GO:0050897

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Name cobalt ion binding
Categary Function
Go Slim No
Go Link GO:0050897
Unique Molecular Interactions 132
Total Molecular Interactions 194
Total Single Events 1372
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cobalt ion binding. They are ordered first by their pain relevance and then by number of times they were reported for cobalt ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
2 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
3 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
4 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
5 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
6 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
7 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95
8 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
9 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
10 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
11 INT149743 Ean5 Positive_regulation of Gene_expression of P2rx2 1 0.10 1.54 1.5
12 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
13 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
14 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
15 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
16 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
17 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
18 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
19 INT43446 Binding of Cpe and H3 1 0.02 0 1.25
20 INT33605 DFP Positive_regulation of Cpe 1 0.16 0 1.16
21 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
22 INT84488 Negative_regulation of Binding of Cpe and Mif-ps1 1 0.06 0 1.13
23 INT84487 Binding of Cpe and Mif-ps1 1 0.05 0 1.13
24 INT172757 Rnpep Positive_regulation of Hps4 1 0.00 0 1.08
25 INT161011 Binding of Cpe and St13 2 0.03 0.61 1.07
26 INT6415 Binding of Cpe and Oprd1 1 0.00 0 1.07
27 INT147232 Binding of tn and Cpe 1 0.03 1.55 0.95
28 INT42482 Binding of Cpe and Pebp1 1 0.02 0 0.95
29 INT12373 SCN5A Negative_regulation of Cpe 1 0.00 0 0.94
30 INT59482 Cpe Positive_regulation of Rbm39 1 0.02 0 0.89
31 INT26984 Cpe Regulation of Ins1 1 0.02 0 0.87
32 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
33 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
34 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
35 INT41865 Avp Regulation of Cpe 1 0.00 0 0.84
36 INT41864 Nts Regulation of Cpe 1 0.01 0 0.84
37 INT41867 GRP Regulation of Cpe 1 0.00 0 0.84
38 INT111743 Negative_regulation of Pcsk2 Positive_regulation of Cpe 1 0.06 0 0.8
39 INT26982 Cpe Regulation of Localization of Pomc 1 0.01 0 0.75
40 INT26983 Cpe Regulation of Localization of Ins1 1 0.02 0 0.75
41 INT26986 Cpe Regulation of Pomc 1 0.01 0 0.73
42 INT26990 Pomc Regulation of Cpe 1 0.01 0 0.73
43 INT31243 Binding of Mme and Cpe 1 0.01 0 0.72
44 INT12052 Xcl1 Negative_regulation of Rnpep 1 0.01 0 0.71
45 INT76654 Cpe Positive_regulation of Transcription of Il6 1 0.05 0 0.68
46 INT267891 Cpe Positive_regulation of Localization of Insrr 1 0.00 0 0.64
47 INT2700 Binding of App and Cpe 1 0.00 0 0.63
48 INT103000 Cpe Regulation of Penk 1 0.07 0.19 0.62
49 INT63525 Cpe Positive_regulation of Gpi1 1 0.03 0 0.59
50 INT270943 Binding of Prkcg and Cpe 1 0.05 0 0.58
51 INT270935 Cpe Regulation of Phosphorylation of Slc6a3 1 0.31 0 0.57
52 INT84489 Cpe Negative_regulation of Binding of Mif-ps1 1 0.06 0 0.56
53 INT28925 Cpe Regulation of Sh2b3 1 0.04 0.14 0.55
54 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
55 INT270937 Cpe Regulation of Slc6a3 1 0.36 0 0.5
56 INT47225 Asap1 Regulation of Cpe 1 0.04 0.18 0.49
57 INT6280 Cpe Regulation of Gene_expression of Mc2r 1 0.09 0 0.46
58 INT6279 Cpe Regulation of Gene_expression of Pomc 1 0.27 0 0.46
59 INT90642 Cpe Negative_regulation of Negative_regulation of Slc6a3 1 0.04 0 0.44
60 INT158104 Binding of Trpv1 and P2rx2 1 0.03 0.27 0.4
61 INT42847 Binding of Cpe and SLTM 1 0.00 0 0.38
62 INT161009 Binding of Cpe and Itgam 1 0.03 0.53 0.37
63 INT80694 Cpe Negative_regulation of Positive_regulation of Fos 1 0.08 0 0.37
64 INT161004 Binding of Cpe and Cpb2 1 0.03 0.53 0.37
65 INT161000 Binding of Cpe and Gfap 1 0.05 0.53 0.37
66 INT270939 Gene_expression of Cpe Positive_regulation of Slc6a3 1 0.20 0 0.36
67 INT75941 Negative_regulation of Binding of Cpe and Frk 1 0.01 1.28 0.34
68 INT75946 Binding of Cpe and Frk 1 0.01 1.28 0.34
69 INT92444 Cpe Negative_regulation of Phosphorylation of Cd3eap 1 0.01 0 0.34
70 INT75942 Positive_regulation of Binding of Cpe and Frk 1 0.02 1.28 0.34
71 INT75949 Negative_regulation of Binding of Cpe and Ptafr 1 0.03 1.27 0.33
72 INT75953 Binding of Cpe and Ptafr 1 0.03 1.27 0.33
73 INT14062 Binding of POMC and RNPEP 1 0.01 0 0.33
74 INT33581 Thop1 Positive_regulation of Cpe 1 0.01 0 0.33
75 INT75940 Positive_regulation of Binding of Cpe and Ptafr 1 0.04 1.27 0.33
76 INT115161 Adora2a Regulation of Gene_expression of Cpe 1 0.04 0.36 0.33
77 INT110464 Cpe Regulation of Phosphorylation of Atf2 1 0.02 0 0.32
78 INT110462 Cpe Regulation of Phosphorylation of Gtf3a 1 0.00 0 0.32
79 INT31276 Oxt Negative_regulation of Cpe 1 0.01 0 0.31
80 INT31275 Avp Negative_regulation of Cpe 1 0.00 0 0.31
81 INT31277 Penk Negative_regulation of Cpe 1 0.12 0 0.29
82 INT270954 Gene_expression of Cpe Positive_regulation of Gene_expression of Slc6a3 1 0.23 0 0.28
83 INT33584 Enpep Positive_regulation of Cpe 1 0.03 0 0.27
84 INT118928 Csf2 Regulation of Cpe 1 0.04 0.27 0.27
85 INT256000 H7 Negative_regulation of Rnpep 1 0.00 0.26 0.27
86 INT255995 Binding of H7 and Negative_regulation of Rnpep 1 0.00 0.26 0.27
87 INT33583 Enpep Regulation of Positive_regulation of Cpe 1 0.03 0 0.27
88 INT33582 Thop1 Regulation of Positive_regulation of Cpe 1 0.01 0 0.26
89 INT74433 Binding of INS and Cpe 2 0.03 0 0.25
90 INT270955 Cpe Regulation of Gene_expression of Slc6a3 1 0.14 0 0.25
91 INT270951 Regulation of Binding of Slc6a3 and Cpe 1 0.23 0 0.25
92 INT270940 Negative_regulation of Binding of Slc6a3 and Cpe 1 0.25 0 0.23
93 INT270948 Cpe Regulation of Regulation of Slc6a3 1 0.14 0.28 0.23
94 INT185142 Rnpep Regulation of Snrpd1 1 0.01 0 0.22
95 INT74437 Negative_regulation of Cpe Positive_regulation of Localization of INS 1 0.06 0 0.2
96 INT74431 Negative_regulation of Cpe Positive_regulation of Localization of PENK 1 0.44 0 0.2
97 INT74439 Negative_regulation of Cpe Positive_regulation of INS 1 0.06 0 0.2
98 INT74436 Negative_regulation of Cpe Positive_regulation of CHGA 1 0.44 0 0.2
99 INT74434 Negative_regulation of Cpe Positive_regulation of PENK 1 0.44 0 0.2
100 INT270947 Cpe Negative_regulation of Phosphorylation of Slc6a3 1 0.25 0 0.2
101 INT223424 Binding of Rnpep and Lta4h 1 0.02 0.37 0.19
102 INT215167 Phosphorylation of Prkaca Positive_regulation of P2rx2 1 0.06 0.13 0.18
103 INT178269 Slc11a2 Regulation of a 1 0.06 0.97 0.16
104 INT105253 Positive_regulation of Binding of Rnpep and F2rl1 1 0.02 0 0.15
105 INT105252 Binding of Rnpep and F2rl1 1 0.01 0 0.15
106 INT336665 Binding of P2rx1 and P2rx2 1 0.07 0 0.14
107 INT204159 Slc11a2 Regulation of Gene_expression of HAMP 1 0.11 1.08 0.14
108 INT288701 Epas1 Regulation of Transcription of Slc11a2 1 0.29 0.38 0.13
109 INT215169 Ptger2 Regulation of P2rx2 1 0.19 0.31 0.11
110 INT227547 Hspa9 Regulation of Gene_expression of Rnpep 1 0.02 0.31 0.08
111 INT227546 Hspa9 Regulation of Rnpep 1 0.01 0.31 0.08
112 INT270983 Binding of Cpe and GSTK1 1 0.01 0.12 0.07
113 INT317426 Binding of CSF2 and PML 1 0.08 1.25 0.06
114 INT223426 Binding of Rnpep and Npepo 1 0.00 0 0.03
115 INT270956 Slc6a3 Positive_regulation of Cpe 1 0.29 0 0.03
116 INT197784 Binding of Cpe and Ptgs1 1 0.20 0 0.03
117 INT270941 Slc6a3 Positive_regulation of Binding of Cpe 1 0.29 0 0.03
118 INT134563 Cpe Positive_regulation of Gene_expression of Ifng 1 0.39 0 0
119 INT223428 Binding of Cndp2 and Rnpep 1 0.02 0 0
120 INT197762 Binding of KRT5 and Cpe 1 0.19 1.14 0
121 INT197760 Binding of C4a and Cpe 1 0.01 1.14 0
122 INT74438 POMC Positive_regulation of Binding of Cpe 1 0.44 0 0
123 INT74432 Binding of POMC and Cpe 1 0.27 0 0
124 INT281097 Binding of P2rx3 and P2rx2 1 0.06 0 0
125 INT134560 Cpe Negative_regulation of Gene_expression of Il2 1 0.17 0 0
126 INT134562 Cpe Regulation of Gene_expression of Ifng 1 0.30 0 0
127 INT69257 Drd2 Regulation of Gene_expression of Cpe 1 0.06 0 0
128 INT249828 Foxm1 Positive_regulation of Transcription of BIRC5 1 0.56 0.12 0
129 INT74435 Binding of PENK and Cpe 1 0.27 0 0
130 INT134561 Cpe Negative_regulation of Gene_expression of Il4 1 0.11 0 0
131 INT296725 Binding of P2rx2 and Afm 1 0.10 0 0
132 INT280483 Binding of Bdnf and Cpe 1 0.01 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cobalt ion binding. They are ordered first by their pain relevance and then by number of times they were reported in cobalt ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67
2 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16
3 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
4 INT1487 Regulation of Cpe 68 0.62 10.24 52.91
5 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22
6 INT5214 Localization of Cpe 49 0.73 13.3 44.36
7 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4
8 INT2699 Binding of Cpe 40 0.48 7.07 33.64
9 INT91285 Negative_regulation of P2rx2 29 0.57 12.74 15.48
10 INT92839 Regulation of P2rx2 36 0.45 13.19 15.38
11 INT17938 Binding of Cpe 28 0.48 11.17 13.62
12 INT22003 Negative_regulation of Cpe 25 0.58 6.23 12.94
13 INT78234 Positive_regulation of Gene_expression of P2rx2 18 0.69 12.86 12.75
14 INT5959 Protein_catabolism of Cpe 17 0.90 0.98 12.43
15 INT12372 Negative_regulation of Localization of Cpe 12 0.53 1.85 11.39
16 INT11208 Gene_expression of Cpe 23 0.78 2.42 11.09
17 INT105304 Negative_regulation of Gene_expression of P2rx2 11 0.28 11.07 9.53
18 INT116705 Positive_regulation of Positive_regulation of P2rx2 13 0.49 9.44 9.47
19 INT20425 Localization of Cpe 23 0.81 5.18 9.14
20 INT9387 Positive_regulation of Cpe 27 0.70 3.99 8.87
21 INT14033 Negative_regulation of Gene_expression of Cpe 10 0.33 3.47 8.2
22 INT9389 Regulation of Cpe 14 0.61 2.23 7.79
23 INT38466 Positive_regulation of Localization of Cpe 7 0.29 1.36 7.2
24 INT120261 Binding of P2rx2 19 0.28 5.8 6.72
25 INT62691 Transcription of Cpe 11 0.40 3.5 6.66
26 INT25822 Negative_regulation of Positive_regulation of Cpe 7 0.29 2.43 6.02
27 INT105306 Regulation of Gene_expression of P2rx2 7 0.21 6.92 5.22
28 INT20064 Regulation of Gene_expression of Cpe 9 0.47 2.05 5.16
29 INT148649 Transcription of P2rx2 8 0.43 8.11 4.79
30 INT15450 Positive_regulation of Gene_expression of Cpe 11 0.34 4.53 4.34
31 INT11872 Protein_catabolism of Rnpep 6 0.87 0 4
32 INT215163 Phosphorylation of P2rx2 19 0.60 1.43 3.62
33 INT81830 Localization of P2rx2 14 0.73 5.42 3.16
34 INT54364 Negative_regulation of Protein_catabolism of Cpe 4 0.53 0.15 3.14
35 INT21343 Regulation of Localization of Cpe 3 0.21 1.38 2.83
36 INT12051 Negative_regulation of Rnpep 7 0.36 0.42 2.59
37 INT9455 Negative_regulation of Rnpep 5 0.31 0.52 2.47
38 INT1488 Negative_regulation of Negative_regulation of Cpe 3 0.42 0.86 2.42
39 INT5958 Positive_regulation of Positive_regulation of Cpe 3 0.38 0.58 2.39
40 INT9386 Transcription of Cpe 7 0.72 0.53 2.31
41 INT9354 Negative_regulation of Binding of Cpe 3 0.21 0.09 2.3
42 INT148648 Negative_regulation of Transcription of P2rx2 3 0.29 3.54 1.94
43 INT87315 Negative_regulation of Transcription of Cpe 3 0.13 1.76 1.81
44 INT64737 Regulation of Regulation of Cpe 1 0.05 0 1.8
45 INT68196 Protein_catabolism of Rnpep 2 0.07 0 1.76
46 INT91560 Positive_regulation of Negative_regulation of Cpe 2 0.40 0.62 1.67
47 INT97062 Binding of PML 10 0.41 11.63 1.65
48 INT168726 Negative_regulation of Positive_regulation of P2rx2 1 0.07 0.09 1.44
49 INT9454 Gene_expression of Rnpep 5 0.65 0.58 1.43
50 INT168727 Negative_regulation of Negative_regulation of P2rx2 1 0.07 0.09 1.43
51 INT111755 Regulation of Positive_regulation of Cpe 1 0.03 0.27 1.37
52 INT142815 Regulation of Regulation of P2rx2 4 0.33 0.69 1.33
53 INT11207 Positive_regulation of Gene_expression of Cpe 3 0.46 0.17 1.33
54 INT11871 Gene_expression of Rnpep 4 0.23 1.88 1.29
55 INT20424 Protein_catabolism of Cpe 3 0.52 0 1.28
56 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21
57 INT122783 Regulation of Transcription of Cpe 2 0.20 0.21 1.21
58 INT154813 Regulation of Transcription of P2rx2 2 0.26 2.38 1.17
59 INT234422 Gene_expression of PML 14 0.75 15.93 1.14
60 INT215499 Positive_regulation of Phosphorylation of P2rx2 3 0.37 0.57 1.07
61 INT39012 Positive_regulation of Rnpep 3 0.44 0.09 0.98
62 INT12888 Positive_regulation of Protein_catabolism of Cpe 1 0.55 0.21 0.94
63 INT39226 Positive_regulation of Negative_regulation of Cpe 2 0.45 0.17 0.93
64 INT41480 Positive_regulation of Binding of Cpe 1 0.15 0.42 0.92
65 INT132883 Gene_expression of Slc11a2 5 0.75 2.96 0.89
66 INT321014 Regulation of Protein_catabolism of Rnpep 1 0.02 0 0.89
67 INT262726 Localization of PML 6 0.57 7.13 0.72
68 INT39013 Negative_regulation of Protein_catabolism of Rnpep 1 0.36 0 0.69
69 INT14063 Gene_expression of RNPEP 1 0.04 0 0.66
70 INT135376 Negative_regulation of Regulation of Cpe 1 0.32 0.13 0.66
71 INT23039 Positive_regulation of Transcription of Cpe 1 0.46 0.06 0.6
72 INT33926 Negative_regulation of Gene_expression of Cpe 2 0.31 0 0.59
73 INT69252 Positive_regulation of Transcription of Cpe 2 0.09 0 0.58
74 INT215501 Positive_regulation of Binding of P2rx2 3 0.37 0.61 0.56
75 INT107819 Positive_regulation of Localization of P2rx2 1 0.24 0.66 0.55
76 INT270969 Regulation of Gene_expression of Cpe 1 0.27 0 0.55
77 INT84880 Regulation of Rnpep 3 0.34 0.15 0.52
78 INT15961 Positive_regulation of Protein_catabolism of Rnpep 1 0.40 0 0.49
79 INT30936 Regulation of Protein_catabolism of Cpe 1 0.35 0.16 0.48
80 INT23152 Regulation of Localization of Cpe 1 0.45 0.1 0.46
81 INT105987 Negative_regulation of Protein_catabolism of Cpe 1 0.04 0 0.45
82 INT40182 Regulation of Binding of Cpe 1 0.01 0 0.41
83 INT321021 Positive_regulation of Rnpep 1 0.02 0 0.4
84 INT42846 Regulation of Binding of Cpe 1 0.01 0 0.38
85 INT23153 Positive_regulation of Positive_regulation of Cpe 1 0.50 0 0.36
86 INT270972 Phosphorylation of Cpe 1 0.33 0 0.33
87 INT217405 Regulation of Positive_regulation of P2rx2 1 0.32 0 0.33
88 INT36120 Positive_regulation of RNPEP 1 0.25 0 0.33
89 INT215492 Negative_regulation of Phosphorylation of P2rx2 1 0.31 0 0.31
90 INT33578 Regulation of Negative_regulation of Cpe 1 0.04 0 0.3
91 INT336951 Positive_regulation of Binding of PML 1 0.09 2.02 0.28
92 INT289317 Positive_regulation of Localization of PML 1 0.23 1.09 0.26
93 INT160516 Positive_regulation of Transcription of P2rx2 1 0.13 0.2 0.24
94 INT278513 Regulation of Localization of PML 1 0.34 1.73 0.24
95 INT45590 Localization of Rnpep 2 0.51 0 0.15
96 INT204148 Regulation of Gene_expression of Slc11a2 1 0.15 1.1 0.15
97 INT288681 Regulation of Transcription of Slc11a2 1 0.44 0.37 0.13
98 INT288683 Transcription of Slc11a2 1 0.69 0.37 0.13
99 INT288682 Binding of Slc11a2 1 0.47 0 0.12
100 INT349072 Positive_regulation of Gene_expression of PML 1 0.13 1.49 0.1
101 INT282824 Regulation of PML 3 0.44 2.66 0.09
102 INT9388 Regulation of Transcription of Cpe 1 0.45 0.38 0.09
103 INT238499 Negative_regulation of BIRC5 1 0.23 1.66 0.08
104 INT223420 Binding of Rnpep 1 0.03 0 0.04
105 INT356186 Positive_regulation of Regulation of PML 1 0.49 1.14 0.04
106 INT249820 Transcription of BIRC5 1 0.67 0.12 0
107 INT249818 Gene_expression of BIRC5 1 0.65 0.12 0
108 INT330665 Negative_regulation of PML 1 0.13 1.15 0
109 INT249819 Positive_regulation of Gene_expression of BIRC5 1 0.49 0.12 0
110 INT249821 Positive_regulation of BIRC5 1 0.45 0.12 0
111 INT223414 Negative_regulation of Negative_regulation of Rnpep 1 0.02 0 0
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