GO:0050840

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Name extracellular matrix binding
Categary Function
Go Slim No
Go Link GO:0050840
Unique Molecular Interactions 696
Total Molecular Interactions 1074
Total Single Events 8304
Pain Genes Associated 29

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for extracellular matrix binding. They are ordered first by their pain relevance and then by number of times they were reported for extracellular matrix binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113550 Binding of FN1 and VTN 6 0.30 5.24 1.91
2 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
3 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71
4 INT151514 Olfr155 Negative_regulation of Gene_expression of VEGFA 1 0.00 1.8 1.42
5 INT351205 VEGFA Positive_regulation of Binding of MRGPRX1 1 0.08 0.65 1.35
6 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
7 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
8 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
9 INT134487 Positive_regulation of TGFBI Positive_regulation of Ltp 1 0.03 1.19 1.11
10 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
11 INT150787 ZNF398 Positive_regulation of Gene_expression of SPARC 1 0.13 1.02 1.05
12 INT161231 Positive_regulation of Htr1a Positive_regulation of Gene_expression of VEGFA 1 0.67 0.16 0.95
13 INT137922 VEGFA Positive_regulation of Oprm1 1 0.06 0 0.94
14 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
15 INT137921 VEGFA Positive_regulation of Ephb2 1 0.03 0 0.93
16 INT116108 VEGFA Positive_regulation of SEC23IP 1 0.10 0.3 0.83
17 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
18 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
19 INT136795 Spp1 Positive_regulation of Chuk 1 0.11 1.54 0.77
20 INT113549 Binding of VTN and alphavbeta3 integrin receptor 1 0.09 2.05 0.76
21 INT295711 MMP9 Positive_regulation of Localization of VEGFA 1 0.06 0.29 0.74
22 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
23 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
24 INT58870 Binding of ap and Bgn 1 0.13 0 0.72
25 INT308167 Binding of Eln and Tnfrsf1b 1 0.01 0.94 0.71
26 INT120018 VEGFA Positive_regulation of CCL3 1 0.01 1 0.7
27 INT120020 VEGFA Positive_regulation of CCL2 1 0.00 1 0.7
28 INT120036 VEGFA Positive_regulation of Prap1 1 0.00 1 0.7
29 INT348129 Bgn Regulation of Regulation of Hspg2 1 0.00 0.69 0.69
30 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
31 INT185802 Binding of MMP7 and SPP1 1 0.33 1.71 0.68
32 INT167355 VEGFA Regulation of RYBP 1 0.01 0.53 0.68
33 INT168295 PROC Regulation of Gene_expression of VEGFA 2 0.00 1.6 0.67
34 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 0.44 0.06 0.65
35 INT174860 VEGFA Positive_regulation of Localization of CCL2 1 0.21 1.68 0.63
36 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
37 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61
38 INT224731 Binding of VEGFA and Cia1 1 0.01 0.91 0.61
39 INT224733 Negative_regulation of Binding of VEGFA and Cia1 1 0.01 0.91 0.61
40 INT98629 VEGFA Positive_regulation of Gene_expression of EGR1 1 0.52 0.42 0.61
41 INT98628 VEGFA Positive_regulation of Transcription of EGR1 1 0.52 0.42 0.61
42 INT145661 Ptger2 Positive_regulation of Gene_expression of VEGFA 4 0.27 2.73 0.6
43 INT299286 VEGFA Positive_regulation of PI3 1 0.16 0.46 0.6
44 INT65285 TGFBI Negative_regulation of Pc 1 0.20 0.79 0.59
45 INT342624 VEGFA Negative_regulation of Mmp2 1 0.09 1.54 0.58
46 INT327339 Gtf3a Positive_regulation of VEGFA 1 0.00 2.34 0.58
47 INT304326 Ptger1 Positive_regulation of Gene_expression of VEGFA 1 0.19 1.37 0.57
48 INT185809 Binding of PDX1 and SPP1 1 0.02 1.69 0.57
49 INT342621 VEGFA Negative_regulation of Timp2 1 0.09 1.53 0.57
50 INT227911 Binding of VTN and MMRN1 1 0.01 1.16 0.56
51 INT150800 THBS3 Negative_regulation of SPARC 1 0.23 0.51 0.53
52 INT194918 Csf2 Positive_regulation of Gene_expression of VEGFA 1 0.02 0.85 0.52
53 INT194919 Kitl Positive_regulation of Gene_expression of VEGFA 1 0.01 0.85 0.52
54 INT127430 VEGFA Negative_regulation of Gene_expression of TIMP1 1 0.43 0.6 0.5
55 INT185800 SPP1 Negative_regulation of Gene_expression of MMP1 1 0.26 1.03 0.49
56 INT327332 VEGFA Positive_regulation of Gene_expression of Hgfac 1 0.00 2.02 0.49
57 INT288376 IL17A Regulation of VEGFA 1 0.00 1.16 0.49
58 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48
59 INT260858 IL6 Positive_regulation of Gene_expression of VEGFA 2 0.31 1.77 0.48
60 INT305547 VEGFA Positive_regulation of Gtf3a 2 0.00 1.83 0.48
61 INT260836 Il18 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.48
62 INT331928 Negative_regulation of Cpox Negative_regulation of VEGFA 1 0.01 0.97 0.47
63 INT314053 VEGFA Positive_regulation of Gene_expression of Mmp2 1 0.02 0.2 0.47
64 INT260843 Il6 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47
65 INT260838 Il17a Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47
66 INT224698 Il17a Positive_regulation of Gene_expression of VEGFA 1 0.01 0.49 0.46
67 INT168445 Positive_regulation of C2 Positive_regulation of Positive_regulation of Dcn 1 0.14 0.66 0.46
68 INT224699 Il18 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.49 0.46
69 INT106001 Binding of PLAUR and VTN 2 0.23 1.5 0.45
70 INT224451 Il1 Positive_regulation of Gene_expression of VEGFA 1 0.10 1.08 0.45
71 INT296827 Binding of BGN and USE1 1 0.01 0 0.44
72 INT224434 TNF Positive_regulation of VEGFA 1 0.10 2.04 0.44
73 INT311587 CXCL10 Regulation of Gene_expression of VEGFA 1 0.23 0.45 0.43
74 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43
75 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43
76 INT299041 SPARC Regulation of Gene_expression of NPEPPS 1 0.01 0.83 0.42
77 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42
78 INT299040 Binding of COL7A1 and SPARC 1 0.02 0.7 0.42
79 INT153720 Binding of VEGFA and Pscs 1 0.32 3.12 0.41
80 INT295709 PTGER2 Regulation of VEGFA 1 0.01 1.61 0.41
81 INT51829 Binding of ITGA2B and ANGPTL5 1 0.35 1.08 0.4
82 INT346148 Binding of ADM and VTN 1 0.15 0.93 0.39
83 INT346142 Positive_regulation of Binding of ADM and VTN 1 0.20 0.93 0.39
84 INT185811 SPP1 Positive_regulation of MMP3 1 0.14 0.83 0.38
85 INT285205 Binding of VEGFA and SLEB1 1 0.05 5.12 0.38
86 INT185814 Binding of MMP3 and SPP1 1 0.15 0.83 0.38
87 INT113551 Binding of ITGA3 and VTN 1 0.02 1.03 0.38
88 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
89 INT342623 Binding of VEGFA and Col18a1 1 0.02 1.15 0.37
90 INT185804 MMP2 Positive_regulation of SPP1 1 0.15 0.88 0.37
91 INT342606 Binding of MMP14 and VEGFA 1 0.08 1.16 0.37
92 INT113555 Negative_regulation of Binding of FN1 and VTN 1 0.23 0.87 0.37
93 INT296828 USE1 Regulation of Gene_expression of BGN 1 0.01 0.17 0.37
94 INT185795 MMP7 Positive_regulation of SPP1 1 0.38 0.81 0.37
95 INT277353 VEGFA Regulation of Mtor 1 0.02 1.11 0.37
96 INT113559 Binding of PLAU and VTN 1 0.28 0.82 0.37
97 INT113554 Negative_regulation of Binding of PLAU and VTN 1 0.32 0.87 0.37
98 INT277355 VEGFA Regulation of Trerf1 1 0.08 1.17 0.37
99 INT277354 Gene_expression of VEGFA Regulation of Mtor 1 0.02 1.1 0.37
100 INT277352 Gene_expression of VEGFA Regulation of Trerf1 1 0.08 1.16 0.37
101 INT113547 Negative_regulation of Binding of PLAUR and VTN 1 0.26 0.87 0.37
102 INT296830 USE1 Regulation of BGN 1 0.00 0.17 0.37
103 INT185798 SPP1 Positive_regulation of Gene_expression of MMP2 1 0.26 0.87 0.37
104 INT185807 SPP1 Positive_regulation of MMP7 1 0.56 0.79 0.36
105 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35
106 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34
107 INT352231 VEGFA Negative_regulation of Cntf 1 0.04 0.22 0.34
108 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
109 INT352230 VEGFA Negative_regulation of Gene_expression of Cntf 1 0.04 0.22 0.34
110 INT352232 VEGFA Negative_regulation of Vegfa 1 0.02 0.21 0.34
111 INT242995 Agt Positive_regulation of Spp1 1 0.36 1.82 0.33
112 INT110691 Lta Positive_regulation of Gene_expression of VEGFA 1 0.24 0.48 0.33
113 INT295717 VEGFA Regulation of MMP9 1 0.01 0.98 0.33
114 INT282420 Spp1 Positive_regulation of Ins1 1 0.20 1.25 0.32
115 INT127974 RAX2 Positive_regulation of SPP1 1 0.03 1.49 0.31
116 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3
117 INT140386 Spp1 Positive_regulation of NFKB1 1 0.21 1.29 0.3
118 INT210953 Binding of VEGFA and Csf2 1 0.00 0.47 0.3
119 INT281797 Positive_regulation of Chrna4 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.43 0.3
120 INT251388 Binding of Fbln2 and Gabbr1 1 0.08 0.07 0.3
121 INT140385 Spp1 Negative_regulation of FOXO3 1 0.04 1.29 0.3
122 INT179844 Nid1 Regulation of Negative_regulation of Il11 1 0.19 0 0.29
123 INT179842 Sparc Regulation of Negative_regulation of Il11 1 0.15 0 0.29
124 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
125 INT266800 Dlst Positive_regulation of Localization of VEGFA 1 0.02 0.88 0.29
126 INT185813 Binding of MMP7 and Positive_regulation of SPP1 1 0.46 0.85 0.28
127 INT185818 SPP1 Positive_regulation of Gene_expression of COL7A1 1 0.10 0.82 0.28
128 INT254353 Binding of VEGFA and MMRN1 1 0.00 0.81 0.28
129 INT344402 Binding of Crp and Spp1 1 0.05 2.92 0.28
130 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27
131 INT320794 Binding of VEGFA and Flt4 4 0.08 3.04 0.27
132 INT103156 Tnf Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.94 0.27
133 INT287699 TNF Regulation of Binding of VEGFA 1 0.02 0.46 0.27
134 INT265831 BGN Positive_regulation of ADCY1 1 0.01 0.41 0.27
135 INT318551 Binding of VEGFA and Adamts1 1 0.13 1.13 0.27
136 INT285238 EGF Positive_regulation of VEGFA 1 0.01 1.55 0.27
137 INT265830 KNG1 Positive_regulation of Localization of BGN 1 0.02 0.33 0.27
138 INT248318 RETN Regulation of VEGFA 1 0.00 0.43 0.26
139 INT203733 Thbs1 Positive_regulation of Negative_regulation of Ppara 1 0.36 1.55 0.26
140 INT109538 Lox Negative_regulation of Transcription of VEGFA 1 0.30 0.69 0.26
141 INT260423 IFNA1 Positive_regulation of Gene_expression of VEGFA 1 0.01 1.28 0.26
142 INT254359 IL1B Positive_regulation of Localization of VEGFA 1 0.01 0.87 0.26
143 INT103152 TNF Positive_regulation of Positive_regulation of VEGFA 1 0.09 0.93 0.26
144 INT126886 Protein_catabolism of SP1 Negative_regulation of Gene_expression of VEGFA 1 0.03 0.49 0.26
145 INT126887 Protein_catabolism of SP4 Negative_regulation of Gene_expression of VEGFA 1 0.15 0.49 0.26
146 INT242991 Agt Positive_regulation of Gene_expression of Spp1 1 0.21 0.66 0.26
147 INT266803 Dlst Positive_regulation of VEGFA 1 0.01 0.96 0.25
148 INT109539 Lox Negative_regulation of VEGFA 1 0.40 0.68 0.25
149 INT145660 Zfp329 Positive_regulation of Gene_expression of VEGFA 1 0.00 0.51 0.25
150 INT241401 VEGFA Positive_regulation of Gene_expression of Gopc 1 0.11 0.85 0.25
151 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
152 INT98631 Negative_regulation of VEGFA Positive_regulation of EGR1 1 0.44 0.18 0.24
153 INT208728 Positive_regulation of Dcn Positive_regulation of Cysltr1 1 0.02 0.3 0.24
154 INT316815 Ctgf Negative_regulation of Gene_expression of Sparc 1 0.47 0.64 0.24
155 INT136798 Spp1 Regulation of Gene_expression of PTGS2 1 0.08 0.65 0.24
156 INT98630 VEGFA Positive_regulation of EGR1 1 0.52 0.18 0.24
157 INT208732 Dcn Positive_regulation of Cysltr1 1 0.02 0.29 0.24
158 INT329311 Spp1 Positive_regulation of IFN1@ 1 0.20 1.2 0.23
159 INT63420 F2 Positive_regulation of Gene_expression of ITGA2B 1 0.14 0.45 0.23
160 INT304323 VEGFA Positive_regulation of Gene_expression of Ptger2 1 0.27 0.16 0.23
161 INT118840 VEGFA Regulation of Positive_regulation of Mb 1 0.05 0.36 0.23
162 INT163403 VEGFA Positive_regulation of MMP2 1 0.52 0.13 0.23
163 INT323436 VEGFA Regulation of Kdr 1 0.03 0.77 0.23
164 INT304321 Ptger4 Positive_regulation of Gene_expression of VEGFA 1 0.27 0.59 0.23
165 INT329306 Spp1 Positive_regulation of Il12a 1 0.08 1.19 0.23
166 INT304324 VEGFA Positive_regulation of Gene_expression of Ptger4 1 0.27 0.16 0.23
167 INT259623 Binding of Eln and Elane 1 0.02 1.38 0.23
168 INT299155 Smcp Negative_regulation of Spp1 1 0.00 0.7 0.22
169 INT245866 Binding of VEGFA and Fgf1 1 0.07 0.52 0.22
170 INT285640 Eln Regulation of Tnfrsf12a 1 0.14 0.16 0.22
171 INT318189 MUC5AC Regulation of Gene_expression of VEGFA 1 0.21 1.17 0.22
172 INT316810 Sparc Regulation of Col1a1 1 0.13 0.48 0.21
173 INT163096 Tlr2 Positive_regulation of Gene_expression of VEGFA 1 0.07 0.16 0.21
174 INT242994 Adipoq Negative_regulation of Spp1 1 0.19 0.59 0.21
175 INT116469 VEGFA Positive_regulation of Amfr 1 0.01 1.39 0.21
176 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21
177 INT345196 Lpar2 Positive_regulation of Gene_expression of VEGFA 1 0.08 2.14 0.2
178 INT51345 Binding of Vtn and Pomc 1 0.03 0 0.2
179 INT174861 Binding of FGF2 and VEGFA 1 0.34 0.59 0.2
180 INT51830 Positive_regulation of Binding of ITGA2B and ANGPTL5 1 0.51 0.57 0.2
181 INT51828 Negative_regulation of Binding of ITGA2B and ANGPTL5 1 0.31 0.51 0.2
182 INT236405 Mthfs Regulation of Gene_expression of VEGFA 1 0.00 0.25 0.2
183 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2
184 INT189553 DCN Negative_regulation of Transcription of VEGFA 1 0.06 0.78 0.2
185 INT93648 Adp Positive_regulation of ITGA2B 1 0.00 0.79 0.2
186 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19
187 INT175727 IL1B Regulation of VEGFA 2 0.04 0.7 0.19
188 INT179683 Binding of Col7a1 and Eln 2 0.00 3.02 0.19
189 INT329310 Spp1 Positive_regulation of Gene_expression of IFN1@ 1 0.48 0.88 0.19
190 INT280275 Tgfb1 Positive_regulation of VEGFA 1 0.02 2.46 0.19
191 INT282866 Bpifa2 Negative_regulation of Gene_expression of VEGFA 1 0.11 1.14 0.19
192 INT336892 Positive_regulation of Epc2 Positive_regulation of Localization of Spp1 1 0.00 0.62 0.19
193 INT336890 Positive_regulation of Epc2 Positive_regulation of Spp1 1 0.00 0.62 0.19
194 INT110692 Lta Regulation of Gene_expression of VEGFA 1 0.14 0.28 0.19
195 INT185805 SPP1 Regulation of MMP7 1 0.25 0.38 0.19
196 INT329309 Spp1 Regulation of Gene_expression of IFN1@ 1 0.26 0.82 0.19
197 INT50153 Positive_regulation of Bcar3 Positive_regulation of Gene_expression of Dcn 1 0.01 0.06 0.19
198 INT280274 Tgfb1 Positive_regulation of Gene_expression of VEGFA 1 0.02 2.58 0.19
199 INT304325 Positive_regulation of Ptger2 Positive_regulation of Gene_expression of VEGFA 1 0.25 0.23 0.19
200 INT337697 FGF2 Regulation of VEGFA 1 0.03 0.51 0.18

Single Events

The table below shows the top 100 pain related interactions that have been reported for extracellular matrix binding. They are ordered first by their pain relevance and then by number of times they were reported in extracellular matrix binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2
2 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65
3 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73
4 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53
5 INT101992 Localization of VEGFA 413 0.81 258.23 36.15
6 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52
7 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1
8 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31
9 INT48692 Binding of VEGFA 345 0.48 210.3 21.31
10 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14
11 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03
12 INT11508 Positive_regulation of TGFBI 24 0.70 19.81 15.78
13 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35
14 INT122901 Positive_regulation of Spp1 67 0.67 58.03 7.49
15 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51
16 INT122902 Positive_regulation of Gene_expression of Spp1 54 0.70 56.3 6.33
17 INT47127 Gene_expression of BGN 11 0.75 17.09 6.25
18 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98
19 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88
20 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78
21 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68
22 INT88935 Positive_regulation of SPP1 36 0.70 31.07 5.49
23 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9
24 INT185877 Negative_regulation of Gene_expression of DCN 3 0.33 2.37 4.85
25 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79
26 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22
27 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17
28 INT97128 Localization of SPP1 32 0.80 21.75 4.02
29 INT51831 Negative_regulation of ITGA2B 20 0.57 10.59 3.91
30 INT33739 Gene_expression of ITGA2B 25 0.75 8.19 3.6
31 INT185148 Negative_regulation of BGN 3 0.20 1.23 3.56
32 INT136791 Negative_regulation of Spp1 24 0.59 23.6 3.33
33 INT99687 Negative_regulation of Transcription of VEGFA 17 0.43 10.3 3.25
34 INT111547 Negative_regulation of Phosphorylation of VEGFA 13 0.42 5.08 3.22
35 INT88130 Gene_expression of Spp1 13 0.74 12.96 3.07
36 INT24821 Binding of VTN 14 0.47 5.83 3
37 INT126323 Regulation of TGFBI 6 0.59 3.17 2.9
38 INT322473 Localization of DCN 1 0.03 0.76 2.9
39 INT136964 Gene_expression of Dmp1 10 0.75 3.69 2.83
40 INT53755 Positive_regulation of Dcn 8 0.43 2.91 2.74
41 INT47128 Regulation of BGN 2 0.41 0.33 2.62
42 INT179791 Negative_regulation of Sparc 21 0.58 15.1 2.61
43 INT179788 Gene_expression of Sparc 42 0.77 19.96 2.57
44 INT113164 Regulation of Regulation of VEGFA 6 0.36 5.96 2.43
45 INT176517 Negative_regulation of Gene_expression of Spp1 18 0.59 15.31 2.28
46 INT136818 Positive_regulation of Phosphorylation of VEGFA 4 0.46 0.81 2.02
47 INT176510 Binding of Spp1 21 0.42 22.1 2
48 INT64709 Gene_expression of VTN 11 0.67 11.01 1.97
49 INT130364 Positive_regulation of Thbs1 7 0.62 7.73 1.97
50 INT47129 Positive_regulation of BGN 4 0.46 2.29 1.93
51 INT122195 Regulation of Localization of VEGFA 13 0.57 10.61 1.92
52 INT176516 Localization of Spp1 28 0.76 19.39 1.9
53 INT89971 Localization of Sparc 10 0.80 10.25 1.85
54 INT179670 Protein_catabolism of Eln 3 0.19 6.16 1.84
55 INT63029 Gene_expression of Vtn 4 0.14 2.8 1.8
56 INT37954 Negative_regulation of Dcn 6 0.41 0.62 1.72
57 INT133311 Binding of SPP1 10 0.37 9.47 1.65
58 INT322472 Negative_regulation of Localization of DCN 1 0.02 0.47 1.64
59 INT126322 Negative_regulation of TGFBI 4 0.41 2.12 1.63
60 INT58864 Regulation of Bgn 2 0.11 0.79 1.63
61 INT97318 Gene_expression of SPARC 11 0.67 5.07 1.59
62 INT88136 Positive_regulation of Gene_expression of Spp1 8 0.66 4.5 1.57
63 INT89116 Regulation of Positive_regulation of VEGFA 8 0.43 6.62 1.5
64 INT88934 Regulation of SPP1 9 0.54 6.94 1.47
65 INT104250 Positive_regulation of Gene_expression of SPP1 17 0.69 13.22 1.44
66 INT33133 Positive_regulation of ITGA2B 13 0.67 4.09 1.44
67 INT88133 Positive_regulation of Spp1 8 0.66 10.07 1.33
68 INT79840 Binding of Itga2b 4 0.16 2.51 1.28
69 INT22235 Gene_expression of Eln 11 0.76 5.4 1.23
70 INT24819 Positive_regulation of VTN 8 0.49 3.52 1.23
71 INT116279 Binding of Dmp1 3 0.04 0 1.2
72 INT50146 Gene_expression of Dcn 18 0.51 0.9 1.17
73 INT203729 Binding of Thbs1 1 0.27 3.83 1.1
74 INT130928 Positive_regulation of Gene_expression of Thbs1 7 0.62 5.62 1.08
75 INT92988 Protein_catabolism of Eln 6 0.47 5.48 1.03
76 INT184547 Localization of Spp1 4 0.58 4.44 1.02
77 INT112717 Negative_regulation of Binding of VEGFA 21 0.56 11.07 0.99
78 INT115987 Positive_regulation of SPARC 4 0.44 1.52 0.99
79 INT47130 Binding of BGN 3 0.33 0.33 0.97
80 INT102333 Positive_regulation of Dmp1 5 0.58 0 0.94
81 INT93804 Gene_expression of Bgn 5 0.38 1.03 0.92
82 INT242988 Positive_regulation of Transcription of Spp1 4 0.28 3.28 0.92
83 INT273038 Regulation of Vtn 3 0.08 2.26 0.91
84 INT44955 Negative_regulation of Eln 8 0.42 3.79 0.83
85 INT211488 Regulation of Binding of VEGFA 5 0.43 3.72 0.83
86 INT89969 Positive_regulation of Sparc 7 0.67 4.14 0.82
87 INT87837 Binding of Dcn 4 0.35 1.28 0.82
88 INT294824 Positive_regulation of Gene_expression of Sparc 10 0.69 7.64 0.81
89 INT115613 Regulation of Gene_expression of ITGA2B 3 0.44 1.43 0.8
90 INT189249 Localization of BGN 2 0.08 2.14 0.8
91 INT173082 Positive_regulation of Binding of VEGFA 20 0.48 11.16 0.79
92 INT87838 Gene_expression of Dcn 7 0.75 0.74 0.79
93 INT176528 Regulation of Spp1 9 0.45 9.05 0.77
94 INT82928 Positive_regulation of Eln 7 0.69 3.54 0.77
95 INT130363 Localization of Thbs1 9 0.75 4.99 0.76
96 INT185838 Protein_catabolism of SPP1 1 0.65 1.68 0.74
97 INT143445 Protein_catabolism of VEGFA 12 0.85 4.14 0.72
98 INT33733 Binding of ITGA2B 12 0.36 3.86 0.71
99 INT111399 Negative_regulation of DCN 2 0.18 1.74 0.7
100 INT176513 Transcription of Spp1 5 0.63 4.32 0.67
101 INT51336 Binding of Vtn 3 0.12 1.5 0.66
102 INT179653 Localization of Eln 3 0.15 2.75 0.65
103 INT58867 Positive_regulation of Regulation of Bgn 1 0.20 0 0.65
104 INT174868 Regulation of Negative_regulation of VEGFA 4 0.43 4.51 0.63
105 INT3503 Localization of COL11A1 3 0.65 2.17 0.63
106 INT346193 Positive_regulation of Gene_expression of VTN 1 0.25 1.54 0.63
107 INT87836 Localization of Dcn 3 0.68 0.6 0.62
108 INT50140 Positive_regulation of Gene_expression of Dcn 1 0.45 0.25 0.62
109 INT37953 Regulation of Dcn 3 0.39 0.51 0.6
110 INT135690 Negative_regulation of Negative_regulation of Dcn 1 0.38 0 0.6
111 INT88933 Regulation of Gene_expression of SPP1 7 0.45 6.05 0.59
112 INT242987 Positive_regulation of Localization of Spp1 3 0.60 7.04 0.59
113 INT179661 Gene_expression of Eln 9 0.56 7.59 0.58
114 INT117145 Negative_regulation of Gene_expression of Thbs1 11 0.43 5.67 0.57
115 INT127975 Negative_regulation of SPP1 15 0.42 11.25 0.56
116 INT11891 Binding of DCN 3 0.23 2.06 0.56
117 INT174873 Regulation of Transcription of VEGFA 8 0.43 3.71 0.55
118 INT150807 Positive_regulation of Gene_expression of SPARC 1 0.43 0.53 0.55
119 INT150806 Localization of SPARC 4 0.53 2.64 0.53
120 INT63028 Positive_regulation of Gene_expression of Vtn 1 0.03 1.01 0.53
121 INT133314 Positive_regulation of Binding of SPP1 2 0.22 2.38 0.52
122 INT264716 Negative_regulation of Gene_expression of Sparc 6 0.43 3.16 0.51
123 INT189634 Regulation of DCN 3 0.25 1.69 0.49
124 INT83273 Gene_expression of Itga2b 4 0.34 6.95 0.46
125 INT168443 Positive_regulation of Positive_regulation of Dcn 1 0.17 0.65 0.46
126 INT50135 Positive_regulation of Dcn 5 0.45 0.7 0.44
127 INT33737 Negative_regulation of Binding of ITGA2B 3 0.41 0.29 0.44
128 INT58862 Positive_regulation of Bgn 3 0.34 0.21 0.44
129 INT122162 Localization of Eln 2 0.69 0.81 0.44
130 INT247568 Negative_regulation of Negative_regulation of VEGFA 5 0.41 5.35 0.43
131 INT179654 Positive_regulation of Eln 5 0.44 4.3 0.43
132 INT162531 Binding of Eln 4 0.43 3.8 0.42
133 INT63424 Negative_regulation of Gene_expression of ITGA2B 2 0.57 0.9 0.42
134 INT203728 Regulation of Binding of Thbs1 1 0.33 2.76 0.42
135 INT203726 Regulation of Thbs1 2 0.33 1.41 0.41
136 INT127976 Negative_regulation of Regulation of SPP1 1 0.37 1.62 0.41
137 INT348126 Negative_regulation of Bgn 1 0.02 0.45 0.4
138 INT3504 Binding of COL11A1 1 0.32 0 0.4
139 INT165342 Gene_expression of TGFBI 13 0.59 5.81 0.39
140 INT27554 Regulation of Eln 6 0.52 6.76 0.39
141 INT289704 Protein_catabolism of Spp1 5 0.27 2.42 0.39
142 INT63422 Positive_regulation of Gene_expression of ITGA2B 4 0.67 1.11 0.39
143 INT50138 Negative_regulation of Dcn 3 0.42 0.45 0.39
144 INT121141 Transcription of Spp1 6 0.34 5.02 0.38
145 INT179827 Binding of Bgn 2 0.17 0.29 0.37
146 INT130927 Negative_regulation of Thbs1 19 0.59 3.72 0.36
147 INT51340 Binding of Vtn 2 0.22 1.38 0.36
148 INT176519 Regulation of Gene_expression of Spp1 7 0.58 8.54 0.35
149 INT156280 Gene_expression of Sdc1 6 0.43 0.55 0.34
150 INT329301 Phosphorylation of Spp1 1 0.62 1.71 0.34
151 INT185830 Positive_regulation of Localization of SPP1 2 0.50 3.39 0.33
152 INT179802 Regulation of Sparc 4 0.41 0.57 0.32
153 INT91820 Regulation of ITGA2B 3 0.44 2.03 0.32
154 INT88134 Negative_regulation of Gene_expression of Spp1 2 0.41 1.94 0.32
155 INT119229 Positive_regulation of Protein_catabolism of Eln 2 0.24 1.8 0.32
156 INT179813 Regulation of Nid1 1 0.33 0 0.29
157 INT176518 Positive_regulation of Positive_regulation of Spp1 5 0.47 3.36 0.28
158 INT277061 Positive_regulation of COL11A1 2 0.43 1.56 0.28
159 INT35283 Negative_regulation of Vtn 2 0.21 0.34 0.27
160 INT265835 Positive_regulation of Localization of BGN 1 0.04 0.33 0.27
161 INT148796 Regulation of Phosphorylation of VEGFA 3 0.35 1.66 0.26
162 INT130853 Transcription of DCN 2 0.67 0.42 0.26
163 INT119451 Negative_regulation of Itga2b 1 0.04 0.35 0.26
164 INT185828 Phosphorylation of SPP1 1 0.62 1.36 0.26
165 INT185908 Gene_expression of COL11A1 4 0.71 6.18 0.25
166 INT248262 Negative_regulation of Positive_regulation of Spp1 1 0.04 0.65 0.24
167 INT103775 Negative_regulation of Gene_expression of Dcn 1 0.41 0.19 0.24
168 INT156282 Positive_regulation of Sdc1 1 0.50 0.17 0.24
169 INT179671 Binding of Eln 5 0.31 5.32 0.23
170 INT97129 Transcription of SPP1 4 0.51 0.67 0.23
171 INT130368 Transcription of Thbs1 2 0.69 1.39 0.23
172 INT185826 Negative_regulation of Gene_expression of SPP1 1 0.42 0.8 0.23
173 INT130360 Positive_regulation of Transcription of Thbs1 1 0.46 1.41 0.23
174 INT274219 Positive_regulation of Gene_expression of Eln 4 0.06 2.69 0.22
175 INT155866 Positive_regulation of Gene_expression of DCN 2 0.49 2.91 0.22
176 INT88131 Negative_regulation of Spp1 3 0.56 0.7 0.21
177 INT50137 Regulation of Gene_expression of Dcn 2 0.26 0.09 0.21
178 INT222635 Gene_expression of Thbs1 4 0.39 15.2 0.2
179 INT206159 Negative_regulation of Regulation of VEGFA 3 0.24 2.38 0.2
180 INT50147 Negative_regulation of Positive_regulation of Dcn 1 0.25 0.07 0.2
181 INT189571 Positive_regulation of DCN 1 0.33 0.85 0.19
182 INT312356 Regulation of COL11A1 1 0.22 1.55 0.19
183 INT130850 Transcription of Bgn 1 0.12 0.46 0.19
184 INT242851 Transcription of TGFBI 2 0.43 1.67 0.18
185 INT24818 Positive_regulation of Binding of VTN 1 0.49 0 0.18
186 INT176522 Negative_regulation of Localization of Spp1 3 0.37 2.65 0.17
187 INT273031 Transcription of Vtn 1 0.12 0.81 0.17
188 INT179672 Positive_regulation of Localization of Eln 1 0.07 1.1 0.17
189 INT251821 Negative_regulation of COL11A1 3 0.42 3.45 0.16
190 INT316803 Negative_regulation of Negative_regulation of Sparc 2 0.43 1.13 0.16
191 INT83274 Negative_regulation of Gene_expression of Itga2b 2 0.11 1.71 0.16
192 INT196355 Protein_catabolism of NID1 1 0.11 0.39 0.16
193 INT251385 Binding of Fbln2 1 0.06 0 0.16
194 INT196358 Positive_regulation of Localization of NID1 1 0.06 0.44 0.16
195 INT196356 Localization of NID1 1 0.09 0.44 0.16
196 INT80386 Positive_regulation of Negative_regulation of ITGA2B 1 0.49 0.2 0.16
197 INT87835 Positive_regulation of Gene_expression of Dcn 1 0.67 0.26 0.16
198 INT196354 Negative_regulation of Localization of NID1 1 0.05 0.44 0.16
199 INT348150 Binding of Thbs1 1 0.24 2.06 0.15
200 INT216725 Negative_regulation of Positive_regulation of ITGA2B 1 0.41 0 0.15
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