression of Hsp90b1 10 0.49 5.21 2.02
50 INT151272 Positive_regulation of Phosphorylation of Syt1 2 0.45 0.32 1.93
51 INT40877 Positive_regulation of APOB 35 0.68 32.47 1.86
52 INT182295 Regulation of MMP13 6 0.27 3.33 1.77
53 INT139475 Negative_regulation of DKK1 14 0.52 9.2 1.76
54 INT150215 Localization of LRPAP1 1 0.73 1.52 1.62
55 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61
56 INT141147 Negative_regulation of Gene_expression of Mmp13 5 0.12 1.37 1.59
57 INT344978 Negative_regulation of Gene_expression of Dkk1 1 0.58 4.38 1.59
58 INT9466 Binding of APOB 27 0.41 19.36 1.56
59 INT120111 Regulation of Mmp13 4 0.29 2.65 1.48
60 INT308527 Regulation of Gene_expression of HSP90B1 2 0.26 5.31 1.46
61 INT106273 Positive_regulation of Positive_regulation of Syt1 2 0.29 1.22 1.42
62 INT321889 Negative_regulation of Dkk1 2 0.38 5.7 1.42
63 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4
64 INT129963 Regulation of Gene_expression of MMP13 8 0.42 2.84 1.39
65 INT113960 Positive_regulation of Gene_expression of APOB 8 0.49 5.88 1.39
66 INT148740 Regulation of Gene_expression of Mmp13 1 0.03 2.58 1.37
67 INT37799 Gene_expression of Apob 13 0.56 10.59 1.36
68 INT171147 Binding of Syt1 7 0.35 6.11 1.36
69 INT97716 Transcription of Apoe 3 0.53 2.61 1.36
70 INT123778 Positive_regulation of Positive_regulation of MMP13 4 0.25 2.51 1.34
71 INT195977 Transcription of Hsp90b1 5 0.56 1.74 1.27
72 INT20238 Regulation of APOB 9 0.61 11.52 1.26
73 INT170294 Regulation of Gene_expression of Mmp13 5 0.44 4.25 1.26
74 INT97715 Regulation of Gene_expression of Apoe 3 0.62 1.98 1.23
75 INT113336 Positive_regulation of Gene_expression of Apoe 3 0.70 1.79 1.23
76 INT120108 Transcription of Mmp13 3 0.51 0.22 1.22
77 INT317972 Positive_regulation of Transcription of Mmp13 5 0.41 3.83 1.21
78 INT220926 Transcription of MMP13 12 0.67 3.03 1.09
79 INT170321 Binding of Mmp13 3 0.36 2.54 1.09
80 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05
81 INT165338 Binding of Dkk1 4 0.37 3.64 1.04
82 INT117622 Positive_regulation of HSP90B1 3 0.43 4.84 1.02
83 INT173552 Protein_catabolism of Mmp13 5 0.96 3.05 1.01
84 INT316724 Negative_regulation of Localization of Mmp13 1 0.13 0.63 1
85 INT97714 Negative_regulation of Localization of Apoe 1 0.58 1.83 0.97
86 INT130005 Protein_catabolism of MMP13 4 0.36 3.02 0.95
87 INT10827 Gene_expression of Apob 16 0.78 13.08 0.9
88 INT9467 Negative_regulation of APOB 14 0.57 10.49 0.88
89 INT224483 Regulation of Regulation of MMP13 2 0.15 1.16 0.86
90 INT338119 Negative_regulation of Transcription of Mmp13 1 0.09 0 0.86
91 INT11949 Negative_regulation of Apob 11 0.09 8.13 0.85
92 INT10828 Regulation of Apob 7 0.39 7.55 0.83
93 INT165337 Regulation of Dkk1 3 0.44 2.16 0.83
94 INT337008 Binding of HSP90B1 2 0.20 4.91 0.81
95 INT142597 Regulation of Binding of Apoe 1 0.34 2.21 0.8
96 INT51739 Negative_regulation of Apob 9 0.42 4.21 0.78
97 INT188251 Localization of DKK1 6 0.50 3.26 0.77
98 INT242131 Localization of Dkk1 5 0.79 6 0.76
99 INT197495 Negative_regulation of Localization of Apoe 6 0.43 2.19 0.73
100 INT344975 Regulation of Gene_expression of Dkk1 1 0.44 3.44 0.73
101 INT44612 Positive_regulation of APOE 16 0.67 5.73 0.72
102 INT129882 Positive_regulation of Gene_expression of Dkk1 4 0.69 4.62 0.72
103 INT270428 Negative_regulation of Binding of APOE 2 0.41 1.16 0.7
104 INT113335 Regulation of Transcription of Apoe 1 0.27 0.51 0.7
105 INT256673 Positive_regulation of Hsp90b1 12 0.49 8.49 0.68
106 INT342507 Regulation of HSP90B1 1 0.26 2.29 0.67
107 INT175580 Localization of APOE 10 0.76 18.84 0.65
108 INT22577 Positive_regulation of Gene_expression of Syt1 6 0.50 1.49 0.65
109 INT77914 Binding of LRPAP1 5 0.47 1.1 0.64
110 INT120113 Positive_regulation of Mmp13 5 0.70 2.02 0.64
111 INT305480 Regulation of Protein_catabolism of Mmp13 1 0.29 0.73 0.64
112 INT97708 Regulation of Localization of Apoe 1 0.61 2.06 0.62
113 INT56481 Regulation of Lrpap1 2 0.05 1.25 0.58
114 INT28931 Negative_regulation of LRPAP1 6 0.57 1.42 0.57
115 INT274679 Regulation of Negative_regulation of Mmp13 2 0.43 1.78 0.57
116 INT113334 Positive_regulation of Positive_regulation of Apoe 1 0.50 0.6 0.56
117 INT327659 Regulation of Syt1 1 0.20 0 0.56
118 INT256690 Binding of Hsp90b1 11 0.30 5.94 0.55
119 INT239247 Positive_regulation of APOA5 7 0.37 3.68 0.51
120 INT197322 Protein_catabolism of Apoe 6 0.71 3.52 0.51
121 INT217370 Phosphorylation of Apoe 2 0.63 1.8 0.49
122 INT37800 Positive_regulation of Apob 7 0.18 11.01 0.48
123 INT222077 Regulation of Hsp90b1 9 0.37 4.78 0.45
124 INT96816 Regulation of APOE 8 0.45 6.62 0.44
125 INT5009 Positive_regulation of Negative_regulation of Mmp13 1 0.06 0.1 0.42
126 INT244505 Regulation of Transcription of HSP90B1 2 0.19 1.47 0.41
127 INT146045 Regulation of Gene_expression of Syt1 4 0.21 0.84 0.4
128 INT244495 Transcription of HSP90B1 2 0.28 1.47 0.4
129 INT97712 Negative_regulation of Transcription of Apoe 1 0.43 1.05 0.4
130 INT173575 Binding of MMP13 2 0.35 0.79 0.36
131 INT243089 Gene_expression of Ldlrap1 2 0.65 0.14 0.35
132 INT222080 Regulation of Gene_expression of Hsp90b1 3 0.50 1.22 0.34
133 INT339386 Negative_regulation of Gene_expression of Apob 3 0.43 1.91 0.34
134 INT198871 Gene_expression of Lrpap1 1 0.18 0.14 0.34
135 INT198897 Positive_regulation of Gene_expression of Lrpap1 1 0.13 0.15 0.34
136 INT131542 Negative_regulation of Gene_expression of APOE 6 0.40 3.92 0.33
137 INT220928 Positive_regulation of Transcription of MMP13 4 0.47 1.93 0.33
138 INT242130 Positive_regulation of Positive_regulation of Dkk1 2 0.49 1.71 0.33
139 INT344976 Positive_regulation of Negative_regulation of Dkk1 1 0.49 1.13 0.33
140 INT264548 Negative_regulation of Positive_regulation of MMP13 1 0.11 0.79 0.31
141 INT83352 Positive_regulation of Negative_regulation of APOB 1 0.01 0.69 0.31
142 INT344977 Negative_regulation of Localization of Dkk1 2 0.42 2.57 0.3
143 INT106271 Negative_regulation of Positive_regulation of Syt1 1 0.25 0.34 0.3
144 INT311128 Positive_regulation of Regulation of Apoe 1 0.30 0.3 0.3
145 INT175687 Transcription of Apoe 4 0.72 2.12 0.29
146 INT96815 Regulation of Gene_expression of APOE 2 0.62 1.1 0.29
147 INT19917 Regulation of DKK1 3 0.24 1.61 0.28
148 INT316764 Localization of Hsp90b1 1 0.53 1.53 0.28
149 INT328216 Regulation of Transcription of Mmp13 1 0.37 0.35 0.28
150 INT354299 Positive_regulation of Syt1 1 0.67 0.1 0.27
151 INT97711 Positive_regulation of Transcription of Apoe 1 0.46 1.06 0.27
152 INT254756 Regulation of Positive_regulation of Apoe 1 0.20 0.22 0.26
153 INT342508 Negative_regulation of Gene_expression of HSP90B1 1 0.25 1.81 0.26
154 INT160928 Negative_regulation of Syt1 4 0.57 1.9 0.25
155 INT316765 Regulation of Localization of Hsp90b1 1 0.32 0.95 0.25
156 INT145234 Binding of Mmp13 1 0.37 0.43 0.23
157 INT247452 Gene_expression of APOA5 4 0.54 5.71 0.22
158 INT168380 Positive_regulation of Positive_regulation of Mmp13 2 0.49 0.48 0.22
159 INT194472 Positive_regulation of Gene_expression of Apob 2 0.15 1.71 0.22
160 INT342506 Localization of HSP90B1 1 0.34 0.73 0.22
161 INT283891 Positive_regulation of Gene_expression of APOA5 1 0.01 1.36 0.22
162 INT323964 Negative_regulation of Binding of Apoe 1 0.39 0.35 0.22
163 INT198892 Regulation of Binding of Apoe 6 0.45 2.94 0.21
164 INT157603 Positive_regulation of Gene_expression of Mmp13 3 0.16 0.91 0.21
165 INT283877 Localization of APOA5 3 0.27 1.48 0.2
166 INT193810 Phosphorylation of APOE 2 0.27 1.13 0.2
167 INT221896 Protein_catabolism of Syt1 2 0.22 0.36 0.2
168 INT195439 Negative_regulation of Regulation of Mmp13 1 0.41 0.53 0.2
169 INT220938 Negative_regulation of Transcription of MMP13 2 0.40 0.32 0.19
170 INT203836 Negative_regulation of Negative_regulation of Apob 1 0.18 0.45 0.19
171 INT144672 Gene_expression of Hsp90b1 1 0.57 1.12 0.19
172 INT344979 Negative_regulation of Gene_expression of DKK1 1 0.17 0.98 0.17
173 INT242127 Positive_regulation of Localization of Dkk1 1 0.05 0.35 0.17
174 INT254754 Regulation of Localization of Apoe 1 0.20 0.39 0.17
175 INT62274 Negative_regulation of Gene_expression of APOB 4 0.32 5.9 0.16
176 INT277049 Regulation of Binding of APOB 1 0.27 0.91 0.16
177 INT344980 Negative_regulation of Localization of DKK1 1 0.17 0.97 0.16
178 INT264448 Positive_regulation of Negative_regulation of MMP13 1 0.47 0.38 0.16
179 INT254755 Positive_regulation of Transcription of Apoe 1 0.16 0.41 0.16
180 INT342503 Negative_regulation of HSP90B1 1 0.18 1.41 0.16
181 INT96772 Positive_regulation of Gene_expression of APOE 5 0.66 5.44 0.14
182 INT198894 Regulation of Gene_expression of Apoe 2 0.44 0.56 0.14
183 INT203827 Localization of Apob 3 0.32 1.81 0.13
184 INT243075 Regulation of Gene_expression of Ldlrap1 2 0.44 0.15 0.13
185 INT240040 Protein_catabolism of Apob 1 0.01 1.79 0.13
186 INT240041 Negative_regulation of Protein_catabolism of Apob 1 0.01 1.8 0.13
187 INT194469 Positive_regulation of Apob 3 0.15 2.29 0.12
188 INT104623 Regulation of Negative_regulation of Apoe 2 0.45 0.73 0.12
189 INT337866 Binding of Ldlrap1 1 0.18 0.56 0.12
190 INT240145 Positive_regulation of Localization of MMP13 1 0.18 0.27 0.12
191 INT322280 Binding of PCSK9 1 0.33 0.94 0.12
192 INT326081 Negative_regulation of Localization of APOE 1 0.56 2.23 0.11
193 INT144669 Positive_regulation of Gene_expression of Hsp90b1 1 0.51 0.59 0.1
194 INT235511 Transcription of Apob 1 0.13 0.45 0.1
195 INT351388 Positive_regulation of Binding of Syt1 1 0.11 0.33 0.1
196 INT49618 Regulation of LRPAP1 2 0.15 1.1 0.09
197 INT303069 Transcription of Syt1 1 0.41 0 0.09
198 INT144670 Positive_regulation of Hsp90b1 1 0.51 0.53 0.09
199 INT300643 Positive_regulation of Binding of APOE 1 0.44 0.8 0.09
200 INT44609 Negative_regulation of Positive_regulation of APOE 1 0.16 0.9 0.09
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