GO:0050786

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Name RAGE receptor binding
Categary Function
Go Slim No
Go Link GO:0050786
Unique Molecular Interactions 127
Total Molecular Interactions 192
Total Single Events 1707
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for RAGE receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for RAGE receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
2 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
3 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
4 INT130839 Gfap Positive_regulation of S100B 1 0.51 1.9 1.56
5 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
6 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
7 INT106312 NFKB1 Regulation of S100A4 1 0.14 1.1 0.83
8 INT274785 S100B Positive_regulation of Ngf 1 0.05 0.61 0.8
9 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76
10 INT152867 HTR1A Negative_regulation of Localization of S100b 1 0.46 0 0.75
11 INT274786 Ngf Positive_regulation of Gene_expression of S100B 1 0.05 0.63 0.71
12 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
13 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
14 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
15 INT290594 BDNF Positive_regulation of Localization of S100B 1 0.08 0.6 0.57
16 INT323611 Il1 Regulation of Hmgb1 1 0.17 2.36 0.55
17 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54
18 INT128431 SLC6A4 Regulation of S100A4 1 0.48 0.65 0.53
19 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
20 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
21 INT224675 S100a4 Positive_regulation of Mmp3 1 0.04 0.94 0.48
22 INT224674 S100a4 Positive_regulation of Gene_expression of Mmp9 1 0.03 0.85 0.45
23 INT224686 S100a4 Positive_regulation of Gene_expression of Mmp13 1 0.05 0.85 0.45
24 INT224692 S100a4 Positive_regulation of Gene_expression of Mmp1a 1 0.02 0.85 0.45
25 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37
26 INT129769 Binding of LYZ and S100B 1 0.33 0.86 0.37
27 INT324823 Tlr4 Positive_regulation of Gene_expression of Hmgb1 1 0.21 0.51 0.37
28 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
29 INT324818 Hmgb1 Positive_regulation of Gene_expression of Tlr4 1 0.21 0.51 0.37
30 INT324819 Hmgb1 Positive_regulation of Gene_expression of Maob 1 0.09 0.44 0.37
31 INT324827 Hmgb1 Positive_regulation of Bad 1 0.02 0.43 0.36
32 INT266383 Binding of Ager and S100b 1 0.01 3.48 0.33
33 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32
34 INT266375 S100b Positive_regulation of Ager 1 0.02 1.8 0.31
35 INT323612 Negative_regulation of Tlr4 Positive_regulation of Hmgb1 1 0.23 0.2 0.25
36 INT323610 Tlr4 Positive_regulation of Hmgb1 1 0.25 0.2 0.25
37 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24
38 INT343914 Hmgb1 Positive_regulation of Gene_expression of IL12A 1 0.01 0.41 0.24
39 INT128432 HTR1B Regulation of S100A4 1 0.49 0.28 0.24
40 INT253771 Gopc Positive_regulation of Hmgb1 1 0.03 1.27 0.24
41 INT343906 Hmgb1 Positive_regulation of Gene_expression of Cd40 1 0.05 0.41 0.24
42 INT266421 Binding of HMGB1 and Il1 1 0.02 0.37 0.24
43 INT253773 TNF Positive_regulation of Hmgb1 1 0.09 1.21 0.23
44 INT266418 Binding of HMGB1 and Tlr4 1 0.09 0.37 0.23
45 INT344833 Binding of Ager and Hmgb1 1 0.08 0.72 0.22
46 INT266405 S100b Positive_regulation of Gene_expression of TFAM 1 0.00 1.02 0.21
47 INT266423 Binding of HMGB1 and Mapk3 1 0.04 0.9 0.2
48 INT266410 Binding of HMGB1 and Mapk14 1 0.03 0.91 0.2
49 INT266416 Binding of HMGB1 and Mapk1 1 0.06 0.9 0.2
50 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2
51 INT266404 Binding of HMGB1 and Thbd 1 0.06 0.3 0.2
52 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19
53 INT324815 Binding of Hmgb1 and Caprin1 1 0.01 0.65 0.19
54 INT154329 Binding of S100A8 and S100A12 1 0.41 0.5 0.19
55 INT324797 Binding of Cd24a and Hmgb1 1 0.19 0.66 0.19
56 INT323613 Il1 Regulation of Localization of Hmgb1 1 0.10 0.75 0.19
57 INT135974 S100a4 Negative_regulation of Nos2 1 0.00 0.26 0.17
58 INT135971 S100a4 Negative_regulation of Gene_expression of Nos2 1 0.00 0.26 0.17
59 INT215094 Il6 Positive_regulation of Hmgb1 1 0.18 1.84 0.17
60 INT344832 Hmgb1 Positive_regulation of Gene_expression of Nos2 1 0.12 0.82 0.17
61 INT266422 HMGB1 Positive_regulation of Binding of Ager 1 0.01 0.92 0.16
62 INT122529 Apoe Regulation of S100B 1 0.18 0.29 0.16
63 INT347335 Binding of S100a4 and S100a9 1 0.39 0.51 0.15
64 INT266412 Binding of S100A12 and Ager 1 0.01 1.03 0.15
65 INT347336 Binding of S100a4 and S100a8 1 0.40 0.51 0.15
66 INT266413 Positive_regulation of Binding of HMGB1 and Col4a1 1 0.02 1.05 0.14
67 INT266411 Binding of HMGB1 and Col4a1 1 0.01 1.05 0.14
68 INT290444 S100A4 Regulation of TIMP1 1 0.00 1.3 0.14
69 INT343920 Binding of TLR4 and Hmgb1 1 0.39 0.97 0.13
70 INT324866 Hmgb1 Positive_regulation of Tlr4 1 0.16 1.29 0.13
71 INT96590 Mog Regulation of S100B 1 0.32 0.97 0.13
72 INT261381 Nsdhl Regulation of Gene_expression of S100b 1 0.06 0.82 0.13
73 INT343917 Binding of IRF6 and Hmgb1 1 0.05 0.98 0.13
74 INT237442 Ass1 Positive_regulation of S100b 1 0.00 0.18 0.13
75 INT330800 Binding of S100A1 and S100B 1 0.32 0.5 0.13
76 INT96589 Mbp Regulation of S100B 1 0.34 0.97 0.13
77 INT253761 Hmgb1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.73 0.12
78 INT253772 Binding of THBD and Hmgb1 1 0.05 0.95 0.12
79 INT253775 Negative_regulation of Binding of THBD and Hmgb1 1 0.06 0.69 0.12
80 INT266396 Binding of Ager and S100a4 1 0.01 0.59 0.1
81 INT215095 Negative_regulation of Il6 Positive_regulation of Hmgb1 1 0.13 1.03 0.09
82 INT137395 Binding of CD99 and S100B 1 0.17 1.04 0.09
83 INT250730 Hmgb1 Positive_regulation of Localization of TNF 1 0.08 0.92 0.09
84 INT316112 Binding of S100B and SAE1 1 0.05 1.5 0.08
85 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
86 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
87 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05
88 INT316109 TEAD1 Regulation of S100B 1 0.00 1.16 0.04
89 INT198639 S100A12 Positive_regulation of TNF 1 0.15 1.49 0.04
90 INT198646 S100A12 Positive_regulation of IL1B 1 0.01 1.49 0.04
91 INT266372 Binding of S100a1 and S100a4 1 0.11 0.15 0.04
92 INT198651 Positive_regulation of S100A12 Positive_regulation of TNF 1 0.15 1.5 0.04
93 INT204247 S100B Regulation of CD68 1 0.03 1.05 0.04
94 INT198650 Positive_regulation of S100A12 Positive_regulation of IL1B 1 0.01 1.5 0.04
95 INT324859 Hmgb1 Positive_regulation of ecs 1 0.03 0.74 0.03
96 INT324798 Hmgb1 Positive_regulation of Positive_regulation of Mthfd1 1 0.04 0.16 0.03
97 INT244656 Binding of S100B and SLC4A1 1 0.14 1.72 0.03
98 INT324561 Hmgb1 Positive_regulation of Gene_expression of Arc 1 0.18 0.65 0
99 INT292882 Binding of S100A12 and TP63 1 0.06 0.51 0
100 INT299709 S100A12 Regulation of CFB 1 0.00 0.05 0
101 INT283183 Binding of S100A4 and ZAK 1 0.06 0 0
102 INT301246 Binding of HMGB1 and Hbp1 1 0.03 0.74 0
103 INT180294 Positive_regulation of Binding of CPB1 and S100B 1 0.09 0 0
104 INT249185 Binding of S100B and Positive_regulation of CYBB 1 0.11 0 0
105 INT249195 Binding of CA2 and S100B 1 0.07 0 0
106 INT190137 Binding of S100A12 and Gfap 1 0.00 0.65 0
107 INT253769 Binding of Hmgb1 and Il1 1 0.01 0.27 0
108 INT180295 Binding of CPB1 and S100B 1 0.08 0 0
109 INT180302 Positive_regulation of Binding of S100B and Tg(EGFR)0Jlj 1 0.05 0 0
110 INT249180 Binding of NCF2 and S100B 1 0.05 0 0
111 INT180303 Binding of S100B and Tg(EGFR)0Jlj 1 0.03 0 0
112 INT235486 S100B Positive_regulation of Binding of CA2 1 0.13 0.08 0
113 INT249155 Binding of CYBA and S100B 1 0.06 0 0
114 INT324558 Hmgb1 Positive_regulation of Gene_expression of Kiss1 1 0.24 0.65 0
115 INT249174 Binding of AKT1 and S100B 1 0.02 0 0
116 INT249194 S100B Positive_regulation of CYBA 1 0.06 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for RAGE receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in RAGE receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4
2 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26
3 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21
4 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51
5 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17
6 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15
7 INT212758 Binding of Hmgb1 40 0.44 35.6 7.41
8 INT112986 Positive_regulation of S100b 19 0.70 17.61 6.86
9 INT117299 Localization of S100b 19 0.78 1.58 6.8
10 INT23465 Gene_expression of S100b 31 0.76 15.09 6.2
11 INT190520 Negative_regulation of Hmgb1 24 0.53 20.08 5.6
12 INT17742 Localization of S100B 44 0.80 17.14 4.65
13 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55
14 INT215071 Positive_regulation of Localization of Hmgb1 34 0.63 22.03 4.15
15 INT215085 Positive_regulation of Gene_expression of Hmgb1 17 0.63 16.81 4.13
16 INT215074 Negative_regulation of Localization of Hmgb1 28 0.57 15.09 4
17 INT184288 Localization of HMGB1 20 0.61 14.5 3.84
18 INT25356 Positive_regulation of S100A12 18 0.69 17.62 3.38
19 INT106318 Gene_expression of S100A4 21 0.75 12.13 3.23
20 INT82168 Positive_regulation of S100b 20 0.68 9.72 3.08
21 INT222742 Regulation of S100A12 4 0.53 12.09 3.03
22 INT15584 Binding of S100A12 14 0.48 15.14 3
23 INT154334 Localization of S100A12 9 0.80 9.32 2.89
24 INT131929 Positive_regulation of Gene_expression of S100B 25 0.67 12.61 2.83
25 INT23775 Regulation of S100B 24 0.62 16.75 2.57
26 INT152865 Positive_regulation of Localization of S100b 3 0.68 0 2.53
27 INT184272 Binding of HMGB1 14 0.37 8.78 2.49
28 INT195085 Gene_expression of S100b 12 0.56 12.26 2.33
29 INT106317 Negative_regulation of Gene_expression of S100A4 6 0.41 2.86 2.11
30 INT128453 Positive_regulation of S100A4 8 0.67 3.24 1.84
31 INT253755 Regulation of Hmgb1 7 0.55 6.23 1.8
32 INT135969 Gene_expression of S100a4 9 0.58 5.32 1.79
33 INT58563 Negative_regulation of S100B 13 0.51 11.75 1.77
34 INT152864 Regulation of Localization of S100b 2 0.52 0 1.66
35 INT198663 Positive_regulation of HMGB1 14 0.52 11.41 1.58
36 INT184271 Positive_regulation of Gene_expression of HMGB1 7 0.41 6.17 1.53
37 INT125767 Positive_regulation of Gene_expression of S100b 6 0.49 4.08 1.52
38 INT992 Regulation of S100A4 21 0.60 1.47 1.46
39 INT126199 Negative_regulation of S100a4 1 0.08 1.45 1.38
40 INT112988 Positive_regulation of Transcription of S100b 2 0.47 1.62 1.36
41 INT112987 Transcription of S100b 2 0.53 1.61 1.35
42 INT51064 Regulation of Gene_expression of S100B 13 0.60 5.02 1.34
43 INT125766 Regulation of S100b 7 0.38 4.31 1.33
44 INT154333 Positive_regulation of Localization of S100A12 4 0.69 3.9 1.19
45 INT219168 Positive_regulation of Localization of HMGB1 5 0.36 4 1.16
46 INT161706 Negative_regulation of Gene_expression of S100B 8 0.43 2.69 1.06
47 INT215077 Negative_regulation of Positive_regulation of Hmgb1 3 0.42 5.09 1.05
48 INT51066 Binding of S100B 24 0.48 13.5 0.97
49 INT215078 Negative_regulation of Gene_expression of Hmgb1 4 0.41 4.3 0.96
50 INT106319 Negative_regulation of S100A4 2 0.41 0.89 0.82
51 INT180300 Positive_regulation of Positive_regulation of S100B 3 0.50 2.07 0.79
52 INT128447 Positive_regulation of Localization of S100B 2 0.67 0.9 0.79
53 INT190522 Regulation of Gene_expression of Hmgb1 1 0.39 1.47 0.77
54 INT152863 Negative_regulation of Localization of S100b 1 0.42 0 0.75
55 INT147008 Negative_regulation of Gene_expression of S100b 2 0.27 0.55 0.74
56 INT195107 Localization of S100b 3 0.51 2.63 0.73
57 INT106320 Positive_regulation of Gene_expression of S100A4 2 0.48 0.84 0.65
58 INT195095 Positive_regulation of Gene_expression of S100b 4 0.36 5.37 0.61
59 INT184277 Regulation of Localization of HMGB1 1 0.37 1.15 0.58
60 INT195094 Binding of S100b 2 0.35 3.49 0.51
61 INT343799 Negative_regulation of Transcription of HMGB1 1 0.32 0.37 0.5
62 INT215070 Regulation of Localization of Hmgb1 4 0.26 2.23 0.49
63 INT220339 Transcription of HMGB1 2 0.53 2.03 0.49
64 INT266326 Positive_regulation of S100a4 4 0.65 1.67 0.46
65 INT219178 Negative_regulation of Localization of HMGB1 1 0.22 1.26 0.45
66 INT352592 Positive_regulation of Negative_regulation of Hmgb1 1 0.44 1.31 0.42
67 INT125765 Negative_regulation of Positive_regulation of S100b 2 0.42 0.06 0.4
68 INT128448 Negative_regulation of Positive_regulation of S100A4 1 0.41 0.29 0.35
69 INT156723 Regulation of Localization of S100B 2 0.44 2.61 0.34
70 INT340345 Positive_regulation of Gene_expression of S100A12 1 0.46 1.94 0.34
71 INT285621 Regulation of S100a4 1 0.39 0.67 0.32
72 INT128450 Transcription of S100A4 2 0.67 0.25 0.31
73 INT128455 Positive_regulation of Transcription of S100A4 1 0.49 0.25 0.31
74 INT128456 Positive_regulation of Positive_regulation of S100A4 1 0.49 0.34 0.31
75 INT258283 Positive_regulation of Positive_regulation of Hmgb1 3 0.44 3.1 0.3
76 INT331591 Transcription of Hmgb1 1 0.28 0.92 0.3
77 INT161705 Positive_regulation of Negative_regulation of S100B 1 0.50 0.56 0.28
78 INT266363 Regulation of Binding of S100A12 1 0.29 0.87 0.26
79 INT165392 Positive_regulation of Regulation of S100B 2 0.50 0.56 0.23
80 INT220336 Negative_regulation of HMGB1 3 0.43 0.97 0.21
81 INT202177 Negative_regulation of Gene_expression of S100A12 1 0.22 0.41 0.21
82 INT266367 Positive_regulation of Binding of HMGB1 1 0.26 0.31 0.21
83 INT93077 Negative_regulation of Localization of S100B 3 0.57 0.58 0.2
84 INT266364 Protein_catabolism of HMGB1 1 0.34 0.29 0.19
85 INT266322 Binding of S100a4 1 0.16 1.17 0.18
86 INT195111 Negative_regulation of Positive_regulation of S100b 1 0.06 1.06 0.18
87 INT51065 Transcription of S100B 3 0.60 0.83 0.17
88 INT266353 Negative_regulation of Binding of HMGB1 1 0.22 0.22 0.17
89 INT258272 Negative_regulation of Binding of Hmgb1 1 0.53 1.82 0.15
90 INT344828 Protein_catabolism of Hmgb1 1 0.48 0.67 0.14
91 INT344810 Positive_regulation of Protein_catabolism of Hmgb1 1 0.27 0.67 0.14
92 INT237441 Positive_regulation of Positive_regulation of S100b 2 0.36 3 0.12
93 INT147009 Regulation of Gene_expression of S100b 2 0.07 0.34 0.1
94 INT237438 Regulation of Gene_expression of S100b 2 0.31 2.45 0.1
95 INT318343 Regulation of Binding of Hmgb1 1 0.11 0.41 0.1
96 INT250773 Positive_regulation of Localization of S100a4 1 0.38 0.49 0.1
97 INT206737 Negative_regulation of Gene_expression of HMGB1 3 0.32 3.48 0.09
98 INT250775 Localization of S100a4 1 0.56 0.49 0.09
99 INT82169 Negative_regulation of S100b 2 0.31 0.69 0.08
100 INT159191 Negative_regulation of S100A12 1 0.05 0.59 0.08
101 INT180298 Regulation of Positive_regulation of S100B 3 0.39 1.09 0.04
102 INT299469 Regulation of HMGB1 2 0.18 2.27 0.03
103 INT266358 Regulation of Binding of HMGB1 1 0.14 0 0.03
104 INT299470 Regulation of Gene_expression of HMGB1 1 0.18 1.58 0
105 INT200568 Negative_regulation of Regulation of S100b 1 0.01 1.03 0
106 INT235488 Negative_regulation of Transcription of S100B 1 0.37 0.09 0
107 INT235487 Regulation of Transcription of S100B 1 0.39 0.09 0
108 INT227019 Regulation of Gene_expression of S100A4 1 0.12 0.4 0
109 INT163587 Positive_regulation of Positive_regulation of S100b 1 0.40 0 0
110 INT283188 Binding of S100A4 1 0.18 0 0
111 INT258279 Positive_regulation of Binding of Hmgb1 1 0.45 0.26 0
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