GO:0050801

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Name ion homeostasis
Categary Process
Go Slim No
Go Link GO:0050801
Unique Molecular Interactions 180
Total Molecular Interactions 320
Total Single Events 2320
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ion homeostasis. They are ordered first by their pain relevance and then by number of times they were reported for ion homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT26824 Crh Positive_regulation of Localization of Penk 7 0.54 0.42 6.49
2 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
3 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
4 INT18793 Crh Regulation of Localization of Penk 1 0.59 0 3.2
5 INT34294 Penk Positive_regulation of Localization of Crh 1 0.16 0.43 3.19
6 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
7 INT62450 Il2 Positive_regulation of Localization of Crh 1 0.43 0.59 2.64
8 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
9 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
10 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
11 INT29716 Crh Negative_regulation of Localization of Gnrh1 5 0.44 0 2.35
12 INT18791 Crh Regulation of Penk 2 0.49 0 2.15
13 INT30954 Crh Negative_regulation of LH 5 0.46 1.4 2.06
14 INT163266 Crh Negative_regulation of Tyr 1 0.01 0.45 1.98
15 INT29715 Crh Negative_regulation of Localization of LH 5 0.43 0 1.78
16 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
17 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
18 INT341372 CRX Positive_regulation of Gene_expression of Crh 1 0.04 1.81 1.7
19 INT94270 Pomc Regulation of Transcription of Crh 1 0.17 0.67 1.6
20 INT151020 Binding of Pdyn and Crh 1 0.14 0.42 1.59
21 INT209087 Crh Positive_regulation of Ceacam3 1 0.24 1.45 1.54
22 INT59547 Avp Positive_regulation of Crh 2 0.14 1.13 1.47
23 INT199494 Crh Positive_regulation of Localization of Pdyn 1 0.02 0.43 1.4
24 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
25 INT62448 Il2 Positive_regulation of Crh 1 0.59 0.36 1.3
26 INT31008 Crh Positive_regulation of Pomc 3 0.49 2.31 1.28
27 INT5518 Pomc Negative_regulation of Crh 2 0.36 0.42 1.26
28 INT29714 Crh Regulation of Localization of LH 2 0.26 0 1.19
29 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
30 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
31 INT29713 Crh Negative_regulation of Localization of Gnrhr 1 0.39 0 1.12
32 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
33 INT38936 Binding of Avp and Crh 7 0.40 0.82 1.04
34 INT210015 Binding of Adcyap1 and Crh 1 0.47 0.88 1
35 INT5612 Cck Positive_regulation of Localization of Crh 1 0.65 0.16 1
36 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 0.12 1.07 0.99
37 INT31494 Pomc Regulation of Crh 2 0.12 0.13 0.97
38 INT36002 Negative_regulation of Crh Negative_regulation of LH 2 0.29 0.66 0.96
39 INT62449 Gnrh1 Regulation of Crh 1 0.40 0.34 0.91
40 INT66371 Pomc Regulation of Gene_expression of Crh 2 0.49 0 0.88
41 INT21006 Oprl1 Regulation of Localization of Crh 1 0.19 0 0.84
42 INT64629 Binding of Gal and Crh 1 0.18 0.1 0.83
43 INT64627 Binding of Oxt and Crh 1 0.07 0.1 0.83
44 INT36003 Crh Positive_regulation of Localization of LH 2 0.45 0 0.79
45 INT79532 Crh Regulation of Ugt1a10 1 0.00 0 0.76
46 INT28620 Penk Regulation of Crh 2 0.40 0.25 0.75
47 INT30838 Crh Negative_regulation of D230030E09Rik 1 0.17 0.1 0.73
48 INT5971 Il1a Positive_regulation of Crh 2 0.51 0.57 0.71
49 INT313778 Gene_expression of Crhq1 Negative_regulation of Localization of Crh 1 0.05 0.66 0.71
50 INT12022 Crh Positive_regulation of Localization of Prl 1 0.02 0.14 0.7
51 INT26198 Positive_regulation of Crh Positive_regulation of Localization of POMC 1 0.38 0 0.7
52 INT55205 Prl Positive_regulation of Localization of Crh 1 0.47 0 0.69
53 INT55209 Prl Positive_regulation of Crh 1 0.51 0 0.69
54 INT253825 Cck Positive_regulation of Crh 1 0.74 0 0.69
55 INT135119 Binding of Pomc and Crh 1 0.35 0 0.67
56 INT103905 Gh Positive_regulation of Positive_regulation of Crh 1 0.08 0.9 0.66
57 INT97508 Negative_regulation of Il1b Positive_regulation of Crh 1 0.31 0.89 0.65
58 INT33561 Crh Positive_regulation of POMC 3 0.45 1.19 0.64
59 INT34212 PSG2 Regulation of Localization of Crh 1 0.02 0.09 0.63
60 INT34211 DNM2 Regulation of Localization of Crh 1 0.01 0.09 0.63
61 INT23576 Binding of Penk and Crh 2 0.18 0 0.62
62 INT20162 Crh Regulation of GNRH1 2 0.02 0.07 0.62
63 INT27067 Crh Positive_regulation of Localization of Avp 3 0.18 0.46 0.61
64 INT91391 Crh Regulation of Localization of Gnrh1 2 0.36 1.78 0.61
65 INT57246 Crh Positive_regulation of Positive_regulation of Caprin2 1 0.01 0.55 0.6
66 INT104050 Binding of Crh and Nts 1 0.40 0 0.6
67 INT59540 Crh Regulation of Gnrh1 2 0.36 2.61 0.58
68 INT91393 Crh Positive_regulation of SST 1 0.01 0.73 0.58
69 INT54620 IL1B Positive_regulation of Crh 1 0.01 0.39 0.58
70 INT62445 Pomc Negative_regulation of Localization of Crh 1 0.12 0.07 0.58
71 INT30268 Binding of Gnrh1 and Crh 1 0.45 0.65 0.57
72 INT77367 IFNA1 Positive_regulation of Positive_regulation of Crh 1 0.05 0.76 0.57
73 INT30267 Binding of Crh and Gnrhr 1 0.33 0.65 0.57
74 INT94499 Tnf Positive_regulation of Gene_expression of Crh 1 0.27 0.97 0.56
75 INT141020 Crh Positive_regulation of Gene_expression of Pomc 1 0.05 0.17 0.55
76 INT87557 Crh Positive_regulation of Prkaca 1 0.27 0 0.52
77 INT55208 Prl Negative_regulation of Localization of Crh 1 0.43 0 0.51
78 INT127337 Crh Regulation of LOC308670 1 0.01 0 0.51
79 INT62446 Il6 Positive_regulation of Crh 1 0.22 0.05 0.5
80 INT27066 Crh Positive_regulation of Localization of Oxt 1 0.40 0 0.48
81 INT59546 Avp Positive_regulation of Localization of Crh 1 0.05 0.08 0.47
82 INT59548 Negative_regulation of Avp Positive_regulation of Crh 1 0.04 0.08 0.47
83 INT28619 Negative_regulation of Penk Regulation of Crh 1 0.41 0 0.46
84 INT62447 Gnrh1 Regulation of Localization of Crh 1 0.40 0.17 0.45
85 INT57983 Il1b Regulation of Crh 1 0.37 0.09 0.44
86 INT57981 Regulation of Il1b Positive_regulation of Crh 1 0.22 0.1 0.44
87 INT30083 Binding of Crh and Lvp1 1 0.00 0.35 0.44
88 INT355540 Gnptg Positive_regulation of AMELX 1 0.00 2.16 0.44
89 INT139486 Oprm1 Positive_regulation of Crh 1 0.27 0.1 0.42
90 INT55202 Crh Positive_regulation of Negative_regulation of Prl 1 0.51 0 0.41
91 INT91107 Positive_regulation of Ptgs1 Positive_regulation of Localization of Crh 1 0.00 0.56 0.41
92 INT73772 NR3C1 Regulation of Regulation of Crh 1 0.02 0.68 0.38
93 INT41460 Crh Regulation of Pomc 1 0.10 0.1 0.36
94 INT26197 Qrfp Regulation of Localization of Crh 1 0.02 0 0.36
95 INT41461 Crh Regulation of Localization of Pomc 1 0.10 0.1 0.36
96 INT66368 Pomc Regulation of Positive_regulation of Crh 1 0.36 0 0.35
97 INT37552 Crh Regulation of Avp 1 0.22 0 0.34
98 INT37551 Positive_regulation of Crh Regulation of Avp 1 0.38 0 0.34
99 INT37553 Crh Regulation of FDX1 1 0.03 0 0.34
100 INT30418 Crh Negative_regulation of Localization of Gh1 1 0.41 0.72 0.33
101 INT30524 Crh Regulation of Oprl1 1 0.15 0.15 0.33
102 INT82904 Crh Negative_regulation of ge 1 0.00 1.3 0.33
103 INT26196 Npy Positive_regulation of Localization of Crh 1 0.40 0 0.33
104 INT26071 Adarb1 Regulation of Localization of Crh 1 0.01 0.21 0.32
105 INT30420 Crh Positive_regulation of Localization of Gh1 1 0.67 0.47 0.32
106 INT107944 Crh Regulation of Adarb1 1 0.06 0 0.32
107 INT141019 Crh Positive_regulation of Gene_expression of Pomc 1 0.20 0.1 0.31
108 INT126696 Binding of Crhr1 and Crh 3 0.50 0.44 0.29
109 INT334499 Binding of AMELX and IL4 1 0.12 0.47 0.29
110 INT74331 Crh Regulation of Transcription of Penk 1 0.40 0.25 0.29
111 INT74335 Penk Regulation of Transcription of Crh 1 0.40 0.25 0.29
112 INT74336 Crh Regulation of Transcription of Egr1 1 0.49 0.24 0.28
113 INT74330 Crh Regulation of Transcription of Fos 1 0.49 0.24 0.28
114 INT346196 AMELX Negative_regulation of CRP 1 0.04 0.36 0.26
115 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26
116 INT56978 Crh Positive_regulation of Localization of Gnrh1 1 0.10 0 0.24
117 INT154523 Binding of Oxt and Crh 1 0.11 0 0.24
118 INT92205 Crh Positive_regulation of Localization of SST 1 0.30 0.87 0.21
119 INT177479 Negative_regulation of Crh Regulation of POMC 1 0.05 0.84 0.21
120 INT33560 Binding of POMC and Crh 1 0.24 0.22 0.2
121 INT62451 Il2 Regulation of Localization of Crh 1 0.53 0.19 0.2
122 INT25053 Crh Regulation of PLOD1 1 0.11 0 0.19
123 INT25052 Crh Regulation of FSHR 1 0.08 0 0.19
124 INT59589 Npy Regulation of Crh 1 0.27 0 0.18
125 INT55988 POMC Positive_regulation of Negative_regulation of Crh 1 0.01 0 0.18
126 INT342647 Negative_regulation of Binding of Avp and Crh 1 0.37 0.64 0.18
127 INT59588 Npy Positive_regulation of Crh 1 0.41 0 0.18
128 INT59587 Npy Regulation of Gene_expression of Crh 1 0.27 0 0.18
129 INT33694 Crh Negative_regulation of Rhd 1 0.08 1.41 0.18
130 INT124236 Crh Regulation of Localization of BTF3 1 0.00 0.32 0.18
131 INT34351 Crh Regulation of DBI 1 0.00 0.25 0.17
132 INT222505 Gene_expression of Crh Negative_regulation of Gene_expression of Hpse 1 0.02 0.55 0.17
133 INT25050 Crh Negative_regulation of PLOD1 1 0.11 0 0.17
134 INT25054 Crh Negative_regulation of FSHR 1 0.07 0 0.17
135 INT17922 Positive_regulation of Crh Positive_regulation of Fos 1 0.23 0.19 0.17
136 INT5520 Negative_regulation of Dbi Negative_regulation of Gene_expression of Crh 1 0.21 0.44 0.16
137 INT5521 Oprd1 Negative_regulation of Gene_expression of Crh 1 0.11 0.43 0.16
138 INT5517 Negative_regulation of Dbi Negative_regulation of Crh 1 0.27 0.44 0.16
139 INT5522 Pomc Negative_regulation of Gene_expression of Crh 1 0.27 0.39 0.16
140 INT5516 Oprd1 Negative_regulation of Crh 1 0.15 0.43 0.16
141 INT30084 Lvp1 Regulation of Localization of Crh 1 0.00 0.14 0.16
142 INT30421 Gnrhr Regulation of Crh 1 0.11 0.27 0.15
143 INT39154 Crh Positive_regulation of Avp 2 0.11 0.15 0.14
144 INT177480 Positive_regulation of Crh Positive_regulation of Regulation of POMC 1 0.06 0.46 0.14
145 INT293119 Agtr1a Regulation of Positive_regulation of Crh 1 0.12 0.37 0.14
146 INT293115 Agt Regulation of Positive_regulation of Crh 1 0.16 0.37 0.14
147 INT33749 Crh Positive_regulation of Localization of Agt 1 0.31 0 0.13
148 INT8162 Fos Regulation of Gene_expression of Crh 1 0.35 0.31 0.13
149 INT62748 Crh Regulation of Gal 1 0.27 0.36 0.12
150 INT168578 Crh Positive_regulation of Hrasls 1 0.06 0 0.12
151 INT5519 Dbi Negative_regulation of Crh 1 0.31 0.28 0.1
152 INT186539 Crh Regulation of Hpse 1 0.09 0.52 0.1
153 INT124235 Crh Regulation of BTF3 1 0.00 0.16 0.09
154 INT75372 ecs Positive_regulation of Gene_expression of Crh 1 0.03 0.62 0.09
155 INT81424 Binding of Crh and Olr1000 1 0.06 0.17 0.09
156 INT25950 Ins1 Regulation of Crh 1 0.14 0.07 0.09
157 INT33471 POMC Positive_regulation of Localization of Crh 1 0.11 0 0.08
158 INT94353 Crh Negative_regulation of Positive_regulation of Dbi 1 0.03 0.14 0.08
159 INT94354 Crh Negative_regulation of Dbi 1 0.03 0.14 0.08
160 INT32745 Crh Positive_regulation of Localization of Pomc 2 0.16 0.49 0.07
161 INT25296 Oxt Regulation of Localization of Crh 1 0.01 0.18 0.07
162 INT53857 Negative_regulation of Crh Positive_regulation of GNRH1 1 0.13 0.5 0.07
163 INT75373 ecs Regulation of Gene_expression of Crh 1 0.01 1.18 0.06
164 INT29385 Positive_regulation of Crh Regulation of Pomc 1 0.00 0.21 0.06
165 INT180344 CYP2A6 Regulation of AMELX 1 0.01 2.01 0.05
166 INT37493 Crh Negative_regulation of Gnrh1 1 0.36 0 0.05
167 INT222544 Binding of Ucn and Crh 1 0.02 0 0.05
168 INT122713 Guca2b Positive_regulation of RTCA 1 0.03 0.16 0.05
169 INT222565 Crh Positive_regulation of Transcription of Pomc 1 0.10 0.35 0.03
170 INT33690 Crh Regulation of Regulation of Gnrh1 1 0.31 0.95 0.03
171 INT186502 Binding of AMELX and HLA-A 1 0.00 0.71 0
172 INT292088 Binding of AMELX and ANGPT1 1 0.00 0.9 0
173 INT210581 Binding of AMELX and Tnfsf11 1 0.01 0.15 0
174 INT25051 Crh Negative_regulation of Localization of FSHR 1 0.07 0 0
175 INT180349 Binding of AMELX and BTG3 1 0.00 0.56 0
176 INT25049 Crh Negative_regulation of Localization of PLOD1 1 0.10 0 0
177 INT222413 Nps Positive_regulation of Localization of Crh 1 0.03 0.66 0
178 INT33693 Crh Regulation of Regulation of Rhd 1 0.06 0.86 0
179 INT355541 Binding of AMELX and Tnfrsf25 1 0.00 1.36 0
180 INT355522 Binding of AMELX and HLA-DRB7 1 0.00 1.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ion homeostasis. They are ordered first by their pain relevance and then by number of times they were reported in ion homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1562 Localization of Crh 499 0.81 126.74 236.68
2 INT438 Gene_expression of Crh 376 0.78 159.11 169.17
3 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14
4 INT1898 Regulation of Crh 220 0.62 61.33 102.64
5 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28
6 INT5509 Positive_regulation of Localization of Crh 91 0.70 30.65 53.92
7 INT5502 Positive_regulation of Gene_expression of Crh 69 0.70 43.06 42.23
8 INT5507 Regulation of Localization of Crh 57 0.61 8.43 30.26
9 INT5514 Negative_regulation of Localization of Crh 64 0.58 8.12 29.29
10 INT16879 Binding of Crh 72 0.48 21.65 28.43
11 INT21379 Transcription of Crh 65 0.72 15.64 27.92
12 INT5503 Negative_regulation of Gene_expression of Crh 38 0.59 16.82 21.34
13 INT440 Regulation of Gene_expression of Crh 44 0.62 17.71 20.73
14 INT5498 Positive_regulation of Positive_regulation of Crh 19 0.70 9.82 7.97
15 INT22336 Positive_regulation of Transcription of Crh 18 0.68 4.61 6.91
16 INT22485 Negative_regulation of Positive_regulation of Crh 13 0.59 4.49 5.46
17 INT18244 Regulation of Positive_regulation of Crh 11 0.45 3.87 5.41
18 INT22338 Negative_regulation of Transcription of Crh 11 0.43 2.09 5.24
19 INT63441 Regulation of Transcription of Crh 9 0.60 4.51 3.9
20 INT28715 Negative_regulation of Regulation of Crh 7 0.43 0.97 3.06
21 INT5510 Negative_regulation of Negative_regulation of Crh 8 0.43 1.05 2.61
22 INT22339 Positive_regulation of Negative_regulation of Crh 5 0.67 1.36 2.59
23 INT30834 Regulation of Negative_regulation of Crh 3 0.45 0.62 1.81
24 INT18710 Regulation of Regulation of Crh 6 0.60 0.79 1.6
25 INT25043 Positive_regulation of Regulation of Crh 5 0.50 1 1.06
26 INT58050 Regulation of Binding of Crh 2 0.42 0.84 0.86
27 INT180361 Positive_regulation of AMELX 7 0.12 6.03 0.76
28 INT180353 Binding of AMELX 10 0.04 15.34 0.4
29 INT83897 Protein_catabolism of Crh 2 0.86 1.75 0.39
30 INT144885 Gene_expression of AMELX 4 0.11 2.89 0.29
31 INT180362 Negative_regulation of AMELX 2 0.11 1.51 0.27
32 INT180352 Regulation of AMELX 1 0.03 4.02 0.21
33 INT55986 Positive_regulation of Binding of Crh 1 0.48 0.76 0.19
34 INT92090 Negative_regulation of Protein_catabolism of Crh 1 0.04 0.99 0.12
35 INT180368 Localization of AMELX 1 0.06 1.9 0.03
36 INT180370 Phosphorylation of AMELX 1 0.06 3.05 0
37 INT193202 Positive_regulation of Gene_expression of AMELX 1 0.04 0.18 0
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