GO:0050860

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Name negative regulation of T cell receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0050860
Unique Molecular Interactions 115
Total Molecular Interactions 143
Total Single Events 2037
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of T cell receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of T cell receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT348175 Binding of NIDDM1 and PTPN22 1 0.01 2.36 0.99
2 INT209061 Il3 Positive_regulation of Elf1 1 0.06 0.38 0.73
3 INT209058 Il4 Positive_regulation of Elf1 1 0.08 0.38 0.73
4 INT209053 Il2 Positive_regulation of Elf1 1 0.06 0.38 0.73
5 INT209029 Il12b Positive_regulation of Elf1 1 0.24 0.37 0.72
6 INT209056 Il6 Positive_regulation of Elf1 1 0.10 0.38 0.72
7 INT209050 Il10 Positive_regulation of Elf1 1 0.10 0.37 0.72
8 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
9 INT74729 Binding of Mpz and Ptprj 1 0.06 0.15 0.66
10 INT207111 F2 Positive_regulation of Pawr 2 0.07 1.38 0.64
11 INT329961 Binding of IL2RA and PTPN22 1 0.35 1.87 0.63
12 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
13 INT151485 Negative_regulation of Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
14 INT151484 Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
15 INT207141 Tlr4 Positive_regulation of Positive_regulation of Pawr 1 0.05 0.79 0.46
16 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43
17 INT231303 Binding of Prnp and Helt 1 0.02 3.23 0.41
18 INT231304 Prnp Negative_regulation of Grin2d 2 0.38 0.5 0.4
19 INT100598 PRNP Positive_regulation of Gene_expression of IL6 1 0.40 0.23 0.4
20 INT353332 Binding of F2r and Pawr 1 0.18 0.67 0.39
21 INT264504 Binding of CRYGD and PTPN22 1 0.04 0.42 0.31
22 INT231306 Prnp Regulation of Grin1 1 0.60 0.35 0.31
23 INT259936 CTLA4 Regulation of PTPN22 1 0.45 1.64 0.28
24 INT271450 Thy1 Regulation of TGFB1 1 0.00 0.62 0.25
25 INT259937 Binding of CSK and PTPN22 1 0.21 1.69 0.25
26 INT271446 Thy1 Regulation of Col1a1 1 0.05 0.61 0.25
27 INT271445 Thy1 Regulation of Acta2 1 0.02 0.62 0.25
28 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24
29 INT165637 Ptpn6 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.57 0.23
30 INT165636 Ptpn6 Regulation of Nfkb1 1 0.01 0.36 0.2
31 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
32 INT231305 Positive_regulation of Binding of Prnp and Helt 1 0.03 1.63 0.19
33 INT172674 Ptpn6 Negative_regulation of Gene_expression of Plat 1 0.02 1.3 0.16
34 INT207144 F2r Positive_regulation of Pawr 1 0.14 0.51 0.16
35 INT346414 Thy1 Positive_regulation of Binding of Tesc 1 0.00 0.16 0.15
36 INT134698 Regulation of Prnp Positive_regulation of Nup214 1 0.26 1.18 0.14
37 INT134697 Prnp Positive_regulation of Nup214 1 0.44 1.18 0.13
38 INT259938 Binding of CTLA4 and PTPN22 1 0.36 0.85 0.08
39 INT231301 Prnp Regulation of Regulation of Grin1 1 0.26 0.24 0.08
40 INT316792 Binding of HLA-DRB1 and Ptpn22 1 0.07 0.33 0.08
41 INT207310 Pik3r1 Positive_regulation of Prnp 1 0.36 0.65 0.08
42 INT243257 Thy1 Regulation of Gene_expression of Cfp 1 0.42 1.49 0.08
43 INT184827 Binding of Thy1 and Tg(CAG-EGFP)D4Nagy 1 0.06 0.18 0.07
44 INT229539 Cpz Negative_regulation of Localization of Prnp 1 0.05 0.58 0.07
45 INT229538 Cpz Negative_regulation of Positive_regulation of Prnp 1 0.05 0.58 0.07
46 INT250153 Binding of PRNP and IKBKG 1 0.09 2.83 0.06
47 INT231300 Positive_regulation of Grin2b Positive_regulation of Prnp 1 0.39 0.16 0.05
48 INT231299 Prnp Regulation of Grin2d 1 0.28 0 0.05
49 INT178430 Pawr Positive_regulation of Phosphorylation of Mapk14 1 0.05 0.29 0.05
50 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05
51 INT231302 Binding of Grin2d and Prnp 1 0.38 0.11 0.05
52 INT178447 Negative_regulation of Pawr Positive_regulation of Phosphorylation of Mapk14 1 0.05 0.29 0.05
53 INT353848 Binding of SCLY and Ubash3a 1 0.30 0.47 0.04
54 INT231311 Prnp Negative_regulation of Helt 1 0.04 0.05 0.03
55 INT231308 Prnp Negative_regulation of Gene_expression of Grin1 1 0.41 0.05 0.03
56 INT259939 Negative_regulation of Binding of CSK and PTPN22 1 0.19 0.62 0.03
57 INT231312 Prnp Negative_regulation of Grin1 1 0.42 0.05 0.03
58 INT220634 Binding of Bace1 and Pawr 2 0.06 0.2 0
59 INT260518 Binding of Prnp and Gopc 2 0.13 1.06 0
60 INT268647 ATP2B3 Positive_regulation of Prnp 1 0.01 0.57 0
61 INT314397 Binding of Ptpn6 and Slc17a7 1 0.05 0 0
62 INT201539 Binding of NPC1 and THY1 1 0.36 1.28 0
63 INT335952 Prnp Positive_regulation of can 1 0.17 0.58 0
64 INT268183 Gene_expression of Rab22a Negative_regulation of Gene_expression of Prnp 1 0.28 0.1 0
65 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
66 INT314393 Ptpn6 Regulation of 1190002H23Rik 1 0.01 0 0
67 INT354566 F2 Positive_regulation of PRNP 1 0.00 0.05 0
68 INT260523 Binding of Cnp and Prnp 1 0.33 0.34 0
69 INT193308 Binding of PRNP and TGFB1 1 0.01 0 0
70 INT267255 Bcl2 Positive_regulation of Gene_expression of Ptprj 1 0.04 0.63 0
71 INT268192 Gene_expression of Rab22a Positive_regulation of Protein_catabolism of Prnp 1 0.30 0.08 0
72 INT260561 Binding of AFM and PRNP 1 0.22 0 0
73 INT260519 Binding of Prnp and Scarb1 1 0.41 0.21 0
74 INT268191 Rab4a Regulation of Gene_expression of Prnp 1 0.23 0.22 0
75 INT260522 Binding of Myc and Prnp 1 0.30 0.35 0
76 INT335950 Negative_regulation of Prnp Positive_regulation of can 1 0.16 0.59 0
77 INT314402 Positive_regulation of Ptpn6 Regulation of 1190002H23Rik 1 0.02 0 0
78 INT268197 Gene_expression of Rab22a Regulation of Prnp 1 0.29 0.08 0
79 INT314403 Ptpn6 Positive_regulation of Gpsm2 1 0.12 0.07 0
80 INT268184 Prnp Regulation of Gene_expression of Rab22a 1 0.34 0.17 0
81 INT314374 Binding of Ptprc and Thy1 1 0.04 0.85 0
82 INT314398 Ptpn6 Regulation of Gene_expression of Ctbs 1 0.03 0 0
83 INT314371 Binding of Cd34 and Thy1 1 0.08 0.9 0
84 INT231313 Prnp Positive_regulation of Grin2d 1 0.47 0.16 0
85 INT268201 Tg(CAG-EGFP)D4Nagy Regulation of Prnp 1 0.01 0.22 0
86 INT268198 Prnp Positive_regulation of Erc1 1 0.04 0.26 0
87 INT299234 Onc1 Negative_regulation of Thy1 1 0.02 0.16 0
88 INT288981 Binding of DEFB1 and PTPN22 1 0.11 0 0
89 INT268194 Erc1 Positive_regulation of Gene_expression of Prnp 1 0.05 0.2 0
90 INT170458 Binding of MKI67 and THY1 1 0.01 0 0
91 INT344000 PROC Positive_regulation of PRNP 1 0.00 0.07 0
92 INT268190 Gene_expression of Rab22a Negative_regulation of Prnp 1 0.32 0.08 0
93 INT268177 Rab4a Regulation of Prnp 1 0.14 0.22 0
94 INT268182 Positive_regulation of Binding of Prnp and Erc1 1 0.06 0.1 0
95 INT314396 Binding of Ptpn6 and Slc17a6 1 0.05 0 0
96 INT189992 Binding of Ptger2 and Pawr 1 0.00 2.89 0
97 INT268188 Binding of Prnp and Erc1 1 0.04 0.27 0
98 INT314400 Binding of Ptpn6 and Gpsm2 1 0.07 0 0
99 INT268185 Rab22a Negative_regulation of Gene_expression of Prnp 1 0.32 0.08 0
100 INT268195 Rab22a Negative_regulation of Prnp 1 0.44 0.09 0
101 INT193307 Binding of PDGFA and PRNP 1 0.01 0 0
102 INT268176 Positive_regulation of Erc1 Positive_regulation of Gene_expression of Prnp 1 0.06 0.2 0
103 INT287034 Pgp Regulation of Positive_regulation of Prnp 1 0.13 0.09 0
104 INT268646 Prnp Positive_regulation of PRNP 1 0.08 0.42 0
105 INT354482 Binding of PRNP and Prnp 1 0.16 0.88 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of T cell receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of T cell receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5
2 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34
3 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25
4 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06
5 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32
6 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11
7 INT50975 Localization of Ptpn6 8 0.65 2.64 5.7
8 INT69572 Localization of Prnp 96 0.81 38.11 5.45
9 INT18681 Gene_expression of Thy1 80 0.71 38.8 5.23
10 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81
11 INT69570 Binding of Prnp 75 0.48 44.26 4.37
12 INT6339 Negative_regulation of Ptpn6 6 0.14 0.71 3.44
13 INT102255 Regulation of Prnp 35 0.62 18.97 3.25
14 INT64 Regulation of Ptpn6 12 0.14 2.45 3.17
15 INT271442 Positive_regulation of Thy1 10 0.40 6.64 3.05
16 INT321018 Protein_catabolism of Ptpn6 1 0.14 0.52 2.73
17 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62
18 INT135040 Regulation of Gene_expression of Prnp 30 0.62 10.52 2.45
19 INT231573 Binding of PTPN22 5 0.44 7.94 2.33
20 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15
21 INT137629 Binding of Ptpn6 10 0.30 0.42 2.15
22 INT321023 Positive_regulation of Localization of Ptpn6 1 0.07 0.27 2.15
23 INT167203 Binding of PRNP 25 0.48 20.09 1.84
24 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57
25 INT29856 Negative_regulation of Positive_regulation of Ptpn6 3 0.38 1.24 1.47
26 INT247885 Regulation of Thy1 8 0.33 5.25 1.44
27 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36
28 INT209022 Gene_expression of Elf1 2 0.58 1.46 1.32
29 INT316787 Binding of Ptpn22 1 0.29 3.61 1.29
30 INT85621 Regulation of PRNP 16 0.60 8.7 1.15
31 INT314388 Positive_regulation of Gene_expression of Ptpn6 3 0.11 0.05 1.15
32 INT321016 Regulation of Positive_regulation of Ptpn6 1 0.05 0.05 1.15
33 INT321020 Regulation of Protein_catabolism of Ptpn6 1 0.06 0.05 1.12
34 INT207091 Positive_regulation of Pawr 2 0.36 1.95 1.1
35 INT204737 Negative_regulation of Gene_expression of Prnp 32 0.59 18.96 1.03
36 INT53197 Binding of Thy1 5 0.36 1.38 0.93
37 INT123154 Positive_regulation of Gene_expression of Thy1 7 0.53 4.34 0.86
38 INT207103 Positive_regulation of Positive_regulation of Pawr 2 0.36 1.45 0.85
39 INT136634 Transcription of Prnp 9 0.72 3.34 0.83
40 INT207108 Gene_expression of Pawr 5 0.40 1.61 0.77
41 INT209024 Positive_regulation of Elf1 1 0.20 0.37 0.72
42 INT100601 Localization of PRNP 17 0.66 13.61 0.71
43 INT190662 Regulation of Positive_regulation of Prnp 4 0.24 1.15 0.7
44 INT69571 Positive_regulation of Positive_regulation of Prnp 6 0.70 5.88 0.67
45 INT321017 Negative_regulation of Protein_catabolism of Ptpn6 1 0.08 0.19 0.63
46 INT6168 Negative_regulation of Regulation of Ptpn6 1 0.15 0 0.62
47 INT60057 Negative_regulation of Localization of Ptpn6 1 0.31 0.39 0.62
48 INT288095 Negative_regulation of Gene_expression of Elf1 1 0.42 1.16 0.61
49 INT123153 Positive_regulation of Thy1 14 0.47 4.13 0.6
50 INT74724 Regulation of Ptprj 2 0.05 0.35 0.51
51 INT74725 Localization of Ptprj 1 0.14 0.15 0.5
52 INT207074 Binding of Pawr 2 0.18 0.87 0.48
53 INT123155 Regulation of Gene_expression of Thy1 4 0.47 1.55 0.47
54 INT151482 Negative_regulation of Binding of Ptpn6 1 0.00 0 0.46
55 INT124164 Protein_catabolism of Prnp 20 1.00 8.58 0.44
56 INT321009 Regulation of Gene_expression of Ptpn6 1 0.05 0.3 0.43
57 INT230980 Positive_regulation of THY1 5 0.18 2.15 0.41
58 INT144611 Regulation of THY1 3 0.16 1.51 0.35
59 INT123156 Negative_regulation of Gene_expression of Thy1 3 0.45 1.23 0.32
60 INT251949 Negative_regulation of Gene_expression of PRNP 6 0.43 4.16 0.3
61 INT335949 Positive_regulation of Positive_regulation of PRNP 2 0.25 0.82 0.29
62 INT184825 Regulation of Thy1 7 0.42 4.14 0.28
63 INT229518 Phosphorylation of Prnp 5 0.69 1.62 0.27
64 INT164514 Binding of THY1 3 0.34 1.23 0.27
65 INT331055 Positive_regulation of Phosphorylation of Prnp 1 0.07 0.24 0.27
66 INT69568 Positive_regulation of Localization of Prnp 5 0.50 2.43 0.26
67 INT31628 Binding of Thy1 2 0.19 0.17 0.26
68 INT115708 Phosphorylation of PRNP 2 0.71 1.61 0.26
69 INT268171 Negative_regulation of Binding of Prnp 3 0.42 0.82 0.25
70 INT325414 Regulation of Regulation of PRNP 1 0.26 0.7 0.16
71 INT312025 Regulation of Gene_expression of THY1 1 0.16 0.51 0.13
72 INT170472 Negative_regulation of Gene_expression of THY1 4 0.41 0.26 0.1
73 INT190664 Regulation of Binding of Prnp 3 0.52 4.29 0.1
74 INT207304 Positive_regulation of Protein_catabolism of Prnp 9 0.69 2.08 0.09
75 INT326713 Negative_regulation of Thy1 2 0.47 1.08 0.09
76 INT293049 Positive_regulation of Localization of PRNP 1 0.07 2.67 0.09
77 INT303459 Transcription of PRNP 4 0.69 1.44 0.08
78 INT354480 Regulation of Gene_expression of PRNP 1 0.39 1.96 0.08
79 INT354479 Positive_regulation of Transcription of PRNP 1 0.50 0.4 0.08
80 INT316785 Gene_expression of Ptpn22 1 0.18 0.33 0.07
81 INT144918 Gene_expression of Thy1 5 0.62 4.39 0.06
82 INT200850 Negative_regulation of Binding of Thy1 1 0.24 0.3 0.06
83 INT207302 Positive_regulation of Transcription of Prnp 1 0.47 0.71 0.06
84 INT345046 Positive_regulation of Positive_regulation of Thy1 1 0.33 0.71 0.06
85 INT189988 Regulation of Pawr 3 0.13 3.26 0.05
86 INT178410 Negative_regulation of Pawr 1 0.12 0.29 0.05
87 INT267251 Gene_expression of Ptprj 1 0.12 2.02 0.05
88 INT229516 Negative_regulation of Positive_regulation of Prnp 5 0.42 0.95 0.04
89 INT353846 Binding of Ubash3a 1 0.27 1.15 0.04
90 INT177776 Positive_regulation of Gene_expression of THY1 1 0.16 0.18 0.04
91 INT247871 Negative_regulation of Thy1 8 0.54 7.23 0.03
92 INT229519 Regulation of Localization of Prnp 4 0.61 0.7 0.03
93 INT293047 Protein_catabolism of PRNP 1 0.57 2 0.03
94 INT287031 Positive_regulation of Negative_regulation of Prnp 1 0.46 0.16 0.03
95 INT353847 Localization of Ubash3a 1 0.54 0.49 0.03
96 INT267249 Positive_regulation of Gene_expression of Ptprj 1 0.08 0.39 0.03
97 INT299228 Regulation of Gene_expression of Thy1 1 0.22 1.47 0.03
98 INT170471 Localization of THY1 7 0.37 0.75 0
99 INT268144 Negative_regulation of Localization of Prnp 3 0.37 0.71 0
100 INT190666 Positive_regulation of Binding of Prnp 2 0.50 1.87 0
101 INT268161 Regulation of Negative_regulation of Prnp 2 0.39 0.33 0
102 INT282314 Negative_regulation of Gene_expression of Ptpn6 2 0.09 0.63 0
103 INT247874 Positive_regulation of Negative_regulation of Thy1 1 0.14 0.51 0
104 INT299217 Positive_regulation of Gene_expression of Thy1 1 0.40 0.39 0
105 INT314379 Regulation of Localization of Ptpn6 1 0.10 0.08 0
106 INT144615 Negative_regulation of THY1 1 0.14 0.5 0
107 INT229517 Regulation of Phosphorylation of Prnp 1 0.39 0.26 0
108 INT329611 Localization of Thy1 1 0.11 0 0
109 INT188131 Negative_regulation of Regulation of PRNP 1 0.41 0.06 0
110 INT293048 Regulation of Protein_catabolism of PRNP 1 0.06 1.01 0
111 INT344005 Regulation of Positive_regulation of PRNP 1 0.20 0.08 0
112 INT299227 Negative_regulation of Gene_expression of Thy1 1 0.34 0.37 0
113 INT268150 Regulation of Binding of Thy1 1 0.07 0.2 0
114 INT240690 Positive_regulation of Binding of PRNP 1 0.07 0.53 0
115 INT177777 Regulation of Localization of THY1 1 0.19 0 0
116 INT299210 Localization of Thy1 1 0.60 0 0
117 INT267250 Positive_regulation of Ptprj 1 0.08 1.31 0
118 INT299196 Transcription of Thy1 1 0.66 1.98 0
119 INT299203 Negative_regulation of Transcription of Thy1 1 0.39 0 0
120 INT289491 Transcription of Thy1 1 0.26 1.05 0
121 INT218006 Regulation of Regulation of Ptpn6 1 0.05 0.25 0
122 INT299226 Positive_regulation of Transcription of Thy1 1 0.46 0 0
123 INT315417 Negative_regulation of Transcription of Prnp 1 0.43 0.14 0
124 INT268173 Negative_regulation of Negative_regulation of Prnp 1 0.37 0 0
125 INT222723 Negative_regulation of Localization of PRNP 1 0.05 2.06 0
126 INT268148 Regulation of Protein_catabolism of Prnp 1 0.45 0 0
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