GO:0050999

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Name regulation of nitric-oxide synthase activity
Categary Process
Go Slim No
Go Link GO:0050999
Unique Molecular Interactions 438
Total Molecular Interactions 648
Total Single Events 5232
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of nitric-oxide synthase activity. They are ordered first by their pain relevance and then by number of times they were reported for regulation of nitric-oxide synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
3 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
4 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
5 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
6 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
7 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
8 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
9 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
10 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
11 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
12 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
13 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
14 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
15 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
16 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
17 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
18 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
19 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
20 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
21 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
22 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
23 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
24 INT258798 Binding of NR3C1 and HSP90AA1 1 0.01 1.09 0.78
25 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
26 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
27 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
28 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
29 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
30 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
31 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
32 INT278228 Binding of MBNL1 and NOS3 1 0.05 2.06 0.54
33 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
34 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
35 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
36 INT352892 Binding of CAV1 and ITGA2 1 0.20 1.61 0.47
37 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
38 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
39 INT69637 Binding of CAV1 and Zfp354a 1 0.00 0 0.46
40 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
41 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
42 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
43 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
44 INT146274 Binding of Rasd1 and Nos1ap 1 0.33 0.18 0.41
45 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
46 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
47 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
48 INT146272 Binding of Nos1 and Nos1ap 1 0.28 0.2 0.39
49 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
50 INT261058 Binding of CALM3 and CHR 1 0.04 0.14 0.38
51 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
52 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
53 INT80444 Binding of EDNRA and SPR 1 0.05 0.1 0.36
54 INT278226 Binding of FOSB and NOS3 1 0.03 1.22 0.36
55 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
56 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
57 INT279705 CALM3 Regulation of TRPV4 2 0.08 0 0.33
58 INT324525 PGE Positive_regulation of Positive_regulation of Egfr 1 0.41 1.05 0.33
59 INT324522 PGE Positive_regulation of Phosphorylation of Egfr 1 0.56 1.04 0.33
60 INT324524 PGE Positive_regulation of Egfr 1 0.38 1.05 0.33
61 INT337410 AKT3 Negative_regulation of AKT1 1 0.09 0.49 0.32
62 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
63 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
64 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
65 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
66 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
67 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
68 INT166093 Negative_regulation of ROS1 Negative_regulation of Positive_regulation of EGFR 1 0.12 0.33 0.28
69 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
70 INT261056 Binding of CALM3 and PLA2G6 1 0.09 0 0.27
71 INT261045 Negative_regulation of Binding of CALM3 and PLA2G6 1 0.10 0 0.27
72 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26
73 INT130056 PPARG Positive_regulation of CAV1 1 0.02 0.53 0.25
74 INT261052 CALM3 Regulation of VIP 1 0.00 0.06 0.25
75 INT246576 EEF1A2 Negative_regulation of Negative_regulation of NOSTRIN 1 0.04 0.63 0.24
76 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24
77 INT171126 Lta Positive_regulation of NOSTRIN 1 0.01 0.76 0.24
78 INT171124 Spg7 Positive_regulation of NOSTRIN 1 0.01 0.76 0.24
79 INT325008 TNF Negative_regulation of Gene_expression of NOSTRIN 1 0.00 1.78 0.23
80 INT325007 TNF Negative_regulation of NOSTRIN 1 0.00 1.78 0.23
81 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23
82 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
83 INT272753 Positive_regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.23
84 INT281901 Binding of KNG1 and NOS3 1 0.05 0.17 0.22
85 INT309729 CALM3 Regulation of TRPV1 1 0.04 0 0.22
86 INT7332 CALM3 Positive_regulation of ADCY1 1 0.46 0.13 0.21
87 INT120716 Binding of AKT1 and TEP1 1 0.05 0.46 0.21
88 INT146271 Nos1ap Positive_regulation of Positive_regulation of Rasd1 1 0.34 0.08 0.21
89 INT352355 Binding of CNR1 and EGFR 1 0.19 0.76 0.2
90 INT145152 Binding of EGF and EGFR 4 0.15 2.45 0.19
91 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19
92 INT137417 MAPK7 Regulation of Gene_expression of NOS3 1 0.00 0.5 0.19
93 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
94 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
95 INT121582 AKT1 Regulation of Gene_expression of GDF15 1 0.21 0.4 0.18
96 INT318324 Binding of AKT1 and PRKCA 1 0.03 0.63 0.18
97 INT176133 AKT1 Regulation of BCL2 2 0.12 1.84 0.17
98 INT105334 PTGER1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.66 0.17
99 INT176134 AKT1 Regulation of Gene_expression of BIRC3 1 0.08 1.09 0.17
100 INT269333 Binding of BDKRB2 and NOS3 1 0.02 0 0.17
101 INT331768 Binding of Arg1 and NOSTRIN 1 0.01 0.6 0.17
102 INT352354 EGFR Regulation of Gene_expression of CNR1 1 0.23 1.16 0.17
103 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
104 INT112132 Gast Positive_regulation of Positive_regulation of Egfr 1 0.33 0.13 0.16
105 INT155644 Binding of CAV1 and HSD11B1 1 0.39 0.77 0.15
106 INT261055 Negative_regulation of Binding of CALM3 and CHR 1 0.04 0 0.14
107 INT249829 CHI3L1 Positive_regulation of AKT1 1 0.47 0.69 0.14
108 INT298639 GDE1 Negative_regulation of AKT1 1 0.00 1.14 0.14
109 INT175401 Binding of EGFR and VEGFA 2 0.13 1.49 0.13
110 INT178446 Binding of Egfr and ras 1 0.04 0.13 0.13
111 INT178431 Positive_regulation of Binding of Egfr and ras 1 0.05 0.13 0.13
112 INT309743 Binding of CA2 and CALM3 1 0.04 0 0.13
113 INT309747 CALM3 Regulation of TRPV5 1 0.03 0 0.13
114 INT309742 CALM3 Regulation of TRPV3 1 0.04 0 0.13
115 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13
116 INT302156 AKT1 Positive_regulation of E2F2 1 0.02 0.88 0.13
117 INT309733 CALM3 Regulation of TRPV6 1 0.01 0 0.13
118 INT299310 RPTOR Positive_regulation of AKT1 1 0.30 0 0.12
119 INT269332 Binding of NOS3 and TMPO 1 0.01 0 0.12
120 INT341828 Binding of BTC and EGFR 1 0.22 0.95 0.12
121 INT315829 Binding of EGFR and TKT 1 0.03 1.14 0.12
122 INT171390 Src Positive_regulation of Phosphorylation of Egfr 1 0.13 0 0.11
123 INT105338 Prkaca Positive_regulation of AKT1 1 0.04 0.93 0.11
124 INT272750 Prkaca Positive_regulation of EGFR 1 0.02 0 0.11
125 INT171385 Ppp1cc Positive_regulation of Phosphorylation of Egfr 1 0.15 0 0.11
126 INT272752 Regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.11
127 INT302161 AKT1 Negative_regulation of CASP9 1 0.03 0.87 0.11
128 INT176130 AKT1 Regulation of Gene_expression of COX18 1 0.13 0.82 0.11
129 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1
130 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
131 INT291353 IL8 Positive_regulation of Binding of EGFR 1 0.32 0.52 0.1
132 INT184814 NOS3 Positive_regulation of Gene_expression of NOS1 1 0.09 0.54 0.1
133 INT343858 Binding of AKT1 and MYD88 1 0.02 0.26 0.1
134 INT356272 Egf Negative_regulation of Gene_expression of Egfr 1 0.15 0.2 0.1
135 INT220743 Binding of AR and EGFR 1 0.01 0.46 0.1
136 INT291351 Binding of EGFR and SHC1 1 0.05 0.57 0.1
137 INT281899 Binding of ANG and NOS3 1 0.12 0.37 0.1
138 INT252790 Binding of NOS1 and NOS3 1 0.03 0.37 0.1
139 INT309725 Gene_expression of CALM3 Negative_regulation of Positive_regulation of TRPC6 1 0.07 0 0.1
140 INT291350 IL8 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.52 0.1
141 INT192249 Angpt1 Positive_regulation of Localization of NOS3 1 0.01 0.46 0.09
142 INT231273 Binding of Egfr and Nrg1 1 0.12 0 0.09
143 INT145153 JUN Positive_regulation of EGFR 1 0.24 0.94 0.09
144 INT230857 Negative_regulation of Binding of HSP90AA1 and NOS1 1 0.05 1.18 0.09
145 INT145154 Positive_regulation of JUN Positive_regulation of EGFR 1 0.24 0.95 0.09
146 INT252803 Binding of NOS3 and ISYNA1 1 0.02 0.32 0.09
147 INT192248 Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
148 INT192250 Positive_regulation of Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
149 INT230856 Binding of HSP90AA1 and NOS1 1 0.04 1.17 0.09
150 INT302167 PTGER2 Positive_regulation of EGFR 1 0.10 3.08 0.09
151 INT309738 CALM3 Positive_regulation of CA2 1 0.04 0 0.08
152 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
153 INT249332 GPNMB Positive_regulation of EGFR 1 0.17 2.63 0.08
154 INT309737 Binding of CALM3 and Positive_regulation of CA2 1 0.04 0 0.08
155 INT265882 IGF1 Positive_regulation of Transcription of AKT1 1 0.08 1.13 0.07
156 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07
157 INT120569 Binding of Egfr and Pik3r1 1 0.40 1.22 0.06
158 INT120570 Positive_regulation of Binding of Egfr and Pik3r1 1 0.55 1.22 0.06
159 INT221368 EGFR Regulation of Gene_expression of MUC1 1 0.05 3.82 0.06
160 INT275105 CALM3 Positive_regulation of Prkcg 1 0.00 0 0.06
161 INT309748 CALM3 Regulation of CA2 1 0.02 0 0.06
162 INT210146 Binding of EGFR and TXN 1 0.15 0.09 0.06
163 INT309732 CALM3 Positive_regulation of Gene_expression of TRPV4 1 0.14 0 0.06
164 INT309752 CALM3 Positive_regulation of Gene_expression of CA2 1 0.04 0 0.06
165 INT339105 ERBB2 Positive_regulation of EGFR 1 0.37 0.68 0.06
166 INT251774 Negative_regulation of TXK Negative_regulation of EGFR 1 0.07 1.06 0.06
167 INT279290 EGFR Regulation of CDCP1 1 0.01 0.98 0.05
168 INT220537 HSPG2 Positive_regulation of NOSTRIN 1 0.04 0 0.05
169 INT183853 Gene_expression of CAV1 Negative_regulation of Positive_regulation of MAPK1 1 0.28 0.25 0.05
170 INT302165 PTGER2 Positive_regulation of Localization of EGFR 1 0.06 1.73 0.05
171 INT249193 Negative_regulation of CA2 Negative_regulation of Binding of AKT1 1 0.03 0.08 0.05
172 INT193966 AKT1 Negative_regulation of Gsk3b 1 0.05 0.75 0.05
173 INT193969 AKT1 Negative_regulation of Phosphorylation of Gsk3b 1 0.05 0.75 0.05
174 INT328429 PRB4 Negative_regulation of Gene_expression of AKT1 1 0.03 0.52 0.05
175 INT355583 Binding of EGFR and ANGPTL4 1 0.12 2.14 0.05
176 INT120573 Positive_regulation of Binding of Egfr and Gab1 1 0.63 1.22 0.05
177 INT120572 Positive_regulation of Binding of Egfr and Cltc 1 0.38 1.21 0.05
178 INT355589 Binding of EGFR and LTBP1 1 0.11 2.15 0.05
179 INT299302 Negative_regulation of RPTOR Regulation of AKT1 1 0.30 0.1 0.05
180 INT120571 Binding of Egfr and Gab1 1 0.44 1.21 0.05
181 INT120568 Binding of Egfr and Cltc 1 0.28 1.21 0.05
182 INT309730 Binding of CALM3 and TYRP1 1 0.01 0 0.05
183 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
184 INT299304 RPTOR Regulation of AKT1 1 0.19 0.1 0.05
185 INT328434 PRB4 Negative_regulation of AKT1 1 0.02 0.29 0.05
186 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04
187 INT89384 Negative_regulation of INS Positive_regulation of AKT1 2 0.36 1.37 0.04
188 INT188737 Egfr Positive_regulation of EGFR 1 0.21 0.6 0.04
189 INT249170 Binding of AKT1 and ARHGDIA 1 0.00 0.15 0.04
190 INT213901 EGFR Positive_regulation of ERBB2 1 0.52 0.41 0.04
191 INT225259 Egfr Regulation of Gene_expression of S100a7a 1 0.04 0.98 0.04
192 INT302166 Positive_regulation of PTGER2 Positive_regulation of EGFR 1 0.07 1.49 0.04
193 INT261057 Binding of CALM3 and CHGA 1 0.04 0.14 0.04
194 INT186097 EGF Positive_regulation of Positive_regulation of EGFR 1 0.20 0.38 0.04
195 INT200645 Binding of AKT1 and TBK1 1 0.02 0.43 0.04
196 INT350434 Negative_regulation of HSP90AA1 Positive_regulation of Gene_expression of ATF3 1 0.32 2.44 0.04
197 INT352356 Gene_expression of CNR1 Positive_regulation of Gene_expression of EGFR 1 0.24 0.95 0.04
198 INT302291 Positive_regulation of EGFR Positive_regulation of Myc 1 0.18 1.3 0.04
199 INT347291 Binding of AKT1 and CCL16 1 0.06 0.99 0.04
200 INT188735 EGFR Positive_regulation of Egfr 1 0.21 0.6 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of nitric-oxide synthase activity. They are ordered first by their pain relevance and then by number of times they were reported in regulation of nitric-oxide synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
2 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
3 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
4 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
5 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
6 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
7 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
8 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
9 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05
10 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
11 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27
12 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68
13 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
14 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92
15 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
16 INT152347 Binding of GCH1 8 0.37 6.13 7.36
17 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
18 INT11154 Binding of EGFR 149 0.48 96.23 6.29
19 INT163776 Regulation of GCH1 7 0.27 4.58 6.16
20 INT97018 Binding of CALM3 7 0.43 0.13 5.82
21 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
22 INT111594 Positive_regulation of Gene_expression of NOSTRIN 20 0.32 8.69 5
23 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
24 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
25 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
26 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
27 INT153666 Gene_expression of CAV1 156 0.77 120.99 3.9
28 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
29 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
30 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
31 INT70958 Binding of NOS3 19 0.37 11.84 3.29
32 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
33 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12
34 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11
35 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
36 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07
37 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
38 INT91869 Transcription of NOS3 13 0.67 6.81 2.86
39 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
40 INT150933 Negative_regulation of Positive_regulation of GCH1 3 0.58 1.8 2.77
41 INT150932 Positive_regulation of Gene_expression of GCH1 3 0.70 2.07 2.57
42 INT165434 Regulation of SPR 4 0.24 2.14 2.33
43 INT283973 Transcription of GCH1 1 0.61 1.99 2.33
44 INT110304 Negative_regulation of Gene_expression of NOSTRIN 6 0.55 2.22 2.27
45 INT283975 Negative_regulation of Localization of GCH1 1 0.38 1.99 2.27
46 INT118791 Binding of AKT1 32 0.48 15.51 2.25
47 INT96856 Localization of NOSTRIN 8 0.49 6.39 2.19
48 INT103917 Positive_regulation of Phosphorylation of Egfr 12 0.68 7.23 2.18
49 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
50 INT82166 Regulation of NOS3 14 0.54 7.57 2.08
51 INT91594 Localization of NOS3 12 0.78 5.39 2.02
52 INT258637 Regulation of Gene_expression of GCH1 1 0.62 1.77 2.02
53 INT65545 Localization of EGFR 35 0.79 20.8 1.88
54 INT112131 Positive_regulation of Positive_regulation of Egfr 10 0.49 9.95 1.85
55 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
56 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82
57 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81
58 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75
59 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73
60 INT94892 Regulation of NOSTRIN 7 0.31 2.99 1.72
61 INT7333 Localization of CALM3 4 0.72 0.4 1.55
62 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54
63 INT167894 Negative_regulation of PTS 3 0.14 3.96 1.54
64 INT125320 Negative_regulation of HSP90AA1 20 0.45 23.93 1.42
65 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41
66 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37
67 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34
68 INT127725 Negative_regulation of Positive_regulation of EGFR 6 0.57 2.69 1.3
69 INT62896 Binding of NOSTRIN 4 0.30 2.86 1.3
70 INT45175 Gene_expression of PTS 5 0.56 1.46 1.24
71 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
72 INT135556 Localization of AKT1 38 0.69 12.78 1.17
73 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15
74 INT139764 Negative_regulation of CAV1 10 0.58 6.57 1.14
75 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13
76 INT283974 Negative_regulation of Transcription of GCH1 1 0.38 0.99 1.13
77 INT283972 Localization of GCH1 1 0.67 0.99 1.13
78 INT283976 Positive_regulation of Binding of GCH1 1 0.45 1.27 1.13
79 INT133898 Binding of HSP90AA1 17 0.30 8.83 1.12
80 INT118293 Regulation of Phosphorylation of EGFR 2 0.61 1.01 1.1
81 INT159477 Phosphorylation of NOS3 14 0.72 1.54 1.08
82 INT97017 Regulation of Binding of CALM3 2 0.40 0 1.06
83 INT150931 Negative_regulation of GCH1 6 0.59 1.23 1.05
84 INT97383 Positive_regulation of Positive_regulation of NOSTRIN 2 0.08 1.53 1.05
85 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04
86 INT7338 Negative_regulation of CALM3 5 0.34 0.19 1
87 INT86384 Negative_regulation of Localization of EGFR 4 0.43 2.5 0.97
88 INT73960 Regulation of Gene_expression of NOSTRIN 3 0.54 1.41 0.97
89 INT97014 Regulation of CALM3 1 0.55 0 0.97
90 INT97020 Negative_regulation of Regulation of CALM3 1 0.52 0 0.97
91 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96
92 INT80450 Positive_regulation of SPR 3 0.41 0.9 0.93
93 INT153670 Positive_regulation of Gene_expression of CAV1 26 0.69 44.27 0.92
94 INT144415 Regulation of Positive_regulation of Egfr 2 0.27 0.42 0.86
95 INT117347 Positive_regulation of Positive_regulation of EGFR 15 0.69 11.17 0.84
96 INT144416 Regulation of Egfr 5 0.57 4.97 0.83
97 INT171361 Regulation of Egfr 16 0.62 8.36 0.81
98 INT144414 Positive_regulation of Positive_regulation of Egfr 1 0.49 0.65 0.8
99 INT7335 Positive_regulation of CALM3 6 0.36 0.28 0.79
100 INT131286 Binding of Egfr 26 0.44 13.58 0.78
101 INT138955 Transcription of EGFR 18 0.71 11.39 0.78
102 INT83375 Gene_expression of CALM3 3 0.58 1.57 0.78
103 INT130057 Positive_regulation of CAV1 12 0.65 8.96 0.77
104 INT186119 Protein_catabolism of EGFR 6 0.98 3.68 0.76
105 INT165430 Gene_expression of SPR 2 0.59 1.27 0.75
106 INT114604 Positive_regulation of Acvr2a 2 0.41 0 0.73
107 INT152562 Regulation of Transcription of NOS3 1 0.23 0.34 0.71
108 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7
109 INT153667 Localization of CAV1 15 0.76 11.92 0.68
110 INT299338 Negative_regulation of Regulation of AKT1 2 0.31 2.32 0.68
111 INT186117 Negative_regulation of Protein_catabolism of EGFR 1 0.42 0.67 0.68
112 INT186118 Positive_regulation of Protein_catabolism of EGFR 1 0.68 0.66 0.68
113 INT69349 Transcription of NOSTRIN 2 0.50 0.49 0.66
114 INT166024 Protein_catabolism of AKT1 5 0.46 2.6 0.64
115 INT146258 Regulation of Nos1ap 1 0.39 0.24 0.63
116 INT199029 Binding of SPR 2 0.06 0.85 0.6
117 INT131001 Regulation of CAV1 6 0.44 3.77 0.59
118 INT123131 Negative_regulation of Negative_regulation of AKT1 6 0.42 3.23 0.58
119 INT159476 Positive_regulation of Phosphorylation of NOS3 6 0.44 1.43 0.58
120 INT165846 Regulation of HSP90AA1 4 0.27 2.19 0.58
121 INT174274 Positive_regulation of Localization of NOSTRIN 2 0.09 2.35 0.58
122 INT94564 Positive_regulation of Negative_regulation of NOSTRIN 1 0.38 0.35 0.57
123 INT320644 Binding of Egfr 7 0.34 5.9 0.56
124 INT128460 Gene_expression of Nos1ap 2 0.59 0.32 0.54
125 INT91864 Negative_regulation of Transcription of NOS3 4 0.54 1.41 0.48
126 INT103916 Negative_regulation of Phosphorylation of Egfr 12 0.59 7.03 0.47
127 INT153672 Negative_regulation of Negative_regulation of CAV1 1 0.25 0.2 0.46
128 INT142943 Phosphorylation of Egfr 5 0.81 1.56 0.45
129 INT142942 Positive_regulation of Phosphorylation of Egfr 4 0.68 1.52 0.45
130 INT169355 Localization of Egfr 6 0.75 3.24 0.43
131 INT159479 Positive_regulation of Binding of NOS3 2 0.50 0.63 0.41
132 INT97384 Negative_regulation of Positive_regulation of NOSTRIN 3 0.12 0.93 0.4
133 INT307593 Localization of PTS 1 0.67 0.4 0.4
134 INT146259 Binding of Nos1ap 1 0.32 0.2 0.39
135 INT80449 Negative_regulation of SPR 1 0.24 0.08 0.38
136 INT185350 Negative_regulation of Gene_expression of Egfr 24 0.59 13.21 0.35
137 INT163277 Negative_regulation of Gene_expression of CAV1 17 0.56 10.77 0.35
138 INT138954 Regulation of Transcription of EGFR 2 0.27 0.82 0.35
139 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33
140 INT186115 Negative_regulation of Negative_regulation of EGFR 5 0.57 3.42 0.33
141 INT173213 Regulation of PTS 2 0.38 2.18 0.31
142 INT146267 Positive_regulation of Nos1ap 1 0.43 0.14 0.27
143 INT146264 Negative_regulation of Nos1ap 1 0.37 0.15 0.27
144 INT261086 Positive_regulation of Negative_regulation of CALM3 1 0.16 0 0.26
145 INT233915 Protein_catabolism of NOSTRIN 1 0.02 1.6 0.24
146 INT323315 Gene_expression of LYPLA1 1 0.50 1.23 0.24
147 INT246583 Negative_regulation of Negative_regulation of NOSTRIN 1 0.04 0.63 0.24
148 INT304603 Positive_regulation of HSP90AA1 1 0.26 7.01 0.24
149 INT223597 Negative_regulation of Binding of EGFR 12 0.43 7.97 0.23
150 INT100914 Binding of PTS 5 0.36 3.81 0.21
151 INT200666 Transcription of AKT1 8 0.66 4.23 0.2
152 INT269409 Regulation of Phosphorylation of NOS3 1 0.18 0 0.2
153 INT92815 Positive_regulation of Negative_regulation of NOS3 1 0.12 1.03 0.2
154 INT269403 Regulation of Positive_regulation of NOS3 1 0.18 0 0.17
155 INT131000 Positive_regulation of Positive_regulation of CAV1 1 0.49 0 0.17
156 INT185352 Regulation of Gene_expression of Egfr 5 0.62 2.33 0.16
157 INT176153 Regulation of Negative_regulation of AKT1 3 0.39 2.13 0.16
158 INT171378 Negative_regulation of Binding of Egfr 3 0.43 1.48 0.16
159 INT171365 Negative_regulation of Regulation of Egfr 1 0.33 0.06 0.16
160 INT135557 Positive_regulation of Localization of AKT1 3 0.46 0.49 0.15
161 INT144682 Negative_regulation of Regulation of Egfr 1 0.43 0.41 0.15
162 INT128459 Regulation of Gene_expression of Nos1ap 1 0.22 0.1 0.15
163 INT163278 Regulation of Gene_expression of CAV1 5 0.45 4.36 0.14
164 INT175416 Regulation of Negative_regulation of EGFR 4 0.60 3.94 0.14
165 INT302248 Negative_regulation of Binding of AKT1 2 0.25 1 0.14
166 INT299514 Localization of Egfr 2 0.37 0.38 0.14
167 INT83316 Positive_regulation of LYPLA1 3 0.50 0.56 0.13
168 INT94893 Regulation of Positive_regulation of NOSTRIN 1 0.01 0.51 0.13
169 INT146270 Positive_regulation of Gene_expression of Nos1ap 1 0.35 0.08 0.13
170 INT285902 Positive_regulation of Transcription of AKT1 1 0.06 0.6 0.13
171 INT222585 Transcription of Acvr2a 1 0.16 0 0.13
172 INT102355 Gene_expression of HSP90AA1 8 0.51 5.2 0.12
173 INT233419 Negative_regulation of Positive_regulation of Egfr 2 0.40 0.97 0.12
174 INT269395 Regulation of Binding of NOS3 2 0.39 1.84 0.12
175 INT7334 Positive_regulation of Localization of CALM3 1 0.42 0.17 0.12
176 INT186558 Negative_regulation of Positive_regulation of NOS3 2 0.37 0.26 0.1
177 INT219647 Negative_regulation of Negative_regulation of Egfr 1 0.19 0.13 0.1
178 INT309767 Negative_regulation of Gene_expression of CALM3 1 0.13 0 0.1
179 INT192238 Positive_regulation of Localization of NOS3 2 0.21 0.76 0.09
180 INT309756 Positive_regulation of Gene_expression of CALM3 1 0.14 0 0.09
181 INT192239 Positive_regulation of Binding of AKT1 2 0.26 0.91 0.08
182 INT226648 Negative_regulation of Positive_regulation of Egfr 1 0.10 0 0.08
183 INT211211 Positive_regulation of Negative_regulation of Egfr 1 0.50 1.36 0.08
184 INT229184 Regulation of Protein_catabolism of EGFR 1 0.25 1.11 0.08
185 INT266934 Regulation of Binding of EGFR 3 0.45 1.16 0.07
186 INT182302 Negative_regulation of Localization of AKT1 5 0.39 3.52 0.06
187 INT234206 Localization of HSP90AA1 4 0.68 2.89 0.06
188 INT234211 Regulation of Negative_regulation of HSP90AA1 2 0.27 1.13 0.06
189 INT299512 Regulation of Localization of Egfr 1 0.13 0.11 0.06
190 INT189245 Binding of LYPLA1 1 0.02 0.56 0.06
191 INT205021 Positive_regulation of Gene_expression of Egfr 3 0.64 4.15 0.05
192 INT279191 Regulation of Negative_regulation of Egfr 2 0.45 1.44 0.05
193 INT234207 Negative_regulation of Binding of HSP90AA1 2 0.26 0.84 0.05
194 INT183275 Positive_regulation of Regulation of EGFR 1 0.36 0.21 0.05
195 INT185349 Transcription of Egfr 8 0.72 4.01 0.04
196 INT314252 Transcription of CAV1 1 0.50 0.07 0.04
197 INT185347 Negative_regulation of Transcription of Egfr 1 0.59 1.1 0.04
198 INT222608 Negative_regulation of Gene_expression of Acvr2a 3 0.10 0.29 0.03
199 INT300989 Positive_regulation of Negative_regulation of AKT1 2 0.41 1.27 0.03
200 INT183878 Negative_regulation of Positive_regulation of CAV1 1 0.41 0.16 0.03
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