GO:0050867

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Name positive regulation of cell activation
Categary Process
Go Slim No
Go Link GO:0050867
Unique Molecular Interactions 121
Total Molecular Interactions 166
Total Single Events 1296
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cell activation. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of cell activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
2 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
3 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
4 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
5 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
6 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
7 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
8 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
9 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
10 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
11 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
12 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
13 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
14 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
15 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
16 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
17 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
18 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
19 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
20 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
21 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
22 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
23 INT132509 Binding of LEP and Cck 1 0.13 0.16 0.45
24 INT332248 Ccl2 Positive_regulation of Ctgf 1 0.04 1.13 0.42
25 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
26 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
27 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
28 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
29 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
30 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
31 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
32 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
33 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
34 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
35 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
36 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
37 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
38 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31
39 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31
40 INT278969 LEP Regulation of PTGER2 1 0.03 0.6 0.31
41 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3
42 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
43 INT316815 Ctgf Negative_regulation of Gene_expression of Sparc 1 0.47 0.64 0.24
44 INT125748 Binding of LEP and Gh 1 0.00 0.52 0.24
45 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23
46 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
47 INT269180 LEP Positive_regulation of Localization of TNF 1 0.01 0.99 0.21
48 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
49 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
50 INT92691 Tgfb1 Positive_regulation of Ctgf 1 0.16 0.91 0.2
51 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19
52 INT153457 Tgfb1 Positive_regulation of Gene_expression of Ctgf 1 0.13 1.15 0.19
53 INT153460 Inhba Positive_regulation of Gene_expression of Ctgf 1 0.77 1.14 0.19
54 INT153461 Tnf Positive_regulation of Gene_expression of Ctgf 1 0.48 1.13 0.19
55 INT300305 Mapk14 Positive_regulation of Gene_expression of Ctgf 1 0.19 1.25 0.17
56 INT153458 Ctgf Positive_regulation of Gene_expression of Il6 1 0.34 1.03 0.15
57 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14
58 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14
59 INT323877 LEP Positive_regulation of SOAT1 1 0.20 1.26 0.14
60 INT139975 Binding of LEP and Prl 1 0.02 0.49 0.13
61 INT328060 LEP Positive_regulation of FAAH 1 0.06 0.7 0.13
62 INT346714 LEP Regulation of GALP 1 0.06 0.08 0.13
63 INT81179 LEP Regulation of Localization of GH1 1 0.11 0.91 0.12
64 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
65 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
66 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
67 INT323871 LEP Regulation of Gene_expression of IGF1 1 0.14 1.19 0.11
68 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11
69 INT188358 Binding of Csf2 and Positive_regulation of Jak2 1 0.34 0.19 0.11
70 INT169340 Binding of UGT8 and Jak2 1 0.36 0.15 0.11
71 INT323879 LEP Regulation of SOAT1 1 0.15 1.15 0.1
72 INT204086 TNF Positive_regulation of Gene_expression of LEP 1 0.48 0.74 0.1
73 INT294448 KLK4 Negative_regulation of CTGF 1 0.01 0 0.1
74 INT306794 Binding of LEP and COPD 1 0.15 3.94 0.09
75 INT300486 LEP Positive_regulation of ROS1 1 0.15 0.91 0.09
76 INT323868 LEP Regulation of Transcription of COL1A2 1 0.10 0.98 0.09
77 INT257342 Mapk4 Positive_regulation of Gene_expression of Ctgf 1 0.01 0.39 0.08
78 INT332287 LEP Positive_regulation of Phosphorylation of IRS1 1 0.20 1.48 0.08
79 INT323881 BMI1 Regulation of Gene_expression of LEP 1 0.03 1.09 0.08
80 INT323876 LEP Regulation of COL1A2 1 0.10 0.86 0.08
81 INT323872 LEP Positive_regulation of Gene_expression of IGF1 1 0.35 0.77 0.07
82 INT242480 Ciapin1 Positive_regulation of Gene_expression of Jak2 1 0.27 1.05 0.07
83 INT200807 Jak2 Positive_regulation of Mvd 1 0.18 3.46 0.06
84 INT316819 Sparc Negative_regulation of Gene_expression of Ctgf 1 0.41 0.24 0.06
85 INT316822 Sparc Regulation of Gene_expression of Ctgf 1 0.68 0.48 0.06
86 INT323878 Binding of LEP and MMP13 1 0.17 0.77 0.05
87 INT267152 Binding of LEP and DDX12P 1 0.00 0.69 0.05
88 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05
89 INT267153 Binding of LEP and SUGT1 1 0.02 0.69 0.05
90 INT200821 Binding of Jak2 and Mvd 1 0.14 0.68 0.04
91 INT200813 Jak2 Positive_regulation of Akt1 1 0.26 1.46 0.03
92 INT253578 Csnk2a2 Negative_regulation of Jak2 1 0.09 0 0.03
93 INT249046 Binding of LEP and ARID1B 1 0.01 1.3 0.03
94 INT253573 Binding of Jak2 and Pik3r1 1 0.06 0 0.03
95 INT200816 Jak2 Positive_regulation of Binding of Mvd 1 0.19 1.51 0.03
96 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03
97 INT254860 Ctgf Negative_regulation of Col7a1 1 0.00 0.51 0.03
98 INT200810 Jak2 Positive_regulation of Src 1 0.29 1.46 0.03
99 INT249597 Jak2 Positive_regulation of Phosphorylation of Stat1 1 0.20 0.13 0.03
100 INT231439 LEP Positive_regulation of Negative_regulation of AKT1 1 0.06 0.32 0.03
101 INT253575 Binding of Jak2 and Pik3r2 1 0.00 0 0.03
102 INT200815 Binding of Epo and Jak2 1 0.36 0.98 0.03
103 INT254867 Ctgf Negative_regulation of Serpine1 1 0.04 0.51 0.03
104 INT200822 Akt1 Regulation of Jak2 1 0.25 1.48 0.03
105 INT213160 AGT Positive_regulation of Gene_expression of LEP 1 0.08 1.29 0.03
106 INT316825 Ctgf Negative_regulation of Sparc 1 0.56 0.14 0
107 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0
108 INT253366 Il6 Positive_regulation of Phosphorylation of Jak2 1 0.31 0.2 0
109 INT187675 DBT Positive_regulation of Gene_expression of LEP 1 0.04 0.27 0
110 INT268517 MYC Regulation of CTGF 1 0.03 0.92 0
111 INT337916 sb Negative_regulation of Ctgf 1 0.00 0.13 0
112 INT249045 CENPJ Regulation of Regulation of LEP 1 0.14 0.81 0
113 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 0.49 0.91 0
114 INT225085 Binding of ADM and Negative_regulation of LEP 1 0.16 1.04 0
115 INT187667 DBT Positive_regulation of Localization of LEP 1 0.05 0.55 0
116 INT204085 Binding of LEP and TNF 1 0.37 0.39 0
117 INT328375 Ghrl Negative_regulation of LEP 1 0.07 0.15 0
118 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0
119 INT249047 CENPJ Negative_regulation of LEP 1 0.22 0.8 0
120 INT353061 HSD11B1 Regulation of Gene_expression of LEP 1 0.20 5.03 0
121 INT332904 Binding of LEP and SNRNP70 1 0.00 1.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cell activation. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of cell activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
2 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
3 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
4 INT75908 Regulation of LEP 77 0.60 60.16 15.19
5 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93
6 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
7 INT75907 Binding of LEP 53 0.46 46.65 8.44
8 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
9 INT65356 Localization of LEP 46 0.79 41.17 5.43
10 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
11 INT92682 Positive_regulation of Gene_expression of Ctgf 17 0.69 12.16 4.51
12 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
13 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
14 INT92681 Positive_regulation of Ctgf 13 0.69 9.78 3.47
15 INT113604 Negative_regulation of Gene_expression of Ctgf 19 0.58 9.37 3.43
16 INT156148 Gene_expression of CTGF 16 0.78 9.98 2.87
17 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
18 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
19 INT140091 Gene_expression of Ctgf 26 0.78 14.21 2.39
20 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
21 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
22 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
23 INT92685 Transcription of Ctgf 7 0.72 3.92 1.44
24 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
25 INT158565 Regulation of Ctgf 3 0.61 3.93 1.14
26 INT158563 Negative_regulation of Ctgf 6 0.56 4.31 1.12
27 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
28 INT105986 Positive_regulation of Transcription of Ctgf 2 0.69 2.43 1.01
29 INT169336 Binding of Jak2 2 0.42 1.31 0.93
30 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
31 INT164079 Regulation of Gene_expression of CTGF 4 0.44 2 0.9
32 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
33 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
34 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
35 INT156533 Transcription of LEP 9 0.69 4.35 0.74
36 INT306798 Protein_catabolism of LEP 1 0.65 2.45 0.58
37 INT167377 Regulation of Gene_expression of Ctgf 2 0.25 1.35 0.48
38 INT184062 Binding of Jak2 5 0.37 3.13 0.47
39 INT158296 Positive_regulation of Gene_expression of Ctgf 5 0.47 4.82 0.47
40 INT82819 Negative_regulation of Negative_regulation of LEP 3 0.56 2.22 0.46
41 INT140090 Negative_regulation of Gene_expression of Ctgf 5 0.58 1.77 0.44
42 INT205890 Transcription of Jak2 1 0.41 0.22 0.43
43 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41
44 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41
45 INT107462 Localization of Jak2 2 0.60 0.78 0.4
46 INT229697 Negative_regulation of Phosphorylation of Jak2 1 0.15 0.54 0.39
47 INT268558 Regulation of CTGF 5 0.23 4.7 0.37
48 INT200786 Positive_regulation of Gene_expression of Jak2 9 0.69 6.03 0.35
49 INT119248 Binding of Ctgf 1 0.35 1.5 0.35
50 INT205910 Negative_regulation of Positive_regulation of Jak2 1 0.33 0.26 0.35
51 INT153465 Regulation of Gene_expression of Ctgf 3 0.61 2.5 0.33
52 INT156534 Positive_regulation of Transcription of LEP 1 0.14 0.34 0.3
53 INT168140 Regulation of Ctgf 2 0.60 2.15 0.29
54 INT141781 Positive_regulation of Negative_regulation of LEP 1 0.46 0.37 0.29
55 INT219162 Localization of CTGF 1 0.50 2.62 0.29
56 INT294476 Negative_regulation of CTGF 1 0.27 1.86 0.29
57 INT164080 Negative_regulation of Gene_expression of CTGF 1 0.41 0.51 0.29
58 INT136840 Positive_regulation of Ctgf 2 0.35 1.34 0.27
59 INT150977 Regulation of Regulation of LEP 3 0.37 2.07 0.23
60 INT158567 Negative_regulation of Transcription of Ctgf 1 0.43 0.73 0.2
61 INT328811 Negative_regulation of Localization of Jak2 1 0.34 0.13 0.17
62 INT200802 Regulation of Jak2 5 0.61 2.86 0.16
63 INT157134 Regulation of Localization of LEP 1 0.09 0.5 0.16
64 INT204088 Regulation of Negative_regulation of LEP 1 0.59 1.16 0.16
65 INT219160 Positive_regulation of CTGF 2 0.29 2.95 0.15
66 INT300489 Negative_regulation of Binding of LEP 1 0.41 1.12 0.15
67 INT337910 Binding of Ctgf 1 0.22 3.04 0.15
68 INT278979 Negative_regulation of Positive_regulation of LEP 2 0.40 0.81 0.14
69 INT187723 Regulation of Positive_regulation of LEP 3 0.42 2.29 0.13
70 INT323898 Regulation of Phosphorylation of LEP 1 0.42 1.25 0.13
71 INT153463 Localization of Ctgf 1 0.65 0.97 0.13
72 INT323895 Phosphorylation of LEP 1 0.76 1.23 0.13
73 INT157241 Negative_regulation of Localization of LEP 5 0.56 2.1 0.12
74 INT278143 Positive_regulation of Negative_regulation of Jak2 1 0.16 0.54 0.11
75 INT200792 Regulation of Gene_expression of Jak2 5 0.61 5.69 0.09
76 INT280234 Localization of Ctgf 3 0.51 2.35 0.09
77 INT184018 Negative_regulation of Protein_catabolism of Jak2 1 0.36 1.76 0.08
78 INT184023 Protein_catabolism of Jak2 1 0.61 1.75 0.08
79 INT187729 Positive_regulation of Binding of LEP 1 0.18 0.3 0.08
80 INT156147 Positive_regulation of Gene_expression of CTGF 1 0.70 0.14 0.07
81 INT271818 Negative_regulation of Ctgf 1 0.21 0.41 0.04
82 INT254801 Phosphorylation of Ctgf 3 0.48 0.62 0
83 INT342935 Positive_regulation of Transcription of Ctgf 1 0.33 0 0
84 INT157243 Negative_regulation of Transcription of LEP 1 0.02 0.09 0
85 INT202420 Transcription of Jak2 1 0.56 0.91 0
86 INT342929 Transcription of Ctgf 1 0.38 0 0
87 INT268556 Regulation of Positive_regulation of CTGF 1 0.23 1.81 0
88 INT352011 Positive_regulation of Localization of Ctgf 1 0.23 0.17 0
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