GO:0051000

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Name positive regulation of nitric-oxide synthase activity
Categary Process
Go Slim No
Go Link GO:0051000
Unique Molecular Interactions 1210
Total Molecular Interactions 1698
Total Single Events 15202
Pain Genes Associated 25

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of nitric-oxide synthase activity. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of nitric-oxide synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
3 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
4 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
5 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
6 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
7 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
8 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
9 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
10 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
11 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
12 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
13 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
14 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
15 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
16 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
17 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
18 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
19 INT158079 Binding of Esr1 and Gper 1 0.31 0.97 1.35
20 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
21 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
22 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
23 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
24 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
25 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
26 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
27 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
28 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
29 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
30 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
31 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96
32 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
33 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
34 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
35 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
36 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
37 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
38 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
39 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
40 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87
41 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
42 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
43 INT41859 Agtr2 Regulation of Cck 1 0.00 0 0.84
44 INT41860 Agtr2 Regulation of Vip 1 0.02 0 0.84
45 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
46 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
47 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
48 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
49 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
50 INT101439 Cck Positive_regulation of Agtr2 1 0.24 0.33 0.8
51 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
52 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
53 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77
54 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
55 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
56 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
57 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
58 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
59 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
60 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
61 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
62 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
63 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
64 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
65 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
66 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
67 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
68 INT9824 Binding of Agtr2 and Bcl2a1a 1 0.16 0.24 0.64
69 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
70 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
71 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
72 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
73 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
74 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
75 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
76 INT74395 Htr2b Negative_regulation of Pdyn 1 0.03 0 0.61
77 INT297344 Apoe Regulation of Binding of Alms1 1 0.08 1.1 0.61
78 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
79 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
80 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
81 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59
82 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
83 INT144864 Htr2b Positive_regulation of Localization of Gh1 1 0.48 0 0.58
84 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
85 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
86 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
87 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
88 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
89 INT50883 Binding of AGTR2 and ALB 1 0.37 0.19 0.56
90 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
91 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
92 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
93 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
94 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
95 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
96 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
97 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
98 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
99 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
100 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
101 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
102 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
103 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52
104 INT311767 INS Negative_regulation of Gene_expression of SLC1A3 1 0.52 0 0.52
105 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
106 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
107 INT150833 Esr1 Positive_regulation of Localization of Prkce 1 0.08 0.29 0.51
108 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
109 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5
110 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
111 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5
112 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
113 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
114 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
115 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
116 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
117 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
118 INT101001 GHRH Regulation of Localization of INS 1 0.28 0 0.47
119 INT155881 Binding of CDX2 and KRAS 1 0.40 1.51 0.47
120 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
121 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
122 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
123 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
124 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46
125 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
126 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
127 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
128 INT136749 COX5A Positive_regulation of Gene_expression of SCARB1 1 0.52 0.36 0.45
129 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44
130 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
131 INT213027 Binding of Apoa1 and Scarb1 6 0.09 7.52 0.43
132 INT346218 Positive_regulation of Kras Positive_regulation of Phosphorylation of Mdk 1 0.01 0.71 0.42
133 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
134 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
135 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
136 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
137 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
138 INT254760 Igh-Dex Positive_regulation of Gene_expression of Apoe 1 0.00 0 0.42
139 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42
140 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
141 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
142 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
143 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41
144 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
145 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
146 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
147 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
148 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
149 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
150 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
151 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
152 INT29052 Binding of INS and INSRR 1 0.02 0.23 0.4
153 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4
154 INT29053 Regulation of Binding of INS and INSRR 1 0.01 0.24 0.4
155 INT78621 PRL Positive_regulation of Localization of INS 2 0.06 0.5 0.39
156 INT291256 INS Negative_regulation of Positive_regulation of Mdk 1 0.01 1.65 0.39
157 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
158 INT199974 ESR1 Negative_regulation of Gene_expression of ITGB3BP 1 0.05 0.47 0.38
159 INT197591 Esr1 Regulation of Pgr 1 0.04 0 0.38
160 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
161 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
162 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
163 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
164 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
165 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
166 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
167 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
168 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35
169 INT291555 Binding of ESR1 and Dlat 1 0.01 0.6 0.35
170 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
171 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
172 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
173 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34
174 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34
175 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
176 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34
177 INT183785 INS Positive_regulation of Gene_expression of NFKBIB 1 0.03 1.83 0.34
178 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34
179 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34
180 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
181 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34
182 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
183 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
184 INT291554 Binding of ESR1 and St8sia2 1 0.01 0.49 0.33
185 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
186 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
187 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
188 INT337410 AKT3 Negative_regulation of AKT1 1 0.09 0.49 0.32
189 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
190 INT238895 Binding of CRP and INS 1 0.00 0.93 0.32
191 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
192 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 0.09 0.45 0.31
193 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
194 INT185072 Bpifa2 Regulation of Fcer2a 1 0.01 0.73 0.31
195 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
196 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
197 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
198 INT230752 Gene_expression of Agtr2 Positive_regulation of Gene_expression of Mcpt1 1 0.01 1.34 0.3
199 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3
200 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of nitric-oxide synthase activity. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of nitric-oxide synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT812 Localization of INS 1026 0.81 515.6 145.31
2 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
3 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
4 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
5 INT251 Regulation of INS 398 0.62 232.47 55.04
6 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
7 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
8 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
9 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
10 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
11 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
12 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
13 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
14 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
15 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
16 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
17 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
18 INT20462 Binding of ESR1 210 0.44 102.7 26.34
19 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
20 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
21 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
22 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
23 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
24 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
25 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
26 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
27 INT92354 Localization of ESR1 77 0.75 33.04 15.51
28 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15
29 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66
30 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
31 INT14572 Binding of INS 205 0.48 175.43 13.38
32 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
33 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
34 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
35 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
36 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
37 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59
38 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4
39 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
40 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
41 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
42 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
43 INT15687 Regulation of ESR1 91 0.60 40.42 7.95
44 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
45 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
46 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
47 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37
48 INT152347 Binding of GCH1 8 0.37 6.13 7.36
49 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
50 INT197493 Localization of Apoe 61 0.79 27.48 7.06
51 INT29583 Positive_regulation of Agtr2 30 0.45 21.47 7.04
52 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
53 INT110987 Transcription of ESR1 45 0.71 24.16 6.72
54 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
55 INT163776 Regulation of GCH1 7 0.27 4.58 6.16
56 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
57 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
58 INT63042 Binding of Apoe 59 0.48 31.23 5.88
59 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69
60 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
61 INT16621 Negative_regulation of Esr1 20 0.54 8.2 4.84
62 INT136754 Gene_expression of SCARB1 64 0.77 43.28 4.82
63 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7
64 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69
65 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
66 INT134657 Localization of Akt1 37 0.68 11.58 4.62
67 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57
68 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56
69 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
70 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41
71 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
72 INT75136 Binding of Akt1 27 0.27 8.81 4.15
73 INT68099 Positive_regulation of Agtr2 21 0.48 16.63 4.07
74 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
75 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
76 INT9822 Binding of Agtr2 9 0.36 3 3.93
77 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
78 INT17819 Regulation of Agtr2 10 0.51 9.33 3.9
79 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
80 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74
81 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
82 INT20461 Binding of Esr1 34 0.48 9.58 3.66
83 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
84 INT136692 Localization of Akt1 12 0.78 2.14 3.65
85 INT53706 Positive_regulation of Kras 13 0.67 9.26 3.57
86 INT39986 Regulation of Agtr2 13 0.45 10.39 3.55
87 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
88 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36
89 INT135815 Transcription of Gch1 1 0.60 0 3.32
90 INT72141 Binding of Apoe 11 0.37 10.91 3.27
91 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
92 INT97710 Localization of Apoe 1 0.79 7.18 3.2
93 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
94 INT73918 Transcription of Esr1 21 0.66 8.74 3.12
95 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
96 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05
97 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
98 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94
99 INT50765 Positive_regulation of Fcer2a 23 0.68 10.22 2.92
100 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
101 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
102 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88
103 INT31541 Regulation of Esr1 15 0.54 4.12 2.82
104 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
105 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
106 INT150933 Negative_regulation of Positive_regulation of GCH1 3 0.58 1.8 2.77
107 INT174727 Positive_regulation of Positive_regulation of ESR1 14 0.44 6.3 2.7
108 INT50080 Binding of APOE 38 0.45 29.61 2.67
109 INT214355 Binding of Akt1 13 0.36 3.72 2.59
110 INT150932 Positive_regulation of Gene_expression of GCH1 3 0.70 2.07 2.57
111 INT32421 Gene_expression of FCER2 19 0.73 17.23 2.53
112 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
113 INT111039 Gene_expression of Kras 20 0.60 15.42 2.39
114 INT283973 Transcription of GCH1 1 0.61 1.99 2.33
115 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
116 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
117 INT283975 Negative_regulation of Localization of GCH1 1 0.38 1.99 2.27
118 INT118791 Binding of AKT1 32 0.48 15.51 2.25
119 INT72890 Positive_regulation of Gene_expression of Fcer2a 12 0.17 6.81 2.25
120 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
121 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
122 INT135827 Positive_regulation of Transcription of Gch1 1 0.58 0 2.2
123 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
124 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17
125 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
126 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13
127 INT49731 Transcription of Agtr2 4 0.44 0.95 2.06
128 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
129 INT258637 Regulation of Gene_expression of GCH1 1 0.62 1.77 2.02
130 INT53036 Binding of Agtr2 9 0.33 3.74 1.99
131 INT73913 Regulation of Gene_expression of Esr1 2 0.41 2.24 1.92
132 INT218959 Negative_regulation of Protein_catabolism of ESR1 3 0.37 0.97 1.9
133 INT141002 Negative_regulation of Fcer2a 15 0.12 7.17 1.88
134 INT135820 Regulation of Gch1 1 0.59 0 1.88
135 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86
136 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
137 INT136752 Positive_regulation of Gene_expression of SCARB1 5 0.69 10.63 1.76
138 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
139 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
140 INT109975 Positive_regulation of Kras 14 0.45 12.72 1.68
141 INT96971 Positive_regulation of Gene_expression of Esr1 6 0.46 2.27 1.67
142 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61
143 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
144 INT112668 Positive_regulation of Gene_expression of Agtr2 7 0.50 3.8 1.58
145 INT161217 Positive_regulation of Htr2b 1 0.67 2.55 1.58
146 INT93624 Negative_regulation of Kras 3 0.41 1.15 1.52
147 INT68100 Positive_regulation of Positive_regulation of Agtr2 2 0.08 0.83 1.51
148 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5
149 INT143443 Localization of HIF1A 14 0.78 10.93 1.49
150 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4
151 INT29986 Binding of Fcer2a 9 0.27 4.34 1.38
152 INT97716 Transcription of Apoe 3 0.53 2.61 1.36
153 INT135822 Gene_expression of Gch1 2 0.50 0.77 1.35
154 INT92383 Gene_expression of KRAS 38 0.65 32.94 1.32
155 INT44147 Positive_regulation of Gene_expression of Agtr2 11 0.50 9.02 1.28
156 INT8511 Localization of Esr1 6 0.80 3.27 1.26
157 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24
158 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
159 INT114294 Negative_regulation of Gene_expression of Fcer2a 7 0.14 4.09 1.23
160 INT97715 Regulation of Gene_expression of Apoe 3 0.62 1.98 1.23
161 INT113336 Positive_regulation of Gene_expression of Apoe 3 0.70 1.79 1.23
162 INT60060 Positive_regulation of KRAS 17 0.67 11.68 1.21
163 INT824 Negative_regulation of Negative_regulation of ESR1 3 0.42 1.53 1.18
164 INT135556 Localization of AKT1 38 0.69 12.78 1.17
165 INT161216 Positive_regulation of Gene_expression of Htr2b 1 0.49 1.87 1.16
166 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15
167 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15
168 INT122891 Negative_regulation of Gch1 4 0.16 1.83 1.15
169 INT161219 Gene_expression of Htr2b 4 0.75 2.01 1.14
170 INT183046 Transcription of INS 25 0.70 11.14 1.13
171 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13
172 INT61100 Localization of Agtr2 7 0.51 2.53 1.13
173 INT283974 Negative_regulation of Transcription of GCH1 1 0.38 0.99 1.13
174 INT283972 Localization of GCH1 1 0.67 0.99 1.13
175 INT283976 Positive_regulation of Binding of GCH1 1 0.45 1.27 1.13
176 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
177 INT150931 Negative_regulation of GCH1 6 0.59 1.23 1.05
178 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05
179 INT102249 Binding of HIF1A 39 0.36 30.47 1.04
180 INT29985 Positive_regulation of Binding of Fcer2a 1 0.00 0 1.04
181 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
182 INT58470 Negative_regulation of Binding of INS 14 0.43 7.2 1.01
183 INT204058 Regulation of Gene_expression of Kras 4 0.24 7.54 1.01
184 INT111035 Positive_regulation of Gene_expression of Kras 5 0.31 3.31 0.99
185 INT71906 Regulation of Gene_expression of ESR1 22 0.41 11.01 0.98
186 INT97714 Negative_regulation of Localization of Apoe 1 0.58 1.83 0.97
187 INT154468 Negative_regulation of Transcription of ESR1 3 0.29 1.14 0.96
188 INT211557 Gene_expression of Scarb1 30 0.75 5.03 0.94
189 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
190 INT30157 Gene_expression of Htr2b 2 0.48 0 0.94
191 INT163508 Regulation of Gene_expression of Akt1 3 0.45 1.65 0.92
192 INT182513 Regulation of AGTR2 4 0.14 4.31 0.91
193 INT294479 Gene_expression of Scarb1 1 0.02 3.08 0.9
194 INT73914 Negative_regulation of Transcription of Esr1 3 0.39 0.75 0.84
195 INT174728 Positive_regulation of Transcription of ESR1 10 0.47 3.3 0.83
196 INT155352 Phosphorylation of HIF1A 3 0.79 3.34 0.83
197 INT125092 Negative_regulation of Binding of ESR1 8 0.42 4.15 0.82
198 INT67797 Localization of Fcer2a 2 0.51 0.06 0.81
199 INT100378 Protein_catabolism of HIF1A 7 0.96 5.05 0.8
200 INT142597 Regulation of Binding of Apoe 1 0.34 2.21 0.8
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