GO:0050803

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Name regulation of synapse structure and activity
Categary Process
Go Slim No
Go Link GO:0050803
Unique Molecular Interactions 220
Total Molecular Interactions 339
Total Single Events 3420
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of synapse structure and activity. They are ordered first by their pain relevance and then by number of times they were reported for regulation of synapse structure and activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
2 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
3 INT154203 Binding of Pick1 and Grm7 1 0.41 1.64 1.28
4 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
5 INT296458 Binding of Gria2 and Pick1 3 0.24 1.86 1.07
6 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
7 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
8 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
9 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
10 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
11 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
12 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
13 INT2700 Binding of App and Cpe 1 0.00 0 0.63
14 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
15 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
16 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
17 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
18 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
19 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
20 INT296463 Binding of Gria1 and Pick1 1 0.16 0.32 0.59
21 INT296486 Binding of Pick1 and GRIP1 1 0.03 0.32 0.59
22 INT296475 Binding of Pick1 and Myo18a 2 0.01 1.63 0.57
23 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
24 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
25 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
26 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
27 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
28 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
29 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
30 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
31 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
32 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
33 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
34 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
35 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
36 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
37 INT354719 Binding of ASIC1 and Pick1 1 0.40 2.34 0.4
38 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
39 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4
40 INT78122 Binding of App and 20S 1 0.16 0.61 0.4
41 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
42 INT296476 Binding of Pick1 and Rbm39 1 0.00 0.57 0.37
43 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37
44 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35
45 INT354697 Positive_regulation of Binding of Gria2 and Pick1 1 0.08 0.73 0.33
46 INT124376 Prodh2 Positive_regulation of App 1 0.00 0.66 0.33
47 INT124379 Prodh2 Positive_regulation of Localization of App 1 0.00 0.66 0.33
48 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32
49 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32
50 INT147434 Psenen Positive_regulation of APP 1 0.01 0.58 0.32
51 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31
52 INT242399 Cyp19a1 Negative_regulation of Gene_expression of Bad 1 0.00 1.32 0.31
53 INT296447 Pick1 Regulation of Gria2 1 0.16 0.49 0.3
54 INT242398 Cyp19a1 Positive_regulation of Bcl2 1 0.00 1.28 0.3
55 INT68977 App Positive_regulation of Localization of Mmp9 1 0.05 0.38 0.3
56 INT334834 Binding of Pick1 and Camkk1 1 0.00 0.5 0.3
57 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
58 INT319220 FSIP1 Regulation of APP 1 0.29 1.46 0.29
59 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
60 INT274946 Binding of Pick1 and Insrr 1 0.00 0 0.28
61 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
62 INT274944 Binding of Dlg4 and Pick1 1 0.04 0 0.28
63 INT274934 Binding of Pick1 and Grip1 1 0.05 0 0.27
64 INT79592 Binding of APP and Reg1 1 0.01 0.16 0.27
65 INT25946 Regulation of Binding of Penk and App 1 0.18 0.19 0.27
66 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27
67 INT25944 Binding of Penk and App 1 0.15 0.19 0.27
68 INT356094 Binding of App and Tg 1 0.08 0.12 0.26
69 INT139980 Negative_regulation of CTSB Negative_regulation of Gene_expression of APP 1 0.15 0.7 0.26
70 INT139981 CTSB Negative_regulation of Gene_expression of APP 1 0.11 0.7 0.26
71 INT39010 App Negative_regulation of Gene_expression of Gnrh1 1 0.05 0.07 0.26
72 INT114244 Cpox Negative_regulation of Gene_expression of APP 1 0.00 0.7 0.25
73 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
74 INT191619 Binding of App and Flna 1 0.04 0.18 0.24
75 INT70082 Binding of APP and TGM1 1 0.00 1.22 0.22
76 INT354710 Pick1 Regulation of ASIC1 1 0.37 1.12 0.21
77 INT319971 App Regulation of Enpp1 1 0.02 0.72 0.21
78 INT354721 Pick1 Regulation of Gene_expression of ASIC1 1 0.37 1.1 0.2
79 INT145140 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP19A1 1 0.13 0.47 0.2
80 INT354700 Binding of Pick1 and Bfar 1 0.05 0.9 0.19
81 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19
82 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19
83 INT25945 Plat Regulation of App 1 0.15 0.25 0.17
84 INT25947 Plat Regulation of Transcription of App 1 0.15 0.25 0.17
85 INT319974 App Negative_regulation of Enpp1 1 0.02 0.58 0.16
86 INT204478 Fmr1 Regulation of Gene_expression of App 1 0.50 1.44 0.16
87 INT201744 Ngf Regulation of Transcription of App 1 0.06 0.39 0.15
88 INT201728 Ntrk1 Regulation of Transcription of App 1 0.03 0.39 0.15
89 INT319972 App Negative_regulation of Gene_expression of Enpp1 1 0.02 1.87 0.15
90 INT286476 Binding of App and Itm2b 1 0.47 5.24 0.14
91 INT153154 OPN1MW Regulation of PTPRF 1 0.03 0.51 0.14
92 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
93 INT139849 Binding of App and Bace1 7 0.41 0.85 0.13
94 INT204489 Fmr1 Regulation of App 1 0.50 1.71 0.13
95 INT220622 App Positive_regulation of Rip 2 0.14 0.24 0.12
96 INT308660 Binding of Ager and App 1 0.08 1.22 0.12
97 INT70084 Negative_regulation of Binding of APP and TGM1 1 0.00 0.61 0.11
98 INT70083 TGM1 Positive_regulation of Binding of APP 1 0.00 0.61 0.11
99 INT123101 Binding of APP and Ache 1 0.07 0.32 0.11
100 INT354712 Pick1 Positive_regulation of Gene_expression of ASIC1 1 0.39 0.74 0.11
101 INT204477 Binding of App and Scn10a 1 0.17 0.36 0.1
102 INT139847 Binding of App and Bace2 1 0.03 0.16 0.1
103 INT139850 Binding of MBTPS1 and App 1 0.00 0.16 0.1
104 INT193963 App Regulation of Gene_expression of Ps 1 0.06 0.93 0.09
105 INT220394 MRXS5 Positive_regulation of Gene_expression of CYP19A1 1 0.00 0.89 0.09
106 INT356112 Binding of App and Apba1 1 0.24 0.29 0.09
107 INT262701 App Positive_regulation of Aplp2 1 0.12 0.25 0.09
108 INT262705 App Positive_regulation of Aplp1 1 0.13 0.25 0.09
109 INT124036 Binding of App and Dnahc8 1 0.03 0.14 0.09
110 INT285070 CCL16 Positive_regulation of Gene_expression of CYP19A1 1 0.02 0.69 0.09
111 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09
112 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
113 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
114 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
115 INT204487 Positive_regulation of Fmr1 Regulation of Gene_expression of App 1 0.30 0.8 0.08
116 INT354713 Pick1 Regulation of Localization of ASIC1 1 0.22 0.48 0.08
117 INT261262 AIS Negative_regulation of Cyp19a1 1 0.01 0.2 0.08
118 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07
119 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
120 INT198934 Binding of App and Lrp1b 2 0.27 1.62 0.05
121 INT288099 Binding of APP and App 1 0.01 1.04 0.05
122 INT356086 Negative_regulation of Binding of App and Lrp1b 1 0.30 1.42 0.05
123 INT356110 Binding of App and Slc5a7 1 0.02 0.25 0.05
124 INT236009 HIST2H2AA3 Positive_regulation of Protein_catabolism of APP 1 0.02 0.19 0.04
125 INT354715 Binding of PKN1 and Pick1 1 0.01 0.19 0.04
126 INT236015 HIST2H2AA3 Positive_regulation of Gene_expression of APP 1 0.02 0.95 0.04
127 INT162753 Binding of APP and Slc30a2 1 0.00 1.25 0.04
128 INT319973 App Regulation of Gene_expression of Mapk12 1 0.02 0.98 0.04
129 INT162754 Negative_regulation of Binding of APP and Slc30a2 1 0.00 1.26 0.04
130 INT354709 Gene_expression of Pick1 Positive_regulation of ASIC1 1 0.39 0.17 0.04
131 INT187732 Binding of CYP19A1 and Cyp11a1 1 0.01 0.68 0.04
132 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
133 INT198921 Binding of App and Lrp1 3 0.32 2.7 0.03
134 INT356102 Negative_regulation of Binding of App and Lrp1 1 0.32 0.71 0.03
135 INT237090 Binding of App and Bnip3l 1 0.18 1.66 0.03
136 INT213262 IL6 Positive_regulation of CYP19A1 1 0.11 1.63 0.03
137 INT230137 OSBP Regulation of APP 1 0.59 0.15 0.03
138 INT356097 Binding of App and Apba3 1 0.12 0.12 0.03
139 INT270432 Lhb Positive_regulation of APP 1 0.03 0.51 0.03
140 INT354711 Regulation of Binding of ASIC1 and Pick1 1 0.51 0.19 0.03
141 INT187676 Binding of CYP19A1 and SHBG 1 0.01 0.63 0.03
142 INT356090 Binding of Apba2 and App 1 0.00 0.12 0.03
143 INT270431 Gnrh1 Positive_regulation of APP 1 0.06 0.51 0.03
144 INT354716 Pick1 Regulation of Binding of ASIC1 1 0.37 0.2 0.03
145 INT133804 Binding of CYP2B6 and CYP19A1 3 0.09 2.26 0
146 INT220628 Gene_expression of Gga1 Positive_regulation of App 2 0.22 0 0
147 INT354722 Pick1 Positive_regulation of Localization of ASIC1 1 0.39 0 0
148 INT220625 Negative_regulation of Binding of App and Bace1 1 0.44 0.09 0
149 INT176564 Binding of Cyp17a1 and Cyp19a1 1 0.03 0.33 0
150 INT278014 Ptprf Regulation of Localization of Gh 1 0.61 0.31 0
151 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0
152 INT356108 App Positive_regulation of Positive_regulation of Lrp1 1 0.43 0.52 0
153 INT333770 Bace1 Regulation of Gene_expression of App 1 0.57 0 0
154 INT204493 App Negative_regulation of Scn10a 1 0.20 0.74 0
155 INT236013 HIST2H2AA3 Regulation of Gene_expression of APP 1 0.01 0 0
156 INT204499 App Regulation of Fmr1 1 0.50 0.59 0
157 INT204492 Negative_regulation of Binding of App and Fmr1 1 0.42 0.28 0
158 INT356083 Binding of App and Notch1 1 0.02 0.2 0
159 INT242176 AIS Negative_regulation of CYP19A1 1 0.07 0.69 0
160 INT354706 Pick1 Positive_regulation of ASIC1 1 0.36 0 0
161 INT356095 Lrp1 Positive_regulation of App 1 0.37 0.53 0
162 INT204502 Binding of App and RNPC3 1 0.01 0.09 0
163 INT356091 Lrp1 Positive_regulation of Positive_regulation of App 1 0.43 0.52 0
164 INT220411 Ptger2 Positive_regulation of Cyp19a1 1 0.09 0.83 0
165 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0
166 INT204481 App Negative_regulation of Positive_regulation of Scn10a 1 0.20 0.74 0
167 INT356100 Binding of Apbb1 and App 1 0.14 0.43 0
168 INT356087 Binding of App and Ncstn 1 0.17 0.07 0
169 INT299459 Foxl2 Positive_regulation of Cyp19a1 1 0.34 0.07 0
170 INT230140 Gene_expression of OSBP Regulation of Localization of APP 1 0.30 0.06 0
171 INT198933 Binding of Apoe and App 1 0.33 0.19 0
172 INT198927 Lrp1 Regulation of App 1 0.14 0.42 0
173 INT204482 Fmr1 Negative_regulation of App 1 0.42 0.74 0
174 INT334643 Binding of APP and HM13 1 0.02 0 0
175 INT354696 Positive_regulation of Binding of Pick1 and Bfar 1 0.06 0.27 0
176 INT242178 CYP19A1 Regulation of Cyp11a1 1 0.01 0.35 0
177 INT356118 Binding of SORL1 and App 1 0.41 0.43 0
178 INT230146 Binding of APP and SORL1 1 0.20 0.17 0
179 INT356109 Rab6a Regulation of App 1 0.14 0.05 0
180 INT176569 Binding of FSHR and Cyp19a1 1 0.04 0.06 0
181 INT180123 Egfl7 Positive_regulation of App 1 0.02 0.07 0
182 INT356106 Gene_expression of Pld1 Positive_regulation of App 1 0.29 0.21 0
183 INT354699 Binding of Accn2 and Pick1 1 0.07 0.22 0
184 INT225629 APP Positive_regulation of Positive_regulation of nr 1 0.01 0.08 0
185 INT217396 Binding of Abca1 and App 1 0.26 0.83 0
186 INT262708 Bace1 Positive_regulation of Gene_expression of App 1 0.44 2.82 0
187 INT198915 Binding of App and Lrp8 1 0.24 0.17 0
188 INT242179 Cyp11a1 Regulation of CYP19A1 1 0.01 0.7 0
189 INT230139 OSBP Regulation of Phosphorylation of APP 1 0.50 0 0
190 INT142955 Positive_regulation of Binding of APP and BACE1 1 0.48 0.5 0
191 INT262713 App Regulation of Transcription of Bace1 1 0.45 0.31 0
192 INT198925 Binding of App and Ldlr 1 0.14 0.15 0
193 INT187670 Gene_expression of FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.16 0 0
194 INT278017 Ptprf Regulation of Igf1 1 0.48 0.31 0
195 INT333773 Bace1 Regulation of App 1 0.25 0 0
196 INT230143 OSBP Regulation of Gene_expression of APP 1 0.50 0.1 0
197 INT142954 Binding of APP and BACE1 1 0.37 0.5 0
198 INT204491 Ass1 Positive_regulation of App 1 0.01 0.43 0
199 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
200 INT50104 Bche Regulation of Localization of App 1 0.43 0.2 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of synapse structure and activity. They are ordered first by their pain relevance and then by number of times they were reported in regulation of synapse structure and activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31
2 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
3 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
4 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
5 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
6 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
7 INT11625 Localization of App 98 0.78 55.46 20.86
8 INT16794 Binding of App 103 0.48 64.87 19.79
9 INT65502 Regulation of App 77 0.62 52.05 19.44
10 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
11 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
12 INT54052 Gene_expression of App 33 0.78 25.08 14.7
13 INT29745 Binding of APP 47 0.48 26.49 12.4
14 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
15 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
16 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
17 INT41569 Regulation of APP 32 0.62 17.15 9.4
18 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
19 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
20 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
21 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
22 INT135760 Regulation of Gene_expression of Cyp19a1 2 0.62 1.15 5.81
23 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37
24 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
25 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
26 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
27 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
28 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
29 INT58003 Localization of APP 32 0.80 13.75 4.2
30 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
31 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
32 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
33 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56
34 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
35 INT154198 Binding of Pick1 9 0.48 6.91 3.16
36 INT116376 Transcription of Cyp19a1 2 0.40 0.74 3.04
37 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99
38 INT113277 Positive_regulation of Gene_expression of CYP19A1 13 0.69 10.23 2.97
39 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96
40 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93
41 INT178772 Transcription of App 17 0.70 10.79 2.79
42 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78
43 INT54054 Binding of App 4 0.48 10.89 2.78
44 INT166378 Positive_regulation of Gene_expression of Pick1 6 0.61 1.94 2.77
45 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36
46 INT11626 Regulation of Localization of App 4 0.45 1.51 2.34
47 INT56030 Regulation of App 8 0.62 4.06 2.32
48 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24
49 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12
50 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09
51 INT342803 Positive_regulation of Transcription of Cyp19a1 1 0.30 0.33 2.08
52 INT39008 Localization of App 13 0.77 9.07 2.05
53 INT166380 Positive_regulation of Pick1 5 0.44 1.26 1.95
54 INT81347 Regulation of Cyp19a1 7 0.40 2.1 1.94
55 INT142774 Regulation of Phosphorylation of App 1 0.59 2.27 1.93
56 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78
57 INT107915 Regulation of Negative_regulation of App 6 0.45 4.47 1.76
58 INT10596 Positive_regulation of Cyp19a1 10 0.42 2.08 1.62
59 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52
60 INT58004 Positive_regulation of Localization of APP 5 0.46 2.1 1.5
61 INT25943 Transcription of App 5 0.53 1.79 1.44
62 INT127889 Regulation of Gene_expression of CYP19A1 11 0.62 6.7 1.41
63 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41
64 INT129700 Regulation of Positive_regulation of App 3 0.43 1.86 1.41
65 INT141529 Regulation of Positive_regulation of APP 3 0.44 0.31 1.34
66 INT103488 Positive_regulation of Localization of App 5 0.50 3.05 1.28
67 INT100137 Positive_regulation of Negative_regulation of App 2 0.41 1.26 1.16
68 INT135899 Regulation of Binding of APP 3 0.45 1.22 1.14
69 INT62237 Gene_expression of Ptprf 2 0.65 1.63 1.08
70 INT39009 Negative_regulation of App 6 0.38 3.37 1.07
71 INT168395 Transcription of Cyp19a1 2 0.51 2.5 1.06
72 INT168397 Gene_expression of Cyp19a1 2 0.06 1.77 1.06
73 INT166377 Gene_expression of Pick1 3 0.68 2.9 0.97
74 INT168398 Localization of Cyp19a1 1 0.08 0.89 0.97
75 INT167607 Positive_regulation of Binding of App 8 0.50 2.97 0.86
76 INT162514 Positive_regulation of Regulation of APP 1 0.41 0.37 0.86
77 INT99375 Positive_regulation of Binding of APP 3 0.61 1.63 0.83
78 INT79344 Binding of Cyp19a1 4 0.33 0.61 0.8
79 INT118078 Phosphorylation of APP 10 0.79 2.5 0.76
80 INT99820 Negative_regulation of Localization of APP 2 0.37 0.75 0.76
81 INT161339 Localization of Cyp19a1 1 0.73 1.32 0.71
82 INT112208 Negative_regulation of Gene_expression of App 4 0.59 1.88 0.68
83 INT25942 Regulation of Transcription of App 3 0.27 0.95 0.68
84 INT141528 Regulation of Localization of APP 2 0.52 0.4 0.67
85 INT61147 Protein_catabolism of App 3 0.60 3.76 0.63
86 INT118077 Negative_regulation of Phosphorylation of APP 1 0.07 0.74 0.61
87 INT142112 Regulation of Regulation of App 3 0.39 2.46 0.59
88 INT171105 Positive_regulation of Positive_regulation of CYP19A1 5 0.39 4.02 0.58
89 INT225462 Positive_regulation of Positive_regulation of APP 3 0.44 1.41 0.55
90 INT353896 Negative_regulation of Phosphorylation of Cyp19a1 1 0.22 0.47 0.55
91 INT353893 Phosphorylation of Cyp19a1 1 0.31 0.46 0.55
92 INT78117 Positive_regulation of Positive_regulation of App 4 0.48 2.6 0.51
93 INT137556 Negative_regulation of Cyp19a1 3 0.35 1.53 0.48
94 INT71046 Localization of CYP19A1 2 0.78 1.38 0.48
95 INT187717 Regulation of Negative_regulation of CYP19A1 11 0.42 2.85 0.45
96 INT127890 Positive_regulation of Negative_regulation of CYP19A1 6 0.50 1.41 0.45
97 INT167614 Positive_regulation of Protein_catabolism of App 1 0.30 0.88 0.44
98 INT166384 Positive_regulation of Positive_regulation of Pick1 1 0.15 0.19 0.44
99 INT84915 Negative_regulation of Gene_expression of Cyp19a1 2 0.15 1.29 0.42
100 INT168101 Positive_regulation of PTPRF 2 0.45 1.04 0.37
101 INT181122 Positive_regulation of Gene_expression of Cyp19a1 1 0.02 0.68 0.36
102 INT209323 Positive_regulation of Transcription of CYP19A1 5 0.32 4.22 0.33
103 INT54056 Negative_regulation of Binding of App 2 0.37 0.99 0.32
104 INT178773 Positive_regulation of Regulation of App 2 0.49 1.01 0.32
105 INT178774 Positive_regulation of Transcription of App 2 0.49 1.17 0.31
106 INT354672 Positive_regulation of Binding of Pick1 1 0.61 1.32 0.31
107 INT212615 Localization of PTPRF 2 0.68 0.34 0.28
108 INT282487 Regulation of Negative_regulation of Cyp19a1 1 0.22 0.6 0.27
109 INT175360 Regulation of Transcription of CYP19A1 1 0.04 1 0.19
110 INT180104 Positive_regulation of Phosphorylation of App 2 0.54 0.87 0.16
111 INT286326 Regulation of Transcription of App 3 0.45 0.26 0.15
112 INT96224 Positive_regulation of Ptprf 1 0.11 0.36 0.14
113 INT69045 Negative_regulation of Positive_regulation of App 1 0.05 0.28 0.13
114 INT354674 Negative_regulation of Pick1 1 0.37 0.48 0.12
115 INT187313 Regulation of PTPRF 1 0.01 0 0.11
116 INT187312 Regulation of Positive_regulation of PTPRF 1 0.03 0 0.11
117 INT142958 Positive_regulation of Protein_catabolism of APP 3 0.55 2.04 0.1
118 INT39007 Negative_regulation of Localization of App 3 0.10 0.94 0.08
119 INT354677 Negative_regulation of Gene_expression of Pick1 1 0.51 0.06 0.08
120 INT238567 Gene_expression of Syngap1 1 0.47 0.15 0.08
121 INT354660 Positive_regulation of Negative_regulation of Pick1 1 0.44 0.49 0.08
122 INT220399 Positive_regulation of Cyp19a1 4 0.43 2.2 0.07
123 INT354856 Regulation of Cyp19a1 1 0.37 1.36 0.06
124 INT187718 Negative_regulation of Positive_regulation of CYP19A1 1 0.33 0.61 0.05
125 INT354664 Regulation of Gene_expression of Pick1 1 0.39 0 0.04
126 INT180116 Negative_regulation of Transcription of App 1 0.38 0 0.04
127 INT182830 Negative_regulation of Protein_catabolism of APP 2 0.35 2.09 0.03
128 INT255657 Negative_regulation of Protein_catabolism of App 1 0.20 1.07 0.03
129 INT354680 Regulation of Binding of Pick1 1 0.39 0.51 0.03
130 INT351386 Negative_regulation of Phosphorylation of App 1 0.42 0.82 0.03
131 INT187720 Negative_regulation of Negative_regulation of CYP19A1 5 0.34 0.99 0
132 INT50103 Regulation of Localization of App 2 0.26 0.2 0
133 INT234255 Transcription of APP 2 0.49 0.98 0
134 INT187725 Positive_regulation of Localization of CYP19A1 1 0.39 0.23 0
135 INT286323 Negative_regulation of Protein_catabolism of App 1 0.11 0.54 0
136 INT220400 Positive_regulation of Transcription of Cyp19a1 1 0.49 0.84 0
137 INT213932 Negative_regulation of Negative_regulation of Cyp19a1 1 0.31 0.7 0
138 INT194353 Negative_regulation of Binding of Cyp19a1 1 0.15 0 0
139 INT145141 Negative_regulation of Transcription of CYP19A1 1 0.59 0.3 0
140 INT187719 Negative_regulation of Localization of CYP19A1 1 0.33 0.78 0
141 INT278004 Localization of Ptprf 1 0.68 0.31 0
142 INT222306 Negative_regulation of Binding of CYP19A1 1 0.20 1.04 0
143 INT354663 Localization of Pick1 1 0.65 0 0
144 INT236037 Positive_regulation of Phosphorylation of APP 1 0.48 0.14 0
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