GO:0050798

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Name activated T cell proliferation
Categary Process
Go Slim No
Go Link GO:0050798
Unique Molecular Interactions 103
Total Molecular Interactions 157
Total Single Events 1264
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activated T cell proliferation. They are ordered first by their pain relevance and then by number of times they were reported for activated T cell proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
2 INT107268 Binding of ITGAL and NCR3 1 0.01 2.76 2.07
3 INT81719 POMC Regulation of Gene_expression of ITGAL 1 0.35 0.34 1.57
4 INT81714 POMC Regulation of ITGAL 1 0.15 0.34 1.54
5 INT107265 Binding of HLA-DRB1 and ITGAL 1 0.01 1.41 1.1
6 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
7 INT272984 Il6 Positive_regulation of Gene_expression of Itgam 1 0.24 0.78 0.96
8 INT140920 Btnl2 Negative_regulation of Itgam 1 0.02 0.88 0.79
9 INT81716 ITGAL Regulation of ITGB2 2 0.30 1.24 0.78
10 INT81717 ITGAL Regulation of Gene_expression of ITGAM 1 0.30 0.17 0.78
11 INT81718 ITGAL Regulation of Gene_expression of FCGR3B 1 0.28 0.17 0.78
12 INT81711 ITGAL Regulation of Gene_expression of ITGB2 1 0.30 0.17 0.78
13 INT81713 ITGAL Regulation of ITGAM 1 0.30 0.17 0.77
14 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75
15 INT265651 Binding of ITGAL and MYCN 1 0.00 0.46 0.62
16 INT277828 Negative_regulation of Binding of ICAM1 and ITGAL 2 0.22 1.27 0.57
17 INT266376 Binding of Ager and Itgam 1 0.00 2.31 0.54
18 INT182813 EEF1A2 Negative_regulation of ITGAL 1 0.10 1.53 0.51
19 INT102691 RETNLB Positive_regulation of ITGAL 1 0.01 0.45 0.45
20 INT220188 EC Positive_regulation of CADM1 1 0.00 1.72 0.44
21 INT161009 Binding of Cpe and Itgam 1 0.03 0.53 0.37
22 INT161006 Itgam Regulation of Cpb2 1 0.07 0.52 0.37
23 INT161003 Binding of Itgam and Cpb2 1 0.10 0.52 0.37
24 INT161001 Itgam Regulation of Gfap 1 0.13 0.52 0.37
25 INT161002 Binding of Itgam and St13 1 0.11 0.52 0.37
26 INT161008 Itgam Regulation of St13 1 0.08 0.52 0.37
27 INT118743 Tlr4 Positive_regulation of Itgam 1 0.39 0.41 0.35
28 INT96158 Itgax Regulation of Gene_expression of H2-D1 1 0.14 0.09 0.35
29 INT61266 Nfkb1 Regulation of Gene_expression of Itgam 1 0.23 0.65 0.32
30 INT170128 Binding of ITGAL and ITGB2 2 0.04 1.6 0.28
31 INT198648 VCAM1 Positive_regulation of CADM1 1 0.00 1.1 0.25
32 INT198644 TNF Positive_regulation of CADM1 1 0.02 1.07 0.24
33 INT198643 CD36 Positive_regulation of CADM1 1 0.01 1.07 0.24
34 INT173405 Binding of FCGR3B and Itgam 1 0.06 0.65 0.23
35 INT20403 FPR1 Positive_regulation of Itgax 1 0.02 0.22 0.22
36 INT224454 TNF Positive_regulation of Gene_expression of Itgam 1 0.27 0.35 0.22
37 INT224445 Il1 Positive_regulation of Gene_expression of Itgam 1 0.21 0.35 0.22
38 INT236362 Binding of Gfap and Itgam 1 0.23 2.31 0.2
39 INT99013 Binding of Itgb2 and Selp 1 0.16 1.36 0.18
40 INT99011 Regulation of Binding of Itgb2 and Selp 1 0.19 1.37 0.18
41 INT314534 Ptger2 Regulation of Gene_expression of Itgam 1 0.02 1 0.17
42 INT277791 Binding of Icam1 and Itgal 1 0.03 0.37 0.17
43 INT141760 Nfkb1 Regulation of CADM1 1 0.02 1.18 0.16
44 INT141761 Nfkb1 Regulation of Positive_regulation of CADM1 1 0.01 1.21 0.16
45 INT273714 Positive_regulation of Binding of Icam1 and Itgb2 1 0.17 1.46 0.15
46 INT281302 Binding of Itgam and Fgg 1 0.00 0.62 0.15
47 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 0.02 1.18 0.15
48 INT273717 Binding of Icam1 and Itgb2 1 0.17 1.45 0.15
49 INT281315 Binding of Gp1bb and Itgam 1 0.00 0.62 0.15
50 INT173404 GPER Regulation of Itgam 1 0.02 0.41 0.13
51 INT173406 Binding of ITGAL and Itgb2 1 0.02 0.41 0.13
52 INT298548 Itgam Regulation of Fig4 1 0.08 0.05 0.12
53 INT234058 Nes Positive_regulation of Itgam 1 0.50 0.08 0.11
54 INT171791 GPER Negative_regulation of Gene_expression of Itgam 1 0.02 0.46 0.11
55 INT266373 Itgam Positive_regulation of Ager 1 0.01 0.84 0.1
56 INT232652 Binding of CD2 and ITGAL 1 0.03 0.28 0.09
57 INT279400 GANAB Regulation of ITGAL 1 0.01 0.75 0.09
58 INT253300 Itgam Positive_regulation of Gene_expression of Ptprc 1 0.19 0.11 0.09
59 INT173371 GPER Regulation of ITGAL 1 0.01 0.23 0.08
60 INT173408 GPER Regulation of Itgb2 1 0.01 0.23 0.08
61 INT267137 ICAM1 Regulation of ITGAL 2 0.12 0.57 0.07
62 INT284501 Positive_regulation of Binding of ICAM1 and ITGAL 1 0.06 0.2 0.07
63 INT20404 Negative_regulation of FPR1 Positive_regulation of Itgax 1 0.02 0.07 0.07
64 INT173400 Negative_regulation of Binding of GPER and Itgam 1 0.01 0.19 0.06
65 INT284504 ITGAL Positive_regulation of Gene_expression of ITGAM 1 0.03 0.2 0.06
66 INT173407 Binding of GPER and Itgam 1 0.01 0.26 0.06
67 INT284564 Binding of Itgax and Mthfd1 1 0.08 0.09 0.05
68 INT173379 Binding of Itgam and Ns5atp9 1 0.01 0.18 0.04
69 INT254390 Binding of FCGR2A and Itgam 1 0.24 0.63 0.04
70 INT173403 GPER Negative_regulation of Binding of Itgam 1 0.01 0.15 0.04
71 INT221639 Fyn Positive_regulation of Phosphorylation of Cdk5 1 0.14 0.28 0.03
72 INT221624 Binding of Fyn and Plxna1 1 0.01 0.29 0.03
73 INT221640 Sema3a Positive_regulation of Phosphorylation of Fyn 1 0.16 0.29 0.03
74 INT221651 Binding of Fyn and Plxna2 1 0.01 0.29 0.03
75 INT221623 Fyn Regulation of Fes 1 0.14 0.2 0.03
76 INT260811 Binding of ITGA4 and ITGAL 1 0.02 0 0.03
77 INT273719 Binding of Itgb2 and Trav6-3 1 0.07 0.47 0.03
78 INT329729 Binding of LCK and Fyn 1 0.00 0.21 0.03
79 INT221613 Binding of Cdk5 and Fyn 1 0.10 0.29 0.03
80 INT221617 Fyn Positive_regulation of Cdk5 1 0.13 0.28 0.03
81 INT170121 ITGAL Regulation of CD44 1 0.07 1.07 0
82 INT314537 Il10 Positive_regulation of Gene_expression of Itgam 1 0.21 1.23 0
83 INT281314 Positive_regulation of Stx2 Positive_regulation of Gene_expression of Itgam 1 0.08 0.21 0
84 INT170119 PECAM1 Regulation of Positive_regulation of ITGAL 1 0.01 1.07 0
85 INT173380 Ns5atp9 Positive_regulation of Binding of Itgam 1 0.01 0.43 0
86 INT79649 RIMS3 Regulation of Positive_regulation of ITGAL 1 0.00 0 0
87 INT170123 ITGAL Regulation of Positive_regulation of PECAM1 1 0.01 1.07 0
88 INT344229 Itgam Regulation of Transcription of Tlr4 1 0.03 0.06 0
89 INT228118 Binding of Fyn and Vav1 1 0.11 0.21 0
90 INT301095 Binding of ITGAL and CHDH 1 0.00 0.71 0
91 INT344220 Itgam Regulation of Transcription of Tlr2 1 0.03 0.06 0
92 INT303090 Akt1 Negative_regulation of CADM1 1 0.14 0.29 0
93 INT273720 Binding of Cd28 and Itgb2 1 0.10 0 0
94 INT191933 Itgam Positive_regulation of Cpox 1 0.07 0.36 0
95 INT303987 Binding of LEPR and Fyn 1 0.02 0.62 0
96 INT173398 GPER Regulation of Binding of Itgam 1 0.01 0 0
97 INT303087 Akt1 Negative_regulation of Gene_expression of CADM1 1 0.14 0.29 0
98 INT170114 ITGAM Regulation of Positive_regulation of ITGAL 1 0.04 1.07 0
99 INT173381 Binding of Itgam and Mfi2 1 0.01 0 0
100 INT170115 PECAM1 Regulation of ITGAL 1 0.00 1.07 0
101 INT221645 Fyn Regulation of Phosphorylation of Fer 1 0.12 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activated T cell proliferation. They are ordered first by their pain relevance and then by number of times they were reported in activated T cell proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26
2 INT66025 Gene_expression of Itgam 61 0.78 31.26 26.08
3 INT66023 Positive_regulation of Gene_expression of Itgam 25 0.64 12.65 16.56
4 INT15172 Positive_regulation of Itgam 45 0.67 23.54 10.3
5 INT108098 Positive_regulation of Itgam 19 0.70 8.09 8.86
6 INT22481 Gene_expression of CADM1 28 0.65 30.26 8.5
7 INT60700 Gene_expression of Itgax 93 0.71 51.89 6.57
8 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15
9 INT15173 Positive_regulation of Gene_expression of Itgam 59 0.49 21.89 5.43
10 INT61252 Negative_regulation of Gene_expression of Itgam 38 0.54 16.48 5.01
11 INT49405 Gene_expression of Itgal 40 0.75 27.3 4.8
12 INT87322 Binding of ITGAL 23 0.47 15.73 4.68
13 INT66024 Negative_regulation of Gene_expression of Itgam 9 0.59 5.5 4.38
14 INT118740 Transcription of Itgam 5 0.70 5.11 4.14
15 INT229912 Phosphorylation of Fyn 5 0.42 2.57 3.78
16 INT119769 Binding of Itgam 27 0.36 6.57 3.29
17 INT61259 Negative_regulation of Itgam 16 0.47 11.11 3.27
18 INT118735 Positive_regulation of Transcription of Itgam 2 0.49 4.24 3.11
19 INT171117 Binding of Itgam 35 0.36 14.87 2.76
20 INT130476 Phosphorylation of Fyn 8 0.80 2.99 2.44
21 INT324955 Phosphorylation of Itgam 1 0.37 1.96 2.4
22 INT61418 Positive_regulation of ITGAL 24 0.14 12.86 2.3
23 INT51461 Gene_expression of Itgb2 7 0.75 5.48 2.2
24 INT173395 Regulation of Itgam 3 0.25 1.23 2.13
25 INT118201 Negative_regulation of Itgam 3 0.22 3.41 1.99
26 INT61262 Negative_regulation of Positive_regulation of Itgam 5 0.57 4.25 1.95
27 INT94117 Regulation of Gene_expression of Itgam 13 0.36 5.9 1.87
28 INT22482 Negative_regulation of Gene_expression of CADM1 6 0.49 3.2 1.8
29 INT98580 Positive_regulation of CADM1 11 0.49 10.16 1.78
30 INT210709 Regulation of Itgam 8 0.28 9.21 1.76
31 INT12942 Regulation of ITGAL 8 0.35 3.29 1.57
32 INT49404 Binding of Itgal 11 0.36 9.16 1.53
33 INT152885 Localization of Itgam 16 0.73 7.62 1.43
34 INT100909 Negative_regulation of Gene_expression of Itgb2 2 0.41 1.79 1.22
35 INT20397 Positive_regulation of Itgax 12 0.46 6.48 1.19
36 INT130477 Negative_regulation of Fyn 3 0.29 1.59 1.14
37 INT119767 Positive_regulation of Binding of Itgam 4 0.49 1.42 1.09
38 INT60699 Negative_regulation of Gene_expression of Itgax 5 0.39 1.94 1.05
39 INT151689 Positive_regulation of Gene_expression of CADM1 6 0.08 4.31 1.02
40 INT100911 Positive_regulation of Itgb2 1 0.51 1.62 0.99
41 INT49406 Positive_regulation of Itgal 7 0.43 8.58 0.95
42 INT87329 Positive_regulation of Gene_expression of Itgax 15 0.64 10.85 0.93
43 INT81723 Regulation of Gene_expression of ITGAL 2 0.32 0.2 0.92
44 INT173394 Regulation of Gene_expression of Itgam 2 0.11 1.05 0.91
45 INT178803 Gene_expression of Itgb2 10 0.44 5.13 0.87
46 INT115964 Negative_regulation of ITGAL 7 0.34 3.76 0.86
47 INT146940 Gene_expression of Fyn 2 0.52 2.76 0.83
48 INT108099 Positive_regulation of Positive_regulation of Itgam 1 0.49 0.23 0.83
49 INT186135 Negative_regulation of Binding of ITGAL 5 0.34 3.27 0.74
50 INT100910 Regulation of Positive_regulation of Itgb2 1 0.20 0.53 0.72
51 INT51459 Positive_regulation of Gene_expression of Itgb2 2 0.37 1.92 0.7
52 INT137204 Localization of Itgax 6 0.70 3.86 0.67
53 INT15171 Positive_regulation of Positive_regulation of Itgam 4 0.49 1.13 0.64
54 INT102695 Localization of ITGAL 2 0.73 1.26 0.61
55 INT282645 Binding of CADM1 1 0.14 3.32 0.58
56 INT20396 Negative_regulation of Positive_regulation of Itgax 4 0.22 1.01 0.57
57 INT63357 Negative_regulation of Gene_expression of ITGAL 3 0.33 1.88 0.56
58 INT249509 Gene_expression of Fyn 2 0.35 1.79 0.56
59 INT253299 Positive_regulation of Localization of Itgam 4 0.29 3.04 0.55
60 INT133729 Positive_regulation of Gene_expression of ITGAL 8 0.49 2.96 0.48
61 INT124990 Regulation of Gene_expression of CADM1 3 0.01 1.89 0.48
62 INT124991 Regulation of CADM1 2 0.01 1.67 0.47
63 INT51462 Regulation of Gene_expression of Itgb2 2 0.34 0.79 0.47
64 INT96152 Regulation of Gene_expression of Itgax 2 0.41 1.15 0.46
65 INT143548 Binding of Itgb2 1 0.35 0 0.44
66 INT307766 Negative_regulation of CADM1 1 0.02 2.13 0.44
67 INT118202 Negative_regulation of Itgb2 1 0.41 1.05 0.42
68 INT173393 Negative_regulation of Binding of Itgam 5 0.24 1.03 0.39
69 INT277788 Negative_regulation of Gene_expression of Itgal 4 0.29 2.05 0.39
70 INT192858 Phosphorylation of Itgam 4 0.47 1.71 0.38
71 INT126827 Negative_regulation of Itgax 4 0.57 2.06 0.36
72 INT249525 Positive_regulation of Gene_expression of Fyn 1 0.21 0.23 0.34
73 INT79260 Negative_regulation of Itgal 2 0.37 2.11 0.33
74 INT249523 Regulation of Localization of Fyn 1 0.19 0.22 0.32
75 INT249516 Negative_regulation of Gene_expression of Fyn 1 0.18 0.23 0.32
76 INT236352 Positive_regulation of Binding of Itgam 4 0.36 2.92 0.29
77 INT114900 Negative_regulation of Positive_regulation of ITGAL 1 0.01 1.32 0.29
78 INT249510 Localization of Fyn 1 0.32 0.22 0.29
79 INT99005 Positive_regulation of Itgb2 8 0.39 6.36 0.27
80 INT98996 Regulation of Itgb2 2 0.25 2.09 0.27
81 INT229586 Localization of Itgam 2 0.38 0.7 0.27
82 INT91496 Binding of Itgax 4 0.34 2.14 0.26
83 INT98579 Positive_regulation of Positive_regulation of CADM1 2 0.01 2.08 0.26
84 INT12940 Positive_regulation of Transcription of ITGAL 1 0.02 0.09 0.26
85 INT12941 Transcription of ITGAL 1 0.03 0.09 0.26
86 INT152888 Transcription of Itgam 4 0.44 1.29 0.25
87 INT185234 Transcription of Itgax 1 0.66 4.83 0.24
88 INT61416 Positive_regulation of Positive_regulation of ITGAL 4 0.11 0.85 0.23
89 INT79259 Regulation of Itgal 4 0.40 2.94 0.23
90 INT117808 Positive_regulation of Gene_expression of Itgal 3 0.10 2.12 0.23
91 INT338874 Binding of Fyn 1 0.08 0.53 0.19
92 INT355260 Positive_regulation of Phosphorylation of Itgam 1 0.09 1.03 0.18
93 INT141757 Negative_regulation of Positive_regulation of CADM1 1 0.01 1.22 0.16
94 INT115522 Regulation of Itgb2 3 0.19 0.5 0.15
95 INT235724 Localization of Itgal 2 0.07 0.94 0.15
96 INT344816 Regulation of Gene_expression of Itgb2 1 0.07 0.56 0.15
97 INT288159 Regulation of Gene_expression of Itgal 1 0.15 1.16 0.14
98 INT273704 Binding of Itgb2 3 0.20 2.59 0.1
99 INT117809 Positive_regulation of Positive_regulation of Itgal 1 0.04 0.84 0.09
100 INT273698 Positive_regulation of Positive_regulation of Itgb2 1 0.39 0.22 0.08
101 INT173389 Regulation of Binding of Itgam 1 0.15 0.22 0.08
102 INT199074 Positive_regulation of Fyn 1 0.18 0.05 0.07
103 INT185230 Regulation of Itgax 1 0.56 3.32 0.07
104 INT277786 Negative_regulation of Binding of Itgal 1 0.29 0.22 0.07
105 INT171951 Localization of CADM1 1 0.11 1.45 0.05
106 INT83483 Regulation of Regulation of ITGAL 2 0.01 0.3 0.04
107 INT149789 Positive_regulation of Phosphorylation of Fyn 2 0.67 0.31 0.04
108 INT329716 Negative_regulation of Fyn 1 0.03 0.21 0.03
109 INT135479 Negative_regulation of Positive_regulation of Itgam 2 0.59 0.19 0
110 INT83476 Positive_regulation of Regulation of ITGAL 1 0.00 0 0
111 INT185232 Positive_regulation of Localization of Itgax 1 0.46 0.47 0
112 INT79661 Phosphorylation of ITGAL 1 0.01 0 0
113 INT185233 Negative_regulation of Binding of Itgax 1 0.39 0.9 0
114 INT356245 Transcription of CADM1 1 0.52 0.1 0
115 INT191932 Negative_regulation of Binding of Itgam 1 0.17 0.48 0
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